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| 1 | MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells显示文摘MicroRNA-132(miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain.Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells(NSCs)and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration(MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, speci?c overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus(DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These ?ndings indicate that miR-132 is involved in opioid addiction,probably by promoting the differentiation of NSCs in the adult DG. | Meng Jia Xuewei Wang Haolin Zhang Can Ye Hui Ma Mingda Yang Yijing Li Cailian Cui | 2019 | Neuroscience Bulletin2019，35，3： | 6 |
| 2 | Efficient production of chemicals from microorganism by metabolic engineering and synthetic biology显示文摘The use of traditional chemical catalysis to produce chemicals has a series of drawbacks,such as high dependence on fossil resources,high energy consumption,and environmental pollution.With the development of synthetic biology and metabolic engineering,the use of renewable biomass raw materials for chemicals synthesis by constructing efficient microbial cell factories is a green way to replace traditional chemical catalysis and traditional microbial fermentation.This review mainly summarizes several types of bulk chemicals and high value-added chemicals using metabolic engineering and synthetic biology strategies to achieve efficient microbial production.In addition,this review also summarizes several strategies for effectively regulating microbial cell metabolism.These strategies can achieve the coupling balance of material and energy by regulating intracellular material metabolism or energy metabolism,and promote the efficient production of target chemicals by microorganisms. | Yang Zhang Jing Yu Yilu Wu Mingda Li Yuxuan Zhao Haowen Zhu Changjing Chen Meng Wang Biqiang Chen Tianwei Tan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 2 |
| 3 | ElectrochimicaAc显示文摘 | Yang Heng Chen Yungui Tao Mingda | 2010 | 2010,55: 6482010，55，： | 1 |
| 4 | Machining of metal matrix composites 显示文摘 | Xu Jiuhua Zuo Dunwen Yang Mingda | 1995 | Transactions of NUAA1995，12，2： | 1 |
| 5 | Machining of metal matrix composites显示文摘 | Xu Jiuhua Zuo Dunwen Yang Mingda | 1995 | Transactions of Nanjing University of Aeronautics & Astronutics1995，12，2： | 1 |
| 6 | Experimental Investigation of Local Scour Around Artificial Reefs in Steady Currents显示文摘Artificial reef is a man-made object that is deployed purposefully on the seafloor to restore the offshore fishery resources and the ecological environment.To secure its ecological effects,it is important to study the possible instability of artificial reefs,like drifting and reversing caused by burial and scour in different seafloor conditions.In the present study,experiments of local scour around an artificial reef are carried out in steady currents.The effect of the open-area ratios and the open-hole heights of the cubic reefs,and the bottom angles of the triangular reefs on the time-scale of the scour process and the equilibrium scour depth are investigated.The results indicate that for the cubic artificial reef,the scour depth decreases with the increasing open-area ratios,and increases with the increasing open-hole heights.In the present study,the optimal prototype of the cubic reef with an open-area ratio of 0.49 and open-height of 0.7 m produces the minimum scour depth.For the triangular reef,the scour depth increases when the bottom angle increases.Moreover,based on the experimental results,empirical equations of the effects of the cut-opening and the bottom angle on the maximum equilibrium scour depth are proposed.The formulas will provide theoretical support and practical guidance for the optimized design and construction of artificial reefs. | TANG Yanli WEI Shuangwu YANG Mingda WANG Xinxin ZHAO Fenfang | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 7 | Carrying Railway 5G Service Application by Multi-technology Convergence显示文摘The application scenarios of railway radio communication are complex,while the existing narrowband communication such as GSM-R and radio train dispatching system fails to meet the requirements of service application development.The carrying capacity of railway 5G-R has been greatly improved,mainly for wide-area train-ground communication services such as dispatching communication,train control and train operation safety monitoring.However,for large passenger stations,freight yards,maintenance bases and other places with densely populated railway operators,it is unable to carry overall railway service applications limited by the spectrum bandwidth of 5G private networks,so it is necessary to consider various radio technologies for supplementation.This paper also elaborates the railway service application scenarios,analyzes the characteristics of radio communication technologies such as 5G mmWave and the 6th-generation wireless LAN technology(Wi-Fi6),and discusses the schemes of multi-technology convergence carrying railway 5G service applications. | YANG Rui GUO Guifang ZHAO Wuyuan ZHENG Mingda | 2023 | Chinese Railways2023，，1： | 0 |
