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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 3 | Effects of Crude Oil Contamination on Soil Physical and Chemical Properties in Momoge Wetland of China显示文摘Large oilfields are often coincidentally located in major river deltas and wetlands,and potentially damage the structure,function and ecosystem service values of wetlands during oil exploration.In the present study,the effects of crude oil contamination during oil exploration on soil physical and chemical properties were investigated in marshes of the Momoge National Nature Reserve in Jilin Province,China.The concentrations of total petroleum hydrocarbons in the marsh soil near the oil wells are significantly higher than those in the adjacent control marsh.Soil water contents in oil-contaminated marshes are negatively correlated with soil temperature and are significantly lower than those in the control area,especially in fall.Crude oil contamination significantly increases the soil pH up to8.0,and reduces available phosphorus concentrations in the soil.The concentrations of total organic carbon are significantly different among sampling sites.Therefore,crude oil contamination could potentially alkalinize marsh soils,adversely affect soil fertility and physical properties,and cause deterioration of the marshes in the Momoge National Nature Reserve.Phyto-remediation by planting Calamagrostis angustifolia has the potential to simultaneously restore and remediate the petroleum hydrocarbon-contaminated wetlands.Crude oil contamination affects the soil physical and chemical properties,so developing an effective restoration program in the Momoge wetland is neccesary. | WANG Ying FENG Jiang LIN Qianxin LYU Xianguo WANG Xiaoyu WANG Guoping | 2013 | Chinese Geographical Science2013，23，6： | 12 |
| 4 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 5 | Pulse labeling and long-term tracing of newborn neurons n the adult subgranular zone显示文摘在过去的十年的研究证明了那个成年大脑生产增殖并且区分到集成到存在电路的新生的神经原的神经祖先房间。然而,详细说明了区别过程和最新产生的神经原的内在的机制由于为把神经祖先房间和新生的神经原标记并且操作的可得到的方法的限制大部分是未知的。在这研究,我们设计了一紧控制了, noninvasive 系统基于 Cre/loxP 再结合到完成在 vivo 的长期的跟踪和成年神经原的基因操作。在这个系统, tamoxifen 可诱导的 recombinase, CreERT2,被 doublecortin 的基于用绳子拖的平底渡船的倡导者驾驶(DCX,新生的神经原的一个标记) 。由带着记者老鼠穿过这根 Cre 线,我们发现在有牙齿的回转(DG ) 的新生的神经原能由黄的导致 tamoxifen 的表示是有选择地标记脉搏的荧光灯蛋白质(YFP ) 。YFP 积极的神经原被 coimmunostaining 与房间识别类型特定的标记并且由记录的 electrophysiological 描绘了。而且,这些神经原的迁居的分析证明这些标记的神经原的多数移居了到小粒房间层的内部部分。而且,新生的小粒神经原的内部分子的层的脊骨生长拿一个动态模式转换 U 形状,与在外部分子的层的楔形的变化相对照。我们的转基因的工具提供一个有效方法有选择地在成年老鼠 DG 把新生的神经原标记并且操作。 | Xuewen Cheng Yang Li Ying Huang Xiaoyan Feng Guoping Feng Zhi-Qi Xiong | 2011 | Cell Research2011，21，2： | 4 |
| 6 | Experimental research on the residual stress of polycrystalline diamond compacts for oil drilling显示文摘Practical experiences gained in the past several years show that the thermal residual stress(TRS) is a main cause leading polycrystalline diamond compacts(PDC) to premature failure.It is the very important to measure the TRS accurately for optimizing the interface and improving the service performance of PDC.In this paper,the TRS in 1913 flat-interface PDC was measured using improved stress-release method(ISRM). The TRS on the surface of polycrystalline diamond(PCD) table was obtained,which can be used to calculate the radial thermal residual stress(RTRS) at the interface of PCD table via a refutation process.The obtained results show that there are compressive residual stress at the PCD table interface and in the most region of PCD table surface.The exception occurs near the outer diameter of the PCD table,where the PDC begins to bend and put the PCD table surface into a tension state,an undesirable state for a brittle material.The ISRM has covered the shortage existing in traditional stress-release method,in which only finite points on the surface of PCD table can be tested for one specimen and one time.Simple as the experimental procedures are,the test results are also very accurate and reliable.This method provides the theoretical and experimental basis for testing TRS of PDC accurately. | Xu Gen~1 Xu Guoping~2 Chen Feng~3 Ma Chunde~3 (1.School of Resources and Safety Engineering,Central South University,Changsha 410083,China) (2.King-ray New Materials Science & Technology Co,Ltd,Changsha 410012,China) (3.Testing Center,Central South University,Changsha 410083,China) | 2008 | 金刚石与磨料磨具工程2008，28，S1： | 3 |
