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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature显示文摘Xanthogranulomatous 胆汁(XGC ) 是胆囊的破坏煽动性的疾病,很少包含邻近的机关并且模仿国王先进胆囊癌。诊断在病理学的检查以后仅仅通常是可能的。46 42 岁的女人被指我们包含肝核,正确的肝脑叶,恰好结肠的弯曲,和十二指肠的怀疑的胆囊癌症的中心。刷细胞学获得了由内视镜后退胆管造影术(ERC ) 出现了高级发育异常。病人经历了团的在团体切除术,由正确叶切除术,正确的半结肠切除术,和部分十二指肠的切除术组成。出人意料地揭示的病理学的检查一 XGC.Only,为有邻近的机关的直接参与的 XGC 的扩大外科的切除术的六个案例到目前为止被报导了。在这些情况中,与癌给 XGC 的可能的共存,恶意不能被排除,甚至在细胞学和 intraoperative 冰冻切片调查以后。在结论,由于源于在另外的方面上包围机关的高度好攻击的煽动性的侵略的一个方面和可能的复杂并发症上的胆囊癌的差的预后,它似乎这些案例应该被当作恶性瘤直到不那样证明。临床医生们应该包括 XGC 在之中可能微分在肝核群众诊断。 | Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi Christoph Benckert Igor M Sauer Johann Pratschke Ulf P Neumann Sven Jonas Jan M Langrehr Peter Neuhaus | 2006 | World Journal of Gastroenterology2006，12，14： | 13 |
| 3 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 4 | Expression of Tissue Factor in High-Grade Carotid Artery Stenosis: Association With Plaque Destabilization显示文摘 | Sebastian Jander Matthias Sitzer Angélique Wendt Michael Schroeter Martin Buchkremer Mario Siebler Wolfram Müller Wilhelm Sandmann Guido Stoll | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 3 |
| 5 | Radioembolization with yttrium‐90 glass microspheres in hepatocellular carcinoma: European experience on safety and long‐term survival显示文摘 | Philip Hilgard Monia Hamami Amr El Fouly André Scherag Stefan Müller Judith Ertle Till Heusner Vito R. Cicinnati Andreas Paul Andreas Bockisch Guido Gerken Gerald Antoch | 2010 | Hepatology2010，，： | 3 |
| 6 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 7 | Population-based epidemiology,risk factors and screening of intraductal papillary mucinous neoplasm patients显示文摘Intraductal papillary mucinous neoplasm(IPMN) was first recognized in the 1980s with increasing publications over the last decade as the incidence increased sharply,especially at tertiary-care referral centers.Populationbased studies have estimated the age and sex-adjusted cumulative incidence of IPMN to be 2.04 per 100 000 person-years(95% conf idence interval:1.28-2.80).It is now understood that IPMN can be classified anywhere along the spectrum of the adenoma to carcinoma sequence and often harbors mutations in genes such as KRAS early in the disease process.Many patients are diagnosed incidentally after imaging of the abdomen for other diagnostic purposes.Patients that present with a history of symptoms such as pancreatitis and abdominal pain are at high risk of harboring a malignancy.Clini-copathologic features such as involvement of the main pancreatic duct,presence of mural nodules,and side branch disease > 3.0 cm in size may indicate that there is an underlying invasive component to the IPMN.In addition,the incidence of extra-pancreatic neoplasms is higher in patients with IPMN,with reported rates of 25% to 50%.There are no current screening recommendations to detect and diagnose IPMN but once the diagnosis is made,screening for extrapancreatic neoplasms such as colon polyps and colorectal cancer should be considered.Surgical resection is the recommend treatment for patients with high-risk features while close observation can be offered to patients without worrisome signs and symptoms of carcinoma. | Saboor Khan Guido Sclabas Kaye M Reid-Lombardo | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 2 |
| 8 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 9 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 10 | Clinical,virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B显示文摘 | Fattovich G Rugge M Brollo L Pontisso P Noventa F Guido M Alberti A Realdi G | 1986 | Hepatology1986，6，2： | 1 |
| 11 | Rate-distortion optimal bit allocation for object-based video coding 显示文摘 | Wang Hao-hong Schuster Guido M | 2005 | IEEE Transactions on Circuits and Systems for Video Technology2005，15，9： | 1 |
| 12 | Zolmitrptan reverses blink reflex changes induced during the migraine attack in humans显示文摘 | De Tommzso M Guido M Libro G | 2000 | Neurosci Lett2000，289，1： | 1 |
| 13 | A distributed operating system for the 1990s显示文摘 | Sape J M Guido V R Andrew S T | 1990 | IEEE Computer1990，23，5： | 1 |
| 14 | Apparent renal cell carcinoma in tuberous sclerosis are heterogeneous显示文摘 | Maurizio P Franco B Guido M | 1998 | Am J Surg Pathol1998，22，2： | 1 |
| 15 | Antioxidant activity and dietary fibre in durum wheat bran by-products显示文摘 | FABRIZIO E GUIDO A BONIFATI A M | 2005 | Food Research International2005，38，10： | 1 |
| 16 | Binary collision of drops in simple shear flow by computer-assisted video optical microscopy 显示文摘 | Guido S Simeone M | 1998 | Journal of Fluid Mechanics1998，357，： | 1 |
| 17 | The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids显示文摘 | Bashir M Rezk Guido R.M.M Haenen Wim J.F van der Vijgh Aalt Bast | 2002 | Biochemical and Biophysical Research Communications2002，，1： | 1 |
| 18 | Serum levels of eosinophile cationic protein in allergic disease sand natural allergen exposure显示文摘 | Margherila T Laura M Guido DP | 1996 | J Allergy Clin Immunol1996，97，6： | 1 |
| 19 | The bigi- nelli reaction with an imidazolium-tagged recyclable iron catalyst : Kinetics, mechanism, and antitumoral activity显示文摘 | Ramos L M Guido B C Nobrega C C | 2013 | Chemistry A European Journal2013，19，13： | 1 |
| 20 | A path model of sarcopenia on bone mass loss in elderly subjects 显示文摘 | Rondanelli M Guido D Opizzi A | 2014 | J Nutr Health Aging2014，18，1： | 1 |
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