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| 1 | Sex determination and maintenance: the role DMRT1 and FOXL2显示文摘 | Shengsong Huang Leping Ye Haolin Chen | 2017 | Asian Journal of Andrology2017，19，6： | 8 |
| 2 | Soil erosion and sediment interception by check dams in a watershed for an extreme rainstorm on the Loess Plateau,China显示文摘The magnitude of soil erosion and sediment load reduction efficiency of check dams under extreme rainstorms is a long-standing concern.The current paper aims to use check dams to deduce the amount of soil erosion under extreme rainstorms in a watershed and to identify the difference in sediment interception efficiency of different types of check dams.Based on the sediment deposition at 12 check dams with 100% sediment interception efficiency and sub-catchment clustering by taking 12 damcontrolled catchments as clustering criteria,the amount of soil erosion resulting from an extreme rainstorm event on July 26,2017(named '7·26' extreme rainstorm) was estimated in the Chabagou watershed in the hill and gully region of the Loess Plateau.The differences in the sediment interception efficiency among the check dams in the watershed were analyzed according to field observations at 17 check dams.The results show that the average erosion intensity under the '7-26' extreme rainstorm was approximately 2.03×10~4 t/km^2,which was 5 times that in the second largest erosive rainfall in 2017(4.15×10~3 t/km^2) and 11-384 times that for storms in 2018(0.53×10~2 t/km^2-1.81×10~3 t/km^2).Under the '7-26' extreme rainstorm,the amount of soil erosion in the Chabagou watershed above the Caoping hydrological station was 4.20 × 106 t.The sediment interception efficiency of the check dams with drainage canals(including the destroyed check dams) and with drainage culverts was 6.48 and 39.49%,respectively.The total actual sediment amount trapped by the check dams was 1.11 × 106 t,accounting for 26.36% of the total amount of soil erosion.In contrast,3.09×106 t of sediment were input to the downstream channel,and the sediment deposition in the channel was 2.23×10~6 t,accounting for 53.15%of the total amount of soil erosion.The amount of sediment transport at the hydrological station was8.60×10~5 t.The Sediment Delivery Ratio(SDR) under the '7·26' extreme rainstorm was 0.21.The results indicated that the amount of soil erosion was huge,and the sediment interception efficiency of the check dams was greatly reduced under extreme rainstorms.It is necessary to strengthen the management and construction technology standards of check dams to improve the sediment interception efficiency and flood safety in the watershed. | Leichao Bai Nan Wang Juying Jiao Yixian Chen Bingzhe Tang Haolin Wang Yulan Chen Xiqin Yan Zhijie Wang | 2020 | International Journal of Sediment Research2020，35，4： | 7 |
| 3 | Rational design of hierarchically porous Fe-N-doped carbon as efficient electrocatalyst for oxygen reduction reaction and Zn-air batteries显示文摘The rational design and construction of hierarchically porous nanostructure for oxygen reduction reaction (ORR) electrocatalysts is crucial to facilitate the exposure of accessible active sites and promote the mass/electron transfer under the gas-solid-liquid triple-phase condition. Herein, an ingenious method through the pyrolysis of creative polyvinylimidazole coordination with Zn/Fe salt precursors is developed to fabricate hierarchically porous Fe-N-doped carbon framework as efficient ORR electrocatalyst. The volatilization of Zn species combined with the nanoscale Kirkendall effect of Fe dopants during the pyrolysis build the hierarchical micro-, meso-, and macroporous nanostructure with a high specific surface area (1,586 m^(2)·g^(−1)), which provide sufficient exposed active sites and multiscale mass/charge transport channels. The optimized electrocatalyst exhibits superior ORR activity and robust stability in both alkaline and acidic electrolytes. The Zn-air battery fabricated by such attractive electrocatalyst as air cathode displays a higher peak power density than that of Pt/C-based Zn-air battery, suggesting the great potential of this electrocatalyst for Zn-air batteries. | Zihan Meng Neng Chen Shichang Cai Jiawei Wu Rui Wang Tian Tian Haolin Tang | 2021 | Nano Research2021，14，12： | 4 |
