|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma:a prospective non.randomized study显示文摘Background: Transarterial chemoembolization(TACE) is recommended as the standard care for unresectable hepatocellular carcinoma(HCC) at Barcelona Clinic Liver Cancer(BCLC) stage A-B. However, the efficacy of TACE on large(> 10 cm) stage A-B HCC is far from satisfactory, and it is proposed that hepatic artery infusion chemotherapy(HAIC)might be a better first-line treatment of this disease. Hence, we compared the safety and efficacy of HAIC with the modified FOLFOX(mFOLFOX) regimen and those ofTACE in patients with massive unresectable HCC.Methods: A prospective, non-randomized, phase II study was conducted on patients with massive unresectable HCC. The protocol involved HAIC with the mFOLFOX regimen(oxaliplatin, 85 mg/m^2 intra-arterial infusion; leucovorin,400 mg/m^2 intra-arterial infusion; and fluorouracil, 400 mg/m2 bolus infusion and 2400 mg/m^2 continuous infusion)every 3 weeks and TACE with 50 mg of epirubicin, 50 mg of lobaplatin, 6 mg of mitomycin, and lipiodol and polyvinyl alcohol particles. The tumor responses, time-to-progression(TTP), and safety were assessed.Results: A total of 79 patients were recruited for this study: 38 in the HAIC group and 41 in the TACE group. The HAIC group exhibited higher partial response and disease control rates than did the TACE group(52.6% vs. 9.8%, P < 0.001;83.8% vs. 52.5%, P = 0.004). The median TTPs for the HAIC and TACE groups were 5.87 and 3.6 months(hazard radio[HR] = 2.35,95% confidence interval [CI] = 1.16-4.76, P = 0.015). More patients in the HAIC group than in the TACE group underwent resection(10 vs. 3,P = 0.033). The proportions of grade 3-4 adverse events(AE) and serious adverse events(SAE) were lower in the HAIC group than in the TACE group(grade 3-4 AEs: 13 vs. 27, P = 0.007;SAEs: 6 vs. 15,p = 0.044). More patients in the TACE group than in the HAIC group had the study treatment terminated early due to intolerable treatment-related adverse events or the withdrawal of consent(10 vs. 2,P = 0.026).Conclusions: HAIC with mFOLFOX yielded significantly better treatment responses and less serious toxicity than did TACE. HAIC might represent a feasible and promising first-line treatment for patients with massive unresectable HCC. | Min-Ke He Yong Le Qi-Jiong Li Zi-Shan Yu Shao-Hua Li Wei Wei Rong-Ping Guo Ming Shi | 2017 | Chinese Journal of Cancer2017，36，12： | 95 |
| 2 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 3 | China’s urban expansion from 1990 to 2010 determined with satellite remote sensing显示文摘Based on the same data source of Landsat TM/ETM+ in 1990s,2000s and 2010s,all urban built-up areas in China are mapped mainly by human interpretation.Mapping results were checked and refined by the same analyst with the same set of criteria.The results show during the last 20 years urban areas in China have increased exponentially more than 2 times.The greatest area of urbanization changed from Northeastern provinces in 1990s to the Southeast coast of China in Jiangsu,Guangdong,Shandong,and Zhejiang in 2010s.Urban areas are mostly converted from croplands in China.Approximately 17750 km 2 croplands were converted into urban lands.Furthermore,the conversion from 2000 to 2010 doubled that from 1990 to 2000.During the 20 years,the most urbanized provinces are Jiangsu,Guangdong,Shandong and Zhejiang.We also analyzed built-up areas,gross domestic production (GDP) and population of 147 cities with a population of greater than 500000 in 2009.The result shows coastal cities and resource-based cities are with high economic efficiency per unit of built-up areas,resource-based cities have the highest population density,and the economic efficiency of most coastal provinces are lower than central provinces and Guangdong.The newly created urban expansion dataset is useful in many fields including trend analysis of urbanization in China;simulation of urban development dynamics;analysis of the relationship among urbanization,population growth and migration;studies of carbon emissions and climate change;adaptation of climate change;as well as land use and urban planning and management. | WANG Lei LI CongCong YING Qing CHENG Xiao WANG XiaoYi LI XueYan HU LuanYun LIANG Lu YU Le HUANG HuaBing GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 64 |
