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| 1 | High matrix metalloproteinase-9 expression induces angiogenesis and basement membrane degradation in stroke-prone spontaneously hypertensive rats after cerebral infarction显示文摘Basement membrane degradation and blood-brain barrier damage appear after cerebral infarction, severely impacting neuronal and brain functioning; however, the underlying pathogenetic mechanisms remain poorly understood. In this study, we induced cerebral infarction in strokeprone spontaneously hypertensive rats by intragastric administration of high-sodium water(1.3% NaCl) for 7 consecutive weeks. Immunohistochemical and immunofluorescence assays demonstrated that, compared with the non-infarcted contralateral hemisphere, stroke-prone spontaneously hypertensive rats on normal sodium intake and Wistar-Kyoto rats, matrix metalloproteinase-9 expression, the number of blood vessels with discontinuous collagen IV expression and microvessel density were significantly higher, and the number of continuous collagen IV-positive blood vessels was lower in the infarct border zones of stroke-prone spontaneously hypertensive rats given high-sodium water. Linear correlation analysis showed matrix metalloproteinase-9 expression was positively correlated with the number of discontinuously collagen IV-labeled blood vessels and microvessel density in cerebral infarcts of stroke-prone spontaneously hypertensive rats. These results suggest that matrix metalloproteinase-9 upregulation is associated with increased regional angiogenesis and degradation of collagen IV, the major component of the basal lamina, in stroke-prone spontaneously hypertensive rats with high-sodium water-induced focal cerebral infarction. | Huilian Hou Guanjun Zhang Hongyan Wang Huilin Gong Chunbao Wang Xuebin Zhang | 2014 | Neural Regeneration Research2014，9，11： | 30 |
| 2 | Additional risk in extreme precipitation in China from 1.5℃to 2.0℃global warming levels显示文摘To avoid dangerous climate change impact, the Paris Agreement sets out two ambitious goals: to limit the global warming to be well below 2 ℃ and to pursue effort for the global warming to be below 1.5 ℃ above the pre-industrial level. As climate change risks may be region-dependent, changes in magnitude and probability of extreme precipitation over China are investigated under those two global warming levels based on simulations from the Coupled Model Inter-Comparison Projects Phase 5. The focus is on the added changes due to the additional half a degree warming from 1.5 ℃ to 2 ℃ . Results show that regional average changes in the magnitude do not depend on the return periods with a relative increase around 7% and 11% at the 1.5 ℃ and 2 ℃ global warming levels, respectively. The additional half a degree global warming adds an additional increase in the magnitude by nearly 4%. The regional average changes in term of occurrence probabilities show dependence on the return periods, with rarer events(longer return periods) having larger increase of risk. For the 100-year historical event, the probability is projected to increase by a factor of 1.6 and 2.4 at the 1.5 ℃ and 2 ℃ global warming levels, respectively.The projected changes in extreme precipitation are independent of the RCP scenarios. | Wei Li Zhihong Jiang Xuebin Zhang Laurent Li Ying Sun | 2018 | Science Bulletin2018，63，4： | 24 |
| 3 | The Complement System in Liver Diseases显示文摘The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety of complement receptors. Recent evidence from several studies suggests that the complement system is also involved in the pathogenesis of a variety of liver disorders including liver injury and repair, fibrosis, viral hepatitis, alcoholic liver disease, and liver ischemia/reperfusion injury. In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases. | Xuebin Qin Bin Gao | 2006 | Cellular & Molecular Immunology2006，3，5： | 19 |
