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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Bircle is the gene within the Lgnl locus associated with resistance to Legionella pneumophila显示文摘 | Diez E Lee S H Gauthier S | 2003 | Nat Genet2003，33，1： | 1 |
| 4 | AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance显示文摘 | Gauthier M S Miyoshi H Souza S C | 2008 | J Biol Chem2008，283，24： | 1 |
| 5 | Three 20th century 'revolutions' in American geography显示文摘 | GAUTHIER H L TAAFFE J E | 2002 | Urban Geography2002，23，6： | 1 |
| 6 | Antihypertensive activ-ity of casein -enriched milk fermented by Lactobacillus helveticus显示文摘 | Leclerc PL Gauthier SF Bachelard H | 2002 | International dairy journal2002，12，12： | 1 |
| 7 | Abiraterone acetate withdrawal syndrome:does it exist?显示文摘 | GAUTHIER H BOUSQUET G POUESSEL D | 2012 | Case Rep Oncol2012，5，2： | 1 |
| 8 | Survival of breast cancerpatients with meningeal carcinomatosis显示文摘 | Gauthier H Guilhaume MN Bidard FC | 2010 | Ann Oncol2010，21，11： | 1 |
| 9 | A 24-week,randomized double-blind study of donepezil in moderate to severe Alzheimer's disesse显示文摘 | Feldman H Gauthier S Hecker J | 2001 | Neurology2001，57，： | 1 |
| 10 | Introducing two indicators for fire risk consideration in the management of boreal forests显示文摘 | Frédéric Raulier Hélo?se Le Goff Sylvie Gauthier Rija Rapanoela Yves Bergeron | 2013 | Ecological Indicators2013，，： | 1 |
| 11 | The effects of donepezil in Alzheimer's disease-results from a multinational trial显示文摘 | Burns A Rossor M Hecker J Gauthier S Petit H M(o)11er H J Rogers SL Friedhoff LT | | 0，，03： | 1 |
| 12 | Antihypertensive activity of casein-enriched milk fermented by Lactobacillus helveticus显示文摘 | Leclerc P L Gauthier S F Bachelard H | 2002 | International Dairy Journal2002，12，： | 1 |
| 13 | DEM-LES of coal combustion in a bubbling fluidized bed partl : gas- solid turbulent flow structure 显示文摘 | ZHOU H FLAMANTG GAUTHIER D | 2004 | Chemical Engineering Science2004，59，8： | 1 |
| 14 | Adsorption of copper(Ⅱ) and chromium (Ⅲ) ions onto amidoximated cellulose显示文摘 | KUBOTA H SHIGEHISA Y GAUTHIER R | | 0，，13： | 1 |
| 15 | A 24-week,randomized, double-blind study of donepezil in moderate to severe Alzheimer ' s disease显示文摘 | Feldman H Gauthier S Heeko J | 2001 | Neurology :2001，57，4： | 1 |
| 16 | Adsorption of heavy metal ions on virgin and chemically modified lignocellulosic materials 显示文摘 | Saliba R Gauthier H Gauthier R | 2005 | Adsorption Science&Technology2005，23，4： | 1 |
| 17 | Antihypertensive activity of casein-enriched milk fermented by LactobaciUus helveticus显示文摘 | LECLERC P L GAUTHIER S F BACHELARDB H | 2002 | International Dairy Journal2002，12，： | 1 |
| 18 | Anergy induction by dimeric TCR ligands显示文摘 | Appel H Seth NP Gauthier L | 2001 | J lmmunol2001，166，： | 1 |
| 19 | Effect of donepezil on behavioral symptoms in patients with moderate to severe Alzheimers disease 显示文摘 | Gauthier S Feldman H Hecker J | 2002 | Int Psychogeriatr2002，14，4： | 1 |
| 20 | Effect of Fe on the constitution of Cu-W alloys at 1 200 ℃显示文摘 | GAUTHIER V ROBAUT F UPADHYAYA A ALLIBERT C H | 2003 | Journal of Alloys and Compounds2003，361，12： | 1 |
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