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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | Establishment of an Objective Standard for the Definition of Binary Tropical Cyclones in the Western North Pacific显示文摘To develop an objective standard for defining binary tropical cyclones(BTCs)in the western North Pacific(WNP),two best-track datasets,from the China Meteorological Administration and the Joint Typhoon Warning Center,were adopted for statistical analyses on two important characteristics of BTCs-two TCs approaching each other,and counterclockwise spinning.Based on the high consistency between the two datasets,we established an objective standard,which includes a main standard for defining BTCs and a secondary standard for identifying typical/atypical BTCs.The main standard includes two requirements:two coexisting TCs are a pair of BTCs if(i)the separation distance is≤1800 km,and(ii)this separation maintains for at least 12 h.Meanwhile,the secondary standard defines a typical BTC as one for which there is at least one observation when the two TCs approach each other and spin counterclockwise simultaneously.Under the standard,the ratio of typical BTCs increases as the BTC duration increases or the minimum distance between the two TCs decreases.Then,using the JTWC dataset,it was found that there are 505 pairs of BTCs during the period 1951−2014,including 328 typical BTCs and 177 atypical BTCs,accounting for 65.0%and 35.0%of the total,respectively.In addition,a study of two extreme phenomena-the maximum approaching speed and the maximum counterclockwise angular velocity in typical BTCs-shows that the configuration of the circulation conditions and the distribution of the BTCs favor the formation of these extreme phenomena. | Fumin REN Yanjun XIE Biwen YIN Mingyang WANG Guoping LI | 2020 | Advances in Atmospheric Sciences2020，37，11： | 3 |
| 3 | Mechanical and thermal properties of mesogen-jacketed liquid crystalline polymer/epoxy resin composites显示文摘The effects of mesogen-jacketed liquid crystalline polymer poly(dipropyl vinylterephthalate)(PDPVT) on the mechanical and thermal properties of diglycidyl ether of bisphenol-A(DGEBA) epoxy resin were investigated by impact test, tensile test and thermogravimetric analysis(TGA). The mechanism underlying the enhancement of mechanical properties of epoxy resin was studied using 1D wide-angle X-ray diffraction(WAXD) and scanning electron microscope(SEM). It was found that the mechanical properties of 1 wt%–5 wt% PDPVT/DGEBA composites were significantly improved compared to neat epoxy resin. Especially, the epoxy resin with 3 wt% PDPVT had the greatest increase in mechanical properties, with the impact strength, tensile strength and elongation while breaking increased by 87%, 59% and 174%, respectively. The increased mechanical strength was due to the fact that PDPVT maintained liquid crystalline phase in cured PDPVT/DGEBA composites, which would blunt the crack tip and prevent crack propagation. Moreover, PDPVT had slight effect on the thermal stability properties of epoxy resin. | Chunpeng Chai Fangfang Yin Guoping Li Yunjun Luo | 2015 | Science China Chemistry2015，58，6： | 3 |
| 4 | Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis显示文摘Senescence of activated hepatic stellate cells(aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression.Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype(SASP).But little is known about how alanine-serine-cysteine transporter type-2(ASCT2),a high affinity glutamine transporter,affects HSC senescence and SASP during liver fibrosis.Here,we identified ASCT2 is mainly elevated in aHSCs and positively correlated with liver fibrosis in human and mouse fibrotic livers.We first discovered ASCT2 inhibition induced HSCs to senescence in vitro and in vivo.The proinflammatory SASP were restricted by ASCT2 inhibition at senescence initiation to prevent paracrine migration.Mechanically,ASCT2 was a direct target of glutaminolysisdependent proinflammatory SASP,interfering IL-1α/NF-κB feedback loop via interacting with precursor IL-1α at Lys82.From a translational perspective,atractylenolide Ⅲ is identified as ASCT2 inhibitor through directly bound to Asn230 of ASCT2.The presence of -OH group in atractylenolide Ⅲ is suggested to be favorable for the inhibition of ASCT2.Importantly,atractylenolide Ⅲ could be utilized to treat liver fibrosis mice.Taken together,ASCT2 controlled HSC senescence while modifying the proinflammatory SASP.Targeting ASCT2 by atractylenolide Ⅲ could be a therapeutic candidate for liver fibrosis. | Feixia Wang Zhanghao Li Li Chen Ting Yang Baoyu Liang Zili Zhang Jiangjuan Shao Xuefen Xu Guoping Yin Shijun Wang Hai Ding Feng Zhang Shizhong Zheng | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 5 | Effects of simvastatin on early oxidative stress and endothelial function in apolipoprotein E-deficient