| 4 | Sources and migration path of chemical compositions in a karst groundwater system during rainfall events显示文摘Physical and chemical dynamics at Jiangjia Spring (JJS), the outlet of the Qingmuguan karst groundwater system in Chongqing, were monitored in situ during rainfall events to acquire a series of high-resolution data. Principal component analysis (PCA) was employed to identify the sources of chemical compositions in the karst groundwater. The coefficients of variations (CVs) of the physical and chemical data of JJS were utilized to interpret the migration path of the chemical compositions. The results showed that water-rock interactions, agricultural activities, and soil erosion were the main sources of the groundwater chemical compositions. Ions of potassium, sodium, nitrate, chloride and phosphate from agricultural activities together with ions of calcium, magnesium, strontium and bicarbonate derived from carbonate dissolution appear to be stored and regulated by the karst unsaturated zone in features such as fissures, pores and solution cracks. The concentrations of the ions remained relatively stable and they showed low CVs owing to their migration by diffuse flow to recharge the underground river. In contrast, concentrations of ions such as total iron, total manganese and aluminum from soil erosion were unstable and showed high CVs owing to their migration by overland flow to recharge the underground river directly via sinkholes. During heavy rainfall events, the nutrients from agricultural activities and sediment from soil erosion could quickly impair the aquatic ecosystem and pose serious threats to water quality. Therefore, it is necessary to reinforce management of the ecological system for better control of the influx of mass nutrients into the karst aquifer system. | YANG PingHeng YUAN DaoXian YE XuChun XIE ShiYou CHEN XueBin LIU ZiQi | 2013 | Chinese Science Bulletin2013，58，20： | 14 |
| 5 | Predicting the distribution of thin bed reservoirs by broad frequency band seismic显示文摘识别薄内部在在 Songliao 盆的中间浅的阶层的 bedded 水库是一个大困难。以便解决这个问题,我们在场为预言使用一个宽广频率乐队和极端高分辨率的薄水库的分发的一种技术地震。基于向前当模特儿,我们认出了那一张薄床地震思考被与改变频率改变振幅描绘(振幅对频率, AVF ) 。我们从他们的 AVF 特征计算薄水库的厚度并且用宽广频率乐队和极端高分辨率预言薄床水库的分发地震。这种技术在 3D 被使用了在 Songliao 盆的北部分的 Zhaoyuan 的地震区域。地震决定在的上到二或三次被增加常规地震并且许多薄水库被识别了。这种技术有广泛的申请到油和气体的探索和发展,例如优化探索井的地点,井(特别水平的井) 的设计,生产测试层的选择,等等在发展井分析水库连续性。 | Li Zishun Guo Xuebin | 2007 | Applied Geophysics2007，4，2： | 12 |
| 6 | Diurnal characteristics of geoelectric fields and their changes associated with the Alxa Zuoqi M_S5.8 earthquake on 15 April 2015(Inner Mongolia)显示文摘In China, efforts are being made to monitor geoelectric fields through a large network of stations deployed and managed by the China Earthquake Administration. The diurnal variations in the geoelectric field waveforms were similar in the quiet magnetic periods when K<5(generally, K<3 indicates a quiet time). The arrival time points of the maxima in the geoelectric field waveforms exhibited differences in local time related to geographic longitude. The amplitude of diurnal variation was several to 16.6 mV/km and decreased with increasing latitude. Further,the amplitude of diurnal variation, which was related to seasonal changes, was larger in summer and autumn than in spring and winter. The periods of diurnal changes during quiet days were 24, 12, 8, 6, 4 hours and several minutes over large areas. Finally, the observed diurnal variations in geoelectric field prior to the Alxa Zuoqi M_S5.8 earthquake on 15 April 2015 were studied, and pronounced changes in the spectral values of the geoelectric fields were found to be associated with the Alxa Zuoqi earthquake in Inner Mongolia. | Qing Ye Ye Fan Xuebin Du Tengfa Cui Kechang Zhou Ramesh P.Singh | 2018 | Earthquake Science2018，31，1： | 12 |
