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| 1 | 精子DNA损伤的机制和临床应用显示文摘在男性配子各种不同的DNA异常中,DNA断裂最为常见,尤其是在不育症患者中。目前越来越多的研究表明,DNA断裂并不显著影响精子细胞的存活率、活动率、形态以及与卵细胞的结合能力。研究还证明,卵母细胞在一定程度上可以修复受损的DNA,其修复程度依赖于精子细胞DNA的损伤类型和卵母细胞的质量。因此,研究精子DNA断裂(SDF)在自然分娩或辅助生殖技术助孕中对胚胎发育、胚胎着床、妊娠结果、子代健康的影响变得非常重要。至今,针对SDF对生殖的影响的研究极少,且研究报道的结论很不一致。导致这种不一致的原因可能与检测SDF的手段不同、实验设计不同和精液标本选择标准不同有关。因此,目前还不能确定是否将SDF检测拽术砬用于受精评估和ART技术中。这表明,制定SDF检测技术的标准化方法势在必行,另外关于SDF对ART的影响有必要进行进一步的临床研究。 | Lara Tamburrino Sara Marchiani Margarita Montoya Francesco Elia Marino Ilaria Natali Marta Cambi Gianni Forti Elisabetta Baldi Monica Muratori | 2012 | Asian Journal of Andrology2012，14，1： | 16 |
| 2 | Hepatocellular carcinoma in viral and autoimmune liver diseases:Role of CD4+CD25+Foxp3+regulatory T cells in the immune microenvironment显示文摘More than 90%of cases of hepatocellular carcinoma(HCC)occurs in patients with cirrhosis,of which hepatitis B virus and hepatitis C virus are the leading causes,while the tumor less frequently arises in autoimmune liver diseases.Advances in understanding tumor immunity have led to a major shift in the treatment of HCC,with the emergence of immunotherapy where therapeutic agents are used to target immune cells rather than cancer cells.Regulatory T cells(Tregs)are the most abundant suppressive cells in the tumor microenvironment and their presence has been correlated with tumor progression,invasiveness,as well as metastasis.Tregs are characterized by the expression of the transcription factor Foxp3 and various mechanisms ranging from cell-to-cell contact to secretion of inhibitory molecules have been implicated in their function.Notably,Tregs amply express checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4 and programmed cell-death 1 receptor and therefore represent a direct target of immune checkpoint inhibitor(ICI)immunotherapy.Taking into consideration the critical role of Tregs in maintenance of immune homeostasis as well as avoidance of autoimmunity,it is plausible that targeting of Tregs by ICI immunotherapy results in the development of immune-related adverse events(irAEs).Since the use of ICI becomes common in oncology,with an increasing number of new ICI currently under clinical trials for cancer treatment,the occurrence of irAEs is expected to dramatically rise.Herein,we review the current literature focusing on the role of Tregs in HCC evolution taking into account their opposite etiological function in viral and autoimmune chronic liver disease,and we discuss their involvement in irAEs due to the new immunotherapies. | Alessandro Granito Luigi Muratori Claudine Lalanne Chiara Quarneti Silvia Ferri Marcello Guidi Marco Lenzi Paolo Muratori | 2021 | World Journal of Gastroenterology2021，27，22： | 11 |
| 3 | ESWL for difficult bile duct stones:A 15-year single centre experience显示文摘AIM:To evaluate the efficacy of extracorporeal shock wave lithotripsy(ESWL)for the management of refractory bile duct cholelithiasis in a third level referral centre.METHODS:The clinical records of all patients treated with a second generation electromagnetic lithotripter (Lithostar Plus,SIEMENS)from October 1990 to April 2005 were evaluated.All patients were monitored during the procedure and antibiotics were administered in case of cholangitis.Theχ 2 test and logistic regression analysis were performed as appropriate.RESULTS:Two hundred and fourteen patients(102 males,112 females;mean age 74.8±0.84 years-single stone 97,multiple stones 117)underwent ESWL.The mean number of sessions and shock waves were 3.5 ±0.13 and 3477.06±66.17,respectively.The maximum stone size was 5 cm.Complete stone clearance was achieved in 192(89.7%)patients.Of the remain-ing patients 15 required surgery,2 a palliative stent and in 5 patients stone fragmentation led to effective bile drainage with clinical resolution despite incomplete clearance.Age,sex and stone characteristics were not related to treatment outcome.Major complications occurred in two patients(haemobilia and rectal bleeding) and minor complications in 25(3 vomiting,22 arrhythmias).No procedure-related deaths occurred.CONCLUSION:ESWL is a safe and effective technique for clearance of refractory bile duct stones. | Rosangela Muratori Francesco Azzaroli Federica Buonfiglioli Flavio Alessandrelli Paolo Cecinato Giuseppe Mazzella Enrico Roda | 2010 | World Journal of Gastroenterology2010，16，33： | 8 |
