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| 1 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 2 | Distribution of Pacific-origin water in the region of the Chukchi Plateau in the Arctic Ocean in the summer of 2003显示文摘The upper ocean thermohaline structures in the region of the Chukchi Plateau are analyzed with the hydrographic data collected by the Chinese National Arctic Research Expedition in the summer of 2003. Three types of the Pacific-origin water were found in the upper ocean, Alaska Coastal Water (ACW), summer Bering Sea Water (sBSW) and winter Bering Sea Water (wBSW) are indicated by two maximums temperature and one minimum temperature, piling up from the upper to the lower respectively. The extreme warm ACW with a maximum temperature of 1.62 ℃ was found in the southwestern Canada Basin at a depth of about 50 m. A pathway of the ACW into the basin from its adjacent area did not existed in the expedition period. So it is speculated that the extreme warm feature of the ACW was formed locally in 2003. The relative weak ACW occurred to the east of the Chukchi Cap and in the southern Chukchi Abyssal Plain. The latter one might originate from a warm downwelling that existed in a small canyon at the shelf break of the Chukchi Sea. The sBSW without the ACW was found only at the southwestern flank of the Chukchi Cap. The ACW and the sBSW were not found in the northernmost station at 81°N,which indicates the north boundary of the upper Pacific-origin water in the Canada Basin. The wBSW, which existed in all deep stations,was exactly uniform at temperature. The difference of the core potential temperature of the wBSW in the deep regions is only 0.08 ℃. | SHI Jiuxin CAO Yong ZHAO Jinping GAO Guoping JIAO Yutian LI Shujiang | 2005 | Acta Oceanologica Sinica2005，24，6： | 15 |
| 3 | Water mass of the northward throughflow in the Bering Strait in the summer of 2003显示文摘The temperature and salinity data obtained by the Chinese national arctic research expedition (CHINARE2003) are used to study the water structure in the Bering Strait and ambient regions. Four water masses appeared in the research region: the intermediate Bering Sea water mass (IBWM), the Alaska coastal water (ACW), the Anadyr water (AW) and the Bering shelf water (BSW). The AW originates from the IBWM, but the upper layer water has been greatly altered. In the cruise on 28/29 July 2003, there were only the BSW and ACW in a section across the Bering Strait (BS section), but in the September 12/13 cruise, the AW, BSW and ACW flowed parallelly into the Bering Strait. The upper waters of these water masses were all altered due to ice melting, runoff, solar radiation, and wind mixing. The waters in the central and northern parts of Bering Strait stratified by two uniform layers,were expressed as the typical feature of the water masses originating from the pacific. A two-layer structure also dominated the vertical stratification in most part of the Chukchi Sea. An obvious subseasonal variation was observed in the BS section, which caused varying transportation of fresh water, heat, and substance, and produced a long-term and extensive impact on the Arctic Ocean. | ZHAO Jinping SHI Jiuxin GAO Guoping JIAO Yutian ZHANG Hongxin | 2006 | Acta Oceanologica Sinica2006，25，2： | 10 |
| 4 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 5 | Impacts of climatic and marine environmental variations on the spatial distribution of Ommastrephes bartramii in the Northwest Pacific Ocean显示文摘Ommastrephes bartramii is an ecologically dependent species and has great commercial values among the AsiaPacific countries. This squid widely inhabits the North Pacific, one of the most dynamic marine environments in the world, subjecting to multi-scale climatic events such as the Pacific Decadal Oscillation(PDO). Commercial fishery data from the Chinese squid-jigging fleets during 1995–2011 are used to evaluate the influences of climatic and oceanic environmental variations on the spatial distribution of O. bartramii. Significant interannual and seasonal variability are observed in the longitudinal and latitudinal gravity centers(LONG and LATG) of fishing ground of O. bartramii. The LATG mainly occurred in the waters with the suitable ranges of environmental variables estimated by the generalized additive model. The apparent north-south spatial shift in the annual LATG appeares to be associated with the PDO phenomenon and is closely related to the sea surface temperature(SST)and sea surface height(SSH) on the fishing ground, whereas the mixed layer depth(MLD) might contribute limited impacts to the distribution pattern of O. bartramii. The warm PDO regimes tend to yield cold SST and low SSH, resulting in a southward shift of LATG, while the cold PDO phases provid warm SST and elevated SSH,resulting in a northward shift of LATG. A regression model is developed to help understand and predict the fishing ground distributions of O. bartramii and improve the fishery management. | YU Wei CHEN Xinjun YI Qian GAO Guoping CHEN Yong | 2016 | Acta Oceanologica Sinica2016，35，3： | 6 |