| 7 | Quantitative calculation for the dissipated energy of fault rock burst based on gradient-dependent plasticity显示文摘The capacity of energy absorption by fault bands after rock burst was calculated quantitatively according to shear stressshear deformation curves considering the interactions and interplaying among microstructures due to the heterogeneity of strain softening rock materials. The post-peak stiffness of rock specimens subjected to direct shear was derived strictly based on gradientdependent plasticity, which can not be obtained from the classical elastoplastic theory. Analytical solutions for the dissipated energy of rock burst were proposed whether the slope of the post-peak shear stress-shear deformation curve is positive or not. The analytical solutions show that shear stress level, confining pressure, shear strength, brittleness, strain rate and heterogeneity of rock materials have important influence on the dissipated energy. The larger value of the dissipated energy means that the capacity of energy dissipation in the form of shear bands is superior and a lower magnitude of rock burst is expected under the condition of the same work done by external shear force. The possibility of rock burst is reduced for a lower softening modulus or a larger thickness of shear bands. | Xuebin Wang Shuhong Dai Long Hai Department of Mechanics and Engineering Sciences, Liaoning Technical University, Fuxin 123000, China | 2004 | Journal of University of Science and Technology Beijing2004，11，3： | 11 |
| 8 | Characteristics of stress distribution in floor strata and control of roadway stability under coal pillars显示文摘给在煤支柱下面在车道支持遇到的困难,我们在车道稳定性上学习了压力分发和他们的效果的特征,用理论分析和数字模拟。当水平应力减少时,结果证明在一个煤支柱下面,在一个地板阶层的垂直应力增加。我们断定垂直、水平的应力之间的增加的差别是为包围岩石的变丑和在煤支柱下面的车道的失败的一个重要原因。基于这,我们在一个煤支柱下面建议一条车道的包围岩石的控制技术例如高力量和高对的门栓支持,打电报加强支持,单个水力由包围岩石的 grouting 与横梁支持和加强支撑,它成功地在一个煤支柱下面在一条车道的一个稳定性控制工程被使用了。 | Tongqiang Xiao Bai Jianbiao Xu Lei Zhang Xuebin | 2011 | Mining Science and Technology2011，21，2： | 9 |
| 9 | The cytokine milieu in the interplay of pathogenic Th1/ Th17 cells and regulatory T cells in autoimmune disease显示文摘The propagation and regulation of an immune response is driven by a network of effector and regulatory T(Treg)cells.The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution in an autoimmune disease setting.In autoimmune diseases,this interplay shifts the balance in favor of the development of autoreactive effector T cells,resulting in inflammatory pathology.The objective of an effective therapeutic approach for autoimmune disease is to restore this balance.In this review,we describe the characteristics and development of pathogenic T helper 1(Th1)and Th17 cells and the beneficial Treg cells in autoimmune diseases and the crucial roles of the cytokine milieu in influencing the balance of these T-cell subsets.Given the importance of cytokines,we discuss current immunotherapeutic strategies using cytokine or cytokine receptor antibodies for the treatment of autoimmune diseases. | Stewart Leung Xuebin Liu Lei Fang Xi Chen Taylor Guo Jingwu Zhang | 2010 | Cellular & Molecular Immunology2010，7，3： | 8 |
| 10 | High-performance computing environment: a review of twenty years of experiments in China显示文摘A high-performance computing environment, also known as a supercomputing environment, e-Science environment or cyberinfrastructure, is a crucial system that connects users' applications to supercomputers,and provides usability, eiciency, sharing, and collaboration capabilities. his review presents important lessons drawn from China's nationwide eforts to build and use a high-performance computing environment over the past 20 years(1995–2015), including three observations and two open problems. We present evidence that such an environment helps to grow China's nationwide supercomputing ecosystem by orders of magnitude, where a loosely coupled architecture accommodates diversity. An important open problem is why technology for global networked supercomputing has not yet become as widespread as the Internet or Web. In the next 20 years, high-performance computing environments will need to provide zetalops computing capability and 10 000 times beter energy eiciency, and support seamless human-cyber-physical ternary computing. | Zhiwei Xu Xuebin Chi Nong Xiao | 2016 | National Science Review2016，3，1： | 8 |