| 7 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 8 | Sideswiping Tropical Cyclones and Their Associated Precipitation over China显示文摘Tropical cyclone(TC)precipitation(TCP)has attracted considerable attention in recent decades because of its adverse socioeconomic impacts.In particular,considerable effort has been devoted to quantifying TCP and investigating the precipitation of TCs that make landfall.However,precipitation over land induced by TCs that do not make landfall(i.e.,offshore),the so-called'sideswiping'TCs(STCs),is an important component of TCP but has attracted little attention from the research community to date.Here,best-track and daily precipitation data from the China Meteorological Administration during the 59 years of 1960-2018 are used to study STC precipitation(STP).Results show that:(i)the annual number of STCs fluctuates significantly from 3 to 17,with a mean frequency of 8.8 STCs per year;(ii)there are decreasing trends in STC frequency and STP amount over the past 59 years;(iii)both STC frequency and STP are high from July to October,with maxima in August;(iv)the distribution of STP,covering most of China’s coastal regions,is dominated by intense STCs,and the annual STP decreases from southeast coastal regions to northwest inland areas,with a maximum value over the islands of Taiwan and Hainan;and(v)extreme STP events could appear not only over the island and coastal areas,but also over inland areas such as Zhumadian of Henan Province due to the influences of local orography and favorable largescale forcing. | Tian FENG Fumin REN Da-Lin ZHANG Guoping LI Wenyu QIU Hui YANG | 2020 | Advances in Atmospheric Sciences2020，37，7： | 2 |
| 9 | Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia显示文摘OBJECTIVE:To review published data on the biological characteristics,differentiation and applications of adipose-derived stem cells in ischemic diseases.DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words 'adipose-derived stem cells','neural-like cells','transplantation','stroke',and 'cerebral ischemia'.SELECTION CRITERIA:The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected,and those published in the last 3-5 years or in authoritative journals were preferred in the same field.Totally 89 articles were obtained in the initial retrieval,of which 53 were chosen based on the inclusion criteria.MAIN OUTCOME MEASURES:Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application.RESULTS:The advantages of adipose-derived stem cells include their ease of procurement,wide availability,rapid expansion,low tumorigenesis,low immunogenicity,and absence of ethical constraints.Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions,reduce small regions of cerebral infarction,promote angiogenesis,and express neuron-specific markers.The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation,but the mechanisms remain unclear.CONCLUSION:Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action. | Guoping Tian Jin Zhou Jing'e Wang Bing Xu Li Li Feng Zhu Jian Han Jianping Li Siyang Zhang Xiaoguang Luo | 2012 | Neural Regeneration Research2012，7，25： | 2 |
| 10 | Neuroligin 3 R451C位点敲入小鼠前额叶皮层的gamma振荡紊乱导致其社交行为缺陷显示文摘文章简介自闭症,又称孤独症,是一种儿童先天性的严重神经发育性疾病,发病率约1%。由于自闭症的致病机制不明,因而也缺乏有效的临床治疗方法。本研究通过一个自闭症遗传模型小鼠,阐明了自闭症中引起社交缺陷的关键脑区及工作机制。 | 曹蔚 林燊 Qiang-qiang Xia Yong-lan Du Qian Yang Meng-ying Zhang Yi-qing Lu Jing Xu Shu-min Duan Jun Xia Guoping Feng 许均瑜 罗建红 | 2019 | 科学新闻2019，0，2： | 2 |
| 11 | The relationships among structure variables of larch forests in China显示文摘Background:Larch(Larix Mill.)forests are widely distributed in the upper parts of mountainous areas in China,playing vital roles in constructing mountain landscapes and maintaining mountain environments.Despite their importance,our knowledges on the large-scale patterns of structure characteristics and the relationships between different structure variables are unclear.In this paper,we investigated 155 plots from 11 natural larch forest types across the country to explore the biogeographic patterns of the structure characteristics and the allometric relationships