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| 1 | 通过TFE-3融合变异体分析Xp11易位癌之间的临床病理关系显示文摘Xp11易位癌包括Xp11易位性肾细胞癌(RCC)、Xp11易位性血管周上皮样细胞肿瘤(PEComa)以及色素性Xp11易位肾癌。在Xp11易位癌中,TFE3与一些不同基因伴侣的融合,从而激活TFE3致癌基因;然而不同的融合变异体对Xp11易位癌的临床病理特点影响尚不清楚。本文使用定制的细菌人工染色体探针来建立TFE3融合基因伴侣,采用原位荧光杂交对60例Xp11易位癌进行分析。5例通过RNA测序进一步分析其融合转录体的特点。60例Xp11易位癌包括47例Xp11易位性RCC、8例Xp11易位性PEComas以及5例色素性Xp11易位肾癌。60例患者中有53例(88%)确定了融合基因伴侣,包括18例SFPQ(PSF)、16例PRCC、12例ASPSCR1(ASPL)、6例NONO及1例DVL2。 | Argani P Zhong M Reuter V E 魏建国 刘勇 | 2016 | 临床与实验病理学杂志2016，32，9： | 13 |
| 2 | 孤儿药的经济潜力显示文摘随着《美国孤儿药法案》的颁布以及世界多个国家相类似法案的出台,刺激了世界范围的孤儿药研究,为制药公司针对罕见病治疗的药物开发提供了潜在的利益刺激。该报告对孤儿药开发和商业运作的经济和投资进行了分析。表明尽管孤儿药比传统主流药物针对的人群小得多,但高昂的治疗费用及各种具有诱惑力的开发动力,如政府的鼓励、临床试验规模小且时间短、独占期长及审核成功率高等,让顶级孤儿药同非孤儿药一样具有生命力。 | Thomson Reuters Pfizer | 2013 | 科学观察2013，8，1： | 6 |
| 3 | Influence of tacrolimus metabolism rate on renal function after solid organ transplantation显示文摘The calcineurin inhibitor(CNI) tacrolimus(TAC) is an integral part of the immunosuppressive regimen after solid organ transplantation. Although TAC is very effective in prevention of acute rejection episodes, its highly variable pharmacokinetic and narrow therapeutic window require frequent monitoring of drug levels and dose adjustments. TAC can cause CNI nephrotoxicity even at low blood trough levels(4-6 ng/m L). Thus, other factors besides the TAC trough level might contribute to CNI-related kidney injury. Unfortunately, TAC pharmacokinetic is determined by a whole bunch of parameters. However, for daily clinical routine a simple application strategy is needed. To address this problem, we and others have evaluated a simple calculation method in which the TAC blood trough concentration(C) is divided by the daily dose(D). Fast TAC metabolism(C/D ratio < 1.05) was identified as a potential risk factor for an inferior kidney function after transplantation. In this regard, we recently showed a strong association between fast TAC metabolism and CNI nephrotoxicity as well as BKV infection. Therefore, the TAC C/D ratio may assist transplant clinicians in a simple way to individualize the immunosuppressive regimen. | Gerold Th?lking Hans Ulrich Gerth Katharina Schuette-Nuetgen Stefan Reuter | 2017 | World Journal of Transplantation2017，7，1： | 6 |
| 4 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 5 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 6 | SURGICAL MANAGEMENT OF RENAL TUMORS 4 CM. OR LESS IN A CONTEMPORARY COHORT显示文摘 | CHERYL T. LEE JARED KATZ WEIJI SHI HOWARD T. THALER VICTOR E. REUTER PAUL RUSSO | 2000 | The Journal of Urology2000，，： | 3 |
| 7 | Gore-Tex膜引导骨再生技术在种植体周围炎治疗中的应用显示文摘目的 :评价Gore_Tex膜引导骨再生技术治疗种植体周围炎的临床疗效。方法 :对3例种植体周围炎患者局部冲冼和药物治疗控制感染后行翻瓣刮治 ,应用Gore_Tex膜覆盖骨缺损 ,术后6月去除膜 ,摄X线片及进行临床评价。结果 :3例骨缺损者均完全再生修复 ,种植体稳定。结论 :局部冲冼和翻瓣刮治后 ,应用Gore_Tex膜覆盖骨缺损治疗种植体周围炎 ,可获得骨组织再生修复。 | 黄盛兴 Erenhard Reuter Elmar Kassan | 2000 | 中国口腔种植学杂志2000，5，4： | 3 |
| 8 | 3D时代即将来临显示文摘汤森路透知识产权解决方案业务部调查了2003-2009年期间3D技术领域的专利活动。通过分析已公布专利申请和授权专利中包含的发明的总数,研究人员确定了专利活动增长最快的3D技术领域。研究发现,3D技术的利润链已延伸至好莱坞之外。数据显示,娱乐领域的3D技术创新呈快速增长之势。实际上,在3D技术专利活动数量最多的三大领域中,3D电影位居末席,排在3D电视和3D摄影之后。按照目前3D技术领域的创新活动水平,通过家庭平板电视观看3D广告以及翻阅孩子们的3D相册将指日可待。 | Thomson Reuters | 2010 | 科学观察2010，5，4： | 3 |
| 9 | The impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis显示文摘 | Constantin J. C. Trepte Kai A. Bachmann Jan H. Stork Till J. Friedheim Andrea Hinsch Matthias S. Goepfert Olliver Mann Jakob R. Izbicki Alwin E. Goetz Daniel A. Reuter | 2013 | Intensive Care Medicine2013，，4： | 2 |
