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| 1 | Reservoir-induced landslides and risk control in Three Gorges Project on Yangtze River,China显示文摘The Three Gorges region in China was basically a geohazard-prone area prior to construction of the Three Gorges Reservoir(TGR).After construction of the TGR,the water level was raised from 70 m to 175 m above sea level(ASL).and annual reservoir regulation has caused a 30-m water level difference after impoundment of the TGR since September 2008.This paper first presents the spatiotemporal distribution of landslides in six periods of 175 m ASL trial impoundments from 2008 to 2014.The results show that the number of landslides sharply decreased from 273 at the initial stage to less than ten at the second stage of impoundment.Based on this,the reservoir-induced landslides in the TGR region can be roughly classified into five failure patterns,i.e.accumulation landslide,dip-slope landslide,reversed bedding landslide,rockfall,and karst breccia landslide.The accumulation landslides and dip-slope landslides account for more than 90%.Taking the Shuping accumulation landslide(a sliding mass volume of 20.7 × 10~6 m^3) in Zigui County and the Outang dip-slope landslide(a sliding mass volume of about 90 × 10~6 m^3) in Fengjie County as two typical cases,the mechanisms of reactivation of the two landslides are analyzed.The monitoring data and factor of safety(FOS) calculation show that the accumulation landslide is dominated by water level variation in the reservoir as most part of the mass body is under 175 m ASL,and the dip-slope landslide is controlled by the coupling effect of reservoir water level variation and precipitation as an extensive recharge area of rainfall from the rear and the front mass is below 175 m ASL.The characteristics of landslide-induced impulsive wave hazards after and before reservoir impoundment are studied,and the probability of occurrence of a landslide-induced impulsive wave hazard has increased in the reservoir region.Simulation results of the Ganjingzi landslide in Wushan County indicate the strong relationship between landslide-induced surge and water variation with high potential risk to shipping and residential areas.Regarding reservoir regulation in TGR when using a single index,i.e.1-d water level variation,water resources are not well utilized,and there is also potential risk of disasters since 2008.In addition,various indices such as 1-d.5-d,and 10-d water level variations are proposed for reservoir regulation.Finally,taking reservoir-induced landslides in June2015 for example,the feasibility of the optimizing indices of water level variations is verified. | Yueping Yin Bolin Huang Wenpei Wang Yunjie Wei Xiaohan Ma Fei Ma Changjun Zhao | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，5： | 45 |
| 2 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 3 | Ductile deformation within Upper Himalaya Crystalline Sequence and geological implications,in Nyalam area,Southern Tibet显示文摘The South Tibet Detachment System(STDS) is a flat normal fault that separates the Upper Himalaya Crystalline Sequence(UHCS) below from the Tethyan Sedimentary Sequence(TSS) above.Timing of deformations related to the STDS is critical to understand the mechanism and evolution of the Himalaya collision zone.The Nyalam detachment(ND)(~86°E) locates in the middle portion of STDS(81°-89°E).Dating of deformed leucocratic dykes that are most probably syntectonic at different depth beneath the ND,allow us to constrain the timing of deformation.(1) Dyke T11N37 located ~3500 m structurally below the ND emplaced at 27.4± 0.2 Ma;(2) Dyke T11N32 located ~1400 m structurally below the ND emplaced at 22.0±0.3 Ma;(3) T11N25 located within the top to the north STD shear zone,~150 m structurally below the ND,emplaced at 17.1±0.2 Ma.Combining ND footwall cooling history and T11N25 deformation temperature,we indicate a probable onset of top to the north deformation at ~16 Ma at this location.These results show an upward younging of the probable timing of onset of the deformation at different structural distance below the ND.We then propose a new model for deformation migration below the ND with deformation starting by pure shear deformation at depth prior to ~27.5 Ma that migrates upward at a rate of ~ 0.3 mm/a until ~18 Ma when deformation switches to top to the north shearing in the South Tibet Detachment shear zone(STDsz).As deformation on the ND stops at 14-13 Ma this would imply that significant top to the North motion would be limited to less than 5 Ma and would jeopardize the importance of lower channel flow. | LIU XiaoBing LIU XiaoHan LELOUP P.H. MAHEO G. PAQUETTE J.L. ZHANG XinGang ZHOU XueJun | 2012 | Chinese Science Bulletin2012，57，26： | 14 |
