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| 1 | Gallbladder carcinoma: prognostic factors and therapeutic options显示文摘The outcome of gallbladder carcinoma is poor,and the overall 5-year survival rate is less than 5%. In early-stage disease,a 5-year survival rate up to 75% can be achieved if stage-adjusted therapy is performed. There is wide geographic variability in the frequency of gallbladder carcinoma,which can only be explained by an interaction between genetic factors and their alteration. Gallstones and chronic cholecystitis are important risk factors in the formation of gallbladder malignancies. Factors such as chronic bacterial infection,primary sclerosing cholangitis,an anomalous junction of the pancreaticobiliary duct,and several types of gallbladder polyps are associated with a higher risk of gallbladder cancer. There is also an interesting correlation between risk factors and the histological type of cancer. However,despite theoretical risk factors,only a third of gallbladder carcinomas are recognized preoperatively. In most patients,the tumor is diagnosed by the pathologist after a routine cholecystectomy for a benign disease and is termed ‘‘incidental or occult gallbladder carcinoma''(IGBC). A cholecystectomy is performed frequently due to the minimal invasiveness of the laparoscopic technique. Therefore,the postoperative diagnosis of potentially curable early-stage disease is more frequent. A second radical re-resection to complete a radical cholecystectomy is required for several IGBCs. However,the literature and guidelines used in different countries differ regarding the radicality or T-stage criteria for performing a radical cholecystectomy. The NCCN guidelines and data from the German registry(GR),which records the largest number of incidental gallbladder carcinomas in Europe,indicate that carcinomas infiltrating the muscularis propria or beyond require radical surgery. According to GR data and current literature,a wedge resection with a combined dissection of the lymph nodes of the hepatoduodenal ligament is adequate for T1 b and T2 carcinomas. The reason for a radical cholecystectomy after simple CE in a formally R0 situation is either occult invasion or hepatic spread with unknown lymphogenic dissemination. Unfortunately,there are diverse interpretations and practices regarding stageadjusted therapy for gallbladder carcinoma. The current data suggest that more radical therapy is warranted. | Thorsten Oliver Goetze | 2015 | World Journal of Gastroenterology2015，21，43： | 43 |
| 2 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 3 | 双离合器变速箱换档动力学和控制显示文摘依据包含一双离分器变速箱的汽车动力传动系统的详细动力模型开发了一个集成的动力传动系的换档控制。基于换高档和换低档以及发生于变速箱相同一部分的换档控制的仿真结果证实了该控制器的工作。采用带有再现单向离合离工作目标为均匀传递发动机转矩离合器滑动的闭环控制制订了控制法则,进一步的要素是通过发动机控制和离合器压力操纵的组合对发动机速度的闭环控制。此外,它证实了变速箱换档时输出转矩的控制可增加控制的持久性以及提供了直接操纵换档品质的方法。最后讨论了通过方便的液力传动锥型同步器在总换档质量方面予选换档的动力影响。 | M. Goetz M. C. Levesley D. A. Crolla 谷雨 | 2006 | 传动技术2006，20，3： | 12 |