| 4 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 5 | A multi-resolution global land cover dataset through multisource data aggregation显示文摘Recent developments of 30 m global land characterization datasets(e.g., land cover, vegetation continues field) represent the finest spatial resolution inputs for global scale studies. Here, we present results from further improvement to land cover mapping and impact analysis of spatial resolution on area estimation for different land cover types. We proposed a set of methods to aggregate two existing 30 m resolution circa 2010 global land cover maps, namely FROM-GLC(Finer Resolution Observation and Monitoring-Global Land Cover) and FROM-GLC-seg(Segmentation), with two coarser resolution global maps on development, i.e., Nighttime Light Impervious Surface Area(NL-ISA) and MODIS urban extent(MODIS-urban), to produce an improved 30 m global land cover map—FROM-GLC-agg(Aggregation). It was post-processed using additional coarse resolution datasets(i.e., MCD12Q1, GlobCover2009, MOD44 W etc.) to reduce land cover type confusion. Around 98.9% pixels remain 30 m resolution after some post-processing to this dataset. Based on this map, majority aggregation and proportion aggregation approaches were employed to create a multi-resolution hierarchy(i.e., 250 m, 500 m, 1 km, 5 km, 10 km, 25 km, 50 km, 100 km) of land cover maps to meet requirements for different resolutions from different applications. Through accuracy assessment, we found that the best overall accuracies for the post-processed base map(at 30 m) and the three maps subsequently aggregated at 250 m, 500 m, 1 km resolutions are 69.50%, 76.65%, 74.65%, and 73.47%, respectively. Our analysis of area-estimation biases for different land cover types at different resolutions suggests that maps at coarser than 5 km resolution contain at least 5% area estimation error for most land cover types. Proportion layers, which contain precise information on land cover percentage, are suggested for use when coarser resolution land cover data are required. | YU Le WANG Jie LI XueCao LI CongCong ZHAO YuanYuan GONG Peng | 2014 | Science China Earth Sciences2014，57，10： | 24 |
| 6 | The first all-season sample set for mapping global land cover with Landsat-8 data显示文摘We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 data.Prior to this,such samples were only available at a single date primarily from the growing season.It is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the year.To answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from them.We compared the performances of training samples in different seasons using Random Forest algorithm.We found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same season.The global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification system.The use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification accuracies.All the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping. | Congcong Li Peng Gong Jie Wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang Qi Wang Xuecao Li Xiaoxuan Liu Yidi Xu Jing Guo Caixia Liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton | 2017 | Science Bulletin2017，62，7： | 21 |
| 7 | 扩展的节点电价算法研究显示文摘首先回顾了最优潮流与安全约束经济调度问题,重点讨论了节点边际电价算法原理。着重分析了在非凸性条件下,基于安全约束机组组合与经济调度算法产生的节点边际电价机制存在的缺陷,阐述了如何利用扩展的节点边际电价机制,减少额外支付成本,促进实现激励相容的定价机制。然后,利用对偶原理,对于典型定价机制,即:Convex Hull Price、节点边际电价、整数松弛定价,产生的额外支付成本给出了严格的理论证明,并从几何角度说明其物理意义。最后,实现了混合整数规划与拉格朗日松弛2种机组组合优化算法。算例结果表明文中提出的节点边际电价与整数松弛定价的额外支付成本与Convex Hull Price最小额外支付成本之间关系原理的正确性。激励相容定价机制的研究将促进分布式可再生能源并网,从而推动电力系统向清洁、高效和智能的目标转型与升级。 | 王宣元 高峰 康重庆 黎灿兵 刘乾 韩颖慧 Chien-Ning Yu Le Xie Gerald Sheble 宋永华 | 2019 | 电网技术2019，0，10： | 20 |
