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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | A review on phospholipids and their main applications in drug delivery systems显示文摘Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity.These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems.The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems,and highlight the relationship between the properties and applications,and the effect of the species of phospholipids on the efficiency of drug delivery.We refer to some relevant literatures,starting from the structures,main sources and properties of phospholipids to introduce their applications in drug delivery systems.The present article focuses on introducing five types of carriers based on phospholipids,including liposomes,intravenous lipid emulsions,micelles,drug-phospholipids complexes and cochleates. | Jing Li Xuling Wang Ting Zhang Chunling Wang Zhenjun Huang Xiang Luo Yihui Deng | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 23 |
| 3 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 4 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 5 | Interdecadal Variability of the Afro-Asian Summer Monsoon System显示文摘The Afro-Asian summer monsoon is a zonally planetary-scale system, with a large-scale rainbelt covering Africa, South Asia and East Asia on interdecadal timescales both in the past century(1901–2014) and during the last three decades(1979–2014). A recent abrupt change of precipitation occurred in the late 1990 s. Since then, the entire rainbelt of the Afro-Asia monsoon system has advanced northwards in a coordinated way. Consistent increases in precipitation over the Huanghe–Huaihe River valley and the Sahel are associated with the teleconnection pattern excited by the warm phase of the Atlantic Multidecadal Oscillation(AMO). A teleconnection wave train, with alternating cyclones/anticyclones, is detected in the upper troposphere. Along the teleconnection path, the configuration of circulation anomalies in North Africa is characterized by coupling of the upper-level anticyclone(divergence) with low-level thermal low pressure(convergence), facilitating the initiation and development of ascending motions in the Sahel. Similarly, in East Asia, a coupled circulation pattern also excites ascending motion in the Huanghe–Huaihe River valley. The synchronous increase in precipitation over the Sahel and Huanghe–Huaihe River valley can be attributed to the co-occurrences and in-phase changes of ascending motion. On the other hand, the warm phase of the AMO results in significant warming in the upper troposphere in North Africa and the northern part of East Asia. Such warming contributes to intensification of the tropical easterly jet through increasing the meridional pressure gradient both at the entrance region(East Asia) and the exit region(Africa). Accordingly, precipitation over the Sahel and Huanghe–Huaihe River valley intensifies, owing to ageostrophic secondary cells. The results of this study provide evidence for a consistent and holistic interdecadal change in the Afro-Asian summer monsoon. | Yi LI Yihui DING Weijing LI | 2017 | Advances in Atmospheric Sciences2017，34，7： | 12 |
| 6 | Combined treatment with erythropoietin and granulocyte colony-stimulating factor enhances neovascularization and improves cardiac function after myocardial infarction显示文摘 | Xue Jingyi Du Guoqing Shi Jing Li Yue Masahiro Yasutake Liu Lei Li Jianqiang Kong Yihui Wang Shuxian Yun Fengxiang Li Weimin | 2014 | Chinese Medical Journal2014，，9： | 12 |
| 7 | The 2016 Summer Floods in China and Associated Physical Mechanisms:A Comparison with 1998显示文摘The characteristics of droughts and floods in China during the summers(May–August)of 2016 and 1998 were compared in great detail,together with the associated atmospheric circulations and external-forcing factors.Following results are obtained.(1)The precipitation was mostly above normal in China in summer 2016,with two main rainfall belts located in the Yangtze River valley(YRV)and North China.Compared with 1998,a similar rainfall belt was located over the YRV,with precipitation 100%and more above normal.However,the seasonal processes of Meiyu were different.A typical'Secondary Meiyu'occurred in 1998,whereas dry conditions dominated the YRV in2016.