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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Few-layer Tellurium:one-dimensional-like layered elementary semiconductor with striking physical properties显示文摘Few-layer Tellurium, an elementary semiconductor, succeeds most of striking physical properties that black phosphorus(BP) offers and could be feasibly synthesized by simple solution-based methods. It is comprised of non-covalently bound parallel Te chains, among which covalent-like feature appears.This feature is, we believe, another demonstration of the previously found covalent-like quasi-bonding(CLQB) where wavefunction hybridization does occur. The strength of this inter-chain CLQB is comparable with that of intra-chain covalent bonding, leading to closed stability of several Te allotropes. It also introduces a tunable bandgap varying from nearly direct 0.31 eV(bulk) to indirect 1.17 eV(2L) and four(two) complex, highly anisotropic and layer-dependent hole(electron) pockets in the first Brillouin zone.It also exhibits an extraordinarily high hole mobility(~10~5 cm^2/Vs) and strong optical absorption along the non-covalently bound direction, nearly isotropic and layer-dependent optical properties, large ideal strength over 20%, better environmental stability than BP and unusual crossover of force constants for interlayer shear and breathing modes. All these results manifest that the few-layer Te is an extraordinary-high-mobility, high optical absorption, intrinsic-anisotropy, low-cost-fabrication, tunable bandgap, better environmental stability and nearly direct bandgap semiconductor. This ‘‘one-dimen sion-like' few-layer Te, together with other geometrically similar layered materials, may promote the emergence of a new family of layered materials. | Jingsi Qiao Yuhao Pan Feng Yang Cong Wang Yang Chai Wei Ji | 2018 | Science Bulletin2018，63，3： | 12 |
| 3 | High-quality genome assembly of 'Cuiguan' pear (Pyrus pyrifolia) as a reference genome for identifying regulatory genes and epigenetic modifications responsible for bud dormancy显示文摘Dormancy-associated MADS-box(DAM)genes serve as crucial regulators of the endodormancy cycle in rosaceous plants.Although pear DAM genes have been identified previously,the lack of a high-quality reference genome and techniques to study gene function have prevented accurate genome-wide analysis and functional verification of such genes.Additionally,the contribution of other genes to the regulation of endodormancy release remains poorly understood.In this study,a high-quality genome assembly for'Cuiguan'pear(Pyrus pyrifolia),which is a leading cultivar with a low chilling requirement cultivated in China,was constructed using PacBio and Hi-C technologies.Using this genome sequence,we revealed that pear DAM genes were tandemly clustered on Chr8 and Chr15 and were differentially expressed in the buds between'Cuiguan'and the high-chilling-requirement cultivar'Suli'during the dormancy cycle.Using a virus-induced gene silencing system,we determined the repressive effects of DAM genes on bud break.Several novel genes potentially involved in the regulation of endodormancy release were identified by RNA sequencing and H3K4me3 chromatin immunoprecipitation sequencing analyses of‘Suli'buds during artificial chilling using the new reference genome.Our findings enrich the knowledge of the regulatory mechanism underlying endodormancy release and chilling requirements and provide a foundation for the practical regulation of dormancy release in fruit trees as an adaptation to climate change. | Yuhao Gao Qinsong Yang Xinhui Yan Xinyue Wu Feng Yang Jianzhao Li Jia Wei Junbei Ni Mudassar Ahmad Songling Bai Yuanwen Teng | 2021 | Horticulture Research2021，8，1： | 5 |
