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| 1 | 2017欧洲心脏病学会/欧洲心胸外科协会心脏瓣膜病管理指南中经导管主动脉瓣置换术相关更新解读显示文摘自2012欧洲心脏协会/欧洲心胸外科协会关于心脏瓣膜病的管理指南发布以来,新的临床证据又大量积累。这些新证据使欧洲心脏协会/欧洲心胸外科协会需要更新瓣膜病的管理指南以达到心内科与心外科医师间的共识。该文将从经导管主动脉瓣置换术出发,解读2017年新指南所作出的更新。 | Tasalak Thonghong Manik Chopra Ole De Backer Lars Sndergaard 王玺 | 2018 | 华西医学2018，33，2： | 12 |
| 2 | 正交异性钢桥面板裂纹扩展的均质化方法显示文摘正交异性钢桥面板往往在焊缝及其附近位置出现过早的疲劳损伤问题。考虑到这一结构形式所含的大量焊接接头,对其中的随机初始裂纹及气孔、夹杂等焊接缺陷对疲劳性能的影响展开研究。首先,利用扩展有限元法在求解几何不连续问题方面的高效性,生成了大量含随机缺陷的代表体积元;而后基于等效裂纹扩展长度准则,对随机缺陷进行了均质化处理,并通过数值算例证明了其在早期裂纹扩展中的适用性。作为重要的多尺度方法之一,该均质化方法可用于计算正交异性钢桥面板焊接接头的裂纹扩展。根据某正交异性钢桥面板的典型车辆荷载的现场实测数据,结合欧洲规范建议的年车流量及轮载横向分布,采用均质化的模型对U肋-顶板焊趾的宏观裂纹形成寿命(初始裂纹扩展至可检测尺度的寿命)进行了计算。结果表明:该方法可有效呈现宏观裂纹形成寿命的概率分布,但在现有假设下,初始裂纹尺度的影响明显高于气孔、夹杂等缺陷;若初始裂纹尺度呈均匀分布,将导致宏观裂纹形成寿命的分布较为离散;所得结果的统计特性依赖于所选择的Paris公式形式及其中的材料常数取值。 | 王本劲 DE BACKER H 陈艾荣 | 2017 | 中国公路学报2017，30，3： | 9 |
| 3 | Modelling fracture propagation and failure in a rock pillar under mechanical and thermal loadings显示文摘The spPillar Stability Experiment (APSE) was conducted to study the rock mass response in a heated rock pillar between two large boreholes. This paper summarizes the back calculations of the APSE using a two-dimensional (2D) fracture propagation code FRACOD. To be able to model all the loading phases of the APSE, including the thermal loading, the code was improved in several ways. A sequential excavation function was developed to model promptly the stepwise changing loading geometry. Prior to the mod-elling, short-term compressive strength test models were set up aiming to reproduce the stress-strain behaviour observed for the sp diorite in laboratory. These models simulate both the axial and lateral strains of radial-controlled laboratory tests. The volumetric strain was calculated from the simulations and compared with the laboratory results. The pillar models include vertical and horizontal 2D models from where the stress in the pillar wall was investigated. The vertical model assesses the stability of the experimental rock volume and suggests the resultant stress below the tunnel floor in the pillar area. The horizontal model considers cross-sections of the pillar between the two large boreholes. The horizontal model is used to simulate the evolution of the stress in the rock mass during the excavation of the boreholes and during and the heating phase to give an estimation of the spalling strength. The modelling results suggest that the excavation-induced stresses will cause slight fracturing in the pillar walls, if the strength of the APSE pillar is set to about 123 MPa. Fracture propagation driven by thermal loading leads to minor spalling. The thermal evolution, elastic behaviour and brittle failure observed in the experiment are well reflected by the models. | Mikael Rinne Baotang Shen Tobias Backers | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，1： | 6 |