(2)During May–July 2016,the Ural high was weaker than normal,but it was stronger than normal in 1998.This difference resulted from fairly different distributions of sea surface temperature anomalies(SSTAs)over the North Atlantic Ocean during the preceding winter and spring of the two years.(3)Nonetheless,tropical and subtropical circulation systems were much more similar in May–July of 2016 and 1998.The circulation systems in both years were characterized by a stronger than normal and more westward-extending western Pacific subtropical high(WPSH),a weaker than normal East Asian summer monsoon(EASM),and anomalous convergence of moisture flux in the mid and lower reaches of the YRV.These similar circulation anomalies were attributed to the similar tropical SSTA pattern in the preceding seasons,i.e.,the super El Ni?o and strong warming in the tropical Indian Ocean.(4)Significant differences in the circulation pattern were observed in August between the two years.The WPSH broke up in August 2016,with its western part being combined with the continental high and persistently dominating eastern China.The EASM suddenly became stronger,and dry conditions prevailed in the YRV.On the contrary,the EASM was weaker in August 1998 and the'Secondary Meiyu'took place in the YRV.The Madden–Julian Oscillation(MJO)was extremely active in August 2016 and stayed in western Pacific for 25 days.It triggered frequent tropical cyclone activities and further influenced the significant turning of tropical and subtropical circulations in August2016.In contrast,the MJO was active over the tropical Indian Ocean in August 1998,conducive to the maintenance of a strong WPSH.Alongside the above oceanic factors and atmospheric circulation anomalies,the thermal effect of snow cover over the Qinghai–Tibetan Plateau from the preceding winter to spring in 2016 was much weaker than that in 1998.This may explain the relatively stronger EASM and more abundant precipitation in North China in 2016than those in 1998. | Yuan YUAN Hui GAO Weijing LI Yanju LIU Lijuan CHEN Bin ZHOU Yihui DING | 2017 | Journal of Meteorological Research2017，31，2： | 11 |
| 8 | Observed Trends in Various Aspects of Compound Heat Waves across China from 1961 to 2015显示文摘Based on combined thresholds of daily maximum and minimum temperatures, a compound heat wave is defined,and then changes in multiple aspects of such heat waves in China are estimated between 1961 and 2015. Our results intriguingly indicate that severe compound heat waves in northern China are characterized by excessively high intensity within short duration, while long duration determines great disaster-causing potential of severe events in the south. In the past few decades, large areas of China have experienced longer, stronger, and more frequent compound heat waves. Northern China has witnessed dramatic intensity increases, with a maximum amplification over 5°C decade^(–1); while remarkable lengthening in duration has been mostly recorded in the south, with a maximum trend over 1day decade^(–1). The spatial extent affected by compound heat waves has significantly expanded since the 1960 s, with the largest expanding rate over 6% decade^(–1) detected in North China and Northeast China. These systematic assessments serve to deepen our understanding of observed changes in compound heat waves across China, and may further shed some light on future adaptations and mitigations against an increasingly warming climate. | Yi LI Yihui DING Weijing LI | 2017 | Journal of Meteorological Research2017，31，3： | 10 |
| 9 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 10 | Re-Assessing Climatic Warming in China since 1900显示文摘The regional mean surface air temperature(SAT)in China has risen with a rate of 1.3–1.7℃(100 yr)^-1 since 1900,based on the recently developed homogenized observations.This estimate is larger than those[0.5–0.8℃(100 yr)^-1]adopted in the early National Reports of Climate Change in China.The present paper reviews the studies of the longterm SAT series of China,highlighting the homogenization of station observations as the key progress.The SAT series of China in early studies showed a prominent warm peak in the 1940s,mainly due to inhomogeneous records associated with site-moves of a number of stations from urban to outskirts in the early 1950s,thus leading to underestimates of the centennial warming trend.Parts of China were relatively warm around the 1940s but with differentphase interdecadal variations,while some parts were even relatively cool.This fact is supported by proxy data and could partly be explained by interdecadal changes in large-scale circulation.The effect of urbanization should have a minor contribution to the observed warming in China,although the estimates of such contributions for individual urban stations remain controversial.Further studies relevant to the present topic are discussed. | Zhongwei YAN Yihui DING Panmao ZHAI Lianchun SONG Lijuan CAO Zhen LI | 2020 | Journal of Meteorological Research2020，34，2： | 9 |
