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| 1 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 2 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 3 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 4 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 5 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 6 | Overexpression of SlOFP20 affects floral organ and pollen development显示文摘The OVATE gene was initially identified in tomato and serves as a key regulator of fruit shape.There are 31 OFP members in the tomato genome.However,their roles in tomato growth and reproductive development are largely unknown.Here,we cloned the OFP transcription factor SlOFP20.Tomato plants overexpressing SlOFP20 displayed several phenotypic defects,including an altered floral architecture and fruit shape and reduced male fertility.SlOFP20 overexpression altered the expression levels of some brassinosteroid(BR)-associated genes,implying that SlOFP20 may play a negative role in the BR response,similar to its ortholog OsOFP19 in rice.Moreover,the transcript accumulation of gibberellin(GA)-related genes was significantly affected in the transgenic lines.SlOFP20 may play an important role in the crosstalk between BR and GA.The pollen germination assay suggested that the pollen germination rate of SlOFP20-OE plants was distinctly lower than that of WT plants.In addition,the tomato pollen-associated genes SlCRK1,SlPMEI,LePRK3,SlPRALF,and LAT52 were all suppressed in the transgenic lines.Our data imply that SlOFP20 may affect floral organ and pollen development by modulating BR and GA signaling in tomato. | Shengen Zhou Zongli Hu Fenfen Li Shibing Tian Zhiguo Zhu Anzhou Li Guoping Chen | 2019 | Horticulture Research2019，6，1： | 4 |
| 7 | Concepts, processing, and recent developments in encapsulating essential oils显示文摘By the virtue of their olfactory,physicochemical,and biological characteristics,essential oils(EOs)have drawn wide attention as additives in daily chemicals like perfume or personal care products.Nevertheless,they are physicochemically unstable and susceptible to degradation or loss.Microencapsulation offers a feasible strategy to stabilize and prolong release of EO.This review summarizes the recognized benefits and functional properties of various preparation and characterization methods,wherein innovative fabrication strategies and their formation mechanisms are especially emphasized.Progress in combining detecting/measuring technologies with kinetic modelling are discussed,to give an integral approach of controlling the dynamic release of encapsulated EOs.Moreover,new development trends of EOs capsules are also highlighted. | Qirui Tian Weiqing Zhou Qiong Cai Guanghui Ma Guoping Lian | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 3 |
| 8 | Sideswiping Tropical Cyclones and Their Associated Precipitation over China显示文摘Tropical cyclone(TC)precipitation(TCP)has attracted considerable attention in recent decades because of its adverse socioeconomic impacts.In particular,considerable effort has been devoted to quantifying TCP and investigating the precipitation of TCs that make landfall.However,precipitation over land induced by TCs that do not make landfall(i.e.,offshore),the so-called'sideswiping'TCs(STCs),is an important component of TCP but has attracted little attention from the research community to date.Here,best-track and daily precipitation data from the China Meteorological Administration during the 59 years of 1960-2018 are used to study STC precipitation(STP).Results show that:(i)the annual number of STCs fluctuates significantly from 3 to 17,with a mean frequency of 8.8 STCs per year;(ii)there are decreasing trends in STC frequency and STP amount over the past 59 years;(iii)both STC frequency and STP are high from July to October,with maxima in August;(iv)the distribution of STP,covering most of China’s coastal regions,is dominated by intense STCs,and the annual STP decreases from southeast coastal regions to northwest inland areas,with a maximum value over the islands of Taiwan and Hainan;and(v)extreme STP events could appear not only over the island and coastal areas,but also over inland areas such as Zhumadian of Henan Province due to the influences of local orography and favorable largescale forcing. | Tian FENG Fumin REN Da-Lin ZHANG Guoping LI Wenyu QIU Hui YANG | 2020 | Advances in Atmospheric Sciences2020，37，7： | 2 |