| 4 | 羟乙基淀粉溶液在复苏肠缺血-再灌注休克中的作用显示文摘目的 比较不同剂量羟乙基淀粉溶液 ( HES)对兔肠缺血再灌注损伤所致休克的复苏作用。方法 32只新西兰白兔随机分为 4组 :模型对照、乳酸林格液复苏组 ( L RS,2 0 m l· kg- 1 · h- 1 ) ,小剂量 HES复苏组 ( HES2 ml· kg- 1· h- 1 + L RS18m l· kg- 1· h- 1 ) ,大剂量 HES复苏组 ( HES2 0 ml· kg- 1· h- 1 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠缺血再灌注休克模型 ,松夹再灌注时同步进行液体复苏。观测各时间点的血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 ) ,并通过测定肠黏膜CO2 分压和动脉血 CO2 分压的差值 (动脉二氧化碳间隙 )、肠黏膜 p H值、动脉血乳酸浓度和氧输送等指标间接评估组织氧合情况。实验结束后累计动物死亡数。结果 HES能明显提高肠缺血再灌注休克时的血流动力学参数 ,与对照组和 L RS组比较差异均有显著性 ( P均 <0 .0 5 ) ;小剂量 HES比大剂量 HES改善血流动力学参数的作用更平稳 ( P均 <0 .0 5 ) ,且较其他 3组能明显降低血乳酸浓度和动脉二氧化碳间隙 ,减轻 p Hi的降低 ( P均 <0 .0 5 ) ;而大剂量 HES对上述参数的影响不明显 ,并可见动物口鼻出血及死亡 ;小剂量或大剂量HES与其他两组比较均能使氧输送回升 ( P均 <0 .0 5 )。 | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo Daniel de Backer 肖献忠 Jean-Louis Vincent | 2004 | 中国危重病急救医学2004，16，8： | 6 |
| 5 | 活性炭在吸附猪体内呕吐毒素(DON)上的功效显示文摘为了评估霉菌毒素吸附剂在动物体内的功效,根据欧洲的相关指南应该测量其特定的毒物代谢动力学参数。出于此目的,研究人员着重介绍了猪吸收模型的吸收动力学。在该模型中,试验猪单独或与活性碳(用作霉菌毒素的粘合剂)一起口服大丸粒霉菌毒素——呕吐毒素(DON)。在单独喂给呕吐毒素后,可从猪的血液中检测到了高水平的呕吐毒素,并用房室模型(compartmental model)计算霉菌毒素在体内的动力学参数。活性炭能够彻底防止呕吐毒素的吸收,因为呕吐毒素与活性碳同时喂给猪后,未能从猪体内检测到该毒素。 | 邵建忠 潘雪男 Mathias Devreese Gunther Antonissen Patrick De Backer Siska Croubels | 2015 | 国外畜牧学(猪与禽)2015，0，5： | 6 |
| 6 | 纤维饲料在母猪的应用显示文摘在繁殖母猪日粮中添加纤维质饲料,更主要的是利用其物理特性而非为了利用其可能具有的营养价值。粗纤维浓缩料(rawfiber concentrates)保持了纤维最有价值的特性,同时又可消除添加传统纤维源所引发的问题(例如可发酵纤维和霉菌毒素污染)。 | 张捷 Thmas Backers | 2005 | 国外畜牧学(猪与禽)2005，，4： | 5 |
| 7 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 5 |
| 8 | ESC/EAS Guidelines for the management of dyslipidaemias显示文摘 | Alberico L. Catapano ?eljko Reiner Guy De Backer Ian Graham Marja-Riitta Taskinen Olov Wiklund Stefan Agewall Eduardo Alegria M. John Chapman Paul Durrington Serap Erdine Julian Halcox Richard Hobbs John Kjekshus Pasquale Perrone Filardi Gabriele Riccardi | 2011 | Atherosclerosis2011，，： | 3 |
| 9 | 不同液体复苏条件下多巴酚丁胺对肠缺血-再灌注休克的疗效比较显示文摘目的 比较多巴酚丁胺在不同液体复苏条件下对兔肠缺血再灌注损伤 (I/ R)所致休克的治疗效果。方法 32只新西兰白兔随机分为乳酸林格液 (L RS)复苏组、L RS+羟乙基淀粉溶液 (HES)复苏组、L RS复苏 +多巴酚丁胺治疗组 (L RS+DOB组 )和 L RS+HES复苏 +多巴酚丁胺治疗组 (L RS+HES+DOB组 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠 I/ R休克模型 ,松夹再灌注时同步进行液体复苏和多巴酚丁胺治疗。观察各时间点血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 )的变化 ,并通过测定动脉二氧化碳间隙〔 Pt a CO2 间隙 =肠黏膜 CO2 分压 (Pt CO2 ) -动脉血 CO2 分压 (Pa CO2 )〕、肠黏膜 p H值 (p Hi)、动脉血乳酸浓度和氧输送 (DO2 )等指标间接评价组织氧合情况。结果 多巴酚丁胺能显著减轻兔肠I/ R休克后平均动脉压、心率、心排血量和肠系膜上动脉血流的下降 ,两多巴酚丁胺治疗组与两复苏组比较 ,差异均有显著性 (P均 <0 .0 5 ) ;且 L RS+HES+DOB组平均动脉压下降程度较 L RS+DOB组明显减轻 (P<0 .0 5 )。与 L RS组比较 ,两多巴酚丁胺治疗组均能明显降低血乳酸浓度和 Pt a CO2 间隙 ,升高 p Hi和 DO2 (P均<0 .0 5 ) ,尤其在 L RS+HES+DOB组效果更显著 (P均 <0 .0 5 ) ,与 L | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo DanielDe Backer 肖献忠 Jean-Louis Vincent | 2005 | 中国危重病急救医学2005，17，2： | 3 |