| 11 | Celastrol specifically inhibits the activation of NLRP3 inflammasome显示文摘Dear Editor,Inflammasomes are vital components of the innate immune system that survey microbial infections or sterile challenges in the cytosol(de Zoete et al.,2014).A typical inflammasome is composed of a sensor protein such as NOD like receptor(NLR)or AIM2 like receptor(ALR),the | Xuesong Sang Yihui Chen Wei Chen Jing Xie Guangxun Meng Jin Zhong Taisheng Li Ailing Lu | 2018 | Science China(Life Sciences)2018，61，3： | 9 |
| 12 | Tropospheric biennial oscillation of the western Pacific subtropical high and its relationships with the tropical SST and atmospheric circulation anomalies显示文摘There is the significant period of tropospheric biennial Oscillation(TBO)over East Asian monsoon region at the interannual timescales,which has the important influences on East China climate.Based on a set of reconstructed indices which describes the western Pacific subtropical high(WPSH)objectively,this paper focuses on the TBO component of WPSH,one of the key members of the East Asian Monsoon system,and its relationships with the tropical SST and atmospheric circulation anomalies.It is found that(1)As an important interannual component of WPSH,the time series of TBO has the obvious transition in the late1970s,and the variability of the WPSH’s TBO component is more significant after the late 1970s.(2)The time-lag correlations between the WPSH’s TBO and the tropical sea surface temperature(SST)anomalies in several key ocean regions are more significant and have longer correlation duration than the raw data.The response of the western boundary index to ENSO is earlier than the intensity index,and the time-lag correlations of them are up to maximum when lagging ENSO by 3–5 months and 5–6months,respectively.(3)In the course of the WPSH’s TBO cycle,the occurrence of the El Ni o-like anomaly in the tropical central-eastern Pacific in winter is always coupled with the weak East Asian winter monsoon,with the most significant enhancing phase of the WPSH’TBO.In contrast,the La Ni a-like anomaly in the central-eastern Pacific in winter is coupled with the strong East Asian winter monsoon,with the most weakening phase of the WPSH’s TBO.(4)The distribution of the tropical SST and atmospheric circulations anomalies are asymmetric in the TBO cycle.The WPSH’s TBO is more significant in the period of the developing El Ni o-like anomaly in central-eastern Pacific than in the period of the developing La Ni a-like anomaly.Therefore,during the period of developing El Ni o-like anomaly,more attention should be paid to the interannual component of TBO signal in the short-term climate prediction. | LIU YunYun DING YiHui GAO Hui LI WeiJing | 2013 | Chinese Science Bulletin2013，58，30： | 8 |
| 13 | Electro-mechanically controlled assembly of reconfigurable 3D mesostructures and electronic devices based on dielectric elastomer platforms显示文摘The manufacture of 3D mesostructures is receiving rapidly increasing attention,because of the fundamental significance and practical applications across wide-ranging areas.The recently developed approach of buckling-guided assembly allows deterministic formation of complex 3D mesostructures in a broad set of functional materials;with feature sizes spanning nanoscale to centimeter-scale.Previous studies mostly exploited mechanically controlled assembly platforms using elastomer substrates;which limits the capabilities to achieve on-demand local assembly;and to reshape assembled mesostructures into distinct 3D configurations.This work introduces a set of design concepts and assembly strategies to utilize dielectric elastomer actuators as powerful platforms for the electro-mechanically controlled 3D assembly.Capabilities of sequential-local loading with desired strain distributions allow access to precisely tailored 3D mesostructures that can be reshaped into distinct geometries,as demonstrated by experimental and theoretical studies of?30 examples.A reconfigurable inductive-capacitive radio-frequency circuit consisting of morphable 3D capacitors serves as an application example. | Wenbo Pang Xu Cheng Haojie Zhao Xiaogang Guo Ziyao Ji Guorui Li Yiming Liang Zhaoguo Xue Honglie Song Fan Zhang Zheng Xu Lei Sang Wen Huang Tiefeng Li Yihui Zhang | 2020 | National Science Review2020，7，2： | 8 |
