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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 产碳青霉烯酶肠杆菌科细菌快速碳青霉烯灭活试验的评价显示文摘碳青霉烯类耐药肠杆菌科细菌(CRE)所致感染病例在全球范围内日益增多,导致病死率高,并增加医疗费用。产生碳青霉烯酶是CRE最主要的耐药机制,导致对其所致感染的治疗药物极其有限。此外,碳青霉烯酶基因往往存在于可移动元件或质粒上,能在不同细菌间水平传播。为控制该类耐药菌的流行播散,实验室需要建立一种快速可靠、低成本检测菌株中碳青霉烯酶的方法。 | 韩仁如 胡付品 Muntean MM Muntean AA Gauthier L | 2018 | 中国感染与化疗杂志2018，18，5： | 4 |
| 3 | Multiwalled carbon nanotube/polymer nanocomposites:processing and properties显示文摘 | Chazeau L Gauthier C | 2005 | Journal of Polymer Science Part B:Polymer Physics2005，43，10： | 1 |
| 4 | The negative inotropic effect of β3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle显示文摘 | Gauthier G Leblais V Kobzik L | 1998 | J Clin Invest1998，102，： | 1 |
| 5 | A strategy for greenhouse climate control,Part Ⅰ:Model development显示文摘 | Trigui M Barrington S Gauthier L | 2001 | Journal of Agricultural Engineering Research2001，78，4： | 1 |
| 6 | In vitro digestibility of bioactive peptides derived from bovine β- lactoglobulin 显示文摘 | Samira Rou k Sylvie F Gauthier Sylvie L Turgeon | 2006 | Int Dairy J2006，16，： | 1 |
| 7 | A fibrin sealant for perforated and preperforated corneal ulcers显示文摘 | Lagoutte FM Gauthier L Comte PR | 1989 | Br J Ophthalmol1989，73，： | 1 |
| 8 | Polymerase chain reaction detection of deformed wing virus(DWV)in Ap~ melliferaand Varroa destructor显示文摘 | TENTCHEVA D GAUTHIER L JOUVE S | | 0，，： | 1 |
| 9 | Three 20th century 'revolutions' in American geography显示文摘 | GAUTHIER H L TAAFFE J E | 2002 | Urban Geography2002，23，6： | 1 |
| 10 | Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia:a pilot randomized controlled trial显示文摘 | Rey E Garneau P David M Gauthier R Leduc L Michon N | 2009 | J Thromb Haemost2009，7，1： | 1 |
| 11 | Light rings in subarctic conifers as a dendrochronological tool显示文摘 | Filion L Payette S Gauthier L | 1986 | Quaternary Research1986，26，： | 1 |
| 12 | Electron magnetic resonance and optical properties of Ga2(1-x) In2p 03 solid solutions 显示文摘 | Binet L Gauthier G Vigreux C Gourier D | 1999 | Journal of Physics and Chemistry of Solids1999，60，10： | 1 |
| 13 | A simple method to determine evaporation duct height in the sea surface boundary layer显示文摘 | Musson-Genon L Gauthier S Bruth E | 1992 | Radio Science1992，27，5： | 1 |
| 14 | Inthencce of SiO2 fillers on the irradiation ageing of silicone rubbers 显示文摘 | Stevenson I David L Gauthier C | 2004 | Polymer2004，42，22： | 1 |
| 15 | Insulin infusion therapy in critically ill patients显示文摘 | Boutin JM Gauthier L | 2014 | Can J Diabetes2014，38，2： | 1 |
| 16 | Apoptosis related to telomere instability and cell cycle alteration in human glioma cells treated by new highly selective G-quadruplex ligands显示文摘 | PENNARUN G GRANOTIER C GAUTHIER L R | 2005 | Oncogene2005，24，18： | 1 |
| 17 | Multiwalled carbon nanotube/polymer nanocomposites:Processing and properties 显示文摘 | Dalmas F Chazeau L Gauthier C | 2005 | J Polym Sci ( Part B) : Polym Phys2005，43，10： | 1 |
| 18 | Genetic diversity of merozoite surface protein-1 gene of Plasmodium vivax solates in mining villages of Venezuela (Bolivar State)显示文摘 | Leclerc MC Gauthier C Villegas L | 2005 | Acta Trop2005，95，： | 1 |
| 19 | Energy consumption due to dehu- midification of greenhouses under northern latitudes 显示文摘 | De Hallaux D Gauthier L | 1988 | Jour- nal of Agricultural Engineering Research1988，69，： | 1 |
| 20 | The negative inotropic effect of β3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle显示文摘 | Leblais V Kobzik L | 1998 | J Clin Invest1998，102，： | 1 |
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