| 4 | 2D nanomaterials for tissue engineering application显示文摘Recently,tissue engineering has developed into a powerful tool for repairing and reconstructing damaged tissues and organs.Tissue engineering scaffolds play a vital role in tissue engineering,as they not only provide structural support for targeted cells but also serve as templates that guide tissue regeneration and control the tissue structure.Over the past few years,owing to unique physicochemical properties and excellent biocompatibility,various types of two-dimensional(2D)nanomaterials have been developed as candidates for the construction of tissue engineering scaffolds,enabling remarkable achievements in bone repair,wound healing,neural regeneration,and cardiac tissue engineering.These efforts have significantly advanced the development of tissue engineering.In this review,we summarize the latest advancements in the application of 2D nanomaterials in tissue engineering.First,each typical 2D nanomaterial is introduced briefly,followed by a detailed description of its applications in tissue engineering.Finally,the existing challenges and prospects for the future of the application of 2D nanomaterials in tissue engineering are discussed. | Jingyang Zhang Haolin Chen Meng Zhao Guiting Liu Jun Wu | 2020 | Nano Research2020，13，8： | 3 |
| 5 | Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid显示文摘The development of two-dimensional(2D)transition metal dichalcogenides has been in a rapid growth phase for the utilization in surface-enhanced Raman scattering(SERS)analysis.Here,we report a promising 2D transition metal tellurides(TMTs)material,hafnium ditelluride(HfTe2),as an ultrasensitive platform for Raman identification of trace molecules,which demonstrates extraordinary SERS activity in sensitivity,uniformity,and reproducibility.The highest Raman enhancement factor of 2.32×10^(6)is attained for a rhodamine 6G molecule through the highly efficient charge transfer process at the interface between the HfTe2 layered structure and the adsorbed molecules.At the same time,we provide an effective route for large-scale preparation of SERS substrates in practical applications via a facile stripping strategy.Further application of the nanosheets for reliable,rapid,and label-free SERS fingerprint analysis of uric acid molecules,one of the biomarkers associated with gout disease,is performed,which indicates arresting SERS signals with the limits of detection as low as 0.1 mmol/L.The study based on this type of 2D SERS substrate not only reveals the feasibility of applying TMTs to SERS analysis,but also paves the way for nanodiagnostics,especially early marker detection. | YANG LI HAOLIN CHEN YANXIAN GUO KANGKANG WANG YUE ZHANG PEILIN LAN JINHAO GUO WEN ZHANG HUIQING ZHONG ZHOUYI GUO ZHENGFEI ZHUANG ZHIMING LIU | 2021 | Photonics Research2021，9，6： | 2 |
| 6 | Effect of surgical factors on the augmentation of cementinjectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite显示文摘Bone cement-augmented pedicle screw system demonstrates great efficacy in spinal disease treatments. However, the intrinsic drawbacks associated with clinically used polymethylmethacrylate (PMMA) cement demands for new bone cement formulations. On the basis of our previous studies, a novel injectable and biodegradable calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was systematically evaluated for its surgical feasibility and biomechanical performance by simulated and animal osteoporotic bone models, and the results were compared with those of clinical PMMA cement. ASTM-standard solid foam and open-cell foam models and decalcified sheep vertebra models were employed to evaluate the augmentation effects of CPN on bone tissue and on the cement-injected cannulated pedicle screws (CICPs) placed in osteoporotic bone. Surgical factors in CICPs application, such as injection force, tapping technique, screw diameter, and pedicle screw loosening scenarios, were studied in comparison with those in PMMA. When directly injected to the solid foam model, CPN revealed an identical augmentation effect to that of PMMA, as shown by the similar compressive strengths (0.73 ± 0.04 MPa for CPN group vs. 0.79 ± 0.02 MPa for PMMA group). The average injection force of CPN at approximately 40-50 N was higher than that of PMMA at approximately 20 N. Although both values are acceptable to surgeons, CPN revealed a more consistent injection force pattern than did PMMA. The dispersing and anti-pullout ability of CPN were not affected by the surgical factors of tapping technique and screw diameter. The axial pullout strength of CPN evaluated by the decalcified sheep vertebra model revealed a similar augmentation level as that of PMMA (1351.6 ± 324.2 N for CPN vs. 1459.7 ± 304.4 N for PMMA). The promising results of CPN clearly suggest its potential for replacing PMMA in CICPs augmentation application and the benefits of further study and development for clinical uses. | Haolin Sun Chun Liu Shunlun Chen Yanjie Bai Huilin Yang Chunde Li Lei Yang | 2019 | Frontiers of Medicine2019，13，5： | 2 |
