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| 1 | Systemic inflammatory response following acute myocardial infarction显示文摘在 infarcted 心的尖锐 cardiomyocyte 坏死产生联系损坏的分子的模式,激活表明,并且被触发强烈煽动性的回答的补充和像使用费的 receptor/interleukin-1。Inflammasomes 也认出危险信号并且调停跟随尖锐心肌的梗塞(AMI ) 的无菌的煽动性的反应。煽动性的反应服务修理心,但是过多的发炎导致不利左室的改变和心失败。除了局部炎症,深刻全身的发炎反应与 AMI 在病人被记录了,它包括传播煽动性的 cytokines, chemokines 和房间的举起外部白血球和血小板的粘附分子,和激活。过多的煽动性的反应能被一个 deregulated 免疫系统引起。AMI 也与骨头髓激活和怒气 monocytopoiesis 被联系,它在发炎的地点支撑单核白血球的连续供应。积累的证据证明了那全身的发炎加重动脉粥样硬化,为全身的发炎的标记是不利临床的结果的预言者(例如死亡,周期性的心肌的梗塞,和心失败) 在有 AMI 的病人。 | Lu FANG Xiao-Lei Moorea Anthony M Dart Le-Min WANG | 2015 | Journal of Geriatric Cardiology2015，12，3： | 36 |
| 2 | Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice显示文摘AIM: To optimize the experimental protocols for a simple, sensitive and accurate bleeding assay.METHODS: Bleeding assay was performed in mice by tail tip amputation, immersing the tail in saline at 37 ℃, continuously monitoring bleeding patterns and measuring bleeding volume from changes in the body weight. Sensitivity and extent of variation of bleeding time and bleeding volume were compared in mice treated with the P2 Y receptor inhibitor prasugrel at various doses or in mice deficient of Fc Rγ, a signaling protein of the glycoprotein VI receptor.RESULTS: We described details of the bleeding assay with the aim of standardizing this commonly used assay. The bleeding assay detailed here was simple to operate and permitted continuous monitoring of bleedingpattern and detection of re-bleeding. We also reported a simple and accurate way of quantifying bleeding volume from changes in the body weight, which correlated well with chemical assay of hemoglobin levels(r2 = 0.990, P < 0.0001). We determined by tail bleeding assay the dose-effect relation of the anti-platelet drug prasugrel from 0.015 to 5 mg/kg. Our results showed that the correlation of bleeding time and volume was unsatisfactory and that compared with the bleeding time, bleeding volume was more sensitive in detecting a partial inhibition of platelet's haemostatic activity(P < 0.01). Similarly, in mice with genetic disruption of Fc Rγ as a signaling molecule of P-selectin glycoprotein ligand-1 leading to platelet dysfunction, both increased bleeding volume and repeated bleeding pattern defined the phenotype of the knockout mice better than that of a prolonged bleeding time.CONCLUSION: Determination of bleeding pattern and bleeding volume, in addition to bleeding time, improved the sensitivity and accuracy of this assay, particularly when platelet function is partially inhibited. | Yang Liu Nicole L Jennings Anthony M Dart Xiao-Jun Du | 2012 | World Journal of Experimental Medicine2012，2，2： | 6 |
| 3 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 4 | Initial experience in children using conventional laparoscopic instruments in single-incision laparoscopic surgery显示文摘 | Yuk Him Tam Kim Hung Lee Jennifer Dart Yin Sihoe Kin Wai Chan Sing Tak Cheung Kristine Kit Yi Pang | 2010 | Journal of Pediatric Surgery2010，，12： | 4 |
| 5 | Immune and inflammatory responses in subjects with stable angina and acute myocardial infarction显示文摘 | Lu FANG Anthony M Dart | 2015 | Journal of Geriatric Cardiology2015，12，3： | 3 |
