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178篇 您的检索式:作者名="Jerums"
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1Effects of glycaemic management on diabetic kidney disease显示文摘Hyperglycaemia contributes to the onset and progression of diabetic kidney disease(DKD). Observational studies have not consistently demonstrated a glucose threshold, in terms of HbA1c levels, for the onset of DKD. Tight glucose control has clearly been shown to reduce the incidence of micro-or macroalbuminuria. However, evidence is now also emerging to suggest that intensive glucose control can slow glomerular filtration rate loss and possibly progression to end stage kidney disease. Achieving tight glucose control needs to be balanced against the increasing appreciation that glucose targets for the prevention of diabetes related complications need be individualised for each patient. Recently, empagliflozin which is an oral glucose lowering agent of the sodium glucose cotransporter-2 inhibitor class has been shown to have renal protective effects. However, the magnitude of empagliflozin's reno-protective properties are over and above that expected from its glucose lowering effects and most likely largely result from mechanisms involving alterations in intra-renal haemodynamics. Liraglutide and semaglutide, both injectable glucose lowering agents which are analogues of human glucagon like peptide-1 have also been shown to reduce progression to macroalbuminuria through mechanisms that remain to be fully elucidated. Here we review the evidence from observational and interventional studies that link good glucose control with improved renal outcomes. We also briefly review the potential reno-protective effects ofnewer glucose lowering agents.Richard J MacIsaac George Jerums Elif I Ekinci 2017World Journal of Diabetes2017,8,5:6
2A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients witb hypercholesterolemia显示文摘Anthony Dart George Jerums Geoffrey Nicholson Michael d’Emden Ian Hamilton-Craig George Tallis James Best Malcolm West David Sullivan Peter Braes Donald Black 1997The American Journal of Cardiology1997,,:2
3Integrating albu-minuria and GFR in the assessment of diabetic nephropathy 显示文摘Jerums G Panagiotopoulos S Premaratne E 2009Na-ture Reviews Nephrology2009,5,7:1
4Lowering of Proteinuria in Response to Antihypertensive Therapy Predicts Improved Renal Function in Late but Not in Early Diabetic Nephropathy: A Pooled Analysis显示文摘Jerums George Panagiotopoulos Sianna Premaratne Erosha Power David A Macisaac Richard J 2008American Journal of Nephrology2008,,4:1
5Estimating glomerular filtration rate in diabetes using serum cystatin C 显示文摘Macisaac R J Premaratne E Jerums G 2011Clin Biochem Rev2011,32,2:1
6Long-term comparison between perindopril and nifedipine in normotensive patients with type Ⅰ diabetes and microalbuminuria 显示文摘Jerums G Allen TJ Campbell DJ 2006Am J Kidney Dis2006,37,5:1
7Integrating albuminuria and GFR in the assessment of diabetic nephropathy显示文摘Jerums G Panagiotopoulos S Premaratne E 0,,:1
8Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 Diabetes and Impaired Renal Function显示文摘Ekinci EI Jerums G Skene A 0,,:1
9long-term Comparison between perimelopril and nifedipine in normotenive patients with type I diabetes and mieroalbuminttria显示文摘Jerums G Campbell DJ 2001Am J Kidney Dis2001,37,5:1
10Integrating albuminuria and GFR in the assessment of diabetic nephropathy显示文摘JERUMS G PANAGIOTOPOULOS S PREMARATNE E 2009Nat Rev Nephrol2009,5,7:1
11Differences in urinary albumin detected by four immunoassays and high-performance liquid chromatography 显示文摘Comper WD Jerums G Osicka TM 2004Clin Biochem2004,37,2:1
12Renal structure in normoalbumi-nuric and albuminuric patients with type 2 diabetes and impaired renal function显示文摘Ekinci EI Jerums G Skene A 2013Diabetes Care2013,36,11:1
13Urinary proteomics for early diagosis in diabetic nephropathy显示文摘Zurbig P Jerums G Hovind P 2012Diabetes2012,61,12:1
14New and old markers of progression of diabetic nephropathy显示文摘Jerums G Premaratne E Panagiotopoulos S Clarke S Power D A Maclsaac R J 2008Diabetes Res Clin Pract2008,82,1:1
15Differences in urinary albumin detected by four immunoassays and high-performance liquid chromatography 显示文摘Comper WD Jerums G Osicka TM 2004Clin Bioehem2004,37,2:1
16Estimating glo merular filtration rate in diabetes using serum cystatin C 显示文摘Maeisaae RJ Premaratne E Jerums G 2011Clin Biochem Rev2011,32,2:1
17Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy显示文摘Kelly DJ Gilbert RE Cox AJ Soulis T Jerums G Cooper ME 2001J Am Soc Nephrol2001,12,:1
18Estimating glomerular fil- tration rate in diabetes using serum cystatin C显示文摘Maeisaae RJ Premaratne E Jerums G 2011Clin Biochem Rev2011,32,2:1
19Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes显示文摘R. E. Gilbert D. J. Kelly A. J. Cox J. L. Wilkinson-Berka J. R. Rumble T. Osicka S. Panagiotopoulos V. Lee E. C. Hendrich G. Jerums M. E. Cooper 2000Diabetologia2000,,11:1
20Differcnccs in urinary alburain detected by four immunoassays and high performance liquid chromatography显示文摘Comper WD Jerums G Osicka TM 2004Clin Biochem2004,37,:1
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