| 10 | Total cavopulmonary conversion and maze procedure for patients with failure of the Fontan operation显示文摘 | Mavroudis C Backer CL Deal BJ at al | 2001 | J Thorac Cardiovasc Surg2001，122，5： | 2 |
| 11 | Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review显示文摘 | A.M. Sadowska B. Manuel-y-Keenoy W.A. De Backer | 2006 | Pulmonary Pharmacology & Therapeutics2006，，1： | 2 |
| 12 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 13 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 14 | ESC/EAS Guidelines for the management of dyslipidaemias显示文摘 | Alberico L. Catapano ?eljko Reiner Guy De Backer Ian Graham Marja-Riitta Taskinen Olov Wiklund Stefan Agewall Eduardo Alegria M. John Chapman Paul Durrington Serap Erdine Julian Halcox Richard Hobbs John Kjekshus Pasquale Perrone Filardi Gabriele Riccardi | 2011 | Atherosclerosis2011，，1： | 2 |
| 15 | Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study显示文摘 | Marc-Jacques Dubois Carlos Orellana-Jimenez Christian Melot Daniel De Backer Jacques Berre Marc Leeman Serge Brimioulle Olivier Appoloni Jacques Creteur Jean-Louis Vincent | 2006 | Critical Care Medicine2006，，： | 2 |
| 16 | Ovarian germ cell tumors in children:a clinical study of 66 patients显示文摘 | De Backer A Madern GC Oosterhuis JW | 2006 | Pediatr Blood Cancer2006，46，6： | 1 |
| 17 | 2007 ESH-ESC practice guidelines for the management of arterial hypertension: ESH-ESC task force on the management of arterial hypertension 显示文摘 | MANCIA G DE BACKER G DOMINICZAK A | 2007 | J hypertension2007，25，6： | 1 |
| 18 | 2007 Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the european society of hypertension (ESH) and of the european society of cardiology (ESC)显示文摘 | Mancia G De Backer G Dominiczak A | 2007 | Eur Heart J2007，28，12： | 1 |
| 19 | 2007 Guidelines for the management of arterial hypertension: The task force for themanagement of arterial hypertension of the European Society of Hypertension(ESH) and of the European Society of Cardiology (ESC) 显示文摘 | Maneia G De Backer G Dominiczak A | 2007 | J Hypertens2007，25，： | 1 |
| 20 | Cardiac failure intrans- gemc mice with myocardial expression of tumor necrosis factor -- a显示文摘 | Bryant D Backer L Richardson J | 1998 | Circulation1998，97，： | 1 |
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