between different structure variables for Chinese larch forests.Results:The structure characteristics were significantly different among larch forest types.For different larch forest types,the power function fits the relationships between tree height and diameter at breast height(DBH),average DBH and stem density,and taper and stem density well,but with different exponents among larch forest types.The power exponents of the allometric relationships between tree height and DBH for different larch forest types varied from 0.61 to 0.93(mean=0.86)by standard major axis regression(SMA),and from 0.51 to 0.78(mean=0.56)by ordinary least square regression(OLS).The 50%,75%and 95%quantile regression(QR)and OLS indicated that the average DBH and taper of the L.gmelinii forests,L.gmelinii var.principis-rupprechtii forests,and L.sibirica forests were significantly correlated with stem density.Conclusions:The relationship between tree height and DBH showed a power function relationship for all larch forest types in China,but with different exponents.Overall,stem density was negatively correlated with average DBH and taper.The Sect.Larix forests exhibited stand density effect.Our findings provide an important basis for recognizing the biogeographic patterns of structure factors and for the management of larch forests in China. | Wenjing Fang Qing Zhao Qiong Cai Anwar Eziz Guoping Chen Yuhao Feng Heng Zhang Jiangling Zhu Chengjun Ji Zhiyao Tang Jingyun Fang | 2020 | Forest Ecosystems2020，7，4： | 2 |
| 12 | Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis显示文摘Senescence of activated hepatic stellate cells(aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression.Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype(SASP).But little is known about how alanine-serine-cysteine transporter type-2(ASCT2),a high affinity glutamine transporter,affects HSC senescence and SASP during liver fibrosis.Here,we identified ASCT2 is mainly elevated in aHSCs and positively correlated with liver fibrosis in human and mouse fibrotic livers.We first discovered ASCT2 inhibition induced HSCs to senescence in vitro and in vivo.The proinflammatory SASP were restricted by ASCT2 inhibition at senescence initiation to prevent paracrine migration.Mechanically,ASCT2 was a direct target of glutaminolysisdependent proinflammatory SASP,interfering IL-1α/NF-κB feedback loop via interacting with precursor IL-1α at Lys82.From a translational perspective,atractylenolide Ⅲ is identified as ASCT2 inhibitor through directly bound to Asn230 of ASCT2.The presence of -OH group in atractylenolide Ⅲ is suggested to be favorable for the inhibition of ASCT2.Importantly,atractylenolide Ⅲ could be utilized to treat liver fibrosis mice.Taken together,ASCT2 controlled HSC senescence while modifying the proinflammatory SASP.Targeting ASCT2 by atractylenolide Ⅲ could be a therapeutic candidate for liver fibrosis. | Feixia Wang Zhanghao Li Li Chen Ting Yang Baoyu Liang Zili Zhang Jiangjuan Shao Xuefen Xu Guoping Yin Shijun Wang Hai Ding Feng Zhang Shizhong Zheng | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 13 | Metamorphic Rock-hosted Disseminated Gold Deposits——A Case Study of the Xiaotongjiapuzi Gold Depositof Eastern Liaoning显示文摘The Xiaotongjiapuzi gold deposit occurs in a Palaeoproterozoic rift accretionary terrene in eastern Liaoning and is hosted by a carbonate formation of the Dashiqiao Formation, Liaohe Group. The metamorphic grade of the host rock is low amphibolite-high greenschist facies. Gold, which is mainly invisible, is distributed in pyrite and arsenopyrite. The grains of Au-bearing sulphide minerals are fine, ranging from 0.0 n to 1 mm. The wall-rock alterations are characterized by low-temperature silification, hydro-sericitization, serialization and carbonatization. The homogenization temperatures of the fluid inclusions in quartz closely associated with gold mineralization range from 140 to 240℃. The metallogenic age represented by the Ar-Ar isotopic age of sericite is 167 Ma. Comparisons and studies show that the Xiaotongjiapuzi gold deposit can be classified as the submicron-sized disseminated deposit (analogous to the Carlin-type) hosted in metamorphic rocks. | LIU Guoping AI Yongfu FENG Kezhu ZHANG Zhimin | 1999 | Acta Geologica Sinica(English Edition)1999，73，4： | 2 |
