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| 1 | A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon显示文摘AIM: To develop a new formulation with hydroxy propyl methyl cellulose and Shellac coating for extended and selective delivery of butyrate in the ileo-caecal region and colon. METHODS: One-gram sodium butyrate coated tablets containing 13C-butyrate were orally administered to 12 healthy subjects and 12 Crohn's disease patients and the rate of 13C-butyrate absorption was evaluated by 13CO2 breath test analysis for eight hours. Tauroursodeoxycholic acid (500 mg) was co-administered as a biomarker of oro-ileal transit time to determine also the site of release and absorption of butyrate by the time of its serum maximum concentration. RESULTS: The coated formulation delayed the 13C-butyrate release by 2-3 h with respect to the uncoated tablets. Sodium butyrate was delivered in the intestine of all subjects and a more variable transit time was found in Crohn's disease patients than in healthy subjects. The variability of the peak 13CO2 in the kinetic release of butyrate was explained by the inter-subject variability in transit time. However, the coating chosen ensured an efficient release of the active compound even in patients with a short transit time. CONCLUSION: Simultaneous evaluation of breath 13CO2 and tauroursodeoxycholic acid concentration- time curves has shown that the new oral formulation consistently releases sodium butyrate in the ileo-cecal region and colon both in healthy subjects and Crohn's disease patients with variable intestinal transit time. This formulation may be of therapeutic value in inflammatory bowel disease patients due to the appropriate release of the active compound. | Aldo Roda Patrizia Simoni Maria Magliulo Paolo Nanni Mario Baraldini Giulia Roda Enrico Roda | 2007 | World Journal of Gastroenterology2007，13，7： | 8 |
| 2 | Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates显示文摘Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity,prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows' breed and the survival and growth rates of their litters.Results: Colostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using1 H–NMR spectroscopy. Principal Components Analysis(PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets' performances.Twenty-five metabolites were identified, comprehending monosaccharides, disaccharides(such as lactose), organic acids(lactate, citrate, acetate and formate), nitrogenous organic acids(such as creatine) and other compounds,including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets' performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets' survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns' impaired ability to survive.Conclusions: The results obtained suggest that colostrum composition is affected by breed, which, together with environmental conditions, may cause changes in colostrum metabolites content with possible consequences on piglets' performances. Among the identified metabolites, acetate, taurine, dimethylamine and cis-aconitate showed consistent associations with piglets' survival rate and litter weight gain, implying that these compounds may affect new-borns' ability to survive. | Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli Leonardo Nanni Costa Paolo Bosi Paolo Trevisi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 6 |
| 3 | Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients显示文摘AIM To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations.METHODS Ninety-nine kidney transplant recipients(KTRs) were assigned to interventional exercise(Group A; n = 52) and a usual care cohort(Group B; n = 47). Blood and urine chemistry, exercise capacity, muscular strength, anthropometric measures and health-related quality of life(HRQo L) were assessed at baseline, and after 6 and 12 mo. Group A underwent a supervised training three times per week for 12 mo. Group B received only general recommendations about home-based physical activities.RESULTS Eighty-five KTRs completed the study(Group A, n = 44; Group B, n = 41). After 12 mo, renal function remained stable in both groups. Group A