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| 1 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 2 | Back Frame Optimization of a Large Radio Telescope Based on Force Cone Method显示文摘A new research perspective is proposed to optimize the topology of truss structure by force cone method,which involves force cone drawing rules and growth rules.Through the comparison with the mature variable density topology optimization method,the effectiveness of force cone method is verified.This kind of new method is simple and easy to understand(no need to master complex structural optimization design theory).Besides,it is time-saving in finite element calculations,and can obtain an optimized truss layout easily.By drawing the force cone,its application on a large radio telescope’s back frame structure shows that,compared with the existing one in terms of structural stiffness,Root Mean Square(RMS)precision,and beam stress distribution,the optimized back frame using the force cone method has higher stiffness,better RMS,more uniform stress,and lighter weight. | WU Qinglong YAO Zhan WU Tanhui FANG Houfei HOU Yangqing | 2022 | Wuhan University Journal of Natural Sciences2022，27，5： | 0 |
| 3 | Alteration of the respiratory microbiome in COVID-19 patients with different severities显示文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients. | Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 4 | Efficacy and safety of the combination of Liushen capsules and Arbidol in the treatment of COVID-19:protocol for a randomized,multi-center pilot study显示文摘Background:From early experience,some Traditional Chinese Medicine and Arbidol had effects of against COVID-19,infer that the combination of Liushen capsules and Arbidol may further increase the therapeutic.Methods/Design:We conducted a randomized,blank parallel-controlled,open-label,multi-center,basal therapy-loaded design clinical trial.A total of 40 patients are going to be recruited after satisfying the criteria.Participants will be allocated randomly into the treatment group with the combination of Arbidol and Liushen capsules and the control group with the basic therapy.Each group will receive treatment at least 7-days or until the virus becomes negative,and visits after drug administration at day 3(visit 1),the day when the virus becomes negative(visit 2),day 7(visit 3),the day before discharge(visit 4)and day 28(visit 5),to collect their survival status and disease prognosis so that the efficacy and safety of a combination of Arbidol and Liushen capsule will be evaluated.Discussion:We described the protocol of the first clinical trial for treatment COVID-19 by using a combination of Arbidol and Liushen capsules.The results of this study will provide a basis for the design and sample size estimate of subsequent large-scale clinical trials.Trial registration:This study has been registered at Chinese clinical trial Registry(chictr.org.cn):ChiCTR2000029993. | Yangqing Zhan Zhengtu Li Jiayang He Shaoqiang Li Ye Lin Jingyi Liang Jie Zhou Yanmei Wu Xuandan Su Feng Ye Zifeng Yang | 2020 | TMR Modern Herbal Medicine2020，3，4： | 0 |
| 5 | Back Frame Section Size Optimization of Large Aperture Telescope显示文摘The back frame structure of a large radio telescope is an important component supporting the reflecting surface,which is directly related to the surface precision.Its optimal design is of key significance for ensuring the surface precision and reducing structural weight.Two methods are constructed to optimize the cross-section size of the telescope back frame in this paper,the criterion method and the first-order optimization method.The criterion method is based on the Lagrangian multiplier method and Kuhn-Tucker condition.This method first establishes the mathematical model by taking the inner and outer radiuses of the back frame beams as the design variables,the structural weight as the constraint condition,and the structural compliance as the objective function,then derives the optimization criterion.The first-order optimization method takes the inner and outer radiuses of the beams as the design variables,the back frame RMS as the objective function,and the structural weight as the constraint condition.Comparison of RMS,structural stress uniformity and optimization efficiency shows that both algorithms can effectively reduce structural deformation and improve RMS,but the criterion method has relatively better result than the first-order method. | Qinglong Wu Zhan Yao Tanhui Wu Yangqing Hou Huazhen Zhang Qian Xu Na Wang | 2023 | Journal of Harbin Institute of Technology(New Series)2023，30，4： | 0 |
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