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| 1 | 组蛋白去乙酰化酶及其抑制剂在多发性骨髓瘤溶骨性病变中的研究进展显示文摘多发性骨髓瘤(multiple myeloma,MM)是浆细胞来源的恶性克隆增殖性疾病,发病率居血液系统肿瘤第2位。骨髓瘤溶骨性病变是骨髓瘤主要临床特征之一,主要是由骨髓瘤疾病状态下破骨细胞异常激活,成骨细胞功能抑制所致。组蛋白去乙酰化酶(histone deacetylases,HDACs)广泛表达于机体多种细胞组织,可以调节细胞的增殖分化,参与肿瘤的发生和发展。HDACs不仅可以促进骨髓瘤细胞的增殖与耐药,也可以正向调节破骨细胞的分化成熟,同时抑制成骨细胞的功能。部分HDACs小分子抑制剂体现出抗骨髓瘤和骨保护的双重作用。因此,进一步深入研究HDACs在骨髓瘤及其溶骨性损害中的作用机制可能为骨髓瘤的治疗提供更新、更精准的靶点和理论依据。 | 陈青骁 蔡真 | 2018 | 实用肿瘤杂志2018，33，5： | 6 |
| 2 | Harnessing the HDAC–histone deacetylase enzymes,inhibitors and how these can be utilised in tissue engineering显示文摘There are large knowledge gaps regarding how to control stem cells growth and differentiation.The limitations of currently available technologies,such as growth factors and/or gene therapies has led to the search of alternatives.We explore here how a cell’s epigenome influences determination of cell type,and potential applications in tissue engineering.A prevalent epigenetic modification is the acetylation of DNA core histone proteins.Acetylation levels heavily influence gene transcription.Histone deacetylase (HDAC) enzymes can remove these acetyl groups,leading to the formation of a condensed and more transcriptionally silenced chromatin.Histone deacetylase inhibitors (HDACis) can inhibit these enzymes,resulting in the increased acetylation of histones,thereby affecting gene expression.There is strong evidence to suggest that HDACis can be utilised in stem cell therapies and tissue engineering,potentially providing novel tools to control stem cell fate.This review introduces the structure/function of HDAC enzymes and their links to different tissue types (specifically bone,cardiac,neural tissues),including the history,current status and future perspectives of using HDACis for stem cell research and tissue engineering,with particular attention paid to how different HDAC isoforms may be integral to this field. | Liam Lawlor Xuebin B. Yang | 2019 | International Journal of Oral Science2019，11，2： | 3 |
| 3 | 组蛋白去乙酰化酶抑制剂调控干细胞分化与体细胞重编程的研究进展显示文摘表观遗传调控,如组蛋白乙酰化修饰,是决定干细胞分化方向的重要机制。组蛋白去乙酰化酶抑制剂(HDACi)通过影响不同亚类的组蛋白去乙酰化酶(HDAC)活性,提高组蛋白乙酰化水平,调控基因表达,从而影响胚胎干细胞自我更新,以及沿神经元、心肌和造血等细胞谱系的定向分化。HDACi类小分子化合物在体细胞重编程中也有广泛的应用,可替代致癌因子c-Myc和Klf4,促进体细胞克隆。研究显示,HDACi的效应与药物剂量、细胞类型和细胞分化状态密切相关。本文主要阐述了HDACi在干细胞分化和体细胞重编程中的应用进展,并对所涉及的分子通路进行讨论,有助于揭示干细胞定向分化的关键分子机制,优化干细胞定向分化诱导策略,对干细胞诱导分化具有重要的理论和实用价值。 | 何泽诏 翁晓菲 李涛(审校) | 2020 | 中华细胞与干细胞杂志(电子版)2020，10，2： | 0 |
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