| 6 | Colonoscopy in Hong Kong Chinese children显示文摘AIM:To investigate the safety and diagnostic yield of colonoscopy in Chinese children in whom the procedure is not often done.METHODS:We conducted a retrospective review of all colonoscopies in consecutive children who underwent their fi rst diagnostic colonoscopy from Jan 2003 to 2008.RESULTS:Seventy-nine children (48 boys,31 girls;mean age 9.2 ± 4.2 years) were identified and reviewed with a total of 82 colonoscopies performed.Successful caecal and ileal intubation rates were 97.6% and 75.6% respectively.Forty patients (50.6%) had a positive diagnosis made in colonoscopy and that included colonic polyps (23),Crohn's disease (12),ulcerative colitis (1),and miscellaneous causes (4).80% of polyps were in the rectosigmoid colon.All but one were juvenile hamartomatous polyps.The exceptionwas an adenomatous polyp.The mean ages for children with inflammatory bowel disease (IBD) and polyps were 11.3 and 4.3 years respectively.There was no procedure-related complication.CONCLUSION:Colonoscopy is a safe procedure in our Chinese children.The increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children. | Yuk Him Tam Kim Hung Lee Kin Wai Chan Jennifer Dart Yin Sihoe Sing Tak Cheung Jennifer Wai Cheung Mou | 2010 | World Journal of Gastroenterology2010，16，9： | 3 |
| 7 | A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients witb hypercholesterolemia显示文摘 | Anthony Dart George Jerums Geoffrey Nicholson Michael d’Emden Ian Hamilton-Craig George Tallis James Best Malcolm West David Sullivan Peter Braes Donald Black | 1997 | The American Journal of Cardiology1997，，： | 2 |
| 8 | Large artery stiffness predicts ischemic threshold in patients with coronary artery disease显示文摘 | Bronwyn A Kingwell Tamara K Waddell Tanya L Medley James D Cameron Anthony M Dart | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 9 | Progesterone as a predictor of ectopic pregnancy when the ultrasound is indeterminate显示文摘 | Dart R Ramanujam R Dart L | 2002 | Am J Emerg Med2002，20，7： | 1 |
| 10 | Use of cyclic variation of integrated backscatter to assess contractile reserve and myocardial viability in chronic ischemic left ventricular dysfunction显示文摘 | Yuda S Dart J Najos O | 2002 | Echocardiography2002，19，： | 1 |
| 11 | Obesity and Weight Loss by Exercise 显示文摘 | CM Reid Dart AM | 1994 | Dart Journal of Hypertension1994，12，3： | 1 |
| 12 | RotatioIlal contr0l of various Dediatric fernur fractures stabilizedwith titanium elastic intramedully nails显示文摘 | Gwyll DT Olney Bw Dart BR | | 0，，02： | 1 |
| 13 | Amniotic membrane grafts, 'fresh' or frozen? A clinical and in vitro comparison显示文摘 | Hunt CJ Dart JK | 2001 | Br J Ophthalmol2001，85，8： | 1 |
| 14 | Use of cyclic variation of integrated backscatter to assess contractile reserve and myocardial viability in chronic ischemic left ventricular dysfunction 显示文摘 | Ynda S Dart J Najos O | 2002 | Echocardiography2002，19，4： | 1 |
| 15 | Subconjunctival bevacizumab induces regression ofcomeal neovascularisation : a pilot randomised placebo-controlled double-masked trial 显示文摘 | Petsoglou C Balaggan KS Dart JK | 2013 | Br J Ophthalmol2013，97，1： | 1 |
| 16 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 17 | Use of cyclic variation of integrated backscatter to assess contractile reserve and myocardial viability in chronic ischemic left ventricular dysfunction显示文摘 | Dart J Najos O | 2002 | Echocardiography2002，19，4： | 1 |
| 18 | 显示文摘 | Pinzur MS Dart HC | 2001 | Foot Ankle2001，6，： | 1 |
| 19 | Progesterone as a predictor of ectopic pregnancy when the ultrasound is indeterminate 显示文摘 | Dart R Ramanujam R Dart L | 2002 | Am J Emerg Med2002，20，7： | 1 |
| 20 | Does therapeutic use of acetaminophen cause acute liver fai lure显示文摘 | Dart RC Bailey E | 2007 | Pharmacotherapy2007，27，9： | 1 |
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