| 9 | Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia显示文摘OBJECTIVE:To review published data on the biological characteristics,differentiation and applications of adipose-derived stem cells in ischemic diseases.DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words 'adipose-derived stem cells','neural-like cells','transplantation','stroke',and 'cerebral ischemia'.SELECTION CRITERIA:The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected,and those published in the last 3-5 years or in authoritative journals were preferred in the same field.Totally 89 articles were obtained in the initial retrieval,of which 53 were chosen based on the inclusion criteria.MAIN OUTCOME MEASURES:Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application.RESULTS:The advantages of adipose-derived stem cells include their ease of procurement,wide availability,rapid expansion,low tumorigenesis,low immunogenicity,and absence of ethical constraints.Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions,reduce small regions of cerebral infarction,promote angiogenesis,and express neuron-specific markers.The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation,but the mechanisms remain unclear.CONCLUSION:Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action. | Guoping Tian Jin Zhou Jing'e Wang Bing Xu Li Li Feng Zhu Jian Han Jianping Li Siyang Zhang Xiaoguang Luo | 2012 | Neural Regeneration Research2012，7，25： | 2 |
| 10 | Efficient circular gene knockout system for Burkholderiales strain DSM 7029 and Mycobacterium smegmatis mc^2 155显示文摘Multiple gene knockouts are often employed in studies of microbial physiology and genetics. However, the selective markers that confer antibiotic resistance are generally limited, so it is necessary to remove these resistance genes before the next round of using, which is time consuming and labor intensive. Here, we created a universal circular gene knockout system for both the gram-negative bacterial Burkholderiales strain DSM 7029 and the gram-positive bacterial Mycobacterium smegmatis mc^2 155, by combining the homologous recombination with multiple serine integrase-meditated site-specific recombination systems. In this system, a resistance gene and an integrase gene were constructed within the two attachment sites corresponding to a second, different integrase to form a cassette for gene disruption, which could be easily removed by the second integrase during the subsequent round of gene knockout. The sacB gene was also employed for negative selection. As the integrase-mediated deletion of the resistance/integrase gene cassette was highly efficient and concurrent with the following knockout round, the cyclic use of three cassettes could achieve multiple gene knockout in a sequential manner. Following the modularity concept in synthetic biology, common components of the knockout plasmids were retained as BioBricks, accelerating the knockout plasmids construction process. The circular gene knockout system can also be used for multiple gene insertions and applied to other microorganisms. | Xiaolai Lei Qiuxia Fan Tian Huang Haiyun Liu Guoping Zhao Xiaoming Ding | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 2 |
| 11 | Cyclooxygenase increase the angiogenic and metastatic potential of tomor cells显示文摘 | Guoping LI Tian Yang Jun Yan | 2002 | Biochemical Biophysical Research Communications2002，299，： | 1 |
| 12 | E-Cadherin/ β -Catenin Complex and the Epithelial Barrier显示文摘 | Xinrui Tian Zhuola Liu Bo Niu Jianlin Zhang Thian Kui Tan So Ra Lee Ye Zhao David C. H. Harris Guoping Zheng Sanford I. Bernstein | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 13 | Temperature drift modeling and compensation for a dynamically tuned gyroscope by combining WT and SVM method 显示文摘 | Guoping Xu Weifeng Tian Zhihua Jin and Li Qian | 2007 | NOLOGY2007，，： | 1 |
| 14 | A novel hybridEMD-based drift denoising method for a DynamicallyTuned Gyroscope(DTG)显示文摘 | Qian Li Xu Guoping Tian Weifeng | 2009 | Measurement2009，42，： | 1 |
| 15 | Changes in Typhoon Regional Heavy Precipitation Events over China from 1960 to 2018显示文摘In earlier studies,objective techniques have been used to determine the contribution of tropical cyclones to precipitation(TCP)in a region,where the Tropical cyclone Precipitation Event(TPE)and the Regional Heavy Precipitation Events(RHPEs)are defined and investigated.In this study,TPE and RHPEs are combined to determine the Typhoon Regional Heavy Precipitation Events(TRHPEs),which is employed to evaluate the contribution of tropical cyclones to regional extreme precipitation events.Based on the Objective Identification Technique for Regional Extreme Events(OITREE)and the Objective Synoptic Analysis Technique(OSAT)to define TPE,temporal and spatial overlap indices are developed to identify the combined events as TRHPE.With daily precipitation data and TC best-track data