| 7 | Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics显示文摘Effective cancer treatment puts high demands for cancer theranostics.For cancer diagnostics,optical coherence tomography(OCT)technology(including photothermal optical coherence tomography(PT-OCT))has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes(such as temperature change for PT-OCT).In this report,redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent.Briefly,black phosphorus quantum dots(BPQDs)are incorporated into cysteine-based poly-(disulfide amide)(Cys-PDSA)to form stable and biodegradable nanoagent.The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles(NPs)as a novel contrast agent for high-resolution PT-OCT bioimaging.The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo.And the obtained NPs exhibit excellent near-infrared(NIR)photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform,with very low chemo drug dosage and side effects.Both of the polymer and BPQD are degradable,indicating this platform is a rare PT-OCT agent that is completely biodegradable.Overall,our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy. | Haolin Chen Zhiming Liu Bo Wei Jun Huang Xinru You Jingyang Zhang Zhiling Yuan Zhilie Tang Zhouyi Guo Jun Wu | 2021 | Bioactive Materials2021，6，3： | 1 |
| 8 | Pervasive hybridization during evolutionary radiation of Rhododendron subgenus Hymenanthes in mountains of southwest China显示文摘Radiations are especially important for generating species biodiversity in mountainous ecosystems.The contribution of hybridization to such radiations has rarely been examined.Here,we use extensive genomic data to test whether hybridization was involved in evolutionary radiation within Rhododendron subgenus Hymenanthes,whose members show strong geographic isolation in the mountains of southwest China.We sequenced genomes for 143 species of this subgenus and 93 species of four other subgenera,and found that Hymenanthes was monophyletic and radiated during the late Oligocene to middle Miocene.Widespread hybridization events were inferred within and between the identified clades and subclades.This suggests that hybridization occurred both early and late during diversification of subgenus Hymenan thes,although the extent to which hybridization,speciation through mixing-isolation-mixing or hybrid speciation,accelerated the diversification needs further exploration.Cycles of isolation and contact in such and other montane ecosystems may have together promoted species radiation through hybridization between diverging populations and species.Similar radiation processes may apply to other montane floras in this region and elsewhere. | Yazhen Ma Xingxing Mao Ji Wang Lei Zhang Yuanzhong Jiang Yuying Geng Tao Ma Liming Cai Shuangquan Huang Pete Hollingsworth Kangshan Mao Minghui Kang Yiling Li Wenlu Yang Haolin Wu Yang Chen Charles C.Davis Nawal Shrestha Richard H.Ree Zhenxiang Xi Quanjun Hu Richard I.Milne Jianquan Liu | 2022 | National Science Review2022，9，12： | 1 |
| 9 | Diagnostic value of S100P for pancreatic cancer: a meta-analysis显示文摘 | Haolin Hu Qi Zhang Chenfei Huang Yi Shen Xundi Chen Xin Shi Wenhao Tang | 2014 | Tumor Biology2014，，10： | 1 |
| 10 | Fabrication of subunit nanovaccines by physical interaction显示文摘Vaccines can improve the quality of human life by preventing the burden of infectious diseases.Also,vaccination is becoming a powerful medication for preventing and treating tumors.Various vaccines have been developed based on the origin of the antigens.Herein,we focus on the subunit vaccines whose antigens are proteins or peptides.The advantage of subunit vaccines is safety for recipients;however,the immunogenicity of subunit antigens is relatively low.Nanoparticular delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes,and effectively present antigens to immune cells.Moreover,adding appropriate molecular adjuvants may strengthen the antigens to elicit immune response.In this perspective article,we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering materials.Herein we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines. | CHEN HaoLin LIU Hong LIU LiXin CHEN YongMing | 2022 | Science China(Technological Sciences)2022，65，5： | 1 |