| 11 | Alkylation Activity of Benzene with Syngas over Cu-based Catalysts显示文摘A series of Cu-based catalysts were developed for alkylation of benzene with syngas. The catalyst samples were prepared by the impregnation method, and were characterized by XRD, XRF, NH3-TPD, and TEM and evaluated in a fixed bed reactor. The optimized reaction temperature of Cu/Al2O3/ZSM-5 catalyst was 350 ℃, while higher contents of copper were conducive to alkylation of benzene with syngas. The new medium strength acid centers in the catalyst created by Cu were beneficial to alkylation. Hydrogenation reaction of CO was executed on the metal centers without dissociation, Dimethyl ether(DME) was the major intermediate over Cu-based catalysts. Higher selectivity of methylation and lower selectivity of heavy aromatics were confirmed after the second metal(Zn, Mn, or V) was added to the copper catalyst. Cu was partly covered by Zn in the Cu-Zn/Al2O3/ZSM-5 catalyst leading to low dispersion and low activity of copper. Cu-Mn/Al2O3/ZSM-5 catalyst possessed the best yield of methylation product. Cu-Mn composite oxides were probably formed in fresh catalyst, which blocked the sintering of Cu in the reaction process. The loading of Cu decreased dramatically after the introduction of V, while causing an increase of the amount of medium strength acid centers at the same time. V prevented the sintering of copper particles during the reducing process and had a promoting effect on the activity of Cu. | Zhao Xuebin Zeng Feng Zhao Bin Gu Haohui | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，1： | 8 |
| 12 | Numerical study on the fracturing mechanism of shock wave interactions between two adjacent blast holes in deep rock blasting显示文摘With the application of electronic detonators, millisecond blasting is regarded as a signifi cant promising approach to improve the rock fragmentation in deep rock blasting. Thus, it is necessary to investigate the fracturing mechanisms of short-delay blasting. In this work, a rectangle model with two circle boreholes is modeled as a particles assembly based on the discrete element method to simulate the shock wave interactions induced by millisecond blasting. The rectangle model has a size of 12 × 6 m (L × W) and two blast holes have the same diameter of 12 cm. The shock waves are simplifi ed as time-varying forces applied at the particles of walls of the two boreholes. Among a series of numerical tests in this study, the spacing between two adjacent boreholes and delay time of millisecond blasting are considered as two primary variables, and the decoupling charge with a coeffi cient of 1.5 is taken into account in each case. The results show that stress superposition is not a key factor for improving rock fragmentation (tensile stress interactions rather than compressive stress superposition could aff ect the generation of cracks), whereas collision actions from isolated particles or particles with weakened constraints play a crucial role in creating the fracture network. The delay time has an infl uence on causing cracks in rock blasting, however, whether it works heavily depends on the distance between the two holes. | Yuan Wei Liu Shangge Wang Wei Su Xuebin Li Zonghong Li Jiaxin Wen Lei Chang Jiangfang Sun Xiaoyun | 2019 | Earthquake Engineering and Engineering Vibration2019，18，4： | 7 |
| 13 | The dynamic and thermodynamic processes dominating the reduction of global land monsoon precipitation driven by anthropogenic aerosols emission显示文摘Changes in monsoon precipitation have profound social and economic impacts as more than two-thirds of the world’s population lives in monsoon regions.Observations show a significant reduction in global land monsoon precipitation during the second half of the 20 th century.Understanding the cause of this change,especially possible anthropogenic origins,is important.Here,we compare observed changes in global land monsoon precipitation during 1948–2005 with those simulated by 5 global climate models participating in the Coupled Model Inter-comparison Project-phase 5(CMIP5)under different external forcings.We show that the observed drying trend is consistent with the model simulated response to anthropogenic forcing and to anthropogenic aerosol forcing in particular.We apply the optimal fingerprinting method to quantify anthropogenic influences on precipitation and find that anthropogenic aerosols may have contributed to 102%(62–144%for the 5–95%confidence interval)of the observed decrease in global land monsoon precipitation.A moisture budget analysis indicates