| 4 | Petrology and ^(40)Ar/^(39)Ar iso-topic ages of blueschists in Gangmar, central Qiangtang, northern Tibet显示文摘The petrology and mineral assemblages of blueschists in the Gangmar, central Qiangtang, northern Tibet were examined, which indicates that the metamorphic condition is high-pressure low-temperature. In this note, we reported the 40Ar/39Ar dating results of glaucophane from two blueschist samples. Their apparent ages are (275.0±1.3) Ma and (287.6±2.3) Ma and similar isochron ages are (275.0±0.9) Ma and (282.4±0.8) Ma, respectively. These iso-topic datings show the high-pressure metamorphism occurring in Lower Permian. The ages also coincide with the evolution of Palaeo-Tethys ocean in Late Palaeozoic. | DENG Xiguang, DING Lin, LIU Xiaohan & ZHOU YongLaboratory of Lithospheric Tectonic Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2001 | Chinese Science Bulletin2001，46，5： | 13 |
| 5 | Puerarin reduces apoptosis in rat hippocampal neurons cultured in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways显示文摘OBJECTIVE: To investigate the neuroprotective effect of puerarin on rat hippocampal neurons cultured in high glucose medium, and to examine the role of the p38 mitogen activated protein kinase(p38 MAPK) and c-Jun N-terminal kinase(JNK) signaling pathways in this effect.METHODS: Primary cultures of hippocampal neurons were prepared from newborn Sprague Dawley rats. Neuron-specific enolase immunocytochemistry was used to identify neurons. The neurons were cultured with normal medium(control group) or with high-glucose medium(high-glucose group),and puerarin(puerarin group), a p38 MAPK inhibitor(SB239063; p38 MAPK inhibitor group) or a JNK inhibitor(SP600125; JNK inhibitor group) were added. After 72 h of treatment, terminal deoxynucleotidyl transferase-mediated d UTP nick end labeling assay was performed to detect apoptosis, and western blotting was used to assess protein levels of p-p38, p38, p-JNK and JNK.RESULTS: In the high-glucose group, the neuronal apoptosis rate and the p-p38/p38 and p-JNK/JNK ratios were higher than in the control group. The p38 MAPK and JNK inhibitors prevented this increase in the apoptosis rate. The apoptosis rates in the puerarin group, the p38 MAPK inhibitor group and the JNK inhibitor group were significantly decreased compared with the high-glucose group.Moreover, protein levels of p-p38 and p-JNK were significantly reduced, and the p-p38/p38 and p-JNK/JNK ratios were decreased in the puerarin group compared with the high-glucose group. In addition, compared with the high-glucose group,p-p38 levels and the p-p38/p38 ratio were reduced in the p38 MAPK inhibitor group, and p-JNK levels and the p-JNK/JNK ratio were decreased in the JNK inhibitor group.CONCLUSION: Puerarin attenuates neuronal apoptosis induced by high glucose by reducing the phosphorylation of p38 and JNK. | Xu Xiaohan Wang Jingbo Zhang Hong Tian Guoqing Liu Yuqin | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 13 |
| 6 | Abscisic Acid Receptors:Past,Present and Future显示文摘Abscisic acid(ABA) is the key plant stress hormone.Consistent with the earlier studies in support of the presence of both membrane-and cytoplasm-localized ABA receptors,recent studies have identified multi-ple ABA receptors located in various subcellular locations.These include a chloroplast envelope-localized receptor(the H subunit of Chloro-plast Mg2+-chelatase/ABA Receptor),two plasma membrane-localized receptors(G-protein Coupled Receptor 2 and GPCR-type G proteins),and one cytosol/nucleus-localized Pyrabactin Resistant(PYR)/PYR-Like(PYL)/Regulatory Component of ABA Receptor 1(RCAR).Although the downstream molecular events for most of the identified ABA receptors are currently unknown,one of them,PYR/PYL/RCAR was found to directly bind and regulate the activity of a long-known central regulator of ABA signaling,the A-group protein phosphatase 2C(PP2C).Together with the Sucrose Non-fermentation Kinase Subfamily 2(SnRK2s) protein kinases,a central signaling complex(ABA-PYR-PP2Cs-SnRK2s) that is responsible for ABA signal perception and transduction is supported by abundant genetic,physiological,biochemical and structural evidence.The identification of multiple ABA receptors has advanced our understanding of ABA signal perception and transduction while adding an extra layer of complexity. | Jianjun Guo Xiaohan Yang David J. Weston Jin-Gui Chen | 2011 | Journal of Integrative Plant Biology2011，53，6： | 13 |
