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| 1 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 4 | Long-Term Outcomes for Patients with Post–Liver Transplant Anastomotic Biliary Strictures Treated by Endoscopic Stent Placement显示文摘 | Joseph Morelli Hugh E Mulcahy Ira R Willner John T Cunningham Peter Draganov | 2003 | Gastrointestinal Endoscopy2003，，3： | 2 |
| 5 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 6 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 7 | 基于三维悬垂模型和织物面密度的织物匹配显示文摘为能够根据织物的悬垂形态快速准确地匹配到与给定织物综合性能相近的织物样本,利用自主搭建的悬垂织物三维扫描装置获取了悬垂织物的三维点云数据。将三维点云封装为三角形网络后,利用局部线性嵌入的方法对悬垂织物三角形网格重采样,使不同的悬垂织物三维模型具有相同的顶点数目和三角形拓扑结构;然后基于重采样三角形网格提出了2种织物匹配方法,即基于传统悬垂指标和织物面密度的织物匹配以及基于曲率统计直方图和织物面密度的织物匹配;最后计算了织物力学特征的相似度,以此相似度为基准对织物匹配结果进行评价。结果表明:基于悬垂指标和织物面密度的织物匹配准确率为86.91%;基于曲率统计直方图和织物面密度的织物匹配准确率为93.79%。 | 余志才 钟跃崎 GONG R Hugh 谢昊洋 HUSSAIN Azmat | 2020 | 纺织学报2020，41，10： | 2 |
| 8 | On drilling degrees of freedom显示文摘 | Hughes T J R Brezzi F | 1989 | Computer Methods in Applied Mechanics and Engineering1989，72，： | 2 |
| 9 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet2005，，9503： | 2 |
| 10 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet . 2005 (9503)2005，，9503： | 2 |
| 11 | Effects of carrier release kinetics on bone morphogenetic protein-2-induced periodontal regeneration in vivo显示文摘 | Talwar R Di Silvio L Hughes FJ | 2001 | J Clin Periodontol2001，28，4： | 1 |
| 12 | Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon 显示文摘 | Hughes R Rowland IR | 2001 | Carcinogenesis2001，22，1： | 1 |
| 13 | Quantum key distribution over a 48 km optical fiber network显示文摘 | | 2000 | Journal of Modern Opticals2000，47，23： | 1 |
| 14 | Fetal health surveillance in labour显示文摘 | Crane J Hughes O | 2002 | Obstet Gynaecol Can2002，24，4： | 1 |
| 15 | Finite element modeling of blood flow in arteries 显示文摘 | Thomas J R Hughes Zarins C K | 1998 | Computer Methods in Applied Mechanics and Engineering1998，158，： | 1 |
| 16 | A new finite element formulation for computational fluid dynamics: Ⅷ: the Galerkin least squares method for advective diffusive equations显示文摘 | HUGHES T J R FRANCA L P HULBERT G M | 1989 | Computer Methods in Applied Mechanics and Engineering1989，73，2： | 1 |
| 17 | Changes in limestone sorbent morphology during CaO-CaCO3 looping at pilot scale显示文摘 | Hughes R W Macchi A Lu D Y | 2009 | Chemical Engineering & Technology2009，32，3： | 1 |
| 18 | Collocation, Dissipation and for Time Integration Schemes in Struc- tural Dynamics显示文摘 | HILBER H M HUGHES T J R | 1978 | Earthquake Engineering & Structural Dynamics1978，6，1： | 1 |
| 19 | Isogeometricanalysis:CAD,finite elements,NURBS,exact geometry andmesh refinement显示文摘 | Hughes T J R Cottrell J A Bazilevs Y | 2005 | Computer Methods in AppliedMechanics and Engineering2005，194，41： | 1 |
| 20 | Climate in Medieval time显示文摘 | Bradley R S Hughes M K Diaz H F | 2003 | Science2003，302，： | 1 |
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