| 11 | Laser peening-A processing tool to sthrength metals or alloys to improve fatigue li retiree and retard stress-induced corrosion eracking显示文摘 | Lloyd H Chen Haolin | 2003 | Laser Sience and Technology2003，，： | 1 |
| 12 | The basis of a more contagious 501Y.V1 variant of SARS-CoV-2显示文摘Dear Editor,The SARS-CoV-2 virus has infected over one hundred million people(COVID-19 patients)and caused more than two million deaths to date.The number of infected people continues to grow quickly,emphasizing the need for rapid use of effective vaccines.Although two mRNA vaccines based on Spike protein(produced by Pfizer-BioNTech and MODERNA)have been approved for emergency use in the US,1,2 the increasing Spike variants that have appeared around the world raise concerns about the continued efficacy of the vaccines.3 Monoclonal antibodies,developed by Regeneron and Eli Lilly,specifically targeting the native form of Spike have been approved by the FDA for emergency use.4,5 An N501Y variant(Y501)of the Spike protein of SARS-CoV-2(B.1.1.7,20I/501Y.V1),first emerged in UK and has now spread to the rest of the world.This variant appears to be much more contagious than the original N501 version.3 Furthermore,Y501 mutation is also found in a variant(B.1.351,20H/501Y.V2)from South Africa and a variant(P1,20J/501Y.V3)from Brazil.3 Unfortunately,this mutation is located at the interaction surface between the RBD and human Angiotensin Converting Enzyme 2(ACE2).6 Thus,the Y501 variation present in B.1.1.7,20I/501Y.V1 might affect the binding ability of the RBD to bind ACE2.We therefore compared the binding affinity of N501 and Y501 RBD for ACE2,uncovering that the affinity for ACE2 of the Y501-RBD was~10 fold higher than that of the N501 version.This may account,at least in part,for the greater infectivity of SARS-CoV-2 with this mutation.Structural modeling data showed that Y501-RBD can form an additional aromatic ring–ring interaction and an additional hydrogen bond with ACE2 by comparison with the RBD of the wild type.In spite of this,sera from individuals immunized with the Pfizer-BioNTech vaccine still efficiently block ACE2 binding to Y501-RBD.Furthermore,Bamlanivimab,the recently FDA approved therapeutic antibody drug for treatment of COVID-19 patients4 still binds the variant Y501-RBD as efficiently as it binds the N501-RBD,giving hope that treatment with the existing monoclonal antibodies may still help COVID-19 patients. | Haolin Liu Qianqian Zhang Pengcheng Wei Zhongzhou Chen Katja Aviszus John Yang Walter Downing Chengyu Jiang Bo Liang Lyndon Reynoso Gregory PDowney Stephen KFrankel John Kappler Philippa Marrack Gongyi Zhang | 2021 | Cell Research2021，31，6： | 1 |
| 13 | Parallel grinding error for a noncoaxial nonaxisymmetric aspheric lens using a fixture with adjustable gradient显示文摘 | Jiang Chen Guo Yinbiao Li Haolin | 2013 | International Journal of Advanced manufacturing Technology2013，66，14： | 1 |
| 14 | Laser Peening--A Processing Tool to Strengthen Metals or Alloys to Improve Fatigue Lifetime and Retard Stress--Induced Corrosion Cracking 显示文摘 | Hackel L A Chen Haolin | 2003 | Laser Science and Technology2003，，9： | 1 |
| 15 | Optimized weak measurement of orbital angular momentum-induced beam shifts in optical reflection显示文摘Tiny but universal beam shifts occur when a polarized light beam is reflected upon a planar interface.Although the beam shifts of Gaussian beams have been measured by the weak measurement technique, the weak measurement for orbital angular momentum(OAM)-induced spatial shifts of vortex beams is still missing.Here, by elaborately choosing the preselection and postselection states, the tiny OAM-induced Goos–H?nchen and Imbert–Fedorov shifts are amplified at an air–prism interface. The maximum shifts along directions both parallel and perpendicular to the incident plane are theoretically predicted and experimentally verified with optimal preselection and postselection states. These maximum shifts can be used to determine the OAM of vortex beams. | Wenjin Long Jintao Pan Xinyi Guo Xiaohe Liu Haolin Lin Huadan Zheng Jianhui Yu Heyuan Guan Huihui Lu Yongchun Zhong Shenhe Fu Li Zhang Wenguo Zhu Zhe Chen | 2019 | Photonics Research2019，7，11： | 1 |
