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| 1 | Gastroesophageal reflux disease and morbid obesity: To sleeve or not to sleeve?显示文摘Laparoscopic sleeve gastrectomy(LSG) has reached wide popularity during the last 15 years, due to the limited morbidity and mortality rates, and the very good weight loss results and effects on comorbid conditions. However, there are concerns regarding the effects of LSG on gastroesophageal reflux disease(GERD). The interpretation of the current evidence is challenged by the fact that the LSG technique is not standardized, and most studies investigate the presence of GERD by assessing symptoms and the use of acid reducing medications only. A few studies objectively investigated gastroesophageal function and the reflux profile by esophageal manometry and 24-h p H monitoring, reporting postoperative normalization of esophageal acid exposure in up to 85% of patients with preoperative GERD, and occurrence of de novo GERD in about 5% of cases. There is increasing evidence showing the key role of the surgical technique on the incidence of postoperative GERD. Main technical issues are a relative narrowing of the mid portion of the gastric sleeve, a redundant upper part of the sleeve(both depending on the angle under which the sleeve is stapled), and the presence of a hiatal hernia. Concomitant hiatal hernia repair is recommended. To date, either medical therapy with proton pump inhibitors or conversion of LSG to laparoscopic Rouxen-Y gastric bypass are the available options for the management of GERD after LSG. Recently, new minimally invasive approaches have been proposed in patients with GERD and hypotensive LES: the LINX? Reflux Management System procedure and the Stretta? procedure. Large studies are needed to assess the safety and long-term efficacy of these new approaches. In conclusion, the recent publication of p H monitoring data and the new insights in the association between sleeve morphology and GERD control have led to a wider acceptance of LSG as bariatric procedure also in obese patients with GERD, as recently stated in the 5^(th) International Consensus Conference on sleeve gastrectomy. | Fabrizio Rebecchi Marco E Allaix Marco G Patti Francisco Schlottmann Mario Morino | 2017 | World Journal of Gastroenterology2017，23，13： | 4 |
| 2 | An ON/OFF biosensor based on blockade of ionic current passing through a solid-state nanopore显示文摘 | Moretti M Di Fabrizio E Cabrini S | 2008 | Biosens Bioeleetron2008，24，1： | 1 |
| 3 | Antioxidant activity and dietary fibre in durum wheat bran by-products显示文摘 | FABRIZIO E GUIDO A BONIFATI A M | 2005 | Food Research International2005，38，10： | 1 |
| 4 | Laparoscopic management of urachal cysts in adulthood显示文摘 | Cadeddu J A Boyle K E Fabrizio M D | | 0，，05： | 1 |
| 5 | Proximity correction for e-beam patterned sub-500 nm diffractive optical elements显示文摘 | Grella L Fabrizio E D Gentili M | 1997 | Microelectronic Engineering1997，35，： | 1 |
| 6 | Spin density of ordered FeCo: a failure of the local-density approximation显示文摘 | Fabrizio E Di Mazzone G Petrillo C | 1989 | Phys Rev B1989，40，： | 1 |
| 7 | Synthesis,cyclic voltammetric studies,and elecogenerated chemiluminescence of a new donors acceptor molecule:3,7-[bis[4-phenyl-2-quinolyl]]-10-methylphenothiazine显示文摘 | LAI R Y FABRIZIO E F LU Liang-de | | 0，，37： | 1 |
| 8 | Synthesis and characterization of the physical, chemical andmechanical properties of isocyanate-crosslinked vanadia aerogels显示文摘 | Luo H Churu G Fabrizio E F | 2008 | Journal of Sol Gel Science and Technology2008，48，： | 1 |
| 9 | Mirtazapine in L - dopa - induced dyskines- ias 显示文摘 | Meco G Fabrizio E Di Rezze S | 2003 | Clin Neuropharmacol2003，26，4： | 1 |
| 10 | Laparoscopic management of uraehal cysts in adulthood显示文摘 | Cadeddu J A Boyle K E Fabrizio M D | 2000 | J Urol2000，164，5： | 1 |
| 11 | The impact of in-door thermal conditions, system controls and buildingtypes on the building energy demand显示文摘 | Corgnati S P Fabrizio E Fiiippi M | 2008 | Energy andBuildings2008，40，4： | 1 |
| 12 | Perceived Importance of Evidence-based Psychosocial Clinical Guidelines for Hong Kong Chinese Women with Breast Cancer: Opinions of Patients and Health Care Providers显示文摘 | Lam W W Fabrizio C Ho E | 2009 | Support Care Cancer2009，17，3： | 1 |
| 13 | A SIMS and XPS study about ions influence on electrodeposited PbO2 films显示文摘 | AMADELLI R ARMELAO L TONDELLO E DAOLIO S FABRIZIO M PAGURA C VELICHENKO A | 1999 | Applied Surface Science1999，142，12： | 1 |
| 14 | The impact of in-door thermal conditions, system controls and buildingtypes on the building energy demand显示文摘 | Corgnati S P Fabrizio E Fiiippi M | 2008 | Energy andBuildings2008，40，4： | 1 |
| 15 | Cognitive improvement during tolcapone treatment in Parkinson's disease显示文摘 | Gasparini M Fabrizio E Bonifati V | 1997 | J Neural Transm1997，104，89： | 1 |
| 16 | The control of catalytic performance of rutile - type Sn/V/Nb/Sb mixed oxides, catalysts for propane ammoxidation to acrylonitrile 显示文摘 | Arcozzi E Nicola B Fabrizio C | 2008 | Catalysis Today2008，138，12： | 1 |
| 17 | Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia显示文摘 | Wei M Morgan T E Fabrizio P | 2002 | J Neurosci2002，22，9： | 1 |
| 18 | Synthesis and characterization of the physical,chemical and mechanical properties of isocyanate-crosslinked vanadia aerogels显示文摘 | Luo H Churu G Fabrizio E F | | 0，，： | 1 |
| 19 | LILIT beamline for soft and deep X-ray lithography atelettramicroelectron显示文摘 | ROMANATOF FABRIZIO E D VACCARI L | 2001 | Eng2001，5758，： | 1 |
| 20 | An on/off biosensor based on blockade of ionic current passing through a solid-state nanopore 显示文摘 | Moretti M Fabrizio E D Cabrini S | 2008 | Biosensors and Bioelectronics2008，24，1： | 1 |
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