mice显示文摘Objective:To investigate the mechanisms that Simvastatin,a 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibitor,plays an important role in primary prevention of atherosclerosis independently of its lipid-lowering effect in Apolipoprotein E-deficient mice in the early stage of atherosclerosis.Methods:Twenty-four 6-week old male apoE-deficient mice were randomly divided into two groups:control group(normal saline) and treatment group[simvastatin(5 mg/(kg·d))].Simvastatin was administered to treatment group mice by gavage and the same volume of normal saline was administered to control group mice by the same method for 2 or 4 weeks.Total cholesterol(TC),super-oxide dismutase(SOD),malondialdehyde(MDA) and serum nitric oxide(NO) were measured by bio-chemical analysis.Results:There was no significant difference in serum TC between control and treatment groups.Compared with the control's,the effects of simvastatin were more significant in decreasing serum MDA level(P < 0.01 vs control's at 2-week;P < 0.006 vs control's at 4-week),increasing serum SOD level(P < 0.03 vs control's at 2-week;P < 0.003 vs control's at 4-week) and NO level(P < 0.01 control's at 2-week;P < 0.001 vs control's at 4-week) either at 2 or 4 weeks.Conclusion:Simvastatin attenuates oxidative stress and protects endothelial function by the mechanisms of decreasing serum MDA level,increasing serum SOD level and NO level ,which were inconsistent with its cholesterol-lowering effect.It may play an important role in primary(if not all) prevention of atherosclerosis and might be independent of lipid-regulation mechanism. | Donghua Yin Meng Liu Guoping Yang Jun Huang Ming Gui | 2007 | Journal of Nanjing Medical University2007，21，6： | 2 |
| 6 | Residual stress and radial stress gradient in polycrystalline diamond compacts显示文摘The differential thermal expansion of the polycrystalline diamond layer and the tungsten carbide substrate results in large residual stresses as PDC cutters cooling after sintering.The residual stresses on the top surface of the diamond layer of PDC were measured at five points along the radial direction of PDC using X-ray Diffraction Residual Stress Instrument,thus the stresses and their radial distribution were obtained.The results show that the stresses on the diamond surface are compressive,the biggest stress appears at the central point(about 1200 MPa),and that from the center to the edge of PDC,the magnitude of the stress decreases. A finite element analysis(FEA) was made to check the validity of the testing results.The FEA modeling results were found to correlate well with the measured values.Factors leading to the deviation between XRD experimental measurements and the calculations of residual stress by FEA were also analyzed. | Xu Guoping~(1,2),Yin Zhimin~1,Chen Qiwu~2,Xu Gen~1 (1.School of Materials Science & Engineering,Central South University,Changsha 410083,Hunan,China) (2.Changsha research institute of mining and metallurgy,Changsha 410012,Hunan,China) | 2008 | 金刚石与磨料磨具工程2008，28，S1： | 2 |
| 7 | Optimization of Formula for Fabricating Acetylated Corn Starch Films显示文摘 | Chen Zhizhou Yin Guoping | 2012 | Applied Mechanics andMaterials2012，200，： | 1 |
| 8 | Experimental realization of nonadiabatic geometric gates with a superconducting Xmon qubit显示文摘Geometric phases are only dependent on evolution paths but independent of evolution details so that they possess some intrinsic noise-resilience features. Based on different geometric phases, various quantum gates have been proposed, such as nonadiabatic geometric gates based on nonadiabatic Abelian geometric phases and nonadiabatic holonomic gates based on nonadiabatic nonAbelian geometric phases. Up to now, nonadiabatic holonomic one-qubit gates have been experimentally demonstrated with superconducting transmons, where the three lowest levels are all utilized in operation. However, the second excited state of transmons has a relatively short coherence time, which results in a decreased fidelity of quantum gates. Here, we experimentally realize Abelian-geometric-phase-based nonadiabatic geometric one-qubit gates with a superconducting Xmon qubit. The realization is performed on the two lowest levels of an Xmon qubit and thus avoids the influence from the short coherence time of the second excited state. The experimental result indicates that the average fidelities of single-qubit gates can be up to 99.6% and 99.7% characterized by quantum process tomography and randomized benchmarking. | PeiZi Zhao ZhangJingZi Dong ZhenXing Zhang GuoPing Guo DianMin Tong Yi Yin | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 1 |
| 9 | Optimization of Formula for Fabricating Acetylated Corn Starch Films显示文摘 | Chen Zhizhou Yin Guoping | 2012 | Applied Mechanics and Materials2012，200，： | 1 |