| 4 | The CRISPR/Cas revolution continues: From efficient gene editing for crop breeding to plant synthetic biology显示文摘Since the discovery that nucleases of the bacterial CRISPR(clustered regularly interspaced palindromic repeat)-associated(Cas) system can be used as easily programmable tools for genome engineering,their application massively transformed different areas of plant biology. In this review, we assess the current state of their use for crop breeding to incorporate attractive new agronomical traits into specific cultivars of various crop plants. This can be achieved by the use of Cas9/12 nucleases for double-strand break induction,resulting in mutations by non-homologous recombinatr e-tion. Strategies for performing such experiments à from Rthe design of guide RNA to the use of different transformation technologies à are evaluated. Furtherweive-more, we sum up recent developments regarding the use of nuclease-deficient Cas9/12 proteins, as DNAbinding moieties for targeting different kinds of enzyme activities to specific sites within the genome. Progress in base deamination, transcriptional induction and transcriptional repression, as well as in imaging in plants, is also discussed. As different Cas9/12 enzymes are at hand, the simultaneous application of various enzyme activities, to multiple genomic sites, is now in reach to redirect plant metabolism in a multifunctional manner and pave the way for a new level of plant synthetic biology. | Jochen Kumlehn Janine Pietralla Goetz Hensel Michael Pacher Holger Puchta | 2018 | Journal of Integrative Plant Biology2018，60，12： | 9 |
| 5 | 独立于RANKL/RANK系统的调控根吸收机制:TNFα的可溶性受体抑制根吸收显示文摘目的 :深入探知TNFα ,IL - 1在根吸收过程中的作用及两种骨吸收调控机制 ,即RANKL/RANK调控系统 ,炎症因子IL - 1,TNFα调控系统相互间的关系。方法 :18只雄Wistar大鼠 ,4周龄 ,随机分为 3组 ,正常对照组 ,IL - 1组 ,TNFα组 ,每组 6只。根据Nakane方法建立大鼠根吸收模型。研究 3组大鼠标本中RANKL ,RANK ,mRNA各自表达程度的差别及相应的ED1(单核巨噬细胞标记物 )阳性细胞在根吸收组织中的分布情况。结果 :T检验证实 :正常组与TNFα组间有显著性差别 ,P <0 .0 1;正常组与IL - 1组无显著性差别。在下列细胞内可以检测到RANKLmRNA的阳性信号 :成骨细胞 ,骨内膜细胞 ,基质细胞 ,近根吸收陷窝处的纺锤状成纤维细胞。3组间的信号表达水平比较无显著差别。结论 :本研究采用ED1作为免疫组化标记物 。 | 张栋梁 欧阳喈 汪玲丽 Werner Goetz Andreas Jaeger | 2004 | 口腔医学研究2004，20，1： | 8 |
| 6 | 肾动脉内支架成形术的临床应用显示文摘目的:对肾动脉阻塞性病变采用Palmaz内支架进行治疗,并对其临床远期疗效进行前瞻性、非随机研究分析。材料与方法:7例(26%)为经皮肾动脉气囊成形术(PTRA)治疗失败者,13例(48%)为PTRA后病变再狭窄,4例(15%)为PTRA后出现并发症,3例(11%)为肾动脉开口处狭窄直接作内支架治疗。共有4枚Palmaz内支架、5枚Palmaz-Schats节段性内支架及18枚Palmaz中号内支架被用于本组病例,内支架透视导向下用气囊导管及8F导引鞘释放到靶血管段。结果:技术成功率为100%(残余狭窄<30%),未发生严重并发症,病变两端平均压差从6.8±1.5kPa(1kPa=7.5mmHg)降至0kPa(P<0.05),随访结果(3~32个月,平均10±6个月)显示4例治愈,20例缓解,总有效率89%,平均收缩压从术前24.8±3.0kPa降至18.9±2.0kPa,舒张压从14.7±1.3kPa降至11.3±1.5kPa(P<0.05),6例肾功能衰竭病人中有2例术后肾功能改善,另4例稳定不变,2例分别于术后3、18个月出现病变内再狭窄,但未出现临床症状,病变两端压力差改变不显著。结论:常规PTRA? | 杨建勇 Thomas Roeren Goetz M Richter Goetz W Kaufmann | 1996 | 中华放射学杂志1996，30，5： | 8 |