| 4 | Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury显示文摘In the hours to weeks following traumatic spinal cord injuries(SCI), biochemical processes are initiated that further damage the tissue within and surrounding the initial injury site: a process termed secondary injury. Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing significantly to both motor and sensory deficits. In particular, efforts have been made to elucidate the mechanisms of acrolein-mediated damage at the cellular level and the resulting paralysis and neuropathic pain. In this review, we will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of SCI. We will also discuss the therapeutic benefits of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following SCI. | Jonghyuck Park Breanne Muratori Riyi Shi | 2014 | Neural Regeneration Research2014，9，7： | 6 |
| 5 | De novo autoimmune hepatitis in liver transplant: State-of-the-art review显示文摘In the two past decades, a number of communications, case-control studies, and retrospective reports have appeared in the literature with concerns about the development of a complex set of clinical, laboratory and histological characteristics of a liver graft dysfunction that is compatible with autoimmune hepatitis. The de novo prefix was added to distinguish this entity from a pre-transplant primary autoimmune hepatitis, but the globally accepted criteria for the diagnosis of autoimmune hepatitis have been adopted in the diagnostic algorithm. Indeed, de novo autoimmune hepatitis is characterized by the typical liver necroinflammation that is rich in plasma cells, the presence of interface hepatitis and the consequent laboratory findings of elevations in liver enzymes, increases in serum gamma globulin and the appearance of nonorgan specific auto-antibodies. Still, the overall features of de novo autoimmune hepatitis appear not to be attributable to a univocal patho-physiological pathway because they can develop in the patients who have undergone liver transplantation due to different etiologies. Specifically, in subjects with hepatitis C virus recurrence, an interferon-containing antiviral treatment has been indicated as a potential inception of immune system derangement. Herein, we attempt to review the currently available knowledge about de novo liver autoimmunity and its clinical management. | Ranka Vukotic Giovanni Vitale Antonia D'Errico-Grigioni Luigi Muratori Pietro Andreone | 2016 | World Journal of Gastroenterology2016，22，10： | 4 |
| 6 | Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro显示文摘Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016. | Michele Fornaro Alessia Giovannelli Angelica Foggetti Luisa Muratori Stefano Geuna Giorgia Novajra Isabelle Perroteau | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 7 | Role of inflammatory cytokines in peripheral nerve injury显示文摘Inflammatory events occurring in the distal part of an injured peripheral nerve have, nowadays, a great resonance. Investigating the timing of action of the several cytokines in the important stages of Wallerian degeneration helps to understand the regenerative process and design pharmacologic intervention that promotes and expedites recovery. The complex and synergistic action of inflammatory cytokines finally promotes axonal regeneration. Cytokines can be divided into pro-and anti-inflammatory cytokines that upregulate and downregulate, respectively, the production of inflammatory mediators. While pro-inflammatory cytokines are expressed in the first phase of Wallerian degeneration and promote the recruitment of macrophages, anti-inflammatory cytokines are expressed after this recruitment and downregulate the production of all cytokines, thus determining the end of the process. In this review, we describe the major inflammatory cytokines involved in Wallerian degeneration and the early phases of nerve regeneration. In particular, we focus on interleukin-1, interleukin-2, interleukin-6, tumor necrosis factor-β, interleukin-10 and transforming growth factor-β. | Federica Fregnan Luisa Muratori Anabel Rodriguez Simǒes Maria Giuseppina Giacobini-Robecchi Stefania Raimondo | 2012 | Neural Regeneration Research2012，7，29： | 3 |
| 8 | Factors Associated With Response to Therapy and Outcome of Patients With Primary Biliary Cirrhosis With Features of Autoimmune Hepatitis显示文摘 | Ersan Ozaslan Cumali Efe Alexandra Heurgué–Berlot Taylan Kav Chiara Masi Tugrul Purnak Luigi Muratori Yücel Ustündag Solange Bresson–Hadni Gérard Thiéfin Thomas D. Schiano Staffan Wahlin Paolo Muratori | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 3 |
| 9 | ARFI elastography in patients with chronic autoimmune liver diseases: A preliminary study显示文摘 | S. Righi E. Fiorini C. De Molo V. Cipriano F. Cassani L. Muratori M. Lenzi A.M. Morselli Labate C. Serra | 2012 | Journal of Ultrasound2012，，4： | 2 |
