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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Corrosion mechanism investigation of TiN/Ti coating and TC4 alloy for aircraft compressor application显示文摘It is imperative to develop multifunctional erosion and corrosion resistant coatings for compressor blades of aircraft engines in harsh environment.PVD(Physical Vapor Deposition)technology has the advances in processing erosion-resistant coatings;however,the performance of PVD coatings to combat corrosion depends on various coating defects.Determining and comparing the corrosion performances of PVD TiN/Ti coating and uncoated TC4 alloy was the main objective of present work.The 960 h salt spray corrosion and 116 h hot corrosion tests were conducted to simulate the grounding and working environments of the aircraft compressors.The corrosion mechanisms due to the coating defects such as pinhole,columnar boundary and large grain were analyzed based on the OM,Confocal microscope,electrochemical measurements,SEM,XRD and EDS results.Owing to the disordered state associated with the columnar boundary and the coating defect,nitrogen could be easily replaced by oxygen in the hot corrosion process,these structures were channels for fast diffusion of oxygen.Moreover,the Gibbs energy changes of Ti oxidation and TiN oxidation were thermodynamically calculated according to the working condition of aircraft compressors,and considerable research effort was focused on mapping out the phase diagram of Ti,TiN and high pressure gases.The findings of this research can provide insights into developing multifunctional coatings for future aircraft engines. | Zhiping SUN Guangyu HE Qingjie MENG Yuqin LI Xiaodong TIAN | 2020 | Chinese Journal of Aeronautics2020，33，6： | 11 |
| 3 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 4 | Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis显示文摘 | Guohong Han Xingshun Qi Chuangye He Zhanxin Yin Jianhong Wang Jielai Xia Zhiping Yang Ming Bai Xiangjie Meng Jing Niu Kaichun Wu Daiming Fan | 2010 | Journal of Hepatology2010，，： | 5 |
| 5 | Correlation analysis and partial least square modeling to quantify typical minerals with Chang'E-3 visible and near-infrared imaging spectrometer's ground validation data显示文摘In 2013, Chang'E-3 program will develop lunar mineral resources in-situ detection. A Visible and Near-infrared Imaging Spectrometer(VNIS) has been selected as one payload of CE-3 lunar rover to achieve this goal. It is critical and urgent to evaluate VNIS' spectrum data quality and validate quantification methods for mineral composition before its launch. Ground validation experiment of VNIS was carried out to complete the two goals, by simulating CE-3 lunar rover's detection environment on lunar surface in the laboratory. Based on the hyperspectral reflectance data derived, Correlation Analysis and Partial Least Square(CA-PLS) algorithm is applied to predict abundance of four lunar typical minerals(pyroxene, plagioclase, ilmenite and olivine) in their mixture. We firstly selected a set of VNIS' spectral parameters which highly correlated with minerals' abundance by correlation analysis(CA), and then stepwise regression method was used to find out spectral parameters which make the largest contributions to the mineral contents. At last, functions were derived to link minerals' abundance and spectral parameters by partial least square(PLS) algorithm. Not considering the effect of maturity, agglutinate and Fe0, we found that there are wonderful correlations between these four minerals and VNIS' spectral parameters, e.g. the abundance of pyroxene correlates positively with the mixture's absorption depth, the value of absorption depth added as the increasing of pyroxene's abundance. But the abundance of plagioclase correlates negatively with the spectral parameters of band ratio, the value of band ratio would decrease when the abundance of plagioclase increased. Similar to plagioclase, the abundance of ilmenite and olivine has a negative correlation with the mixture's reflectance data, if the abundance of ilmenite or olivine increase, the reflectance values of the mixture will decrease. Through model validation, better estimates of pyroxene, plagioclase and ilmenite's abundances are given. It is concluded that VNIS has the capability to be applied on lunar minerals' identification, and CA-PLS algorithm has the potential to be used on lunar surface's in-situ detection for minerals' abundance prediction. | LIU Bin LIU Jianzhong ZHANG Guangliang LING Zongcheng ZHANG Jiang HE Zhiping YANG Benyong ZOU Yongliao | 2014 | Chinese Journal Of Geochemistry2014，33，1： | 3 |