| 14 | The 2020/21 Extremely Cold Winter in China Influenced by the Synergistic Effect of La Niña and Warm Arctic显示文摘In the first half of winter 2020/21,China has experienced an extremely cold period across both northern and southern regions,with record-breaking low temperatures set in many stations of China.Meanwhile,a moderate La Niña event which exceeded both oceanic and atmospheric thresholds began in August 2020 and in a few months developed into its mature phase,just prior to the 2020/21 winter.In this report,the mid−high-latitude large-scale atmospheric circulation anomalies in the Northern Hemisphere,which were forced by the negative phase of Arctic Oscillation,a strengthened Siberian High,an intensified Ural High and a deepened East Asian Trough,are considered to be the direct reason for the frequent cold surges in winter 2020/21.At the same time,the synergistic effect of the warm Arctic and the cold tropical Pacific(La Niña)provided an indispensable background,at a hemispheric scale,to intensify the atmospheric circulation anomalies in middle-to-high latitudes.In the end,a most recent La Niña prediction is provided and the on-coming evolution of climate is discussed for the remaining part of the 2020/21 winter for the purpose of future decision-making and early warning. | Fei ZHENG Yuan YUAN Yihui DING Kexin LI Xianghui FANG Yuheng ZHAO Yue SUN Jiang ZHU Zongjian KE Ji WANG Xiaolong JIA | 2022 | Advances in Atmospheric Sciences2022，39，4： | 7 |
| 15 | Operative treatment of acromioclavicular joint dislocation:a new technique with suture anchors显示文摘ObjectiveTo 在在 acromioclavicular 关节 dislocationMethodsTwenty 的外科的治疗加强 acromioclavicular 和 coracoclavicular 系带评估缝术锚的临床的结果 -- 有尖锐创伤的 Rockwood III, IV 和 acromioclavicular 关节的 V 脱臼的八个病人通过手术在我们在 2010 年 10 月之间的研究所对待, 2012 年 1 月被招募。所有病人经历了与缝术锚相结合的开的减小。功能用 Constant-Murley 肩膀分数被评估。临床、 X 光线照相术的肩膀级别在 3, 6 和 12 用 Taft 标准被评估;有固定松开的 months.ResultsTwo 盒子没在最后的统计分析被包括。另外的病人获得了完整的关节在立即的手术后的拍上重新定位。后续与 15.6 的一般水准被执行;月(范围, 12-19 ) 。在运动锻练的早范围以后, 96.2% 病人(25/26 ) 能诱拐并且提高他们的肩膀在内的超过 90 度手术后 3 月。没有感染。平均 Constant-Murley 分数是 96.3 个点(范围, 94-100 )并且吝啬的 Taft 肩膀评价是 10.7 个点(范围, 8-12 )在 12 ; months.ConclusionThe 缝术锚是一种相对简单的技术并且能避免在重建有用的螺丝钉移动在尖锐创伤的 acromioclavicular 的 acromioclavicular 和 coracoclavicular 系带连接脱臼。 | Zhang Jingwei Li Min He Xianfeng Yu Yihui Zhu Limei | 2014 | Chinese Journal of Traumatology2014，17，4： | 7 |
| 16 | Progress involving new techniques for liposome preparation显示文摘The article presents a review of new techniques being used for the preparation of liposomes.A total of 28 publications were examined.In addition to the theories,characteristics and problems associated with traditional methods,the advantages and drawbacks of the latest techniques were reviewed.In the light of developments in many relevant areas,a variety of new techniques are being used for liposome preparation and each of these new technique has particular advantages over conventional preparation methods.However,there are still some problems associated with these new techniques that could hinder their applications and further improvements are needed.Generally speaking,due to the introduction of these latest techniques,liposome preparation is now an improved procedure.These applications promote not only advances in liposome research but also the methods for their production on an industrial scale. | Zhenjun Huang Xuan Li Ting Zhang Yanzhi Song Zhennan She Jing Li Yihui Deng | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 7 |