| 10 | Machine-learning driven global optimization of surface adsorbate geometries显示文摘The adsorption energies of molecular adsorbates on catalyst surfaces are key descriptors in computational catalysis research.For the relatively large reaction intermediates frequently encountered,e.g.,in syngas conversion,a multitude of possible binding motifs leads to complex potential energy surfaces(PES),however.This implies that finding the optimal structure is a difficult global optimization problem,which leads to significant uncertainty about the stability of many intermediates.To tackle this issue,we present a global optimization protocol for surface adsorbate geometries which trains a surrogate machine learning potential on-the-fly.The approach is applicable to arbitrary surface models and adsorbates and minimizes both human intervention and the number of required DFT calculations by iteratively updating the training set with configurations explored by the algorithm.We demonstrate the efficiency of this approach for a diverse set of adsorbates on the Rh(111)and(211)surfaces. | Hyunwook Jung Lena Sauerland Sina Stocker Karsten Reuter Johannes T.Margraf | 2023 | npj Computational Materials2023，，1： | 2 |
| 11 | 癌症免疫疗法最新进展显示文摘免疫疗法在癌症治疗中具有独特优势,故越来越受到制药企业和研究机构的青睐,研发的癌症免疫治疗药物新品种也在不断扩增。介绍癌症免疫治疗产品研发的最新动态。 | Thomson Reuters | 2015 | 药学进展2015，39，3： | 2 |
| 12 | 2016年最具市场前景的药物预测显示文摘回顾2015年值得关注的11种药物的上市和销售情况。重点介绍2016年值得关注的7种药物的适应证、上市申请、临床开发情况以及市场前景展望等。 | Thomson Reuters | 2016 | 药学进展2016，40，3： | 2 |
| 13 | Imaging-based diagnosis of acute renal allograft rejection显示文摘Kidney transplantation is the best available treatment for patients with end stage renal disease. Despite the introduction of effective immunosuppressant drugs, episodes of acute allograft rejection still endanger graft survival. Since efficient treatment of acute rejection is available, rapid diagnosis of this reversible graft injury is essential. For diagnosis of rejection, invasive core needle biopsy of the graft is the 'gold-standard'. However, biopsy carries the risk of significant graft injury and is not immediately feasible in patients taking anticoagulants. Therefore, a non-invasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review current imaging-based state of the art approaches for non-invasive diagnostics of acute renal transplant rejection. We especially focus on new positron emission tomography-based as well as targeted ultrasoundbased methods. | Gerold Th?lking Katharina Schuette-Nuetgen Dominik Kentrup Helga Pawelski Stefan Reuter | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 14 | Aberrant Nuclear Immunoreactivity for TFE3 in Neoplasms With TFE3 Gene Fusions: A Sensitive and Specific Immunohistochemical Assay显示文摘 | Pedram Argani Priti Lal Brian Hutchinson Man Yee Lui Victor E. Reuter Marc Ladanyi | 2003 | The American Journal of Surgical Pathology2003，，6： | 2 |
| 15 | Nonlinear effects in LMS adaptive equalizers 显示文摘 | REUTER M ZEIDLER J | 1999 | IEEE Trans Signal Processing1999，，47： | 2 |
| 16 | The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis 显示文摘 | Burgess J Reuter H Carstens ME | 2002 | Chest2002，122，3： | 1 |
| 17 | Cation exchange capacities of organomineral particle-size fraction显示文摘 | Leinweber P Reuter G Brozio K | 1993 | Journal of Soil Science1993，44，： | 1 |
| 18 | 显示文摘 | MüLLER A REUTER H DILLINGER S | 1995 | Angew Chem Int Ed Eng1995，34，： | 1 |
| 19 | Orexins and their receptors: structural aspects and role in peripheral tissues显示文摘 | Voisin T Rouet-Benzineb P Reuter N | 2003 | Cell Mol Life Sci2003，60，1： | 1 |
| 20 | Blood group antigens in normal and neoplastic urothelium显示文摘 | Sheinfeld J Reuter V E Sarkis A S | 1992 | J Cell Biochem Suppl1992，161，1： | 1 |
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