| 6 | Characteristics of Staring Imaging Spectrometer and Its Application Prospect in Asteroid Exploration显示文摘Compared with traditional ground asteroid obsen/ations,deep space exploration is an important way to explore and comprehensively understand the characteristics of asteroids.Imaging spectrometer integrates morphological measurement and spectral measurement,and has the ability to acquire image and spectral data simultaneously.By combining morphometry and spectrometry,it is possible to achieve efficient identification and quantitative analysis of the chemical comp orients of the explorati on target,and has the strong advantage in the field of asteroid exploration.This paper analyzes the principle of the staring imaging spectrometer and the technological progress in various countries.Based on the requirements of light,small payloads and the space characteristics of spectroscopic devices,the application of staring imaging spectrometer is discussed.Then,this paper introduces the conceptual design of an acousto-optic staring imaging spectrometer,combined with the technical characteristics of its area array stare frame imaging and fast electronic control spectrum selection.An experimental verification is carried out,which provides a reference for the feasibility of this type of instrument in asteroid exploration. | HE Zhiping ZHAO Haiting LI Jinning | 2019 | Aerospace China2019，20，3： | 2 |
| 7 | Mineralogy of Chang’e-4 landing site:preliminary results of visible and near-infrared imaging spectrometer显示文摘The exploration of mafic anomaly in South Pole-Aitken(SPA,the largest confirmed)basin on the Moon provides important insights into lunar interior.The landing of Chang’e-4(CE-4)and deployment of Yutu-2 rover on the discontinuous ejecta from Finsen crater enabled in-situ measurements of the unusual mineralogy in the central portion of SPA basin with visible and near-infrared imaging spectrometer(VNIS).Here we present detailed processing procedures based on the level 2B data of CE-4 VNIS and preliminary mineralogical results at the exploration area of Yutu-2 rover.A systematic processing pipeline is developed to derive credible reflectance spectra,based on which several spectral and mineral indices are calculated to constrain the mafic mineralogy.The mafic components in the soils and boulder around CE-4 landing site are concluded as clinopyroxene-bearing with intermediate composition and probably dominated by pigeonite although the possibility of mixing orthopyroxen(OPX)and calcic clinopyroxene(CPX)also exists.These mineralogical results are more consistent with a petrogenesis that the CE-4 regolith and rock fragment are derived from rapid-cooling magmatic systems and we interpret that the materials at the CE-4 landing site ejected from Finsen crater are probably recrystallized from impact melt settings. | Jian CHEN Zongcheng LING Le QIAO Zhiping HE Rui XU Lingzhi SUN Jiang ZHANG Bo LI Xiaohui FU Changqing LIU Xiaobin QI | 2020 | Science China(Information Sciences)2020，63，4： | 2 |
| 8 | An ionic liquid-type carbon paste electrode and its polyoxometalate-modified properties 显示文摘 | LIU Hongtao HE Ping LI Zhiping | 2005 | Electrochemistry Communications2005，7，12： | 1 |
| 9 | Stray light analysis of basic model Gaussian beam显示文摘 | Cen Zhaofeng Li Xiaotong He Zhiping | 2002 | SPIE2002，4914，： | 1 |
| 10 | Mesoporous silica films-characterization and reduction of their water uptake显示文摘 | HUANG Kuoying HE Zhiping CHAO Kueijung | 2006 | Thin Solid Films2006，495，： | 1 |
| 11 | Chinese herbal extract dl-3n-butylphthalide A commonly used drug for the treatment of ischemic stroke as a novel therapeutic approach to treat neurodegenerative diseases显示文摘Dl-3n-butylphthalide is the active component isolated from the seeds of Apium graveolens Linn.A number of pharmacological and clinical studies have proven that dl-3n-butylphthalide is highly potent and multi-targeted with low toxicity and has a long time-window for the treatment of ischemic cerebrovascular disease.The mechanisms underlying dl-3n-butylphthalide include improving mi-tochondrial function and microcirculation,inhibiting apoptosis and reducing oxidative stress.Fur-thermore,dl-3n-butylphthalide may also be promising for the treatment of neurodegenerative dis-eases,such as Alzheimer's disease,vascular dementia and Parkinson's disease. | Wenfang He Wensheng Zhou Zhiping Hu | 2011 | Neural Regeneration Research2011，6，35： | 1 |
| 12 | Effect of the filler structure of carbon nanomaterials on the electrical, thermal, and rheological properties of epoxy composites显示文摘 | Zhiping He Xiaohua Zhang Minghai Chen Min Li Yizhuo Gu Zuoguang Zhang Qingwen Li | 2013 | J Appl Polym Sci2013，，6： | 1 |
