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| 1 | WJBC 5^(th) Anniversary Special Issues(2): Proteomics In 2014, can we do better than CA125 in the early detection of ovarian cancer?显示文摘Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years with the five-year overall survival remaining between 20% and 40% for stage Ⅲ and Ⅳ disease. In contrast patients with stage Ⅰ disease have a greater than 90% five-year overall survival. Detection of ovarian cancer at an early stage would likely have significant impact on mortality rate. Screening biomarkers discovered at the bench have not translated to success in clinical trials. Existing screening modalities have not demonstrated survival benefit in completed prospective trials. Advances in high throughput screening are making it possible to evaluate the development of ovarian cancer in ways never before imagined. Data in the form of human '-omes' including the proteome, genome, metabolome, and transcriptome are now available in various packaged forms. With the correct pooling of resources including prospective collection of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies. | Joshua G Cohen Matthew White Ana Cruz Robin Farias-Eisner | 2014 | World Journal of Biological Chemistry2014，5，3： | 18 |
| 2 | Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach显示文摘Physical rehabilitation of lung transplant candidates and recipients plays an important in optimizing physical function prior to transplant and facilitating recovery of function post-transplant. As medical and surgical interventions in lung transplantation have evolved over time, there has been a demographic shift of individuals undergoing lung transplantation including older individuals, those with multiple co-morbidites, and candidates with respiratory failure requiring bridging to transplantation. These changes have an impact on the rehabilitation needs of lung transplant candidates and recipients. This review provides a practical approach to rehabilitation based on research and clinical practice at our transplant centre. It focuses on functional assessment and exercise prescription during an uncomplicated and complicated clinical course in the pre-transplant, early and late post-transplant periods. The target audience includes clinicians involved in pre- and posttransplant patient care and rehabilitation researchers. | Lisa Wickerson Dmitry Rozenberg Tania Janaudis-Ferreira Robin Deliva Vincent Lo Gary Beauchamp Denise Helm Chaya Gottesman Polyana Mendes Luciana Vieira Margaret Herridge Lianne G Singer Sunita Mathur | 2016 | World Journal of Transplantation2016，6，3： | 8 |
| 3 | Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis显示文摘 | Kurt Degenhardt Robin Mathew Brian Beaudoin Kevin Bray Diana Anderson Guanghua Chen Chandreyee Mukherjee Yufang Shi Céline Gélinas Yongjun Fan Deirdre A. Nelson Shengkan Jin Eileen White | 2006 | Cancer Cell2006，，1： | 2 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 6 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 7 | The efects of starvation and subsequent feeding on survival growth of Fulton channel sockeye salmon ( Oncorhynchus nerka) 显示文摘 | Bihon H T Robins G L | 1973 | J Fish Res Board1973，30，： | 1 |
| 8 | Glacier depth sounding from the air显示文摘 | Evans S Robin G Q | 1966 | Nature1966，210，： | 1 |
| 9 | A novel tunnd structure containing enclathrated hydrogen peroxide:4Na2SO4 · 2H2O2· NaCl显示文摘 | ADAMS JOHN M PRITCHARD ROBIN G THOMAS JOHN M | 1978 | Journal of Chemical Society Chem Conm1978，，3： | 1 |
| 10 | Generation of hair cells by stepwise differentiation of embryonic stem cells显示文摘 | Li H Robin G Liu H | 2003 | PNAS2003，100，13： | 1 |
| 11 | Collagen Type X:a component of the surface of normal human,pig,and rat articular cartilage显示文摘 | Rucklidge GJ Milne G Robins SP | 1996 | Biochem Biophys Res Commun1996，224，： | 1 |
| 12 | A new class of iterative Steiner tree heuristics with good performance显示文摘 | A Kahng G Robins | 1992 | IEEE Trans Computer-Aided Design1992，11，： | 1 |
| 13 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status 显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 14 | Contribution of fibronectin - binding protein to pathogenesis of Streptococcus suis serotype 2 显示文摘 | Astrid de G Henna B Robin V | 2002 | Infect Imm2002，70，3： | 1 |
| 15 | Risk perceptions, stigma, and health policy 显示文摘 | ROBIN G PAUL S FLYNN J | 1996 | Health & Place1996，2，： | 1 |
| 16 | Bimodal targeting of microsomal CYP2E1 tomitochondria through activation of an N-terminalchimeric signal by cAMP-mediated phosphorylation显示文摘 | ROBIN M A ANANDATHEERTHAVARADA H K BISWAS G | 2002 | J Biol Chem2002，277，40： | 1 |
| 17 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 18 | Biochemical attributes of tea flowers (Camellia sinensis)at different developmental stages in the Kangra region of India显示文摘 | ROBIN J POONA M ASHU G | 2011 | Scientia Horticulturaef2011，130，： | 1 |
| 19 | Gaseous emissions from composting bark/manure mixtures 显示文摘 | Morand P Peres G Robin P emissions during composting | 2005 | Compost Science & Utilization2005，13，1： | 1 |
| 20 | Newall-vanadium redox cell显示文摘 | SKYLLAS-KAZACOS M RYCHCIK M ROBINS R G | 1986 | J Electrochem Soc1986，133，： | 1 |
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