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| 1 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 2 | Nutritional care in hospitalized patients with chronic liver disease显示文摘AIM: To evaluate the practice of nutritional assessment and management of hospitalised patients with cirrhosis and the impact of malnutrition on their clinical outcome.METHODS: This was a retrospective cohort study on patients with liver cirrhosis consecutively admitted to the Department of Gastroenterology and Hepatology at the Royal Adelaide Hospital over 24 mo. Details were gathered related to the patients' demographics, disease severity, nutritional status and assessment, biochemistry and clinical outcomes. Nutritional status was assessed by a dietician and determined by subjective global assessment. Estimated energy and protein requirements were calculated by Simple Ratio Method. Intake was estimated from dietary history and/or food charts, and represented as a percentage of estimated daily requirements. Median duration of follow up was 14.9(0-41.4) mo. RESULTS: Of the 231 cirrhotic patients(167 male, age: 56.3 ± 0.9 years, 9% Child-Pugh A, 42% ChildPugh B and 49% Child-Pugh C), 131(57%) had formal nutritional assessment during their admission and 74(56%) were judged to have malnutrition. In-hospitalcaloric(15.6 ± 1.2 kcal/kg vs 23.7 ± 2.3 kcal/kg, P = 0.0003) and protein intake(0.65 ± 0.06 g/kg vs 1.01 ± 0.07 g/kg, P = 0.0003) was significantly reduced in patients with malnutrition. Of the malnourished cohort, 12(16%) received enteral nutrition during hospitalisation and only 6(8%) received ongoing dietetic review and assessment following discharge from hospital. The overall mortality was 51%, and was higher in patients with malnutrition compared to those without(HR = 5.29, 95%CI: 2.31-12.1; P < 0.001). CONCLUSION: Malnutrition is common in hospitalised patients with cirrhosis and is associated with higher mortality. Formal nutritional assessment, however, is inadequate. This highlights the need for meticulous nutritional evaluation and management in these patients. | Dep K Huynh Shane P Selvanderan Hugh AJ Harley Richard H Holloway Nam Q Nguyen | 2015 | World Journal of Gastroenterology2015，21，45： | 6 |
| 3 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 4 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 5 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 6 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet2005，，9503： | 2 |
| 7 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet . 2005 (9503)2005，，9503： | 2 |
| 8 | TrkB expression in dentate granule cells is associated with a late phase of long-term potentiation显示文摘 | Hughes P Mason-parker SE | 1997 | Mol Brain Res1997，46，12： | 1 |
| 9 | Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous syeterm 显示文摘 | Dragunow M | 1995 | Pharmacol Rev1995，47，1： | 1 |
| 10 | A new finite element formulation for computational fluid dynamics: Ⅷ: the Galerkin least squares method for advective diffusive equations显示文摘 | HUGHES T J R FRANCA L P HULBERT G M | 1989 | Computer Methods in Applied Mechanics and Engineering1989，73，2： | 1 |
| 11 | Free radicals accelerate the decay of long-term potentiation in field CA1 of guinea-pig hippocampus 显示文摘 | Pellmar T C kaisho Y Hughes P | 1991 | Neurosci1991，44，2： | 1 |
| 12 | Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters显示文摘 | Wu L F Hughes T R Davierwala A P | 2002 | Nat Genet2002，31，7： | 1 |
| 13 | Formation and use of coal combustion residues from three types power plants burning Illinois coals 显示文摘 | DEMIR I HUGHES R E DEMARIES P J | 2001 | Fuel2001，，80： | 1 |
| 14 | Turbulent two-phase flow in faceshaft seals 显示文摘 | Beatty P A Hughes W F | 1986 | ASLE Transactions1986，109，1： | 1 |
| 15 | TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells显示文摘 | Lars G Hugh P Joop G | | 0，，05： | 1 |
| 16 | Photochemical decomposition of hydrazobenzene, studied by the use of nitrogen isotopes 显示文摘 | Holt P F Hughes B P | 1955 | J Chem Soc1955，，： | 1 |
| 17 | A hidden Markov model for downscaling synoptic atmospheric patterns to precipitation amounts显示文摘 | Bellone E Hughes J P Guttorp P | 2000 | Climate Research2000，15，1： | 1 |
| 18 | Dynamics of an elastic multibody chain:Part D-modelling of joints显示文摘 | Sincarsin G B D'Eleuterio G M T Hughes P C | 1993 | Dynamics and Stability of Systems1993，8，2： | 1 |
| 19 | 显示文摘 | Hughes M Chen G Z Shaffer M S P | 2002 | Chem Mater2002，14，： | 1 |
| 20 | Non-starch polysaccharide-degrading enzymes increase the performance of broiler chickens fed wheat of low apparent metabolizable energy显示文摘 | Choct M J Hughes R P Trimble R | 1995 | J Nutr1995，125，3： | 1 |
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