significantly increased maximum workload(+13 W, P = 0.0003), V'O2 peak(+3.1 mL/kg per minute, P = 0.0099), muscular strength in plantar flexor(+12 kg, P = 0.0368), height in the countermovement jump(+1.9 cm, P = 0.0293) and decreased in Body Mass Index(-0.5 kg/m^2, P = 0.0013). HRQo L significantly improved in physical function(P = 0.0019), physical-role limitations(P = 0.0321) and social functioning scales(P = 0.0346). Noimprovements were found in Group B.CONCLUSION Twelve-month of supervised aerobic and resistance training improves the physiological variables related to physical fitness and cardiovascular risks without consequences on renal function. Recommendations alone are not sufficient to induce changes in exercise capacity of KTRs. Our study is an example of collaborative working between transplant centres, sports medicine and exercise facilities. | Giulio Sergio Roi Giovanni Mosconi Valentina Totti Maria Laura Angelini Erica Brugin Patrizio Sarto Laura Merlo Sergio Sgarzi Michele Stancari Paola Todeschini Gaetano La Manna Andrea Ermolao Ferdinando Tripi Lucia Andreoli Gianluigi Sella Alberto Anedda Laura Stefani Giorgio Galanti Rocco Di Michele Franco Merni Manuela Trerotola Daniela Storani Alessandro Nanni Costa | 2018 | World Journal of Transplantation2018，8，1： | 4 |
| 4 | Liver transplantation from hepatitis B surface antigen positive donors: A safe way to expand the donor pool显示文摘 | Elisabetta Loggi Lorenzo Micco Giorgio Ercolani Alessandro Cucchetti Florian K. Bihl Gian Luca Grazi Stefano Gitto Andrea Bontadini Mauro Bernardi Paolo Grossi Alessandro Nanni Costa Antonio Daniele Pinna Christian Brander Pietro Andreone | 2011 | Journal of Hepatology2011，，3： | 2 |
| 5 | Value of FDG PET/CT in Patients with Treated Ovarian Cancer and Raised CA125 Serum Levels显示文摘 | Azahara Palomar Cristina Nanni Paolo Castellucci Valentina Ambrosini Gian Carlo Montini Vincenzo Allegri Cinzia Pettinato Adil Al-Nahhas Angel Soriano Gaia Grassetto Domenico Rubello Stefano Fanti | 2012 | Molecular Imaging and Biology2012，，： | 2 |
| 6 | Assay of ghrelin concentration in infant formulas and breast milk显示文摘AIM: To test if total ghrelin is present in infant formulas. METHODS: Using a radioimmunoassay, we measured total ghrelin concentrations in 19 samples of commercial infant formulas and in 20 samples of human milk. We also determined ghrelin concentration in the serum of infants and lactating mothers. RESULTS: Ghrelin concentrations were significantly higher in artificial milk (2007.1 ± 1725.36 pg/mL) than in human milk (828.17 ± 323.32 pg/mL) (P = 0.005). The mean ghrelin concentration in infant serum (n = 56) was 1115.86 ± 42.89 pg/mL, and was significantly higher (P = 0.023) in formula-fed infants (1247.93 ± 328.07 pg/mL) than in breast-fed infants (1045.7 ± 263.38 pg/mL). The mean serum ghrelin concentration (mean ± SD) in lactating mothers (n = 20) was 1319.18 ± 140.18 pg/mL. CONCLUSION: This study provides evidence that total ghrelin is present in infant formulas. This findingraises diverse questions regarding the uptake, absorption and metabolic effects of this hormone. | Francesco Savino Elisa Petrucci Maria Maddalena Lupica Giuliana Eva Nanni Roberto Oggero | 2011 | World Journal of Gastroenterology2011，17，15： | 2 |
| 7 | Parametric study of beams with externally bonded FRP reinforcement显示文摘 | Arduini M Nanni A | 1997 | ACI Structural Journal1997，94，5： | 2 |
| 8 | 18 F-FDG PET/CT in the evaluation of recurrent ovarian cancer: a prospective study on forty-one patients显示文摘 | C. Nanni D. Rubello M. Farsad P. De Iaco M. Sansovini P. Erba L. Rampin G. Mariani S. Fanti | 2005 | European Journal of Surgical Oncology2005，，： | 2 |
| 9 | Cluster-Based Nearest-Neighbour Classifier and Its Application on the Lightning Classification显示文摘在这篇论文处理的问题为一个基于簇的近邻居的分类器使原型产生担心。它考虑,到分类一个测试模式,连接培训装置和一套原型的模式的线。一个有效方法这里基于聚类被使用与被用作原型的矩心发现类似的模式的亚群。一个学习方法反复地被用于调整位置并且原型本地度量标准。最后,我们证明简单适应距离测度改进我们的 nearest-neighbour-based 分类器的表演。关于另外的 nearest-neighbour-based 分类器的性能改进被用从短暂事件(长处) 卫星记录的快在轨道上获得的数据在一项闪电分类任务测试我们的方法验证,而且性能改进与几基准数据集通过实验被验证。建议方法的表演也用 Wilcoxon 症状等级测试被验证。 | Loris Nanni Alessandra Lumini | 2008 | Journal of Computer Science & Technology2008，23，4： | 2 |