| 8 | Fluvial diversity in relation to valley setting in the source region of the Yangtze and Yellow Rivers显示文摘山谷设定的空间分发(旁边地自由,部分限制,或限制) 并且在 Yangtze 和黄河的来源区域的河的形态学被对比并且分析。长江的来源区域被划分成 3 宽广的节(我, II 和 III )基于山谷设定和隧道坡度,与被描绘由的在上游、下游的节限制(一些活动范围部分限制)山谷,当中间的节被描绘与时宽、浅,旁边地自由的山谷。峡在节是突出的我和 III,当编织隧道模式统治节 II 时。由对比,黄河的来源区域基于山谷特征和隧道坡度被划分成 5 宽广的节(节 IV ) 。节我, II 和 IV 是冲积活动范围与主要旁边地自由(一些短活动范围部分限制) 山谷。节 III 和 V 主要被限制或部分限制。更大的词法差异在相对上面的长江的黄河的来源区域是明显的。这包括编织, anabranching,吻合,蜿蜒地流并且笔直地冲积的模式,与在限制活动范围的峡。这个区域的宏消除(举起,坡度,方面,山谷排列和监禁) ,直接连接了到 Qinghai 西藏高原的构造运动,系住到气候, hydrologic 和关於生命的考虑,是在在这个区域的河差异的模式之上的主要控制。 | YU Guo-an LIU Le LI Zhiwei LI Yanfu HUANG Heqing Gary BRIERLEY Brendon BLUE WANG Zhaoyin PAN Baozhu | 2013 | Journal of Geographical Sciences2013，23，5： | 14 |
| 9 | Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013显示文摘 | Ying Peng Song-Hua Chen Le Zhang Bin Chen Ming-Wu Zhang Tie-Niu He Fei Wang Cheng-Liang Chai Lin Zhou Yu Zhang Xiao-Meng Wang Zhongwei Jia | 2017 | Chinese Medical Journal2017，，17： | 13 |
| 10 | Prevalence of asthenopia and its risk factors in Chinese college students显示文摘AIM:To determine the prevalence of asthenopia and identify any associated risk factors in the college students in Xi'an,China. METHODS:From April to September 2012,1 500 students from five universities in Xi'an were selected according to a multi-stage stratified cluster sampling method.Data on demographic features,lifestyle or dietary habits,health status,living environment conditions,sleep and mental status,and asthenopia symptoms were collected through a self-administered validated questionnaire.Univariate logistic regression and multivariate logistic regression analysis modified by the factor analysis were performed to evaluate risk factors for asthenopia.RESULTS:Fifty-seven percent of the college students complained of asthenopia.Statistically significant risk factors for asthenopia in the univariate analysis included 13 variables.Multivariate analysis revealed a significant relationship between the use of computer and asthenopia(OR 1.21,95% CI:1.09 to 1.35).Good sleep and mental status(OR 0.86,95% CI:0.76 to 0.97),good living environment conditions(OR 0.67,95% CI:0.60 to 0.76),and high intake of green leafy vegetables(OR 0.89,95% CI:0.80 to 0.98) were found to be strong predictors of decreasing the occurrence of asthenopia complaints.CONCLUSION:Asthenopia symptom appeares to be common among college students;and it is strongly associated with computer use,psychosocial state,environment conditions and dietary habits,suggesting that additional studies are warranted to verify these risk factors and establish prevention guidelines,especially for college students. | Cheng-Cheng Han Rong Liu Ru-Ru Liu Zhong-Hai Zhu Rong-Bin Yu Le Ma | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 12 |
| 11 | Annual 30-m land use/land cover maps of China for 1980–2015 from the integration of AVHRR, MODIS and Landsat data using the BFAST algorithm显示文摘Annual land use land cover(LULC)change information at medium spatial resolution(i.e.at 30 m)is required in numerous subjects,such as biophysical modelling,land management and global change studies.Annual LULC information,however,is usually not available at continental or national scale due to reasons such as insufficient remote sensing data coverage or lack of computational capabilities.Here we integrate high temporal resolution and coarse spatial resolution satellite images(i.e.,Moderate Resolution Imaging Spectroradiometer(MODIS)and Global Inventory Modelling and Mapping Studies(GIMMS)normalized difference vegetation index(NDVI))with high spatial resolution datasets(China’s Land-Use/cover Datasets(CLUDs)derived from 30-meter Landsat TM/ETM+/OLI)to generate reliable annual nominal 30 m LULC maps for the whole of China between 1980 and 2015.We also test the performance of a statistical based change detection algorithm(Breaks for Additive Seasonal and Trend),originally designed for tracking forest change,in classifying all-type LULC change.As a result,a nominal 30 m annual land use/land