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| 1 | Probiotics for the treatment of Helicobacter pylori infection in children显示文摘The combination of a proton pump inhibitor and two antibiotics(clarithromycin plus amoxicillin or metronidazole)has been the recommended first-line therapy since the first guidelines for Helicobacter pylori(H.pylori)infection in children were published.In recent years,the success of eradication therapies has declined,in part due to the development of H.pylori resistant strains.Alternative anti-H.pylori treatments are currently becoming more popular than the traditional eradication methods.Components that may be used either as a monotherapy or,in combination with antimicrobials,resulting in a more effective anti-H.pylori therapy have been investigated in depth by several researchers.One of the potential therapies is probiotic cultures;promising results have been observed in initial studies with numerous probiotic strains.Nevertheless,many questions remain unanswered.In this article,we comprehensively review the possible mechanisms of action of probiotics on H.pylori infection,and present the results of published studies using probiotics as possible agents to control H.pylori infection in children.The effect of the addition of probiotics to the standard H.pylori eradication therapy for the prevention of antibiotic associated side-effects is also discussed. | Lucia Pacifico John Frederick Osborn Enea Bonci Sara Romaggioli Rossella Baldini Claudio Chiesa | 2014 | World Journal of Gastroenterology2014，20，3： | 8 |
| 2 | Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease显示文摘AIM:To investigate the potential association of circulating zonulin with the stage of liver disease in obese children with biopsy-confirmed nonalcoholic fatty liver disease(NAFLD).METHODS:A case-control study was performed.Cases were 40 obese children with NAFLD.The diagnosis of NAFLD was based on magnetic resonance imaging(MRI)with high hepatic fat fraction(HFF≥5%),and confirmed by liver biopsy with≥5%of hepatocytes containing macrovesicular fat.Controls were selected from obese children with normal levels of aminotransferases,and without MRI evidence of fatty liver as well as of other causes of chronic liver diseases.Controls were matched(1-to 1)with the cases on age,gender,pubertal stage and as closely as possible on body mass index-standard deviation score.All participants underwent clinical examination,laboratory testsincluding zonulin,inflammatory and metabolic parameters,and MRI for measurement of HFF and visceral adipose tissue.RESULTS:Zonulin values were significantly greater in obese subjects with NAFLD than in those without NAFLD[median(interquartile range),4.23(3.18-5.89)vs 3.31(2.05-4.63),P<0.01].In patients with NAFLD,zonulin concentrations increased significantly with the severity of steatosis and the Spearman’s coefficient revealed a positive correlation between zonulin values and steatosis(r=0.372,P<0.05);however,we did not find a significant correlation between zonulin and lobular inflammation(P=0.23),ballooning(P=0.10),fibrosis score(P=0.18),or presence of nonalcoholic steatohepatitis(P=0.17).Within the entire study population,zonulin levels were positively associated with gamma-glutamyl transferase,2-h insulin,HFF,and negatively associated with whole-body insulin sensitivity index(WBISI),after adjustment for age,gender and pubertal status.When the associations were restricted to the group of NAFLD patients,2-h insulin,hepatic fat,and WBISI retained statistical significance.CONCLUSION:Circulating zonulin is increased in children and adolescents with NAFLD and correlates with the severity of steatosis. | Lucia Pacifico Enea Bonci Lidia Marandola Sara Romaggioli Stefano Bascetta Claudio Chiesa | 2014 | World Journal of Gastroenterology2014，20，45： | 4 |
| 3 | Gastrointestinal symptoms in infancy: A population-based prospective study显示文摘 | G. Iacono R. Merolla D. D’Amico E. Bonci F. Cavataio L. Di Prima C. Scalici L. Indinnimeo M.R. Averna A. Carroccio | 2005 | Digestive and Liver Disease2005，，6： | 2 |
| 4 | Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia显示文摘 | Andrea Caporali Marco Meloni Christine V?llenkle Desiree Bonci Graciela B. Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H. Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli | 2011 | Circulation2011，，3： | 2 |
| 5 | The miR-15a-miR-16-1 cluster controls prostatecancer by targeting multiple oncogenic activities显示文摘 | Bonci D Coppola V Musumeci M | 2008 | Nat Med2008，14，11： | 1 |
| 6 | The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities显示文摘 | Bonci D Coppola V Musumeci M | 2008 | Nat Med2008，14，11： | 1 |
| 7 | The miR - 15a - miR - 16 - 1 cluster controis prostate cancer by targeting multiple oncogenic activities 显示文摘 | Bonci D Coppola V | 2008 | Nature Medicine2008，14，： | 1 |
| 8 | Long - term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine显示文摘 | Thomas M J Beurrier C Bonci A | 2001 | Nat Neurosci2001，4，12： | 1 |
| 9 | Synaptic plasticity and drug addiction显示文摘 | Jones S Bonci A | 2000 | Curr Opin Pharmacol2000，5，： | 1 |
| 10 | Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo显示文摘 | Bonci D Cittadini A Latronico MY | 2003 | Gene Ther2003，10，： | 1 |
| 11 | The miR-15a-miR- 16-1 cluster controls prostate cancer by targeting multiple on- cogenic activities显示文摘 | Bonci D Coppola V Musumeci M | 2008 | Nat Med2008，14，11： | 1 |
| 12 | The neurobiology ofmodafinil as an enhancer of cognitive performance and a poten-tial treatment for substance use disorders显示文摘 | Mereu M Bonci A Newman AH | 2013 | Psychopharma-cology (Berl)2013，229，3： | 1 |
| 13 | Titanium anchors for the repair of distal Achilles tendon ruptures:preliminary report of a new surgical technique显示文摘 | Maniscalco P Bertone C Bonci E | 1998 | J Foot Ankle Surg1998，37，2： | 1 |
| 14 | A Bayesian Approach to the Hough Transform for Line Detection显示文摘 | BONCI A LEO T LONGHI S | 2005 | IEEE Transactions on System Man and Cybernetics: Part A2005，35，6： | 1 |
| 15 | Diagnostic and clinical obser- vation on the infectious bronchitis virus strain Q1 in Italy显示文摘 | Toffan A Bonci M Bano L | 2013 | Vet Ital2013，49，4： | 1 |
| 16 | Single cocaine expo- sure in vivo induces long-term potentiation in dopamine neurons 显示文摘 | Ungless MA Whistler JL Malenka RC Bonci A | 2001 | Nature2001，411，： | 1 |
| 17 | The inhibition of the highly expressed mill-221 and mill-222 impairs the growth of prostate carcinoma xenografts in mice显示文摘 | Mercatelli N Coppola V Bonci D | 2008 | PLoS One2008，3，12： | 1 |
| 18 | Titanium anchors for the re- pair of distal Achilles tendon ruptures: preliminary report of a new surgical technique显示文摘 | Maniscalco P Bertone C Bonci E | 1998 | The Journal of Foot and Ankle Surgery1998，37，2： | 1 |
| 19 | Respiratory syncytial virus, human bocavinis and rhinovirus bronchiolitis in infants 显示文摘 | F Midulla C Scagnolari E Bonci | 2010 | Arch Dis Child2010，95，10： | 1 |
| 20 | A Bayesian Approach to the Hough Transform for Line Detection 显示文摘 | Bonci A Leo T Longhi S | 2005 | IEEE Trans on Systems Man and Cybernetics2005，35，6： | 1 |
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