| 7 | Formal Definition of a User-Adaptive and Length-Optimal Routing Graph for Complex Indoor Environments显示文摘Car routing solutions are omnipresent and solutions for pedestrians also exist.Furthermore,public or commercial buildings are getting bigger and the complexity of their internal structure has increased.Consequently,the need for indoor routing solutions has emerged.Some prototypes are available,but they still lack semantically-enriched modelling (e.g.,access constraints,labels,etc.) and are not suitable for providing user-adaptive length-optimal routing in complex buildings.Previous approaches consider simple rooms,concave rooms,and corridors,but important characteristics such as distinct areas in huge rooms and solid obstacles inside rooms are not considered at all,although such details can increase navigation accuracy.By formally defining a weighted indoor routing graph,it is possible to create a detailed and user-adaptive model for route computation.The defined graph also contains semantic information such as room labels,door accessibility constraints,etc.Furthermore,one-way paths inside buildings are considered,as well as three-dimensional building parts,e.g.,elevators or stairways.A hierarchical structure is also possible with the presented graph model. | GOETZ Marcus ZIPF Alexander | 2011 | Geo-Spatial Information Science2011，14，2： | 7 |
| 8 | In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy显示文摘瞄准:为在活体内评估一根最新发达的手持的共焦的探针在啮齿类动物的完全的胃肠道的显微镜的成像。方法:一根新奇僵硬共焦的探针(直径 7 公里) 为 fluorophore 刺激用 488 nm 单身者线激光在人为使用与类似于灵活 endomicroscopy 系统的光特征被设计。轻排放在 505 ~ 750 nm 被检测。看法的地多样地是 475 妈妈 475 妈妈。光片厚度是有 0.7 妈妈的侧面的分辨率的 7 妈妈。在不同深度(到 250 妈妈的表面) 的表面下的连续图象多样地在 1024 点在实时被产生由在轻轻的、稳定的接触把探查放到织物上的 1024 个象素(0.8 frames/s ) 。织物标本为组织病理学说的关联被取样。结果:食管,胃,小并且大肠和中央,肝,胰和胆囊是在在 n = 的高分辨率的视觉 ised 在活体内 48 个鼠标。有共焦的微型显微镜学探查的实时显微镜的成像是容易的完成。不同染色协议(荧光黄,吖啶黄,标记 FITC 的葡聚糖和 L。可食用嗯植物凝血素) 织物的每个加亮的特定的方面,和在活体内成像与常规组织学最优地相关。在活体内血流监视把功能的质量加到词法成像。结论:共焦的显微镜学是在甚至表面下的织物结构的高分辨率允许完全的官方补给的道的可视化的可行在活体内。在这研究评估的新共焦的探查设计与腹腔镜检查兼容并且显著地扩展可能的应用的地到 intra 腹的机关。它允许新在活体内染色和申请选择的立即的测试因此在病人从动物研究允许快速的转移到临床的使用。 | Martin Goetz Beena Memadathil Stefan Biesterfeld Constantin Schneider Sebastian Gregor Peter R Galle Markus F Neurath Ralf Kiesslich | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 9 | Polarized Defense Against Fungal Pathogens Is Mediated by the Jacalin-Related Lectin Domain of Modular Poaceae-Specific Proteins显示文摘模块化的蛋白质是一个进化答案优化身体上为功能与对方一起交往的蛋白质的性能。用基因、生物化学的实验的联合,我们描绘了米饭蛋白质 OsJAC1,它由领域预言了绑包含甘露糖的 oligosaccharides,和可能在 monolignols 联合的 stereoselective 工作的一个 dirigent 领域的 jacalin 相关的 lectin (JRL ) 组成。在米饭的 OsJAC1 的转基因的 overexpression 包括细菌, oomycetes,和真菌对不同病原体导致了量的用途广泛的抵抗。在大麦的这基因或它的小麦 ortholog TAJA1 的 Overexpression 对粉的霉真菌提高了抵抗。OsJAC1 的两个蛋白质领域被要求建立由单个领域的单个或联合的短暂表示显示了的抵抗。表示人工地分开了,标注荧光的蛋白质领域证明 JRL 领域为指向粉的霉穿入地点是足够的。不过, lectinand 的合作本地化 dirigent 领域发生了。种系发生的分析专门在 Poaceae 植物家庭以内揭示了 OsJAC1 的 orthologs。Dicots 由对比,仅仅与 JRL 或 dirigent 领域包含蛋白质。总的来说,我们的结果从植物作为抵抗 proteinderived 的一种新奇类型的一个代表识别 OsJAC1 为在本地病原体防卫的更好的功能的系特定的基因熔化事件。 | Denise Weidenbach Lara Esch Claudia Moller Goetz Hensel Jochen Kumlehn Caroline Hofle Ralph Huckelhoven Ulrich Schaffrath | 2016 | Molecular Plant2016，9，4： | 4 |