| 13 | A Fully Integrated 60GHz Four Channel CMOS Receiver with 7GHz Ultra-Wide Bandwidth for IEEE 802.11ad Standard显示文摘In this paper, a fully integrated CMOS receiver frontend for high-speed short range wireless applications centering at 60 GHz millimeter wave(mmW) band is designed and implemented in 90 nm CMOS technology. The 60 GHz receiver is designed based on the super-heterodyne architecture consisting of a low noise amplifier(LNA) with inter-stage peaking technique, a singlebalanced RF mixer, an IF amplifier, and a double-balanced I/Q down-conversion IF mixer. The proposed 60 GHz receiver frontend derives from the sliding-IF structure and is designed with 7GHz ultra-wide bandwidth around 60 GHz, supporting four 2.16 GHz receiving channels from IEEE 802.11 ad standard for next generation high speed WiFi applications. Measured results show that the entire receiver achieves a peak gain of 12 dB and an input 1-dB compression point of-14.5dBm, with a noise figure of lower than 7dB, while consumes a total DC current of only 60 mA from a 1.2V voltage supply. | ZHANG Lei ZHOU Chunyuan WANG Hongrui WANG Yan QIAN He YU Zhiping | 2014 | China Communications2014，11，6： | 1 |
| 14 | The operational model of a network for managing patients with convulsive epilepsy in rural West China显示文摘 | Ling Liu Qin Zhang Zhiping Yao Xiaowen Wang Cairong Zhu Yali Gao Jun He Zhuo Wang Ningmei Zhang Wendyl D’Souza Dong Zhou | 2009 | Epilepsy and Behavior2009，，1： | 1 |
| 15 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 16 | Chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells in type I collagen-hydrogel for cartilage engineering显示文摘 | Xuebin Chen Fang Zhang Xinhong He Yinsheng Xu Zhiping Yang Li Chen Shaomei Zhou Yishu Yang Zhixiang Zhou Wang Sheng Yi Zeng | 2012 | Injury2012，，： | 1 |
| 17 | Characteristics and development model of karst reservoirs in the fourth member of Sinian Dengying Formation in central Sichuan Basin,SW China显示文摘The reservoir space,types and distribution characteristics of karst carbonate gas reservoirs in the fourth member of Sinian Dengying Formation(Deng 4 Member)in central Sichuan Basin are analyzed based on the drilling,logging and seismic data.A development model of karst reservoirs is constructed to support the high-efficiency development of gas pools.The research shows that the reservoirs in Deng 4 Member have mainly small-scale karst vugs and fractures as storage space,and can be divided into three types,fracture-vug,pore-vug and pore types.The development patterns of the karst reservoirs are determined.On the plane,the karst layers increase from 65 m to 170 m in thickness from the karst platform to the karst slope,and the high-quality reservoirs increase from 25.0 m to 42.2 m in thickness;vertically,the reservoirs at the top of Deng 4 Member appear in multiple layers,and show along-bedding and along fracture dissolution characteristics.The reservoirs at the bottom are characterized by the dissolution parallel to the water level during the karstification period,and have 3-5 large-scale fracture-cave systems.Based on the reservoir development characteristics and the genetic mechanism,three types of reservoir development models of karst reservoir are established,i.e.,bed-dissolved body,fracture-dissolved body and paleohorizon-dissolved body.The construction of karst reservoir development models and seismic response characteristics of the three types of reservoirs can provide parameter for well placement and trajectory design,and substantially improve productivity and development indices of individual wells and gas reservoirs.The designed production capacity of the gas reservoir has enhanced from the initial 3.6 billion to 6 billion cubic meters,making the profit of the reservoir development increase noticeably. | YAN Haijun HE Dongbo JIA Ailin LI Zhiping GUO Jianlin PENG Xian MENG Fankun LI Xinyu ZHU Zhanmei DENG Hui XIA Qinyu ZHENG Guoqiang YANG Shan SHI Xiaomin | 2022 | Petroleum Exploration and Development2022，49，4： | 1 |
| 18 | Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861patients with non-small cell lung cancer显示文摘 | Jianping Xu Jiaying He Huiyi Yang Xiaodi Luo Zhangmin Liang Jiaxin Chen Zhiping Cai Jiasen Xu Lifen Ren-Heidenreich | 2012 | Cancer Biomarkers2012，，： | 1 |
| 19 | Assessment and control of metro-construction induced settlement of a pile-supported urban overpass 显示文摘 | Yanyong Xiang Zhiping Jiang Haijian He | 2008 | Tunnelling and Underground Space Technology2008，23，： | 1 |
| 20 | Assessmentand control of metro-construction induced settlementof a pile-supported urban overpass显示文摘 | Yanyong Xiang Zhiping Jiang Haijian He | 2008 | Tunnelling andUnderground Space Technology2008，23，3： | 1 |
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