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| 1 | Improved characteristics and protective efficacy in an animal model of E. coli -derived recombinant double-layered rotavirus virus-like particles显示文摘 | Tingdong Li Haijun Lin Yue Zhang Min Li Daning Wang Yaojian Che Yinbin Zhu Shaowei Li Jun Zhang Shengxiang Ge Qinjian Zhao Ningshao Xia | 2014 | Vaccine2014，，： | 2 |
| 2 | Fourier Descriptors with Different Shape Signatures:a Comparative Study for Shape Based Retrieval of Kinematic Constraints显示文摘Fourier Descriptors(FD) has been widely used in image analysis and computer vision for shape recognition as they can be made independent of translation,rotation,as well as scaling.They have also been used for developing methods for the analysis and synthesis of four-bar linkages for path generation.This paper focuses on a comparative study of Fourier descriptors derived from various shape signatures of planar closed curves.This includes representations based on Cartesian coordinates,centroid distance,cumulative angle,and curvature.The comparison is conducted not only using commonly used criteria for shape representation and identification but also in the context of shape based retrieval of kinematic constraints for task centered mechanism design.Examples are provided to seek to extract geometric constraints such as circle,circular arc,ellipse and line-segment from a given motion. | WU Jun GE Qiaode Jeffrey GAO Feng SU Haijun | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 1 |
| 3 | Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells显示文摘 | Yuping Luo Volkan Coskun Aibing Liang Juehua Yu Liming Cheng Weihong Ge Zhanping Shi Kunshan Zhang Chun Li Yaru Cui Haijun Lin Dandan Luo Junbang Wang Connie Lin Zachary Dai Hongwen Zhu Jun Zhang Jie Liu Hailiang Liu Jean deVellis Steve Horvath Yi Eve Sun | 2015 | Cell2015，，5： | 1 |
| 4 | Homo-harringtonine,highly effective against coronaviruses,is safe in treating COVID-19 by nebulization显示文摘Dear Editor,Coronaviruses have increasingly become the causal agent of epidemics in humans as well as in domesticated animals(Perlman and Mc Intosh,2020;Wu et al.,2021).Since the beginning of this century,there have been 3 such epidemics. | Huajuan Ma Haijun Wen Yaoxu Qin Shijie Wu Ge Zhang Chung-I Wu Qichun Cai | 2022 | Science China(Life Sciences)2022，65，6： | 0 |
| 5 | Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients显示文摘Primary ciliary dyskinesia(PCD)is a highly heterogeneous recessive inherited disorder.FAP54,the homolog of CFAP54 in Chlamydomonas reinhardtii,was previously demonstrated as the C1d projection of the central microtubule apparatus of flagella.A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes.Through whole-exome sequencing,compound heterozygous variants c.2649_2657delinC(p.E883Dfs*47)and c.7312_7313insCGCAGGCTGAATTCTTGG(p.T2438delinsTQAEFLA)in a new suspected PCD-relevant gene,CFAP54,were identified in an individual with PCD.Two missense variants,c.4112A>C(p.E1371A)and c.6559C>T(p.P2187S),in CFAP54 were detected in another unrelated patient.In this study,a minigene assay was conducted on the frameshift mutation showing a reduction in mRNA expression.In addition,a CFAP54 in-frame variant knock-in mouse model was established,which recapitulated the typical symptoms of PCD,including hydrocephalus,infertility,and mucus accumulation in nasal sinuses.Correspondingly,two missense variants were deleterious,with a dramatic reduction in mRNA abundance from bronchial tissue and sperm.The identification of PCD-causing variants of CFAP54 in two unrelated patients with PCD for the first time provides strong supportive evidence that CFAP54 is a new PCD-causing gene.This study further helps expand the disease-associated gene spectrum and improve genetic testing for PCD diagnosis in the future. | Xinyue Zhao Haijun Ge Wenshuai Xu Chongsheng Cheng Wangji Zhou Yan Xu Junping Fan Yaping Liu Xinlun Tian Kai-Feng Xu Xue Zhang | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 6 | Visual tracking using discriminative representation with l2 regularization显示文摘In this paper,we propose a novel visual tracking method using a discriminative representation under a Bayesian framework.First,we exploit the histogram of gradient (HOG)to generate the texture features of the target templates and candidates.Second,we introduce a novel discriminative representation and l2-regularized least squares method to solve the proposed representation model.The proposed model has a closed-form solution and very high computational efficiency.Third,a novel likelihood function and an update scheme considering the occlusion factor are adopted to improve the tracking performance of our proposed method. Both qualitative and quantitative evaluations on 15 challenging video sequences demonstrate that our method can achieve more robust tracking results in terms of the overlap rate and center location error. | Haijun WANG Hongjuan GE | 2019 | Frontiers of Computer Science2019，13，1： | 0 |
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