| 7 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 8 | An Improved Dynamic Core for a Non-hydrostatic Model System on the Yin-Yang Grid显示文摘A 3D dynamic core of the non-hydrostatic model GRAPES(Global/Regional Assimilation and Prediction System) is developed on the Yin-Yang grid to address the polar problem and to enhance the computational efficiency. Three-dimensional Coriolis forcing is introduced to the new core, and full representation of the Coriolis forcing makes it straightforward to share code between the Yin and Yang subdomains. Similar to that in the original GRAPES model, a semi-implicit semi-Lagrangian scheme is adopted for temporal integration and advection with additional arrangement for cross-boundary transport. Under a non-centered second-order temporal and spatial discretization, the dry nonhydrostatic frame is summarized as the solution of an elliptical problem. The resulting Helmholtz equation is solved with the Generalized Conjugate Residual solver in cooperation with the classic Schwarz method. Even though the coefficients of the equation are quite different from those in the original model, the computational procedure of the new core is just the same. The bi-cubic Lagrangian interpolation serves to provide Dirichlet-type boundary conditions with data transfer between the subdomains. The dry core is evaluated with several benchmark test cases, and all the tests display reasonable numerical stability and computing performance. Persistency of the balanced flow and development of both the mountain-induced Rossby wave and Rossby–Haurwitz wave confirms the appropriate installation of the 3D Coriolis terms in the semi-implicit semi-Lagrangian dynamic core on the Yin-Yang grid. | LI Xiaohan PENG Xindong LI Xingliang | 2015 | Advances in Atmospheric Sciences2015，32，5： | 11 |
| 9 | Coal and rock fissure evolution and distribution characteristics of multi-seam mining显示文摘Henan Pingdingshan No.10 mine is prone to both coal and gas outbursts.The E_(9-10)coal seam is the main coal-producing seam but has poor quality ventilation,thus making it relatively difficult for gas extraction.The F_(15)coal seam,at its lower section,is not prone to coal and gas outbursts.The average seam separation distance of 150 m is greater than the upper limit for underside protective seam mining.Based on borehole imaging technology for field exploration of coal and rock fracture characteristics and discrete element numerical simulation,we have studied the evolution laws and distribution characteristics of the coal and rock fissure field between these two coal seams.By analysis of the influential effect of group F coal mining on the E_(9-10)coal seam,we have shown that a number of small fissures also develop in the area some 150 m above the overlying strata.The width and number of the fissures also increase with the extent of mining activity.Most of the fissures develop at a low angle or even parallel to the strata.The results show that the mining of the F_(15)coal seam has the effect of improving the permeability of the E_(9-10)coal seam. | Zhang Dongming Qi Xiaohan Yin Guangzhi Zheng Binbin | 2013 | International Journal of Mining Science and Technology2013，23，6： | 11 |
| 10 | Economic Optimization Dispatching Strategy of Microgrid for Promoting Photoelectric Consumption Considering Cogeneration and Demand Response显示文摘A system combining photovoltaic power generation and cogeneration is proposed to improve the photoelectric absorption capacity. First, a time-of-use price strategy is adopted to guide users to change their electricity consumption habits for participation in the demand response, and a demand response model is established. Then, particle swarm optimization(PSO)is used with the aim of minimizing the operation cost of the microgrid to achieve economic dispatching of the microgrid. This considers power balance equation constraints, unit operation constraints, energy storage constraints, and heat storage constraints. Finally, the simulation results show the improved level of photoelectric consumption using the proposed scheme and the economic benefits of the microgrid. | Chunxia Dou Xiaohan Zhou Tengfei Zhang Shiyun Xu | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 10 |
| 11 | Caspases control antiviral innate immunity显示文摘Caspases are a family of cysteine proteases whose functions have been scrutinized intensively in recent years.Beyond their established roles in programmed cell death and inflammatory response,some caspases are also fundamental players in antiviral immunity by fine-tuning the levels of antiviral signaling adapters and cytokines,such as type I interferons,which serves as a major,sophisticated weapon against viruses.Viral infections can result in inflammasome activation and the initiation of cell death,including apoptosis and pyroptosis,and multiple caspases are significantly involved in these processes.This review will focus on the cutting-edge discoveries regarding the multifaceted roles of caspases in antiviral innate immunity. | Huihui Chen Xiaohan Ning Zhengfan Jiang | 2017 | Cellular & Molecular Immunology2017，14，9： | 10 |