| 14 | Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation显示文摘Fragile X syndrome(FXS) patients carry the expansion of over 200 CGG repeats at the promoter of fragile X mental retardation 1(FMR1), leading to decreased or absent expression of its encoded fragile X mental retardation protein(FMRP). However, the global transcriptional alteration by FMRP deficiency has not been well characterized at single nucleotide resolution, i.e., RNA-seq. Here,we performed in-vitro neuronal differentiation of human induced pluripotent stem(iPS) cells that were derived from fibroblasts of a FXS patient(FXS-iPSC). We then performed RNA-seq and examined the transcriptional misregulation at each intermediate stage during in-vitro differentiation of FXS-iPSC into neurons. After thoroughly analyzing the transcriptomic data and integrating them with those from other platforms, we found up-regulation of many genes encoding TFs for neuronal differentiation(WNT1, BMP4,POU3F4, TFAP2 C, and PAX3), down-regulation of potassium channels(KCNA1, KCNC3, KCNG2, KCNIP4, KCNJ3, KCNK9,and KCNT1) and altered temporal regulation of SHANK1 and NNAT in FXS-iPSC derived neurons, indicating impaired neuronal differentiation and function in FXS patients. In conclusion, we demonstrated that the FMRP deficiency in FXS patients has significant impact on the gene expression patterns during development, which will help to discover potential targeting candidates for the cure of FXS symptoms. | Ping Lu Xiaolong Chen Yun Feng Qiao Zeng Cizhong Jiang Xianmin Zhu Guoping Fan Zhigang Xue | 2016 | Science China(Life Sciences)2016，59，11： | 2 |
| 15 | Cloning and characterization of a calcium channel α1 subunit from Drosophila melanogaster with similarity to the rat brain type D isoform显示文摘 | Zheng Wei Feng Guoping Ren Dejian | 1995 | J Neurosci1995，15，2： | 1 |
| 16 | Establishment of an artificial diet for successive rearing of Apolygus lucorum (Hemiptera: Miridae) 显示文摘 | Feng Hongqiang Jin Yinli Li Guoping | 2012 | Journal of Economic Entomology2012，105，6： | 1 |
| 17 | Diapause in- duction in Apolygus lucorum and Adelphocoris suturalis (He- miptera: Miridae) in Northern China 显示文摘 | Feng Hongqiang Chen Peiyu Li Guoping | 2012 | Environmental En- tomology2012，41，6： | 1 |
| 18 | Stability analysis for linear switched systems with time-varying delay显示文摘 | SUN Ximing WANG Feng LIU Guoping | 2008 | IEEE Trans Syst Man Cybern B2008，38，2： | 1 |
| 19 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 20 | Revealing the working mechanism of a multi-functional block copolymer binder for lithium-sulfur batteries显示文摘The lithium-sulfur(Li-S)battery is one of the most promising substitutes for current energy storage systems because of its low cost,high theoretical capacity,and high energy density.However,the high solubility of intermediate products(i.e.,lithium polysulfides)and the resultant shuttle effect lead to rapidly fading capacity and a low coulombic efficiency,which hinder the practical application of Li-S batteries.In this study,block copolymers are constructed with both an ethylene oxide unit and a styrene unit and then used as binders for Li-S batteries.Electrochemical performance improvements are attributed to the synergistic effects contributed by the different units of the block copolymer.The ethylene oxide unit traps polysulfide,which bonds strongly with the intermediate lithium polysulfide,and enhances the transport of lithium ions to reach high capacity.Meanwhile,the styrene unit maintains cathode integrity by improving the mechanical properties and elasticity of the constructed block copolymer to accommodate the large volume changes.By enabling multiple functions via different units in the polymer chain,high sulfur utilization is achieved,polysulfide diffusion is confined,and the shuttle effect is suppressed during the cycle life of Li-S batteries,as revealed by operando ultraviolet-visible spectroscopy and S Kedge X-ray absorption spectroscopy. | Xin He Zhimeng Liu Guoping Gao Xiaotao Liu Michal Swietoslawski Jun Feng Gao Liu Lin-Wang Wang Robert Kostecki | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
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