| 4 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 5 | Development and application research of light weight heat treated B-grade bulletproof steel显示文摘The light weight heat treated B-grade bulletproof steel was developed through composition design and optimization based on multiplex alloying,multiplex micro-alloying design ideas and complex phase structure strengthening theory.The puzzle how to avoid the quenching deformation problem of super high strength thin sheet was solved through heat treatment in a die with a set of cooling system.Such B-grade bulletproof steel plate has fine tempered lath martensite structure.The shooting and certification test results showed that the shoot resistance of B-grade bulletproof steel plate can meet the protection demand of Protection specification for cash carrying vehicles(GA 164—2005).In comparison with B-grade bulletproof steel plate made by one of the companies in Sweden,the weight of the developed B-grade bulletproof steel plate can be decreased by 8 %under the same shoot resistance condition.It will be meaningful for cash truck and anti-hijacking vehicle to realize light weight,energy conservation and emission reduction. | Ma Mingtu Chen Gang Ma Yuhao Li Zhigang Feng Yi | 2014 | Engineering Sciences2014，12，5： | 2 |
| 6 | The relationships among structure variables of larch forests in China显示文摘Background:Larch(Larix Mill.)forests are widely distributed in the upper parts of mountainous areas in China,playing vital roles in constructing mountain landscapes and maintaining mountain environments.Despite their importance,our knowledges on the large-scale patterns of structure characteristics and the relationships between different structure variables are unclear.In this paper,we investigated 155 plots from 11 natural larch forest types across the country to explore the biogeographic patterns of the structure characteristics and the allometric relationships between different structure variables for Chinese larch forests.Results:The structure characteristics were significantly different among larch forest types.For different larch forest types,the power function fits the relationships between tree height and diameter at breast height(DBH),average DBH and stem density,and taper and stem density well,but with different exponents among larch forest types.The power exponents of the allometric relationships between tree height and DBH for different larch forest types varied from 0.61 to 0.93(mean=0.86)by standard major axis regression(SMA),and from 0.51 to 0.78(mean=0.56)by ordinary least square regression(OLS).The 50%,75%and 95%quantile regression(QR)and OLS indicated that the average DBH and taper of the L.gmelinii forests,L.gmelinii var.principis-rupprechtii forests,and L.sibirica forests were significantly correlated with stem density.Conclusions:The relationship between tree height and DBH showed a power function relationship for all larch forest types in China,but with different exponents.Overall,stem density was negatively correlated with average DBH and taper.The Sect.Larix forests exhibited stand density effect.Our findings provide an important basis for recognizing the biogeographic patterns of structure factors and for the management of larch forests in China. | Wenjing Fang Qing Zhao Qiong Cai Anwar Eziz Guoping Chen Yuhao Feng Heng Zhang Jiangling Zhu Chengjun Ji Zhiyao Tang Jingyun Fang | 2020 | Forest Ecosystems2020，7，4： | 2 |
| 7 | Spontaneous low-temperature crystallization of α-FAPbI3 for highly efficient perovskite solar cells显示文摘Formamidinium lead triiodide(HC(NH2)2PbI3 or FAPbI3)is a promising light absorber for high-efficiency perovskite solar cells because of its superior light absorption range and thermal stability to CH3NH3PbI3(MAPbI3).Unfortunately,it is difficult to fabricate high-quality FAPbI3 thin films to surpass the MAPbI3-based cells due to easily forming unwanted but more stable yellow d-phase and thus requiring high annealing-temperature for wanted photovoltaic-active black a-phase.Herein,we reported a novel low-temperature fabrication of highly crystallized a-FAPbI3 film exhibiting uniaxial-oriented nature with large grain sizes up to 2 lm.First-principles energetic calculations predicted that this novel deposition should be ascribed to the formation of a high-energy metastable two-dimensional(2D)intermediate of MAFAPbI3 Cl followed by a spontaneous conversion to a-FAPbI3.The ions exchange reaction during this MAFAPbI3 Cl-FAPbI3 conversion account for the perovskite film uniaxial-oriented grown along the(111)direction.This large-grain and uniaxial-oriented grown a-FAPbI3 based solar cells exhibited an efficiency up to 20.4%accompanying with low density-voltage(J-V)hysteresis and high stability. | Taiyang Zhang Qiaoling Xu Feng Xu Yuhao Fu Yong Wang Yanfa Yan Lijun Zhang Yixin Zhao | 2019 | Science Bulletin2019，64，21： | 2 |