cover datasets(CLUD-A)from 1980 to 2015 was developed for the whole China.The mapping results were assessed with a change sample dataset,a regional annual validation sample set and a three-year China sample set.Of the detected change years,75.61%matched the exact time of conversion within±1 year.Annual mapping results provided a detail process of urbanization,deforestation,afforestation,water and cropland dynamics over the past 36 years.The consistent characterization of land change dynamics for China can be further used in scientific research and to support land management for policy-makers. | Yidi XU Le YU Dailiang PENG Jiyao ZHAO Yuqi CHENG Xiaoxuan LIU Wei LI Ran MENG Xinliang XU Peng GONG | 2020 | Science China Earth Sciences2020，63，9： | 12 |
| 12 | Electroacupuncture inhibits annulus fibrosis cell apoptosis in vivo via TNF-α-TNFR1-caspase-8 and integrin β1/Akt signaling pathways显示文摘OBJECTIVE: To examine whether electroacupuncture(EA) treatment inhibited cell apoptosis of intervertebral annulus fibrosis(AF) via tumor necrosis factor-α(TNF-α)-tumor necrosis factor receptor 1(TNFR1)-caspase-8 and integrin β1/Akt signaling pathways in a rat model of cervical intervertebral disc degeneration caused by unbalanced dynamic and static forces.METHODS: Thirty-two Sprague-Dawley rats were included in this study, of which 24 rats underwent surgery to induce cervical intervertebral disc degeneration, while eight rats received EA treatment at Dazhui(GV 14). Immunohistochemical staining was used to detect TNF-α, TNFR1, and caspase-8Apoptosis of AF cells was examined with terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The m RNA and protein expression levels of integrin β1 andAkt were evaluated with real-time polymerase chain reaction and western blot analysis, respectively.RESULTS: Treatment with EA decreased TUNEL-positive AF cells and lowered TNF-α, TNFR1 and caspase-8 positive cells compared with control groups. EA treatment also increased integrin β1and Akt m RNA and protein levels compared with controls.CONCLUSION: Treatment with EA inhibits AF cell apoptosis through suppression of the TNF-α-TNFR1-caspase-8 signal pathway and increases the expression of integrin β1 and Akt. EA may be a good alternative therapy for treating cervical spondylosis. | Jun Liao Le Zhang Jiaxuan Zheng Debiao Yu Meigui Ke Teng Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 12 |
| 13 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 14 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 15 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 16 | Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition显示文摘The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic factor in vertebrate developmental,physiological and pathological conditions for decades.Here we report a novel finding that genetic ablation of CDP-diacylglycerol synthetase-2(CDS2),a metabolic enzyme that controls phosphoinositide recycling,switches the output of VEGFA signaling from promoting angiogenesis to unexpectedly inducing vessel regression.Live imaging analysis uncovered the presence of reverse migration of the angiogenic endothelium in cds2 mutant zebrafish upon VEGFA stimulation,and endothelium regression also occurred in postnatal retina and implanted tumor models in mice.In tumor models,CDS2 deficiency enhanced the level of tumorsecreted VEGFA,which in-turn trapped tumors into a VEGFA-induced vessel regression situation,leading to suppression of tumor growth.Mechanistically,VEGFA stimulation reduced phosphatidylinositol(4,5)-bisphosphate(PIP2)availability in the absence of CDS2-controlled-phosphoinositide metabolism,subsequently causing phosphatidylinositol(3,4,5)-triphosphate(PIP3)deficiency and F0X01 activation to trigger regression of CDS2-null endothelium.Thus,our data indicate that the effect of VEGFA on vasculature is context-dependent and can be converted from angiogenesis to vascular regression. | Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan | 2019 | Cell Research2019，29，11： | 9 |