| 10 | Chinese experts' consensus on diagnosis, prevention, and treatment of chemotherapyinduced hepatotoxicity显示文摘Overview Drug-induced liver injury(DILI)due to acetaminophen overdose and idiosyncratic drug reactions usually occurs 5–90 days after exposure to the causative drug.Ninety percent of DILI cases are acute.As one of the most common non-infectious liver diseases,DILI represents a growing challenge for clinicians.According to data from WHO[1],DILI is the fifth leading cause of liver disease mortality.In China,DILI accounts for 1%–5%of hospitalized patients with liver diseases,10%of patients | Wenxi Yu Yuanjue Sun Yang Yao Shiying Yu Feng Yu Jun Ma Jiejun Wang Jifeng Feng Guoping Sun Jiliang Yin Yuan Chen Li Zhang Mei Hou Xianglin Yuan Jun Liang Cheng Huang Guangru Xie Qing Xie Wen Xie | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，1： | 1 |
| 11 | Infragravity waves with internal wave characteristics in the south of the Bohai Sea of China显示文摘The measurements by using ADCP (500 KH) and CTD were made during August 2000 in the south (37°55'N, 120°25'E) of the Bohai Sea, where the water depth was about 16.5 m. The data of horizontal velocity with sampling interval of 2 min in 7 layers were obtained. The power spectrum analysis of these data indicates that there are very energetic infragravity waves with a period of about 6 min. The coherence spectrum analysis and the analysis of temporal variation of shear show that these infragravity waves are mainly the free wave model (properties of edge waves), in the meantime they possess some characteristics of internal waves, which are likely due to the distinctive marine environment in this area. It is speculated on that the instability processes (chiefly shear instability) of sheared stratified tidal flow owing to the effect of sea-floor slope in the coastal area might be the main mechanism generating these infragravity waves. | Fan Zhisong, Gao Guoping, Yin Xunqiang, Fan Yu, Wu Wei Marine Environment College,Ocean University of China,Qingdao 266003, China | 2003 | Acta Oceanologica Sinica2003，22，2： | 1 |
| 12 | Optimization of formula for fabricating acetylated corn starch films显示文摘 | Chen Zhizhou Yin Guoping | 2012 | Applied Mechan- ics and Materials2012，200，： | 1 |
| 13 | AR5395:OBSERVATIONS ON THE ASYMMETRIES OF THE Hα AND CaⅡ K LINE PROFILES OF THE FLARES ON MARCH 9 AND 14,1989显示文摘The most powerful method to diagnose the velocity field in solar flare atmosphere isspectral analyses. That is to analyse the asymmetry and the Doppler shift of flare spectralline profiles. Recent observations indicated that at the impulsive phase of flares thereare obvious red asymmetry of Hα profiles and a downward velocity of 40-100km/s | Fang Cheng, Hu Ju, Ji Guoping, Yin Suying, Zhang QizhouDepartment of Astronomy, Nanjing University | 1990 | 天文研究与技术1990，，4： | 0 |
| 14 | Transparent glassy composites incorporating lead-free anti-perovskite halide nanocrystals enable tunable emission and ultrastable X-ray imaging显示文摘Lead halide perovskite materials exhibit excellent scintillation performance,which,however,suffer from serious stability and toxicity problems.In contrast,the heavy metal-free anti-perovskite materials[MX_(4)]XA_(3)(A=alkali metal;M=transition metal;X=Cl,Br,I),a class of electron-inverted perovskite derivatives,exhibit robust structural and photophysical stability.Here,we design and prepare a lead-free[MnBr_(4)]BrCs_(3) anti-perovskite nanocrystal(NC)-embedded glass for efficient X-ray-excited luminescence with high-resolution X-ray imaging with a spatial resolution of 19.1 Ip mm^(-1).Due to the unique crystal structure and the protection of the glass matrix,the Cs_(3)MnBr_(5) NC-embedded glass exhibits excellent X-ray irradiation stability,thermal stability,and water resistance.These merits enable the demonstration of real-time and durable X-ray radiography based on the developed glassy composite.This work could stimulate the research and development of novel metal halide anti-perovskite materials and open a new path for future development in the field of high-resolution and ultrastable X-ray imaging. | Yakun Le Xiongjian Huang Hao Zhang Zhihao Zhou Dandan Yang Bozhao Yin Xiaofeng Liu Zhiguo Xia Jianrong Qiu Zhongmin Yang Guoping Dong | 2023 | Advanced Photonics2023，5，4： | 0 |