| 6 | Preparation and characterization of Al/B/Fe_2O_3 nanothermites显示文摘A sol-gel synthetic approach combined with an ultrasonic method was utilized to prepare Al/B/Fe2O3 nanothermites.The structure and properties of the prepared nanothermites were characterized by thermogravimetric analysis,differential scanning calorimetry,scanning electron microscopy,X-ray diffraction,and an impact sensitivity test.The results verified that the nano-aluminum and the micro-boron were uniformly dispersed in the pores of the iron oxide gel.The heat of the prepared Al/B/Fe2O3 nanothermites was 1.3 times that of the simple physically mixed sample.In addition,the heat of the combustion test showed that these materials were indeed energetic.Small-scale safe experiments also showed that the prepared materials through sol-gel were relatively insensitive to standard impact. | SHEN LianHua LI GuoPing LUO YunJun GAO Kun GE Zhen | 2014 | Science China Chemistry2014，57，6： | 6 |
| 7 | Nutrient maximums related to low oxygen concentrations in the southern Canada Basin显示文摘The phenomenon of nutrient maximums at 70~200 m occurred only in the region of the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injection of the low-temperature high-nutrient brines from the Chukchi Sea shelf (<50 m) in winter provided the nutrient maximums. However, we found that there are five problems in the direct injection process. Formerly Jin et al. considered that the formation of nutrient maximums can be a process of locally long-term regeneration. Here we propose a regeneration-mixture process. Data of temperature, salinity, oxygen and nutrients were collected at three stations in the southern Canada Basin during the summer 1999 cruise. We identified the cores of the surface, near-surface, potential temperature maximum waters and Arctic Bottom Water by the diagrams and vertical profiles of salinity, potential temperature, oxygen and nutrients. The historical 129I data indicated that the surface and near-surface waters were Pacific-origin, but the waters below the potential temperature maximum core depth was Atlantic-origin. Along with the correlation of nutrient maximums and very low oxygen contents in the near-surface water, we hypothesize that, the putative organic matter was decomposed to inorganic nutrients; and the Pacific water was mixed with the Atlantic water in the transition zone. The idea of the regeneration-mixture process agrees with the historical observations of no apparent seasonal changes, the smooth nutrient profiles, the lowest saturation of CaCO3 above 400 m, low rate of CFC-11 ventilation and 3H-3He ages of 8~18 a around the nutrient maximum depths. | JIN Ming-ming SHI Jiuxin LU Yong CHEN Jianfang GAO Guoping WU Jingfeng ZHANG Haisheng | 2005 | Acta Oceanologica Sinica2005，24，6： | 5 |
| 8 | Seasonal and Interannual Variability of Bering Strait Throughflow from AO-FVCOM and Observation显示文摘A high-resolution Arctic Ocean-Finite Volume Community Ocean Model(AO-FVCOM) and observational current data from 14 mooring stations in Bering Strait and surrounding regions between 1990 and 2015 were used to study the seasonal and interannual variability of Bering Strait throughflow(BST). AO-FVCOM represented the BST with a climatological northward flux of 1.06 Sv, which was close to the observational mean of 0.94 ± 0.26 Sv. From the model results, the strongest volume flux was in summer, approximately 45% larger than that in winter. Interannual variability of BST was also indicated in the model results, and the maximum and minimum annual mean transports are in 2007 and 2012, respectively. AO-FVCOM showed larger differences from the observations in 2000, 2002, and 2015 than in other years, which may be related to the limitation of atmospheric forcing for the model. According to the driving mechanisms of BST, sea level difference(SLD) across the strait dominates the northward volume transport, and local wind is also important in forcing the seasonal variability of the BST and SLD patterns to change the BST indirectly. | DENG Yongfei GAO Guoping ZHANG Yu CHEN Changsheng | 2019 | Journal of Ocean University of China2019，18，3： | 3 |