| 16 | Ionic Liquid Modified Inorganic Nanoparticles for Gaseous Phenol Adsorption显示文摘Ionic liquid modified silica nanoparticles were synthesized using a simple silane chemistry,followed by substitution reaction. The phenol adsorption performance was tested using temperature programmed desorption technique. The experimental results reveal that the introduction of ionic liquids on the surface of silica nanoparticles can improve the adsorption capacity of phenol compared to the pure silica nanoparticles.The initial adsorption capacity reaches 0.312 mmol·g^-1 at 25 ℃ under total pressure of 0.2 bar and it decreases slightly in the following adsorption-desorption cycles. The results demonstrate that introduction of ionic liquids can improve the phenol adsorption capacity and the simple material preparation process is feasible for industrial applications. | 宋旭艳 LI Dan 李冉 CHEN Yikun HUANG Long WEI Min PAN Xi ZHOU Hongshen TANG Haolin | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 1 |
| 17 | GCR-Net:3D Graph convolution-based residual network for robust reconstruction in cerenkov luminescence tomography显示文摘Cerenkov Luminescence Tomography(CLT)is a novel and potential imaging modality which can display the three-dimensional distribution of radioactive probes.However,due to severe ill-posed inverse problem,obtaining accurate reconstruction results is still a challenge for traditional model-based methods.The recently emerged deep learning-based methods can directly learn the mapping relation between the surface photon intensity and the distribution of the radioactive source,which effectively improves the performance of CLT reconstruction.However,the previously proposed deep learning-based methods cannot work well when the order of input is disarranged.In this paper,a novel 3D graph convolution-based residual network,GCR-Net,is proposed,which can obtain a robust and accurate reconstruction result from the photon intensity of the surface.Additionally,it is proved that the network is insensitive to the order of input.The performance of this method was evaluated with numerical simulations and in vivo experiments.The results demonstrated that compared with the existing methods,the proposed method can achieve efficient and accurate reconstruction in localization and shape recovery by utilizing threedimensional information. | Weitong Li Mengfei Du Yi Chen Haolin Wang Linzhi Su Huangjian Yi Fengjun Zhao Kang Li Lin Wang Xin Cao | 2023 | Journal of Innovative Optical Health Sciences2023，16，1： | 0 |
| 18 | A Frost Heaving Prediction Approach for Ground Uplift Simulation Due to Freeze-Sealing Pipe Roof Method显示文摘Freeze-sealing pipe roof method is applied in the Gongbei tunnel,which causes the ground surface uplift induced by frost heave.A frost heaving prediction approach based on the coefficient of cold expansion is proposed to simulate the ground deformation of the Gongbei tunnel.The coefficient of cold expansion in the model and the frost heaving rate from the frost heave test under the hydration condition can achieve a good correspondence making the calculation result closer to the actual engineering.The ground surface uplift along the lateral and longitudinal direction are respectively analyzed and compared with the field measured data to validate the model.The results show that a good agreement between the frost heaving prediction model and the field measured data verifies the rationality and applicability of the proposed model.The maximum uplift of the Gongbei tunnel appears at the center of the model,gradually decreasing along with the lateral and longitudinal directions.The curve in the lateral direction presents a normal distribution due to the influence of the constraint of two sides,while the one along the lateral direction shapes like a parabola with the opening downward due to the temperature field distribution.The model provides a reference for frost heaving engineering calculation. | Shengjun Deng Haolin Chen Xiaonan Gong Jiajin Zhou Xiangdong Hu Gang Jiang | 2022 | Computer Modeling in Engineering & Sciences2022，，7： | 0 |
| 19 | A universal hydrochloric acid-assistant powder-to-powder strategy for quick and mass preparation of lead-free perovskite microcrystals显示文摘Lead-free halide perovskite materials possess low toxicity,broadband luminescence and robust stability compared with conventional lead-based perovskites,thus holding great promise for eyes-friendly white light LEDs.However,the traditionally used preparation methods with a long period and limited product yield have curtailed the commercialization of these materials.Here we introduce a universal hydrochloric acid-assistant powder-to-powder strategy which can accomplish the goals of thermal-,pressure-free,eco-friendliness,short time,low