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| 1 | Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy显示文摘Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms.PD is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain regions.Definite diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the brain.Compelling evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM analysis.In particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and PSP.Results:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same effect.Notably,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their discrimination.Conclusions:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-synuclein.Additional studies are required for(i)estimating sensitivity and specificity of the technique and for(ii)evaluating its application for the diagnosis of PD and neurodegenerative parkinsonisms.RT-QuIC analyses of OM and cerebrospinal fluid(CSF)can be combined with the aim of increasing the overall diagnostic accuracy of these diseases,especially in the early stages. | Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna Narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 2 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 5 |
| 3 | 左心室舒张功能的遗传性和其他影响因素:以家庭为基础的人口研究显示文摘确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法:随机抽取316个家庭样本,包括452名父母和600名后代,平均年龄分别为58.5和33.3岁, | 刘莉 叶鹏 Kloch-Badelek M Knez J Tikhonoff V Thijs L Sakiewicz W Ryabikov A Stolarz-Skrzypek K Jin Y Malyutina S Casiglia E Narkiewicz K Czarnecka D Kawecka-Jaszcz K Staessen JA Kuznetsova T | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 4 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 5 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 6 | Sulfur Poisoning of Iron Ammonia Catalyst Probed by Potassium Desorption显示文摘 | Andrzej Kotarba Jaromir Dmytrzyk Urszula Narkiewicz Andrzej Barański | 2001 | Reaction Kinetics and Catalysis Letters2001，，1： | 1 |
| 7 | Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea 显示文摘 | Narkiewicz K Kato M Phillips BG | 1999 | Circulation1999，100，23： | 1 |
| 8 | 2013 ESH/ESC guidelines for the management of arterial hypertension显示文摘 | GIUSEPPEMANCIA ROBERT FAGARD KRZYSZTOF NARKIEWICZ | 2013 | Eur Heart J2013，34，28： | 1 |
| 9 | 2013 ESH/ESC Guidelines for the management of arterial hypertension:the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Mancia G Fagard R Narkiewicz K | 2013 | J Hypertens2013，31，7： | 1 |
| 10 | Sympa thetic activity in obese subjects with and without obstructive sleep apnea 显示文摘 | Narkiewicz K van de Borne PJ Cooley RL et ai | 1998 | Circulation1998，98，8： | 1 |
| 11 | Effects of obstructive sleep apnea on endothelin-1 and blood pressure显示文摘 | Phillips BG Narkiewicz K Pesek CA | 1999 | J Hypertens1999，17，： | 1 |
| 12 | Sympathetic nervous system and arterial hypertension: new perspectives, new data显示文摘 | HERING D NARKIEWICZ K | 2013 | KardiolPol2013，71，5： | 1 |
| 13 | Noctrnal con- tinuous positive airway pressure decreases daytime sym- pathetic traffic in obstructive sleep apnea显示文摘 | Narkiewicz K Kato M Phillips BG | 1999 | Circulation1999，100，： | 1 |
| 14 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 1 |
| 15 | 2013 ESH/E- SC guidelines for the management of arterial hyperten- sion: the task force for the management of arterial hyper- tension of the European society of hypertension (ESH) and of the european society of cardiology (ESC) 显示文摘 | Mancia G Fagard R Narkiewicz K | 2013 | Eur Heart J2013，34，28： | 1 |
| 16 | 2013 ESH/ ESCguidelines for the management of arterial hypertension:Thetask force for the management of arterial hypertension of theEuropean Society of Hypertension(ESH) and of theEuropean Society of Cardiology(ESC)显示文摘 | Mancia G Fagard R Narkiewicz K | 2013 | J Hypertens2013，31，10： | 1 |
| 17 | 2013 ESH/ESC guidelines for the management of arterial hypertension:the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) 显示文摘 | Mancia G Fagard R Narkiewicz K | 2013 | Eur Heart J2013，38，28： | 1 |
| 18 | 2013 ESH/ESC guidelines for themanagement of arterial hypertension:The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Mancia G Fagard R Narkiewicz K | | 0，，： | 1 |
| 19 | 2013 ESH/ESC guidelines for the management of arterial hypertension : the task force for the management of arterial hypertension of the European Society of Hypertension(ESH)and of the European Society of Cardiology(ESC)显示文摘 | Mancia G Fagard R Narkiewicz K | 2013 | Eur Heart J2013，34，28： | 1 |
| 20 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B? hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Sté pha | 2013 | Blood Pressure2013，，4： | 1 |
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