| 9 | Sirtl regulates testosterone biosynthesis in Leydig cells via modulating autophagy显示文摘Dear Editor,Steroid hormones are crucial signal molecules that regulate a large number of physiological and developmental pro-cesses.Testosterone is the key steroid hormone required for the development of male characteristics and also supports the physiology of the male reproductive system(Sinclair et al.,2015).Testosterone is primarily produced by the Leydig cells residing in the testicular interstitium.The cholesterol acts as a substrate for the biosynthesis of testosterone.Since steroidogenic cells are capable of stor-ing only very ltte hormone,rapid synthesis of hormone requires the mobilization of the precursor cholesterol,chiefly stored as intracellular lipid droplets(LDs)(Danielsen et al.,2016).Leydig cells are the major sites to produce testos-terone,there are extremely active autophagy in them,and a decline in steroidogenesis has also been associated with the decline of autophagic flow.Moreover,the disruption of autophagy leads to decreased intracellular LDs,and there-fore affects testosterone synthesis in the Leydig cells(Danielsen et al..2016;Gao et al,2018). | Muhammad Babar Khawar Chao Liu Fengyi Gao Hui Gao Wenwen Liu Tingting Han Lina Wang Guoping Li Hui Jiang Wei Li | 2021 | Protein & Cell2021，12，1： | 3 |
| 10 | Preliminary Theoretical Studies on the Combination of Halogen Ions with Crown Tetraalanylpeptide显示文摘 | Hongtao Song Guoping Liu Yuqing Yang Hui Gao Hongyuan Wei Shunzhong Luo | 2010 | Journal of Chemistry and Chemical Engineering2010，4，4： | 3 |
| 11 | Viability of primary cultured retinal neurons in a hyperglycemic condition显示文摘The retina of Wistar rats within 1-3 days of birth were dissociated into a retinal cell suspension using 0.05% trypsin digestion. The cell suspension was incubated in Dulbecco's modified Eagle's medium for 24 hours, followed by neurobasal medium for 5-7 days. Nissl staining showed that 79.86% of primary cultured retinal cells were positive and immunocytochemical staining showed that the purity of anti-neurofilament heavy chain antibody-positive cells was 71.53%, indicating that the primary culture system of rat retinal neurons was a reliable and stable cell system with neurons as the predominant cell type. The primary cultured retinal neurons were further treated with 0, 5.5, 15, 25, and 35 mM glucose for 24, 48, and 72 hours. The thiazolyl blue tetrazolium bromide test and flow cytometry showed that with increasing glucose concentration and treatment duration, the viability of retinal neurons was reduced, and apoptosis increased. In particular, 35 mM glucose exhibited the most significant effect at 72 hours. Thus, rat retinal neurons treated with 35 mM glucose for 72 hours can be used to simulate a neuronal model of diabetic retinopathy. | Yu Liu Xueliang Xu Renhong Tang Guoping Chen Xiang Lei Limo Gao Wenjie Li Yu Chen | 2013 | Neural Regeneration Research2013，8，5： | 3 |
| 12 | Robust fault-tolerant control for wing flutter under actuator failure显示文摘Many control laws, such as optimal controller and classical controller, have seen their applications to suppressing the aeroelastic vibrations of the aeroelastic system. However, those control laws may not work effectively if the aeroelastic system involves actuator faults. In the current study for wing flutter of reentry vehicle, the effect of actuator faults on wing flutter system is rarely considered and few of the fault-tolerant control problems are taken into account. In this paper, we use the radial basis function neural network and the finite-time H_∞ adaptive fault-tolerant control technique to deal with the flutter problem of wings, which is affected by actuator faults, actuator saturation, parameter uncertainties and external disturbances. The theory of this article includes the modeling of wing flutter and fault-tolerant controller design. The stability of the finite-time adaptive fault-tolerant controller is theoretically proved. Simulation results indicate that the designed fault-tolerant flutter controller can effectively deal with the faults in the flutter system and can promptly suppress the wing flutter as well. | Gao Mingzhou Cai Guoping | 2016 | Chinese Journal of Aeronautics2016，29，4： | 2 |
| 13 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 2 |
| 14 | Probability Forecast of Regional Landslide Based on Numerical Weather Forecast显示文摘The regional forecast of landslide is one of the key points of hazard mitigation. It is also a hot and difficult point in research field. To solve this problem has become urgent task along with Chinese economy fast development. This paper analyzes the principle of regional landslide forecast and the factors for forecasting. The method of a combination of Information Value Model and Extension Model has been put forward to be as the forecast model. Using new result of Numerical Weather Forecast Research and that combination model, we discuss the implementation feasibility of regional landslide forecast. Finally, with the help of Geographic Information System, an operation system for southwest of China landslide forecast has been developed. It can carry out regional landslide forecast daily and has been pilot run in NMC. Since this is the first time linking theoretical research with meteorological service, further works are needed to enhance it. | GAO Kechang WEI Fangqiang CUI Peng HU Kaiheng XU Jing ZHANG Guoping BI Baogu | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 2 |
| 15 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 1 |