cost and high product yield,simultaneously.The obtained Cs_(2)Na_(0.9)Ag_(0.1)In_(0.95)Bi_(0.05)Cl_(6)microcrystals exhibit bright self-trapped excitons emission with quantum yield of(98.3±3.8)%,which could retain(90.5±1.3)%and(96.8±0.8)%after continuous heating or ultraviolet-irradiation for 1000 h,respectively.The phosphor converted-LED exhibited near-unity conversion efficiency from ultraviolet chip to self-trapped excitons emission at~200 mA.Various ions doping(such as Cs_(2)Na_(0.9)Ag_(0.1)InCl_(6):Ln^(3+))and other derived lead-free perovskite materials(such as Cs_(2)ZrCl_(6)and Cs_(4)MnBi_(2)Cl_(12))with high luminous performance are all realized by our proposed strategy,which has shown excellent availability towards commercialization. | Huanxin Yang Xiangxiang Chen Yiyue Chu Changjiu Sun Haolin Lu Mingjian Yuan Yuhai Zhang Guankui Long Libing Zhang Xiyan Li | 2023 | Light(Science & Applications)2023，12，4： | 0 |
| 20 | Metastable Iron Sulfides: A Versatile Antibacterial Candidate with Multiple Mechanisms against Bacterial Resistance显示文摘Bacterial infections pose an ongoing threat to global human health,an issue of growing urgency due to the emergence of resistance against many currently available antibiotics.Recently,the World Health Organization(WHO)launched a global appeal for the development of novel antibiotics to combat this issue.Ideal antibiotics should possess specific antibacterial effects,without causing resistance.However,the discovery of different antibiotics is lagging the development of drug-resistant bacteria.Many newly developed antibiotics not only are rapidly resisted by bacteria but also are ineffective against persistent bacteria embedded in biofilms and host cells.To tackle these challenges,innovative concepts and approaches are required for the discovery of novel antibacterial candidates.Agents for use against pathogenic bacteria were developed long before the discovery of antibiotics.For 3000 years,garlic has been considered an efficient antibacterial compound,utilized to prevent and treat bacterial infection worldwide,although the specific mechanisms remain unclear.Modern research shows that sulfur-containing chemicals are the primary active constituents of garlic and play key roles in its inherent antimicrobial activity,such as diallyl disulfide(DADS)and diallyl trisulfide(DATS).In contrast,inorganic sulfides for antibacterial use have not been deeply studied.It has been well-known that iron sulfides are an essential part of the geochemical and biological sulfur cycles.Both stable and metastable iron sulfides can be formed under abiotic sediment conditions and biotic process.In particular,certain bacteria species growth need iron sulfide as nutrient source or produce iron sulfide.In addition,iron sulfur clusters as special metastable iron sulfide take part in many important metabolic pathways in most organisms.These physicochemical and biological properties inspire us that iron sulfides are a type of valuable material for investigation and utilization.Below we will introduce a new antibacterial candidate based on iron sulfides,which kill bacteria via multiple mechanisms of action(MoAs).We will first discuss the types of iron sulfides with inherent antibacterial activity,i.e.,metastable species that can release iron ions and polysulfides in aqua.The intrinsic properties of iron sulfides and released iron and polysulfides are analyzed in regard to antibacterial effects under different physiological conditions.In particular,ferrous ion−polysulfide synergized ferroptosis-like death is proposed to kill bacteria with broad spectrum and selectivity.In addition,the versatile MoAs enable metastable iron sulfides(mFeSs)to kill resistant bacteria,eradicate biofilms,and suppress intracellular persistent species without causing new drug resistance.Importantly,the efficient antibacterial properties have been validated in animal models bearing infections including wounds,pneumonia,caries,and bacterial vaginosis,demonstrating great translational potential.Lastly,we will summarize the challenges of iron sulfides,proposing a possible development direction in the future.Our studies on iron sulfides can serve as a paradigm for the design and discovery of antibacterial nanomaterials,which may contribute for the war against drug-resistant pathogenic bacteria. | Haolin Cao Qian Wang Xiaonan Wang Lei Chen Jing Jiang Lizeng Gao | 2023 | Accounts of Materials Research2023，4，2： | 0 |
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