| 10 | Two-stage surgical treatment for septic non-union of the forearm显示文摘AIM To investigate the effectiveness of a two-stage surgical procedure for the treatment of septic forearm non-union.METHODS Septic non-unions are rare complications of forearm fractures. When they occur, they modify the relationship between forearm bones leading to a severe functional impairment. Treatment is challenging and surgery and antibiotic therapy are required to achieve infection resolution. It is even harder to obtain non-union healing with good functional results. The aim of this study is to present a two stages surgical treatment for septic forearm non-union with revision and temporary stabilization of the non-union until infection has cleared and subsequently perform a new synthesis with plate, opposite bone graft strut and intercalary graft. We retrospectively reviewed 18 patients with a mean age at the time of primary injury of 34.5 years(19-57 years) and a mean follow-up of 6 years(2-10 years). All patients presented an atrophic nonunion with a mean length of the bone defect of 1.8 cm(1.2-4 cm). Complications and clinical results after surgical treatment were recorded. RESULTS Mean time to resolution of the infectious process was 8.2 wk(range 4-20 wk) after the first surgery and specific antibiotic therapy. All the non-union healed with an average time of 5 mo(range 2-10 mo) after the second step surgery. Cultures on intraoperative samples werepositive in all cases. No major intraoperative complications occurred. Two patients developed minor complications and one needed a second surgical debridement for infection resolution. At the last follow-up functional results were excellent in 5(27.8%) patients, satisfactory in 10(55.5%) and unsatisfactory in 3(16.7%) patients. No activities of daily living(ADLs) limitations were reported by 12(66.6%) patients, slight by 3(16.6%) and severe limitation by 3(16.6%) patients. Mean visual analog scale at the last follow-up was 1(0-3).CONCLUSION The two-step technique has proven to be effective to achieve resolution of the infectious process and union with good functional results and low rate of complications. | Fabrizio Perna Federico Pilla Matteo Nanni Lisa Berti Giada Lullini Francesco Traina Cesare Faldini | 2017 | World Journal of Orthopedics2017，8，6： | 2 |
| 11 | Semi -dynamic algorithms for maintaining singlesource shortest paths trees 显示文摘 | FRIGIONI D MARCHETTI- S A NANNI U | 1998 | Algorithmica1998，，3： | 1 |
| 12 | Novel purification method for recombinant 3AB1 nonstructural protein of foot-and-mouth disease virus for use in differentiation between infected and vaccinated animals 显示文摘 | NANNI M ALEGRE M COMPAIRED D | 2005 | J Vet Diagn Invest2005，17，3： | 1 |
| 13 | A reliable method for cell phenotype image classification 显示文摘 | Nanni L Lumini A | 2008 | Artificial Intelligence in Medicine2008，43，2： | 1 |
| 14 | An experimental comparison of ensemble of classifiers for bankruptcy prediction and credit scoring显示文摘 | Nanni L Lumini A | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 15 | Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis ofcolorectal cancer显示文摘 | Flamini E Mercatali L Nanni O | 2006 | Clin Cancer Res2006，12，23： | 1 |
| 16 | The mutational spectrum of the sonic hedgehog gene in holorosencephaly: SHH mutations cause a significant proportion of autosomal dominant holorosencephaly显示文摘 | Nanni L Ming JE Bocian M | 1999 | Hum Mol Genet1999，8，13： | 1 |
| 17 | Potential pitfalls of ^18F -FDG PET in a large series of patients treated for malignant lymphoma:prevalence and scan interpretation显示文摘 | Castellucci P Nanni C Farsad M | 2005 | Nucl Med Commun2005，26，8： | 1 |
| 18 | Flexural Behavior and Design of RC Members Using FRP Reinforcement显示文摘 | Nanni A | 1993 | Journal of Structure Engineering ASCE1993，119，11： | 1 |
| 19 | Evidence for anautoimmune pathogenesis Ofvitiligo显示文摘 | KatiaOngenae Nanny Van Geel Jean-Made Naeyaert | 2003 | Pigment Cell Res)2003，16，2： | 1 |
| 20 | Contamination of vegetable oils marketed in Italy by phthalic acid esters 显示文摘 | NANNI N FISELIER K GROB K | 2011 | Food Control2011，22，： | 1 |
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