| 16 | Catalytic reduction of S02 by CO over PttAum(CO)n: A first-principles investigation显示文摘 | GAO Guoping WEI Shiaho DUAN Xiangmei | 2012 | Journal of Physical Chemistry2012，116，24： | 1 |
| 17 | The ketogenic diet for paediatric patients with super-refractory status epilepticus in febrile infection-related epilepsy syndrome显示文摘Objective:To investigate the effect and safety of ketogenic diet(KD)for the treatment of paediatric patients with super-refractory status epilepticus(SRSE)in febrile infection-related epilepsy syndrome(FIRES).Method:From January 1,2015 to October 31,2017,ten critically ill paediatric patients with SRSE in FIRES were included in this study and treated with KD.The treatment effects of KD were evaluated by using continuous encephalography(CEEG)and amplitude-integrated electro-encephalography(aEEG).Results:All 10 patients fulfilled the diagnostic criteria of SRSE in FIRES and achieved ketosis within 24–72 h following the administration of KD.CEEG and aEEG were monitored for several weeks to assess the efficacy of KD on status epilepticus(SE).SE was contained in 8 patients within 2 to 19 days after initiation of KD,and KD was discontinued in the other 2 patients.One of the 10 patients demonstrated severe adverse effects.Conclusion:KD may be an alternative and safe treatment option in critical paediatric patients with SRSE in FIRES. | Xinhua Wang Xuan Gao Guoping Lu Zhongying Lu Shuizhen Zhou Yi Wang Yuanfeng Zhou | 2020 | Acta Epileptologica2020，2，1： | 1 |
| 18 | Revealing the working mechanism of a multi-functional block copolymer binder for lithium-sulfur batteries显示文摘The lithium-sulfur(Li-S)battery is one of the most promising substitutes for current energy storage systems because of its low cost,high theoretical capacity,and high energy density.However,the high solubility of intermediate products(i.e.,lithium polysulfides)and the resultant shuttle effect lead to rapidly fading capacity and a low coulombic efficiency,which hinder the practical application of Li-S batteries.In this study,block copolymers are constructed with both an ethylene oxide unit and a styrene unit and then used as binders for Li-S batteries.Electrochemical performance improvements are attributed to the synergistic effects contributed by the different units of the block copolymer.The ethylene oxide unit traps polysulfide,which bonds strongly with the intermediate lithium polysulfide,and enhances the transport of lithium ions to reach high capacity.Meanwhile,the styrene unit maintains cathode integrity by improving the mechanical properties and elasticity of the constructed block copolymer to accommodate the large volume changes.By enabling multiple functions via different units in the polymer chain,high sulfur utilization is achieved,polysulfide diffusion is confined,and the shuttle effect is suppressed during the cycle life of Li-S batteries,as revealed by operando ultraviolet-visible spectroscopy and S Kedge X-ray absorption spectroscopy. | Xin He Zhimeng Liu Guoping Gao Xiaotao Liu Michal Swietoslawski Jun Feng Gao Liu Lin-Wang Wang Robert Kostecki | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 19 | Modified function projective lag synchronization of chaotic systems with distur- bance estimations 显示文摘 | Gao Yanbo Sun Binghua Lu Guoping | 2013 | Applied Mathematical Modelling2013，37，7： | 1 |
| 20 | Synthesis of photo-reactive poly(vinyl alcohol)and construction of scaffold-free cartilage like pellets in vitro显示文摘Photo-reactive poly(vinyl alcohol)(PRPVA)was synthesized by introduction of phenyl azido groups into poly(vinyl alcohol)(PVA)and applied for surface modification.PRPVA was grafted onto cell culture plate surface homogeneously or in a micropattern.Human mesenchymal stem cells(hMSCs)cultured on cell culture plate surface and PVA-modified surface showed different behaviors.Cells adhered and spread well on cell culture plate surface,while they did not adhere on PVA-grafted surface at all.When hMSCs were cultured on PVA-micropatterned surface,they formed a cell micropattern.Cells formed pellets after cultured on PVA homogeneously modified surface in chondrogenic induction medium for 2 weeks.The pellets were positively stained by hematoxylin/eosin,safranin-O/fast green and toluidin blue,and they were also stained brown by Type II collagen and proteoglycan immunohistological staining.Real-time PCR analysis was conducted to investigate the expression of colI,colII,colX,aggrecan and sox9 mRNA.Results of gene expression were in agreement with those of histological and immunohistological observations.These results indicated that hMSCs cultured on PVA-modified surface performed chondrogenic differentiation,and it was possible to construct scaffold-free cartilage like pellets with PVA-modified surface in vitro. | Bao Li Yongli Gao Likun Guo Yujiang Fan Naoki Kawazoe Hongsong Fan Xingdong Zhang Guoping Chen | 2018 | Regenerative Biomaterials2018，5，3： | 1 |
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