| 10 | DNA fragmentation in two cytometric sperm populations: relationship with clinical and ultrasound characteristics of the male genital tract显示文摘我们调查了是否在二张 cytometric 精子人口的 DNA 破碎(PI 更暗淡的 和 PI 有不同生物特征和临床的关联的更明亮的 ) 与有关临床并且男生殖道的 color-Doppler 超声(CDUS ) 参数。没有基因畸形的不肥沃的夫妇的 160 男性被评估为临床,阴囊,并且 transrectal CDUS 特征,像前列腺炎的症状的存在(与公民一起,健康长期的前列腺炎症状的研究所索引)并且在 PI 更暗淡的和 PI 更明亮的人口(用 TUNEL/PI ,方法结合了流动 cytometry )。数据好久被调整(模型 1 ) 与腰围,睾丸激素层次,吸烟习惯,和性节制(模型 2 ) 一起。根据统计模型 2, PI 更暗淡的 sDF 与阴囊的畸形被联系,包括降低临床并且超声体积(r = 0.21 并且 r = 0.20 分别地;P < 0.05 ) ,更高的 FSH 层次(r = 0.34, P < 0.0001 ) 并且阴囊的不同类的出现(P < 0.05 ) 并且 hypoechogenicity (P < 0.05 ) 。 PI 更明亮的 sDF 与前列腺相关的症状和反常符号被联系包括全部的更高的 NIH-CPSI 和子域分数,像前列腺炎的症状并且象宏石灰化那样的 CDUS 改变的更高的流行,严重回响质地不同类, hyperemia (所有 P < 0.05 ),并且更高动脉的山峰收缩速度( r = 0.25 , P < 0.05 )。我们的结果在 PI 更暗淡的 精子,与差的精液质量有关,主要在睾丸发源,由于 apoptosis 可能。相反地,在 PI 更明亮的 精子看起来主要通过前列腺发源在期间或在运输以后,与机关的煽动性的地位的存在增加。这些结果能导致新观点让治疗学的目标的鉴定减少 sDF。 | Francesco Lotti Lara Tamburrino Sara Marchiani Elisa Maseroli Pasquale Vitale Gianni Forti Monica Muratori Mario Maggi Elisabetta Baldi | 2017 | Asian Journal of Andrology2017，19，3： | 2 |
| 11 | Genetic distinctions between autoimmune hepatitis in Italy and North America显示文摘AIM: Our goals were to analyze the known genetic predispositions for autoimmune hepatitis (AIH) in AIH Italian population and to compare them with North American counterparts.METHODS: Human leukocyte antigens (HLA) B8, C7, DR3,DR4, DR7, DR11, DR13, DQ2 and the B8-DR3-DQ2phenotype were determined by microlymphocytotoxicity and polymerase chain reaction in 74 Italian patients (57with type 1 and 17 with type 2 AIH) and 149 North American patients with type 1 AIH, and in adequate controls.RESULTS: B8-DR3-DQ2 occurred more frequently in Italian patients with type 1 AIH than in Italian controls (30% vs 7%, P<0.0001), but less frequently than in North American counterparts (30% vs48%, P = 0.02). DR4 occurred less frequently in Italian patients with type 1 AIH (23% vs43%,P= 0.01) and in controls (16% vs34%, P= 0.0003) than in North American counterparts. No differences were found in alleles' frequency between type 1 and type 2Italian AIH patients. DR11 had a frequency lower in type 1 Italian AIH patients than controls (17% vs35%, P= 0.01).CONCLUSION: HLA DR4 is not associated with AIH in Italy. The known HLA risk factors for ATH occur similarly in Italian patients with type 1 and type 2 AIH, and they are less frequent than in North American patients. B8-DR3-DQ2 is the predominant phenotype of type 1 AIH also in Italy, and HLA DR11 may be a regionally distinctive protective factor against type 1 AIH. | Paolo Muratori Albert J.Czaja Luigi Muratori Georgios Pappas Silvana Maccariello Fabio Cassani Alessandro Granito Rodolfo Ferrari Vilma Mantovani Marco Lenzi Francesco B.Bianchi | 2005 | World Journal of Gastroenterology2005，11，12： | 2 |
| 12 | A Separation Condition for the Existence of Limit Cycles in Slow-fast Systes 显示文摘 | Muratori | 1991 | Appl Math Modeling1991，15，： | 2 |
| 13 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Paolo Muratori Luigi Muratori Rodolfo Ferrari Fabio Cassani Giampaolo Bianchi Marco Lenzi Luis Rodrigo Antonio Linares Dolores Fuentes Francesco B Bianchi | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 14 | Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome and associated extrahepatic autoimmune diseases显示文摘 | Cumali Efe Staffan Wahlin Ersan Ozaslan Alexandra Heurgue Berlot Tugrul Purnak Luigi Muratori Chiara Quarneti Osman Yüksel Gérard Thiéfin Paolo Muratori | 2012 | European Journal of Gastroenterology & Hepatology2012，，5： | 2 |
| 15 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Muratori P Muratori L Ferrari R | 2003 | Am J Gasteroenterol2003，，2： | 1 |
| 16 | Smoking as a risk factor for autoimmune liver disease :what we can learn from primary biliary cirrho- sis显示文摘 | Smyk DS Rigopoulou El Muratori L | 2012 | Ann Hepatol2012，11，1： | 1 |
| 17 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Muratori P Muratori L Ferrari R | 2003 | Am J Gasteroenterol2003，，2： | 1 |
| 18 | Essential amino acids increase the growth and alkaline phosphatase activity in osteoblasts cultured in vitro 显示文摘 | Conconi MT Tommasini M Muratori E | 2001 | Il Farmaco2001，56，11： | 1 |
| 19 | Circulating non-organ specificautoantibodies ( NOSA ) and cryoglobulins ( CG ) in HCV-related chronic liver disease (CLD) 显示文摘 | Mele L Muratori P Cassani F | 2003 | J Hepatol2003，38，2： | 1 |
| 20 | New autoantibodies and autoantigens in autoimmune hepatitis显示文摘 | Francesco B Bianchi Paolo Muratori Luigi Muratori | 2002 | Clinics in Liver Disease2002，，3： | 1 |
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