|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Irritable bowel syndrome: A concise review of current treatment concepts显示文摘Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, 'classic' treatments for IBS as well as newer agents and 'alternative' therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients. | Geoffrey C Wall Ginelle A Bryant Michelle M Bottenberg Erik D Maki rew R Miesner | 2014 | World Journal of Gastroenterology2014，20，27： | 5 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients witb hypercholesterolemia显示文摘 | Anthony Dart George Jerums Geoffrey Nicholson Michael d’Emden Ian Hamilton-Craig George Tallis James Best Malcolm West David Sullivan Peter Braes Donald Black | 1997 | The American Journal of Cardiology1997，，： | 2 |
| 5 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 6 | A Factor Decomposing Model of Water Use Efficiency at Sector Level and Its Application in Beijing显示文摘The paper explores the contribution of different factors affecting water use efficiency(WUE) of each sector and explores ways to improve WUE.A new Multi-Sector and Multi-Factors Logarithmic Mean Divisia Index(MLMDI) decomposition method was developed that enabled the identification of WUE by sector into 11 factors in terms of their order of importance.An application to Beijing at the 19 sector level was made for the period between 2002–2007.The water conservation effects of six measures proposed during the 12th-Five-Year-Plan of Beijing were assessed.It was found that,to decrease the transferred out and export of agriculture products and increasing water prices would be the top two most effective measures to promote water conservation.While the adjustment of direct water use structure would contribute in less significant way,the adjustment of industrial structure would have a negative effect. | LIU Xiuli HEWINGS J D Geoffrey CHEN Xikang WANG Shouyang | 2016 | Journal of Systems Science & Complexity2016，29，2： | 2 |
| 7 | Aorta and Iliac Arteries:Single versus Multiple Detector-Row Helical CT Angiography显示文摘 | Geoffrey D Maria C Ann N | 2000 | Radiology2000，215，： | 1 |
| 8 | Environmental Beliefs and Attitudes in Sweden and the Baltic States显示文摘 | Gooch Geoffrey D | 1995 | Environment and Behavior1995，27，4： | 1 |
| 9 | Cyclietest of four-story steel plate sheawall显示文摘 | Driver Robert G Kulak Geoffrey L Kenned D J Laurie | 1998 | Journal of Structural Engineering1998，124，2： | 1 |
| 10 | Review article:spinal mechanisms of chronic pain显示文摘 | Geoffrey T D | | 0，，01： | 1 |
| 11 | Cyclic Test of Four-Story Steel Plate Shear Wall显示文摘 | Robert G Driver Geoffrey L Kulak Laurie Kennedy D J | | 0，，02： | 1 |
| 12 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 13 | The use of precision dendrometers in research on daily stem size and wood property variation: A review显示文摘 | David M D Geoffrey M D | 2009 | Dendrochronologia2009，27，： | 1 |
| 14 | Spinal mechanisms of pain control显示文摘 | Geoffrey T D | | 0，，07： | 1 |
| 15 | Pressurised steam drying of Australian low-rank coals显示文摘 | Geoffrey D Bongers W.Roy Jackson Fedir Woskoboenko | 2000 | Fuel Processing Technology2000，，1： | 1 |
| 16 | Interactive SLAM using Laser and Advanced Sonar 显示文摘 | Albert D Geoffrey T Lindsay K | 2005 | the IEEEIntemational Conference on Robotics and Automation2005，，： | 1 |
| 17 | von Willebrand factor and urinary albumin excretion are possible indicators of endothelial dysfunction in cardiopulmonary bypass显示文摘 | Allen S Pagano D | 1998 | Fur J Cardiothorac Surg1998，，4： | 1 |
| 18 | Terpenoids form the seeds of Artemisia annua显示文摘 | Geoffrey D B Liang G Y Lai-King Sy | 2003 | Phytochemistry2003，64，： | 1 |
| 19 | A sound type system for secure flow analysis显示文摘 | Volpano D Geoffrey S Irvine Cynthia | 1996 | Journal of Computer Security1996，4，3： | 1 |
| 20 | Morphological and chemical characterisation of the G-layer in tension wood fibres of Populus tremula and Betula verrucosa: labelling with cellulose- binding module CBMlnjc~17^ and fluorescence and FE-SEM microscopy显示文摘 | GEOFFREY D LADA F ASA M K | 2006 | Holzforschung2006，60，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员