| 10 | Academic Emotions in Students’ Self-Regulated Learning and Achievement: A Program of Qualitative and Quantitative Research显示文摘 | Reinhard Pekrun Thomas Goetz Wolfram Titz Raymond P. Perry | 2002 | Educational Psychologist2002，，2： | 3 |
| 11 | Interbank tiering and money center banks显示文摘 | Ben Craig Goetz von Peter | 2011 | Journal of Financial Intermediation2011，，： | 3 |
| 12 | The impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis显示文摘 | Constantin J. C. Trepte Kai A. Bachmann Jan H. Stork Till J. Friedheim Andrea Hinsch Matthias S. Goepfert Olliver Mann Jakob R. Izbicki Alwin E. Goetz Daniel A. Reuter | 2013 | Intensive Care Medicine2013，，4： | 2 |
| 13 | 雷沙吉兰在治疗老年帕金森病患者中的安全性显示文摘The authors examined age effects on adverse events from two randomized, controlled trials of rasagiline, comparing younger (younger than 70 years) and older (70 years and older) subjects. Older patients were more prone to serious adverse effects than younger patients, but there was no statistical interaction between age and rasagiline exposure. This absence of an age-rasagiline interaction suggests that rasagiline does not require special safety precautions for elderly subjects with Parkinson disease. | Goetz C. G. Schwid S. R. Eberly S. W. 张嘉靖(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 2 |
| 14 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 15 | Increasing Prevalence of HCC and Cirrhosis in Patients With Chronic Hepatitis C Virus Infection显示文摘 | Fasiha Kanwal Tuyen Hoang Jennifer R. Kramer Steven M. Asch Matthew Bidwell Goetz Angelique Zeringue Peter Richardson Hashem B. El–Serag | 2011 | Gastroenterology2011，，4： | 2 |
| 16 | The transjugular intrahepatic portosystemic Stent-Shunt (TIPSS): Results of a pilot study显示文摘 | Goetz M. Richter M.D. Gerd Noeldge Julio C. Palmaz Martin Roessle | 1990 | Cardiovascular and Interventional Radiology1990，，3： | 2 |
| 17 | The five-minute rule ten years later, and other computer storage rules of thumb显示文摘 | Jim Gray Goetz Graefe | 1997 | ACM SIGMOD Record1997，，4： | 2 |
| 18 | Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry显示文摘 | Thorsten Oliver Goetze Vittorio Paolucci | 2010 | Surgical Endoscopy2010，，9： | 2 |
| 19 | In vivo molecular imaging with cetuximab, an anti-EGFR antibody, for prediction of response in xenograft models of human colorectal cancer显示文摘 | M. Goetz M. Hoetker M. Diken P. Galle R. Kiesslich | 2013 | Endoscopy2013，，： | 2 |
| 20 | Chromoscopy-Guided Endomicroscopy Increases the Diagnostic Yield of Intraepithelial Neoplasia in Ulcerative Colitis显示文摘 | Ralf Kiesslich Martin Goetz Katharina Lammersdorf Constantin Schneider Juergen Burg Manfred Stolte Michael Vieth Bernhard Nafe Peter R. Galle Markus F. Neurath | 2007 | Gastroenterology2007，，3： | 2 |
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