| 17 | Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma显示文摘Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma(HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C16-GNNQQNYKD-OH-based nanofibers as gelators and carriers for triptolide. Sustained triptolide release from the hydrogel was achieved over 14 days in vitro, with higher accumulation in and cytotoxicity against human HCC Bel-7402 in comparison with L-02 fetal hepatocytes. After intraperitoneal injection, the hydrogel showed prolonged retention over 13 days and preferential accumulation in the liver, realizing HCC growth inhibition by99.7 ± 0.1% and animal median survival extension from 19 to 43 days, without causing noticeable pathological changes in the major organs. These results demonstrate that injectable peptide hydrogel can be a potential carrier for localized chemotherapy of HCC. | Xiyue Zhao Xiaoyu Liu Pengcheng Zhang Yiran Liu Wei Ran Ying Cai Junyang Wang Yihui Zhai Guanru Wang Yaping Ding Yaping Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 7 |
| 18 | Recruitment of endogenous progenitor cells by erythropoietin loaded particles for in situ cartilage regeneration显示文摘Cartilage injury affects millions of people throughout the world,and at this time there is no cure.While transplantation of stem cells has shown some success in the treatment of injured cartilage,such treatment is limited by limited cell sources and safety concerns.To overcome these drawbacks,a microscaffolds system was developed capable of targeting,reducing the inflammatory response and recruiting endogenous progenitor cells to cartilage-defect.Erythropoietin(EPO)-loaded-hyaluronic acid(HA)microscaffolds(HA+EPO)were fabricated and characterized.HA-microscaffolds showed good cell-compatibility and could target chondrocytes via CD44 receptors.HA+EPO was designed to slowly release EPO while recruiting progenitor cells.Finally,the ability of HA+EPO to repair cartilage-defects was assessed using a rabbit model of full-thickness cartilagedefect.Our results showed that the intra-articular administration of EPO,HA,and EPO+HA reduced the number of inflammatory cells inside the synovial-fluid,while EPO+HA had the greatest anti-inflammatory effects.Furthermore,among all groups,EPO+HA achieved the greatest progenitor cell recruitment and subsequent chondrogenesis.The results of this work support that,by targeting and localizing the release of growthfactors,HA+EPO can reduce inflammatory responses and promote progenitor cells responses.This new platform represents an alternative treatment to stem-cell transplantation for the treatment of cartilage injury. | Amirhossein Hakamivala Shuxin li Kayti Robinson YiHui Huang Shuai Yu Baohong Yuan Joseph Borrelli Jr. Liping Tang | 2020 | Bioactive Materials2020，5，1： | 7 |
| 19 | Electroacupuncture at Tianshu (ST 25) for diarrhea-predominant irritable bowel syndrome using positron emission tomography Changes in visceral sensation center显示文摘Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome (IBS). We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions: resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range: bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu (ST 25) manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain. | Huirong Liu Li Qi Xiaolong Wang Yihui Guan Chuantao Zuo Linying Tan Lingsong Yuan Xiaopeng Ma Xiaomei Wang Enhua Zhou Huangan Wu | 2010 | Neural Regeneration Research2010，5，16： | 6 |
| 20 | Preparation of berberine hydrochloride long-circulating liposomes by ionophore A23187-mediated ZnSO_(4)gradient method显示文摘The aim of the study was to prepare berberine hydrochloride long-circulating liposomes and optimize the formulation and process parameters,and investigate the influence of different factors on the encapsulation efficiency.Berberine hydrochloride liposomes were prepared in response to a transmembrane ion gradient that was established by ionophore A23187.Free and liposomal drug were separated by cation exchange resin,and then the amount of intraliposomal berberine hydrochloride was determined by UV spectrophotometry.The optimized encapsulation efficiency of berberine hydrochloride liposomes was 94.3%2.1%when the drug-to-lipid ratio was 1:20,and the mean diameter was 146.9 nm3.2 nm.As a result,the ionophore A23187-mediated ZnSO_(4)gradient method was suitable for the preparation of berberine hydrochloride liposomes that we could get the desired encapsulation efficiency and drug loading. | Xiang Luo Jing Li Ligang Guo Xiaobo Cheng Ting Zhang Yihui Deng | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 5 |
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