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| 1 | Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L.in growing pigs by transcriptomics, metabolomics and lipidomics显示文摘Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing pigs.To test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor L.for 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using omics-techniques.Results:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(P<0.05).Transcriptomics of liver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(P<0.05).Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(P<0.05).Only one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(P<0.05).Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across groups.Lipidomics of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between groups.The percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(P<0.05).In line with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(P<0.05).Conclusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement of a conventional protein source by IM in the diet has only a weak impact on the intermediary metabolism of growing pigs.Thus,it is concluded that IM from Tenebrio molitor L.can be used as a dietary source of protein in pigs without causing adverse effects on metabolism. | Sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most Marcus Höring Gerhard Liebisch Holger Zorn Klaus Eder Robert Ringseis | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 2 | Enrichment of Babesia caballi -infected erythrocytes from microaerophilous stationary-phase cultures using Percoll gradients显示文摘 | C. Bhushan I. Müller K. T. Friedhoff | 1991 | Parasitology Research1991，，2： | 1 |
| 3 | Metabolism and elimination of ^14C-donepezil in healthy volunteers: a single-dose study 显示文摘 | TISEO PJ PERDOMO CA FRIEDHOFF LT | 1998 | Br J Clin Pharmacol1998，46，1： | 1 |
| 4 | Pharmacokinetic and pharmacodynamic profile of donepezil HCL following single oral doses显示文摘 | Friedhoff LT | | Br J Clin Pharmacol0，6，1： | 1 |
| 5 | The effects of donepezil in Alzheimer's disease-results from a multinational trial显示文摘 | Burns A Rossor M Hecker J Gauthier S Petit H M(o)11er H J Rogers SL Friedhoff LT | | 0，，03： | 1 |
| 6 | The effect of multiple doses of donepezil HCl on the pharmacokinetic and pharmacodynamic profile of warfarin显示文摘 | Tiseo PJ Foley K Friedhoff LT | 1998 | Br J Clin Pharmacol1998，46，1： | 1 |
| 7 | ConcuiTent administration of donepezil HC1 and ketoconazole: assessment of pharmacokinetic changes following single and muhiple doses 显示文摘 | TISEO P J PERDOMO C A FRIEDHOFF L T | 1998 | Br J Clin Pharmacol1998，46，1： | 1 |
| 8 | The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre, randomized, double-blind, placebo-controlled trial显示文摘 | ROGERS SL FRIEDHOFF LT | 1996 | Dementia1996，7，6： | 1 |
| 9 | The efficacy and safety of donepezil in paitents with Alzheimer's Disease:Results of a US multicentre randomized double-bline placebo-controlled trial:The donepezil study group显示文摘 | FRIEDHOFF LT | 1996 | Dementia1996，6，： | 1 |
| 10 | The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicenter,randomized,double-blind,placebo,controlled trial显示文摘 | Rogers SI Friedhoff LT | 1996 | Dementia1996，7，： | 1 |
| 11 | Role of maternal biochemistry in fetal brain development:effect of maternal thyroidectomy on behaviour and biogenic amine metabolism in rat progeny显示文摘 | FRIEDHOFF AJ MILLER JC ARMOUR M | 2000 | Int J Neuropsychopharmacol2000，3，： | 1 |
| 12 | Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life显示文摘 | Bondareff W Alpert M Friedhoff AJ | 2000 | Am J Psychiatry2000，157，： | 1 |
| 13 | Experimental infections in chickens with Chilomastiac gallinarum, Tetratrichomonas gallinarum and Tritrichomonas eberthi 显示文摘 | Friedhoff K T Kuhnigk C Mailer I | 1991 | Parasitol Res1991，，77： | 1 |
| 14 | Pharmaookinetic and pharmacodynamic profile of donepazil HCI following single oral doses显示文摘 | Rogers S L Friedhoff L T | 1998 | Br J Clin Pharmaool1998，46，1： | 1 |
| 15 | Metabolism and elimination of 14C-dinepezil in healthy volunteers:a single-dose study显示文摘 | Tiseo P J Rogers S L Friedhoff L T | 1998 | Br J Clin Pharmaool1998，46，1： | 1 |
| 16 | The efficacy and safety of polyethylene glycol 3350 in the treatment of constipation in children 显示文摘 | Kinservik MA Friedhoff MM | 2004 | Pediatr Nurs2004，30，3： | 1 |
| 17 | Tick-borne diseases of sheep and goats caused by Babesia,Theileria or Anaplasma spp 显示文摘 | Friedhoff K T | 1997 | Parassitologia1997，39，： | 1 |
| 18 | Interleukin-1 stimulates the beta-amyloid precursor protein promoter显示文摘 | Donnelly RJ Friedhoff AJ Beer B | 1990 | Cell Mol Neurobiol1990，10，4： | 1 |
| 19 | Tick-borne diseases of sheep and goats caused by Babesia, Theileria or Anaplasma spp显示文摘 | Friedhoff K T | 1997 | Parassitologia1997，39，： | 1 |
| 20 | Role of maternal biochemistry in fetal brain development:effect of maternal thyroidectomy on behaviour and biogenic amine metabolism in rat progeny显示文摘 | FRIEDHOFF A J MILLER J C ARMOUR M | 2000 | Int J Neuropsychopharmacol2000，3，3： | 1 |
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