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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | What is the accuracy of the clinical diagnosis of multiple system atrophy? A clinicopathologic study显示文摘 | LITVAN I GOETZ C G JANKOIYZ J | 1997 | Arch Neurol1997，54，8： | 2 |
| 3 | New developments in acoustic and electroacoustic spectroscopy for characterizing concentrated dispersions 显示文摘 | DUKHIN A S GOETZ P J | 2001 | Colloids and Surfaces: A Physicochemical and Engineering Aspects2001，192，3： | 1 |
| 4 | Method for improving extended Kalman filter performance for angle-only passive ranging 显示文摘 | Guerci J R Goetz R A DiModica J | 1994 | IEEE Transactions on Aerospace and Electronic Systems (S0018-9251)1994，30，4： | 1 |
| 5 | Pro-brain natriuretic peptide as marker of cardiovascular or pulmonary causes of dyspnea in patients with terminal parenchymal lung disease显示文摘 | GOETZE J P VIDEBAEK R BOESGAARD S | 2004 | J Heart Lung Transplant2004，23，1： | 1 |
| 6 | An iron delivery pathway mediated by a lipocalin 显示文摘 | Yang J Goetz D Li JY | 2002 | Mol Cell2002，10，5： | 1 |
| 7 | Tracheostomy with invasive ventilation for ALS patients: Neurologists' roles in the US and Japan显示文摘 | Rabkin J Ogino M Goetz R | 2013 | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration2013，14，2： | 1 |
| 8 | Enforcing promises : an examination of the basis of contract 显示文摘 | CHARLES J GOETZ ROBERT E SCOTt | 1980 | The Yale Law Journal1980，89，7： | 1 |
| 9 | Subsidence resulting from simula- ted postoperative neck movements:an in vitro investigation with a new cervical fusion cage 显示文摘 | Wilke H J Kettler A Goetz C | 2000 | Spine2000，21，： | 1 |
| 10 | Apelin:A new plasma marker of cardiopulmonary disease显示文摘 | Goetze JP Rehfeld JF Carlsen J | 2006 | Regul Pept2006，133，13： | 1 |
| 11 | Hyaluro- nan microspheres for sustained gene delivery and site-specific targeting 显示文摘 | YUN Y H GOETZ D J YELLEN P | 2004 | Biomaterials2004，25，1： | 1 |
| 12 | Predictors of gastric emptying in Parkinson' s disease 显示文摘 | Goetze O Nikodem A B Wiezcorek J | 2006 | Neurogastro- enlerol Motil2006，18，5： | 1 |
| 13 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | Goetze J P | 2003 | FASEB J2003，17，9： | 1 |
| 14 | Self-employment in rural America:The new economic reality显示文摘 | GOETZ S J | 2008 | Rural realities2008，2，3： | 1 |
| 15 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | GOETZE J P CHRISTOFFERSEN C PERKO M | 2003 | FASEB J2003，17，： | 1 |
| 16 | The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen显示文摘 | Goetz MP Knox SK Suman V J | 2007 | Breast Cancer Res Treat2007，101，1： | 1 |
| 17 | ^13C-methacetin breath test :isotope-selective nondispersive infrared spectrometry in comparison to isotope ratio mass spectrometry in volunteers and patients with liver cirrhosis 显示文摘 | Adamek R J Goetze O Boedeker C | 1999 | Z Gastroenterol1999，37，12： | 1 |
| 18 | Image spectrometry for earth remote sensing 显示文摘 | Goetz Alexander F H Vane G Solomon J E | 1985 | Science1985，228，4704： | 1 |
| 19 | Increased cardiac BNP ex- pression associated with myocardial isehemia显示文摘 | J Goetze C Christoffersen M Perko | 2003 | Faseb J2003，17，9： | 1 |
| 20 | Pediatric adenoidal hypertrophy and nasal airway obstruction:reduction with aqueous nasal beclomethasone显示文摘 | Demain J G Goetz D W | 1995 | Pediatrics1995，95，3： | 1 |
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