| 8 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 9 | Design of a real- time adaptive NURBS interpolator with axis acceleration limit显示文摘 | Jingchun Feng Yuhao Li Yuhan Wang | 2009 | Int J Adv Manuf Technol2009，09，： | 1 |
| 10 | Sulfur vs. tellurium: the heteroatom effects on the nonfullerene acceptors显示文摘The effect of chalcogen heteroatom variation on donor materials has been systematically investigated. However, this effect on acceptors has rarely been explored. Herein, nonfullerene acceptors BFPSP and BFPTP were reported by simply changing the chalcogen atoms from S to Te. The differences between BFPSP and BFPTP in light absorption, energy levels, excited-state lifetimes, energy loss, charge mobilities, morphology, and photovoltaic properties were systematically investigated to understand the heteroatom effects. More importantly, the electroluminescence spectra, external quantum efficiency of photovoltaics and TDDFTcalculations revealed that the triplet excited state(T1) in energy of BFPTP equals to the charge transfer(CT) state in PBDBT:BFPTP, which allows T1 excitons, generated by intersystem crossing, to split into free charges to contribute to the efficiency.This contribution provides a strategy for tuning the photophysical properties of nonfullerene acceptors and designing high performance triplet materials for OSCs. | Lei Yang Linqing Qin Yunxiao Xu Huotian Zhang Lei Lv Kepeng Chen Xinyu Sui Yangguang Zhong Yuan Guo Feng Gao Jianzhang Zhao Yuhao Li Xinfeng Liu Yuanping Yi Xinhui Lu Aidong Peng Hui Huang | 2019 | Science China Chemistry2019，62，7： | 1 |
| 11 | Design of a real-time adaptive NURBS interpolator with axis acceleration limit 显示文摘 | Feng Jingchun Li Yuhao Wang Yuhan | 2010 | The International Journal of Advanced Manufacturing Technology2010，48，14： | 1 |
| 12 | Design of a real-time adaptive NURBS interpolator with axis acceleration limit显示文摘 | Jingchun Feng Yuhao Li Yuhan Wang | 2010 | Int J Adv Manuf Technol2010，48，： | 1 |
| 13 | Manipulating cavity photon dynamics by topologically curved space显示文摘Asymmetric microcavities supporting Whispering-gallery modes(WGMs)are of great significance for on-chip optical information processing.We establish asymmetric microcavities on topologically curved surfaces,where the geodesic light trajectories completely reconstruct the cavity mode features.The curvature-mediated photon-lifetime engineering enables the enhancement of the quality factors of periodic island modes by up to 200 times.Strong and weak coupling between modes of very different origins occurs when the space curvature brings them into resonance,leading to fine tailoring of the cavity photon energy and lifetime and the observation of non-Hermitian exceptional point(EP).At large space curvatures,the role of the WGMs is replaced by high-Q periodic modes protected by the high stability of island-like light trajectory.Our work demonstrates interesting physical mechanisms at the crosspoint of optical chaotic dynamics,non-Hermitian physics,and geodesic optical devices,and would initiate the novel area of geodesic microcavity photonics. | Yongsheng Wang Yuhao Ren Xiaoxuan Luo Bo Li Zaoyu Chen Zhenzhi Liu Fu Liu Yin Cai Yanpeng Zhang Jin Liu Feng Li | 2022 | Light(Science & Applications)2022，11，11： | 1 |
| 14 | Upper Darriwilian(Middle Ordovician) Radiolarians and Ostracods from the Hulo Formation, Zhejiang Provicnce, South China显示文摘Considerable research has been done on the Ordovician marine fossils from South China, including macrofossils such as brachiopods, graptolites, bivalves, trilobites, some microfossils like conodonts and acritarches. However, radiolarians and ostracods that are also important constituents of the Ordovician marine ecosystem have been paid little attention in this region. In this study, ten radiolarians species belonging to four genera and sixteen ostracods species grouped into nine genera were found from the Hulo Formation at the Hengdu Section of the Jiangshan District, western Zhejiang Province, South China. The fossil-bearing strata belong to the graptolite Pterograptus elegans Zone which indicates the Late Darriwilian Age. This radiolarian fauna