| 15 | Relationships between leaf color changes,pigment levels,enzyme activity,photosynthetic fluorescence characteristics and chloroplast ultrastructure of Liquidambar formosana Hance显示文摘Liquidambar formosana Hance is an attractive landscape tree species because its leaves gradually change from green to red,purple or orange in autumn.In this study,the red variety of L.formosana was used to establish a quantitative model of leaf color.Physiological changes in leaf color,pigment levels,enzyme activity,photosynthetic fluorescence characteristics and chloroplast ultrastructure were monitored.The relationship between leaf color and physiological structure indices was quantitatively analyzed to systematically explore the mechanisms behind leaf color.Our data showed that with a decrease in external temperatures,chloroplast numbers and sizes gradually decreased,thylakoid membranes became distorted,and chlorophyll synthesis was blocked and gradually decreased.As a result,chloroplast membranes could not be biosynthesized normally;net photosynthesis,maximum and actual photochemical efficiency,and rate of electron transfer decreased rapidly.Excess light energy caused leaf photoinhibition.With intensification of photoinhibition,leaves protected themselves using two mechanisms.In the first,anthocyanin synthesis was promoted by increasing chalcone isomerase and flavonoid glycosyltransferase activities and soluble sugar content so as to increase anthocyanin to filter light and eliminate reactive oxygen species to reduce photoinhibition.In the second,excessive light energy was consumed in the form of heat energy by increasing the non-photochemical quenching coefficient.These processes tuned the leaves red. | Guoping Yin Yong Wang Yufei Xiao Jisheng Yang Renjie Wang Ying Jiang Ronglin Huang Xiongsheng Liu Yi Jiang | 2022 | Journal of Forestry Research2022，33，5： | 0 |
| 16 | Prototypes,modifications,and hydrocarbon enrichment variations in basins influenced by Tethyan evolution:A comparative analysis of the Persian Gulf Basin and the Sichuan Basin显示文摘The hydrocarbon accumulation modes and differences in the Tethyan realm serve as a hot research topic in the petroleum geology community at home and abroad.Both the Persian Gulf Basin in the Middle East and the Sichuan Basin in China,situated on the southern and northern sides of the Tethyan realm,respectively,record the whole geological process of the opening and closure of the Prototethys,the Paleotethys,and the Neotethys sequentially,exhibiting anomalous hydrocarbon enrichment.Based on the analysis of the plate tectonic evolution in the Tethyan realm,this study dissects the structures and hydrocarbon accumulation conditions of both basins.Followed by a systematic comparative analysis of the factors controlling hydrocarbon enrichment in the process of plate breakup and convergence in the Tethyan realm,this study proposes petroleum exploration targets in the realm.The results are as follows:(1)Since the Meso-Neoproterozoic,the Persian Gulf Basin and the Sichuan Basin have undergone similar tectonic evolution in the early stage but different in the late stage.Under the influence of the formation and evolution of the Prototethys,Paleotethys,and Neotethys oceans,both basins experienced multi-stage development and modification,forming two major extension-convergence cycles.Consequently,both basins are characterized by the vertical orderly superimposition of various basin prototypes in the order of rift-intracratonic basin(passive continental margin)-foreland.(2)The fact that the Tethyan realm was long located at medium-low latitudes and the local anoxic environment formed in the process of plate breakup and convergence played a vital role in the formation of extensive source rocks.The source rocks are predominantly distributed in underfilled rifts and deep depressions that were connected to the ocean in the unidirectional continental breakup process;basin-slopes and intra-shelf basins on passive continental margins;basinal lows within intracratonic basins,and underfilled foredeeps in foreland basins.The favorable areas for the formation of carbonate reservoirs include platform margins,submarine highs and paleo-uplifts within platforms,and fault zones.The evaporite cap rocks,intimately associated with the basin evolutionary stages and global dry-hot events,are critical for large-scale hydrocarbon preservation.(3)Under the influence of Tethyan evolution,the Persian Gulf Basin and the Sichuan Basin share similar primary factors controlling hydrocarbon enrichment.The moderate tectono-sedimentary differentiation and structural modification in the process of prototype basin superimposition,as well as the spatio-temporal matching of elements critical for hydrocarbon accumulation,are beneficial for the development of large oil and gas fields.The macroscopic hydrocarbon distribution is dictated by source rock-cap rock assemblages,while the local hydrocarbon distribution is governed by trap-reservoir assemblages.The critical factors determining the differential hydrocarbon enrichment in the Persian Gulf Basin and the Sichuan Basin include plate size and position,basement stability,eustatic movement,paleoclimate,and tectonic transformation.Besides,different tectonic modification intensities are closely related to the type,enrichment degree,and distribution of hydrocarbon reservoirs. | Zhiliang HE Zhijun JIN Shuangjian LI Guoping BAI Xueyan LV Jinrui GUO Jian GAO Jinyin YIN Yingqiang LI Dingye ZHENG | 2023 | Science China Earth Sciences2023，66，12： | 0 |
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