| 17 | Adaptive changes in autophagy after UPS impairment in Parkinson's disease显示文摘 | Yu-fei SHEN Yu TANG Xiao-jie ZHANG Kai-xing HUANG Wei-dong LE | 2013 | Acta Pharmacologica Sinica2013，34，5： | 9 |
| 18 | Stability of interbed for salt cavern gas storage in solution mining considering cusp displacement catastrophe theory显示文摘Cusp displacement catastrophe theory can be introduced to propose a new method about instability failure of the interbed for gas storage cavern in bedded salt in solution mining.We can calculate initial fracture drawing pace of this interbed to obtain 2D and 3D gas storage shapes at this time.Moreover,Stability evaluation of strength reduction finite element method(FEM)based on this catastrophe theory can used to evaluate this interbed stability after initial fracture.A specific example is simulated to obtain the influence of the interbed depth,cavern internal pressure,and cavern building time on stability safety factor(SSF).The results indicate:the value of SSF will be lower with the increase of cavern building time in solution mining and the increase of interbed depth and also this value remains a rise with the increase of cavern internal pressure Especially,we can conclude that the second-fracture of the interbed may take place when this pressure is lower than 6 MPa or after 6 days later of the interbed after initial fracture.According to above analysis,some effective measures,namely elevating the tube up to the top of the interbed,or changing the circulation of in-and-out lines,can be introduced to avoid the negative effects when the secondfracture of the interbed may occur. | Le Yu Jianjun Liu | 2015 | Petroleum2015，1，1： | 9 |
| 19 | Climate effects of the GlobeLand30 land cover dataset on the Beijing Climate Center climate model simulations显示文摘Land cover is one of the most basic input elements of land surface and climate models. Currently, the direct and indirect effects of land cover data on climate and climate change are receiving increasing attentions. In this study, a high resolution(30 m) global land cover dataset(Globe Land30) produced by Chinese scientists was, for the first time, used in the Beijing Climate Center Climate System Model(BCC_CSM) to assess the influences of land cover dataset on land surface and climate simulations. A two-step strategy was designed to use the Globe Land30 data in the model. First, the Globe Land30 data were merged with other satellite remote sensing and climate datasets to regenerate plant functional type(PFT) data fitted for the BCC_CSM. Second, the up-scaling based on an area-weighted approach was used to aggregate the fine-resolution Globe Land30 land cover type and area percentage with the coarser model grid resolutions globally. The Globe Land30-based and the BCC_CSM-based land cover data had generally consistent spatial distribution features, but there were some differences between them. The simulation results of the different land cover type dataset change experiments showed that effects of the new PFT data were larger than those of the new glaciers and water bodies(lakes and wetlands). The maximum value was attained when dataset of all land cover types were changed. The positive bias of precipitation in the mid-high latitude of the northern hemisphere and the negative bias in the Amazon, as well as the negative bias of air temperature in part of the southern hemisphere, were reduced when the Globe Land30-based data were used in the BCC_CSM atmosphere model. The results suggest that the Globe Land30 data are suitable for use in the BCC_CSM component models and can improve the performance of the land and atmosphere simulations. | SHI XueLi NIE SuPing JU WeiMin YU Le | 2016 | Science China Earth Sciences2016，59，9： | 8 |
| 20 | Inhibition of corneal fibrosis by Smad7 in rats after photorefractive keratectomy显示文摘 | WANG Ti ZHOU Xing-tao YU Yan ZHU Jing-yin DAI Jin-hui QU Xiao-mei LE Qi-hua CHU Ren-yuan | 2013 | Chinese Medical Journal2013，，8： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员