is the first record of the Middle Ordovician radiolarian body fossils and also the earliest Ordovician radiolarian fauna reported from South China. The occurrence of Beothuka in this fauna extends the stratigraphic range of the genus to the Upper Darriwilian. Reviews of previous literatures suggest that the diversity of Beothuka was greater during the Early Ordovician, and then declined gradually from the Early Ordovician to the Middle Ordovician before its extinction. The co-occurring ostracod fauna belongs to a shallow-water ecotype. This is contrary to the host lithofacies of the ostracod fauna which represent a deep-water environment. Therefore, these ostacods may have been transported from the shallow-water environment, most likely from the Yangtze carbonate platform. If this conjecture is the truth, then the Jiangshan District was near the shallow-water carbonate platform and received its sediments during the Darriwilian. It is still essential to do more work in the future to better understand the ecology of the Ordovician ostracod fanuas and their role in the sedimentary system of South China. | Yuhao Yi Aihua Yuan Jonathan C Aitchison Qinglai Feng | 2018 | Journal of Earth Science2018，29，4： | 1 |
| 15 | Design of a real-time adaptive NURBS interpolator with axis acceleration limit显示文摘 | Jingchun Feng Yuhao Li Yuhan Wang Ming Chen | 2010 | 2010 (1-4)2010，，1： | 1 |
| 16 | Epidermal radio frequency electronics for wireless power transfer显示文摘Epidermal electronic systems feature physical properties that approximate those of the skin,to enable intimate,long-lived skin interfaces for physiological measurements,human–machine interfaces and other applications that cannot be addressed by wearable hardware that is commercially available today.A primary challenge is power supply;the physical bulk,large mass and high mechanical modulus associated with conventional battery technologies can hinder efforts to achieve epidermal characteristics,and near-field power transfer schemes offer only a limited operating distance.Here we introduce an epidermal,farfield radio frequency(RF)power harvester built using a modularized collection of ultrathin antennas,rectifiers and voltage doublers.These components,separately fabricated and tested,can be integrated together via methods involving soft contact lamination.Systematic studies of the individual components and the overall performance in various dielectric environments highlight the key operational features of these systems and strategies for their optimization.The results suggest robust capabilities for battery-free RF power,with relevance to many emerging epidermal technologies. | Xian Huang Yuhao Liu Gil Woo Kong Jung Hun Seo Yinji Ma Kyung-In Jang Jonathan A.Fan Shimin Mao Qiwen Chen Daizhen Li Hank Liu Chuxuan Wang Dwipayan Patnaik Limei Tian Giovanni A.Salvatore Xue Feng Zhenqiang Ma Yonggang Huang John A.Rogers | 2016 | Microsystems & Nanoengineering2016，2，1： | 1 |
| 17 | Recent Progress on Hydrogeodesy in China显示文摘Modern geodetic technologies,including high-precision ground-based gravity measurements,satellite gravimetry,satellite altimetry,Global Navigation Satellite Systems(GNSS),and Interferometric Synthetic Aperture Radar(InSAR),offer a wealth of observations for monitoring global hydrological processes with exceptional accuracy and spatio-temporal resolutions.Mass redistribution and Earth’s surface deformation over land related to global and regional water cycling can be inferred from modern gravimetry,altimetry,GNSS,and InSAR techniques.Hydrogeodesy becomes an emerging field of geodesy aiming to analyze the changes of water in the Earth system.The paper introduces the China’s advances in hydrogeodesy in recent years.It brings together multiple geodetic teams’work from China,showcasing the application of modern geodetic technologies in the field of hydrology,including research on terrestrial water storage,groundwater storage,glaciers/ice sheets,and reservoir water storage. | Wei FENG Yuhao XIONG Shuang YI Bo ZHONG Xiaodong CHEN Yulong ZHONG Yuanjin PAN Lin LIU Wei WANG Min ZHONG | 2023 | Journal of Geodesy and Geoinformation Science2023，6，3： | 0 |