| 8 | Adjusting Nitrogen Application in Accordance with Soil Water Availability Enhances Yield and Water Use by Regulating Physiological Traits of Maize under Drip Fertigation显示文摘Knowledge of the interactive effects of water and nitrogen(N)on physio-chemical traits of maize(Zea mays L.)helps to optimize water and N management and improve productivity.A split-plot experiment was conducted with three soil water conditions(severe drought,moderate drought,and fully water supply referring to 45%-55%,65%-75%,and 85%-95%field capacity,respectively)and four N application rates(N0,N150,N240,and N330 referring to 0,150,240,330 kg N ha^(-1)respectively)under drip fertigation in 2014 and 2015 in the Huang-Huai-Hai Plain of China.The results indicated that drought stress inhibited physiological activity of plants(leaf relative water content,root bleeding sap,and net photosynthetic rate),resulting in low dry matter accumulation after silking,yield,and N uptake,whereas increased WUE and NUE.N application rates over than 150 kg ha^(-1)aggravated the inhibition of physiological activity under severe drought condition,while it was offset under moderate drought condition.High N application rates(N330)still revealed negative effects under moderate drought condition,as it did not consistently enhance plant physiological activity and significantly reduced N uptake as compared to the N240 treatment.With fully water supply,increasing N application rates synergistically enhanced physiological activity,promoted dry matter accumulation after silking,and increased yield,WUE,and N uptake.Although the N240 treatment reduced yield by 5.4%in average,it saved 27.3%N under full water supply condition as compared with N330 treatment.The results indicated that N regulated growth of maize in aspects of physiological traits,dry matter accumulation,and yield as well as water and N use was depended on soil water status.The appropriate N application rates for maize production was 150 kg ha^(-1)under moderate drought or 240 kg ha^(-1)under fully water supply under drip fertigation,and high N supply(>150 kg ha^(-1))should be avoided under severe drought condition. | Mingda Yang Shouchen Ma Fujian Mei Li Wei Tongchao Wang Xiaokang Guan | 2021 | Phyton-International Journal of Experimental Botany2021，90，2： | 0 |
| 9 | Plant Membrane Transport Research in the Post-genomic Era显示文摘Membrane transport processes are indispensable for many aspects of plant physiology including mineral nutrition,solute storage,cell metabolism,cell signaling,osmoregulation,cell growth,and stress responses.Completion of genome sequencing in diverse plant species and the development of multiple genomic tools have marked a new era in understanding plant membrane transport at the mechanistic level.Genes coding for a galaxy of pumps,channels,and carriers that facilitate various membrane transport processes have been identified while multiple approaches are developed to dissect the physiological roles as well as to define the transport capacities of these transport systems.Furthermore,signaling networks dictating the membrane transport processes are established to fully understand the regulatory mechanisms.Here,we review recent research progress in the discovery and characterization of the components in plant membrane transport that take advantage of plant genomic resources and other experimental tools.We also provide our perspectives for future studies in the field. | Ren-Jie Tang Mingda Luan Chao Wang Dhondup Lhamo Yang Yang Fu-Geng Zhao Wen-Zhi Lan Ai-Gen Fu Sheng Luan | 2020 | Plant Communications2020，1，1： | 0 |
| 10 | Paleohydrological Changes in the Western Tibetan Plateau over the Past 16,000 years Based on Sedimentary Records of n-Alkanes and Grain Size显示文摘Both monsoons and westerlies have exerted influence on climate dynamics over the Tibetan Plateau(TP) since the last deglaciation, producing complex patterns of paleohydroclimatic conditions. Diverse proxy records are essential to forge a robust understanding of the climate system on the TP. Currently, there is a general lack of understanding of the response of inland lakes over the TP to climate change, especially glacier-fed lakes. Paleohydrological reconstructions of such lakes could deepen our understanding of the history of lake systems and their relationship to regional climate variability. Here we use records of n-alkanes and grain size from the sediments of Bangong Co in the western TP to reconstruct paleohydrological changes over the past 16,000 years. The Paq record(the ratio of non-emergent aquatic macrophytes versus emergent aquatic macrophytes and terrestrial plants) is generally consistent with the variations in summer temperature and precipitation isotopes. The changes in grain-size distributions show a similar trend to Paq but with less pronounced fluctuations in the early-middle Holocene. The new data combined with previous results from the site demonstrate that: 1) Bangong Co experienced relatively large water-level fluctuations during the last deglaciation, with a steadily high lake-level during the early-middle Holocene and a decreasing lake-level in the late Holocene;2) The lake level fluctuations were driven by both high summer temperatures via the melting water and monsoon precipitation. However, the dominant factor controlling lake level changed over time. The lake-level history at Bangong Co deduced from the n-alkanes and grain-size records reveals the past hydrological changes in the catchment area, and stimulates more discussion about the future of glacier-fed lakes under the conditions of unprecedented warming in the region. | WANG Mingda YANG Yaping ZHANG Jiawu HOU Juzhi | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 0 |