| 12 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 13 | The age of the plant fossil assemblage in the Liuqu Conglomerate of southern Tibet and its tectonic significance显示文摘Liuqu 集团企业,位于到 Yarlung Tsangbo 缝术地区(YTSZ ) 的南方,一套糖蜜在在印第安人和 Eurasion 的二个盘子之间的碰撞以后在喜玛拉雅的 orogenic 带的低岬盆被形成。大意义大意义构造进化和西藏高原的高举的历史。然而,这件糖蜜西装的年龄和它到在南部的西藏散布的另外的同步阶层的关联很长时间在大争论。特别在最近的年里,在它的年龄争论与这糖蜜的大沉积构造意义的识别猛烈地正在成长。在最近在这件糖蜜西装上执行的域工作期间,很多计划石块被发现阶层在这的上面的部分处于相当好的条件保存了,它具有在决定的大帮助是它的年龄。由鉴定,植物 fosils 的集合属于一条回归线代替在中间期间在北半球超级大陆的南部的边缘开发到以后的 Eocence 的回归线植物群,它能在它的形成年龄提供好限制。这篇论文是给植物集合和它的年龄的简短介绍,并且讨论他们的构造意义。 | FANG Aimin YAN Zhen LIU Xiaohan PAN Yusheng LI Jiliang YU Liangjun HUANG Feixing TAO Junrong | 2006 | Progress in Natural Science:Materials International2006，16，1： | 9 |
| 14 | Overview of China's Antarctic research progress 1984–2016显示文摘It is more than 30 years since the first Chinese National Antarctic Research Expedition(CHINARE) landed in Antarctica in 1984, representing China's initiation in polar research. This review briefly summarizes the Chinese Antarctic scientific research and output accomplished over the past 30 years. The developments and progress in Antarctic research and the enhancement of international scientific cooperation achieved through the implementation of the CHINARE program have been remarkable. Since the 1980 s, four permanent Chinese Antarctic research stations have been established successively and 33 CHINAREs have been completed. The research results have been derived from a series of spatiotemporal observations in association with various projects and multidisciplinary studies in the fields of oceanography, glaciology, geology, geophysics, geochemistry, atmospheric science, upper atmospheric physics, Antarctic astronomy, biology and ecology, human medicine, polar environment observation, and polar engineering. | CHEN Liqi LIU Xiaohan BIAN Lingen CHEN Bo HUANG Hongliang HU Hongqiao LUO Wei SHI Guitao SHI Jiuxin XU Chengli YANG Guang ZHAO Yue ZHANG Shaohua | 2017 | Advances in Polar Science2017，28，3： | 9 |
| 15 | A numerical simulation study on mechanical behaviour of coal with bedding planes under coupled static and dynamic load显示文摘To investigate the bedding influence on coal mechanical behaviour in underground environments such as coal or rock burst, simulations of dynamic SHPB tests of pre-stressed coal specimens with different bedding angles were carried out using a particle flow code 2-dimensional(PFC2D). Three impact velocities of 4, 8 and 12 m/s were selected to study dynamic behaviours of coal containing bedding planes under different dynamic loads. The simulation results showed that the existence of bedding planes leads to the degradation of the mechanical properties and their weakening effect significantly depends on the angle h between the bedding planes and load direction. With h increaseing from 0° to 90°, the strength first decreased and subsequently increased and specimens became most vulnerable when h was 30° or 45°.Five failure modes were observed in the specimens in the context of macro-cracks. Furthermore, energy characteristics combined with ultimate failure patterns revealed that maximum accumulated energy and failure intensity have a positive relation with the strength of specimen. When bedding planes were parallel or perpendicular to loading direction, specimens absorbed more energy and experienced more violent failure with increased number of cracks. In contrast, bedding planes with h of 30° or 45° reduced the specimens' ability of storing strain energy to the lowest with fewer cracks observed after failure. | Lihai Tan Ting Ren Xiaohan Yang Xueqiu He | 2018 | International Journal of Mining Science and Technology2018，28，5： | 7 |
| 16 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 17 | Water-use efficiency in response to simulated increasing precipitation in a temperate desert ecosystem of Xinjiang, China显示文摘Water-use efficiency(WUE) is a key plant functional trait that plays a central role in the global cycles of water and carbon. Although increasing precipitation may cause vegetation changes, few studies have explored the linkage between alteration in vegetation and WUE. Here, we analyzed the responses of leaf WUE, ecosystem carbon and water exchanges, ecosystem WUE, and plant community composition changes under normal conditions and also under extra 15% or 30% increases in annual precipitation in a temperate desert ecosystem of Xinjiang, China. We found that leaf WUE and ecosystem WUE showed inconsistent responses to increasing precipitation. Leaf WUE consistently decreased as precipitation increased. By contrast, the responses of the ecosystem WUE to increasing precipitation are different in different precipitation regimes: increasing