| 18 | Nanodiamonds decorated yolk-shell ZnFe_(2)O_(4) sphere as magnetically separable and recyclable composite for boosting antibiotic degradation performance显示文摘Photocatalysis is an environmentally friendly and energy-saving technology, which can effectively remove persistent dangerous pollutants in the water. Pitifully, optical absorption capacity and carrier separation have become major bottlenecks for marvelous photocatalytic performance of photocatalysts.Herein, to address these issue, Nanodiamonds/yolk-shell ZnFe_(2)O_(4) spheres(NDs/ZFO) nanocomposites were successfully constructed via a facile two-step of solvothermal and calcination methods. The synthesized optimal NDs/ZFO-10 nanocomposite exhibits superior photocatalytic degradation activity of antibiotic under visible light, approximately 85% of the total tetracycline(TC) is degraded, and this photocatalyst shows durable cycling stability. This stems from two aspects of refinement: improvement of light absorption capacity and photo-induced charges migration and separation. In addition, the NDs/ZFO composite photocatalyst features excellent magnetic recovery capability, facilitating the recovery of photocatalyst in industry. This study opens a new chapter in the combination of NDs with magnetic materials, and deepens the understanding of the application of NDs modified composite photocatalysts. | Jingjing Pan Haoran Sun Keyi Chen Yuhao Zhang Pengnian Shan Weilong Shi Feng Guo | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 19 | Experimental study of primary and secondary side coupling natural convection heat transfer characteristics of the passive residual heat removal system in AP1000显示文摘Passive residual heat removal heat exchanger(PRHR HX),which is a newly designed equipment in the advanced reactors of AP1000 and CAP1400,plays an important role in critical accidental conditions.The primary and secondary side coupling heat transfer characteristics of the passive residual heat removal system(PRHRS)determine the capacity to remove core decay heat during the accidents.Therefore,it is necessary to investigate the heat transfer characteristics and develop applicable heat transfer formulas for optimized design.In the present paper,an overall scaled-down natural circulation loop of PRHRS in AP1000,which comprises a scaleddown in-containment refueling water storage tank(IRWST)and PRHR HX models and a simulator of the reactor core,is built to simulate the natural circulation process in residual heat removal accidents.A series of experiments are conducted to study thermal-hydraulic behaviors in both sides of the miniaturized PRHR HX which is simulated by 12 symmetric arranged C-shape tubes.For the local PRHR HX heat transfer performance,traditional natural convection correlations for both the horizontal and vertical bundles are compared with the experimental data to validate their applicability for the specific heat transfer condition.Moreover,the revised natural convection heat transfer correlations based on the present experimental data are developed for PRHR HX vertical and lower horizontal bundles.This paper provides essential references for the PRHRS operation and further optimized design. | Zhimin QIU Daogang LU Jingpin FU Li FENG Yuhao ZHANG | 2021 | Frontiers in Energy2021，15，4： | 0 |
| 20 | Organocatalytic Stereoselective[8+2]Cycloaddition of Tropones with Azlactones显示文摘Herein,we report an organocatalytic asymmetric[8+2]higher-order cycloaddition of tropones with azlactones employing bifunctional guanidines as hydrogen-bond-mediated catalysts via a 1,8-addition/annulation process.The reaction has a broad scope with respect to both cycloaddition partners and hence offers rapid access to an array of[5.3.0]bicyclic compounds with excellent outcomes[up to 95%yield,>19:1 diastereomeric ratio(dr),and 96%enantiomeric excess(ee)].Besides,the synthetic utility of the protocol provides rapid transformation into enantioenrichedα-amino acid derivatives.Moreover,the isolated[1,5]-H shift isomer,X-ray crystal structure of chiral guanidinium salt,and density functional theory(DFT)calculations provide convincing evidence for the interpretation of diastereo-and enantioselection. | Jinzhao Li Yuhao Mo Liqiao Yan Xiaoming Feng Zhishan Su Xiaohua Liu | 2022 | CCS Chemistry2022，4，2： | 0 |
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