that the reduction in precipitation results from reduced vertical moisture advection in response to aerosol forcing.Since much of the monsoon regions,such as India and China,have been experiencing rapid developments with increasing aerosol emissions in the past decedes,our results imply a further reduction in monsoon precipitation in these regions in the future if effective mitigations to reduce aerosol emissions are not deployed.The observed decline of aerosol emission in China since 2006 helps to alleviate the reducing trend of monsoon precipiptaion. | Tianjun ZHOU Wenxia ZHANG Lixia ZHANG Xuebin ZHANG Yun QIAN Dongdong PENG Shuangmei MA Buwen DONG | 2020 | Science China Earth Sciences2020，63，7： | 7 |
| 14 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 15 | Mycorrhizal symbiosis modulates the rhizosphere microbiota to promote rhizobia–legume symbiosis显示文摘Plants establish symbioses with mutualistic fungi,such as arbuscular mycorrhizal(AM)fungi,and bacteria,such as rhizobia,to exchange key nutrients and thrive.Plants and symbionts have coevolved and represent vital components of terrestrial ecosystems.Plants employ an ancestral AM signaling pathway to establish intracellular symbioses,including the legume–rhizobia symbiosis,in their roots.Nevertheless,the relationship between the AM and rhizobial symbioses in native soil is poorly understood.Here,we examined how these distinct symbioses affect root-associated bacterial communities in Medicago truncatula by performing quantitative microbiota profiling(QMP)of 16S rRNA genes.We found that M.truncatula mutants that cannot establish AM or rhizobia symbiosis have an altered microbial load(quantitative abundance)in the rhizosphere and roots,and in particular that AM symbiosis is required to assemble a normal quantitative root-associated microbiota in native soil.Moreover,quantitative microbial co-abundance network analyses revealed that AM symbiosis affects Rhizobiales hubs among plant microbiota and benefits the plant holobiont.Through QMP of rhizobial rpoB and AM fungal SSU rRNA genes,we revealed a new layer of interaction whereby AM symbiosis promotes rhizobia accumulation in the rhizosphere of M.truncatula.We further showed that AM symbiosis-conditioned microbial communities within the M.truncatula rhizosphere could promote nodulation in different legume plants in native soil.Given that the AM and rhizobial symbioses are critical for crop growth,our findings might inform strategies to improve agricultural management.Moreover,our work sheds light on the co-evolution of these intracellular symbioses during plant adaptation to native soil conditions. | Xiaolin Wang Huan Feng Yayu Wang Mingxing Wang Xingguang Xie Huizhong Chang Like Wang Jicheng Qu Kai Sun Wei He Chunyan Wang Chuanchao Dai Zhaohui Chu Changfu Tian Nan Yu Xuebin Zhang Huan Liu Ertao Wang | 2021 | Molecular Plant2021，14，3： | 6 |
| 16 | Progress on design and related R&D activities for the water-cooled breeder blanket for CFETR显示文摘The water-cooled ceramic breeder (WCCB) blanket is one of the blanket candidates for Chinese fusion engineering testing reactor (CFETR) and is being developed at the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP). This paper reviews design and evolution of the WCCB blanket for CFETR, and presents a new WCCB blanket design according to the latest CFETR core parameters (major and minor radii are R = 7.2 m and a = 2.2 m, respectively) and missions. This new design is expected to satisfy multiple CFETR operation modes of 0.2, 0.5, 1.0, and 1.5 GW fusion power and achieve tritium self-sufficiency. The feasibility of the updated blanket design is evaluated from the aspects of neutronics and thermo-hydraulics. Furthermore, the research and development (R&D) activities supporting to the WCCB blanket for CFETR are reported, including the design code, the water loop experiments, the pebble bed modeling and experiments, and the components fabrication technology. | Songlin Liu Xiaoman Cheng Xuebin Ma Lei Chen Kecheng Jiang Xia Li Hui Bao Jichao Wang Wanjing Wang Changhong Peng Peng Lu Min Li Kai Huang | 2019 | Theoretical & Applied Mechanics Letters2019，9，3： | 6 |