by 33.9% in the wet year(i.e., the normal precipitation years)and decreasing by 4.1% in the dry year when the precipitation was about 30% less than that in the wet year.We systematically assessed the herbaceous community dynamics, community composition, and vegetation coverage to explain the responses of ecosystem WUE, and found that the between-year discrepancy in ecosystem WUE was consistent with the extent to which plant biomass was stimulated by the increase in precipitation. Although there was no change in the relative significance of ephemerals in the plant community, its greater overall plant biomass drove an increased ecosystem WUE under the conditions of increasing precipitation in 2011. However, the slight increase in plant biomass exerted no significant effect on ecosystem WUE in 2012. Our findings suggest that an alteration in the dominant species in this plant community can induce a shift in the carbon-and water-based economics of desert ecosystems. | HUANG Gang LI Yan MU Xiaohan ZHAO Hongmei CAO Yanfeng | 2017 | Journal of Arid Land2017，9，6： | 7 |
| 18 | DropConnect Regularization Method with Sparsity Constraint for Neural Networks显示文摘Drop Connect is a recently introduced algorithm to prevent the co-adaptation of feature detectors.Compared to Dropout, Drop Connect gains state-of-the-art results on several image recognition benchmarks. Motivated by the success of Drop Connect, we extended this algorithm with the ability of sparse feature selection. In Drop Connect algorithm, the dropping masks of weights are generated using Bernoulli gating variables that are independent of the weights and activations. We introduce a new strategy to generate masks depending on the outputs of previous layer. Using this method, neurons which are promising to produce sparser features will be assigned a bigger possibility to keep active in the forward and backward propagations. We then evaluate such sparsity constrained Drop Connect on MNIST and CIFAR datasets in comparison with ordinary Drop Connect and Dropout method. The results show that our new method improves the sparsity of features significantly, while not degrading the precision. | LIAN Zifeng JING Xiaojun WANG Xiaohan HUANG Hai TAN Youheng CUI Yuanhao | 2016 | Chinese Journal of Electronics2016，25，1： | 6 |
| 19 | Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution显示文摘Alveolar bone is the thickened ridge of jaw bone that supports teeth.It is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and immunomodulation.Alveolar bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling pattern.However,a systematic explanation of alveolar bone at single-cell level is still lacking.Here,we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing(scRNA-seq).A more active immune microenvironment is identified in alveolar bone,with a higher proportion of mature immune cells than in long bone.Among all immune cell populations,the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells(MSCs)subpopulation.Alveolar bone monocytes/macrophages express a higher level of Oncostatin M(Osm)compared to long bone,which promotes osteogenic differentiation and inhibits adipogenic differentiation of MSCs.In summary,our study reveals a unique immune microenvironment of alveolar bone,which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases. | Weimin Lin Qiwen Li Danting Zhang Xiaohan Zhang Xingying Qi Qian Wang Yaqian Chen Caojie Liu Hanwen Li Shiwen Zhang Yuan Wang Bin Shao Li Zhang Quan Yuan | 2021 | Bone Research2021，9，1： | 6 |
| 20 | Generatrix shape optimization of stiffened shells for low imperfection sensitivity显示文摘According to previous studies,stiffened shells with convex hyperbolic generatrix shape are less sensitive to imperfections.In this study,the effects of generatrix shape on the performances of elastic and plastic buckling in stiffened shells are investigated.Then,a more general description of generatrix shape is proposed,which can simply be expressed as a convex B-spline curve(controlled by four key points).An optimization framework of stiffened shells with a convex B-spline generatrix is established,with optimization objective being measured in terms of nominal collapse load,which can be expressed as a weighted sum of geometrically imperfect shells.The effectiveness of the proposed framework is demonstrated by a detailed comparison of the optimum designs for the B-spline and hyperbolic generatrix shapes.The decrease of imperfection sensitivity allows for a significant weight saving,which is particularly important in the development of future heavy-lift launch vehicles. | WANG Bo HAO Peng LI Gang WANG XiaoJun TANG XiaoHan LUAN Yu | 2014 | Science China(Technological Sciences)2014，57，10： | 6 |
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