over the western North Pacific from 1960 to 2018,86 TRHPEs have been identified.TRHPEs contribute as much as 20%of the RHPEs,but100%of events with extreme individual precipitation intensities.The major TRHPEs continued for approximately a week after tropical cyclone landfall,indicating a role of post landfall precipitation.The frequency and extreme intensity of TRHPEs display increasing trends,consistent with an observed positive trend in the mean intensity of TPEs as measured by the number of daily station precipitation observations exceeding 100 mm and 250 mm.More frequent landfalling Southeast and South China TCs induced more serious impacts in coastal areas in the Southeast and the South during 1990-2018 than1960-89.The roles of cyclone translation speed and'shifts'in cyclone tracks are examined as possible explanations for the temporal trends. | Yangmei TIAN John LMCBRIDE Fumin REN Guoping LI Tian FENG | 2022 | Advances in Atmospheric Sciences2022，39，2： | 1 |
| 16 | E-Cadherin/ β -Catenin Complex and the Epithelial Barrier显示文摘 | Xinrui Tian Zhuola Liu Bo Niu Jianlin Zhang Thian Kui Tan So Ra Lee Ye Zhao David C. H. Harris Guoping Zheng Sanford I. Bernstein | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 17 | Research on Stress Corrosion Sensitivity of C110 Casing in Wellbore Protection Fluid显示文摘 | Dezhi Zeng Rui Chen Zhi Zhang Liyun Shao Guoping Li Gang Tian Taihe Shi | 2012 | Energy Procedia2012，，： | 1 |
| 18 | Genomic insights into the genetic basis of cotton breeding in China显示文摘The excellent Upland cotton(Gossypium hirsutum)cultivars developed since 1949 have made a huge contribution to cotton production in China,the world's largest producer and consumer of cotton.However,the genetic and genomic basis for the improvements of these cotton cultivars remains largely unclear.In this study,we selected 16 Upland cotton cultivars with important historical status in Chinese cotton breeding and constructed a multiparent,advanced generation,intercross(MAGiC)population comprising 920 recombinant inbred lines.A genome-wide association study using the MAGIC population identified 54 genomic loci associated with lint yield and fiber quality.Of them,25(46.30%)pleiotropic genomic loci cause simultaneous changes of lint yield and/or fiber quality traits,revealing complex trade-offs and linkage drags in Upland cotton agronomic traits.Deep sequencing data of 11 introduced ancestor cultivars and publicly available resequencing datasets of 839 cultivars developed in China during the past 70 years were integrated to explore the historical distribution and origin of the elite or selected alleles.Interestingly,85%oftheseelitealleles were selectedandfixed fromdifferent Americanancestors,consistentwithcotton breeding practices in China.However,seven elite alleles of native origin that are responsible for Fusarium wilt resistance,early maturing,good-quality fiber,and other characteristics were not found in American an-cestors but have greatly contributed to Chinese cotton breeding and wide cultivation.Taken together,these results provide a genetic basis for further improving cotton cultivars and reveal that the genetic composition of Chinese cotton cultivars is narrow and mainly derived from early introduced American varieties. | Yiqian Li Zhanfeng Si Guoping Wang Zhuolin Shi Jinwen Chen Guoan Qi Shangkun Jin Zegang Han Wenhao Gao Yue Tian Yun Mao Lei Fang Yan Hu Hong Chen Xiefei Zhu Tianzhen Zhang | 2023 | Molecular Plant2023，16，4： | 0 |
| 19 | A new method for evaluating the firing precision of multiple launch rocket system based on Bayesian theory显示文摘How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%. | Yunfei Miao Guoping Wang Wei Tian | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 20 | The design and fabrication on gate type resonant tunneling transistor显示文摘In light of fabricating resonant tunneling diode(RTD),in this paper a GaAs-based resonant tunneling transistor with gate structure(GRTT)has been designed and fabricated successfully.A systematic depiction centers on the designs of material structure,device structure,photo-lithography mask,fabrication of device and the measurement and analysis of parameters.The fabricated GRTT has a maximum PVCR of 46 and a maximum transconductance of 8 mS.The work lays the foundation for further improve-ment on the performance and parameters of RTT. | Weilian GUO Huilai LIANG Ruiliang SONG Shilin ZHANG Luhong MAO Liuchang HU Jianheng LI Haitao QI Zhen FENG Guoping TIAN Yuehui SHANG Yongqiang LIU Yali LI Mingwen YUAN Xiaobai LI | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，2： | 0 |
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