| 17 | Similar simulation study on the deformation and failure of surrounding rock of a large section chamber group under dynamic loading显示文摘Large and super-large section chamber groups in coal mines are frequently affected by dynamic loads resulting from production activities such as roadway driving and blasting.The stability of the surrounding rock is poor,and it is difficult to control.In this paper,a similar simulation test was used to study the deformation and evolution laws of the surrounding rock of a triangle-shaped chamber group under different dynamic loads.The results showed that under dynamic loading,the vertical stress of the surrounding rock of the chamber group increased in an oscillatory form.The maximum stress concentration coefficient reached 4.09.The damage degree of the roof was greater than that of the two sides.The deformation of the roof was approximately 1.2 times that of the two sides.For the chamber closer to the power source,the stress oscillation amplitude of the surrounding rock was larger,and the failure was more serious.The force of the anchorage structure showed a phased increasing characteristic;additionally,the force of the anchorage structure on the adjacent side of the chambers was greater than that on the other side.This study reveals the deformation and failure evolution laws of the surrounding rock of large section chamber groups under dynamic loading. | Xuesheng Liu Shilin Song Yunliang Tan Deyuan Fan Jianguo Ning Xuebin Li Yanchun Yin | 2021 | International Journal of Mining Science and Technology2021，31，3： | 6 |
| 18 | Application of a novel inhibitor of human CD59 for the enhancement of complement-dependent cytolysis on cancer cells显示文摘Many monoclonal antibodies(mAbs)have been extensively used in the clinic,such as rituximab to treat lymphoma.However,resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy.Complement is one of the main mediators of antibody-based cancer therapy via the complement-dependent cytolysis(CDC)effect.CD59 plays a critical role in resistance to mAbs through the CDC effect.In this paper,we attempted to investigate whether the novel CD59 inhibitor,recombinant ILYd4,was effective in enhancing the rituximab-mediated CDC effect on rituximab-sensitive RL-7 lymphoma cells and rituximab-induced resistant RR51.2 cells.Meanwhile,the CDC effects,which were mediated by rituximab and anti-CD24 mAb,on the refractory multiple myeloma(MM)cell line ARH-77 and the solid tumor osteosarcoma cell line Saos-2,were respectively investigated.We found that rILYd4 rendered the refractory cells sensitive to the mAb-mediated CDC effect and that rILYd4 exhibited a synergistic effect with the mAb that resulted in tumor cells lysis.This effect on tumor cell lysis was apparent on both hematological tumors and solid tumors.Therefore,rILYd4 may serve as an adjuvant for mAb mediated-tumor immunotherapy. | Tao You Weiguo Hu Xiaowen Ge Jingnan Shen Xuebin Qin | 2011 | Cellular & Molecular Immunology2011，8，2： | 6 |
| 19 | Arc corrosion behavior of Cu-Ti_3AlC_2 composites in air atmosphere显示文摘The arc corrosion evolution of Cu-20 vol.% Ti_3 AlC_2 cathodes is presented here. After eroded by 3, 4, 5, 6, 7, 8, 9, 10 kV DC voltage, respectively, the surface morphologies were characterized by field emission scanning electron microscope with craters and protrusions. Compared to small craters and dense protrusions of the morphology by high voltage, the eroded surface was covered with bigger craters and sparse protrusions at low voltage. No crack was discovered on the surface even at 10 kV. By means of energy dispersive spectroscopy and Raman spectroscopy, the decomposition of Cu-20 vol.% Ti_3 AlC_2 cathode to CuO,Al__2 O_3 and TiO_2 were proved. Meanwhile, W anode is oxidized to WO_2. The peak current increases with the increasing breakdown voltage, which is recorded by a digital memory oscilloscope. | HUANG XiaoChen FENG Yi QIAN Gang ZHAO Hao SONG ZhaoKun ZHANG JingCheng ZHANG XueBin | 2018 | Science China(Technological Sciences)2018，61，4： | 6 |
| 20 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
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