| 11 | Corrigendum to“Bioinspired supramolecular nanofiber hydrogel through self-assembly of biphenyl-tripeptide for tissue engineering”[Bioact.Mater.8(2022)396-408]显示文摘The authors regret that the published version of the above article contained error in Fig.6F,which was not identified during the proofing stage.The wrong live/dead stain,F-actin stain,and SEM images of BPAA-GFF gel were selected during the assembly of Fig.6F.The images of Fig.6F have been replaced with the correct images as follow.The authors apologize for this error and state that the figure’s correction did not change the scientific conclusions of the article in any way. | Yong Sun Xing Li Mingda Zhao Yafang Chen Yang Xu Kefeng Wang Shaoquan Bian Qing Jiang Yujiang Fan Xingdong Zhang | 2023 | Bioactive Materials2023，，5： | 0 |
| 12 | Seroprevalence of human enterovirus A71 in Guangzhou,China,2019-2021显示文摘Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely studied. In this study, we analyzed the incidence of EV-A71 infection and seroepidemiology in Guangzhou City, China. From 2019 to 2021, 167,920 clinically confirmed HFMD cases were reported in Guangzhou. In 6,868 enterovirus-positive samples, Coxsackievirus A6 and Coxsackievirus A16 were dominant genotypes, and only 3 EV-A71-positive samples were detected, highlighting the deficient epidemic activity of EV-A71. Microneutralization assay was performed on 1,000 representative serum samples. Notably, the seroprevalence and geometric mean titer (GMT) decreased significantly in 2020, and that in the < 3-year age group were increased and even higher than that in 3–5-year age group in 2019 and 2021, which was contrary to our previous surveillance result and other studies in Guangzhou. Furthermore, a moderate decline of GMT level was observed following the vaccination, but the seropositive serums were still detected for 49 months after second immunization, suggesting the long-term persistence of the immunity. Our seroepidemiology study revealed relatively higher neutralizing antibody activity in the susceptible population after the EV-A71 vaccine was adopted in 2016 in Guangzhou. It may be one of the reasons for the lower epidemic activity of EV-A71 in Guangzhou from 2019 to 2021. | Huimin Lian Huimin Jianng Lina Yi Jing Sun Huaping Xie Ming Qiu Limei Sun Huifang Lin Mingda Yang Lin Qu Haiyi Yang Jing Lu Hanri Zeng | 2023 | Biosafety and Health2023，5，3： | 0 |
| 13 | Bioinspired supramolecular nanofiber hydrogel through self-assembly of biphenyl-tripeptide for tissue engineering显示文摘Supramolecular nanofiber peptide assemblies had been used to construct functional hydrogel biomaterials and achieved great progress.Here,a new class of biphenyl-tripeptides with different C-terminal amino acids sequences transposition were developed,which could self-assemble to form robust supramolecular nanofiber hydrogels from 0.7 to 13.8 kPa at ultra-low weight percent(about 0.27 wt%).Using molecular dynamics simulations to interrogate the physicochemical properties of designed biphenyl-tripeptide sequences in atomic detail,reasonable hydrogen bond interactions and“FF”brick(phenylalanine-phenylalanine)promoted the formation of supramolecular fibrous hydrogels.The biomechanical properties and intermolecular interactions were also analyzed by rheology and spectroscopy analysis to optimize amino acid sequence.Enhanced L929 cells adhesion and proliferation demonstrated good biocompatibility of the hydrogels.The storage modulus of BPAA-AFF with 10 nm nanofibers self-assembling was around 13.8 kPa,and the morphology was similar to natural extracellular matrix.These supramolecular nanofiber hydrogels could effectively support chondrocytes spreading and proliferation,and specifically enhance chondrogenic related genes expression and chondrogenic matrix secretion.Such biomimetic supramolecular short peptide biomaterials hold great potential in regenerative medicine as promising innovative matrices because of their simple and regular molecular structure and excellent biological performance. | Yong Sun Xing Li Mingda Zhao Yafang Chen Yang Xu Kefeng Wang Shaoquan Bian Qing Jiang Yujiang Fan Xingdong Zhang | 2022 | Bioactive Materials2022，7，2： | 0 |
| 14 | A synergetic strategy of NIR-Ⅱ squaraine dyes with ultrahigh photothermal conversion efficiency for photothermal therapy显示文摘Recent research on photothermal therapy(PTT) has sparked significant interest in the development of new organic photothermal agents(PTAs),ranging from single-molecule to aggregated levels.However,controlling aggregation pathways for PTAs with ultrahigh photothermal conversion efficiency(PCE) remains a major challenge.Herein,a two-pronged approach utilizing “Haggregation” and “intramolecular motion” was employed to enhance the PCE of an acceptor-substituted squaraine dye(NSQs).The C2vmolecular symmetry of the NSQs,which possess a ground state dipole moment(μg),promotes H-dimeric aggregates through dipole-dipole counteraction.Peripheral triphenylethylene or diphenylamine groups were added to this H-dimeric nanoplatform.This was done to enhance intramolecular motions for heat generation and also to extend conjugation,which redshifted the optical absorption and balanced the blue-shift induced by H-aggregation.With this technique,an organic PTA with NIR-II absorption was developed,and its nanoparticle achieved a remarkable PCE of 86.3% under 1,064 nm laser excitation.Femtosecond transient absorption spectroscopy and quantum mechanical calculations demonstrated the accelerated internal conversion process in NIR-II PTAs for rapid heat generation.The NSQs nanoparticles exhibit superior photothermal therapeutic properties for in vivo photoacoustic imaging-guided PTT,demonstrating the potential of bottom-up design to enable synergistic engineering strategies towards efficient phototheranostic agents. | Yigang Wang Guomin Xia Junhui Wang Mingda Wang Weihan Guo Manman Tan Leilei Si Yang Yang Hua Wang Hongming Wang | 2024 | Science China Chemistry2024，67，2： | 0 |
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