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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Calibration of a hysteretic model for glass fiber reinforced gypsum wall panels显示文摘Glass fi ber reinforced gypsum(GFRG) wall panels are prefabricated panels with hollow cores, originally developed in Australia and subsequently adopted by India and China for use in buildings. This paper discusses identifi cation and calibration of a suitable hysteretic model for GFRG wall panels fi lled with reinforced concrete. As considerable pinching was observed in the experimental results, a suitable hysteretic model with pinched hysteretic rule is used to conduct a series of quasi-static as inelastic hysteretic response analyses of GFRG panels with two different widths. The calibration of the pinching model parameters was carried out to approximately match the simulated and experimental responses up to 80% of the peak load in the post peak region. Interestingly, the same values of various parameters(energy dissipation and pinching related parameters) were obtained for all fi ve test specimens. | Maganti Janardhana Robin Davis P S.S.Ravichandran A.M.Prasad D.Menon | 2014 | Earthquake Engineering and Engineering Vibration2014，13，2： | 4 |
| 3 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 4 | Why momentum width matters for atom interferometry with Bragg pulses显示文摘 | S S Szigeti J E Debs J J Hope N P Robins J D Close | 2012 | New Journal of Physics2012，，2： | 2 |
| 5 | Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS显示文摘 | Simon P Dunlop David Jenkins Keith R Neal Robin C Spiller | 2003 | Gastroenterology2003，，6： | 2 |
| 6 | Free-ranging automatic guided-vehicle system显示文摘 | ROBINS M P | 1986 | GEC Review1986，2，2： | 1 |
| 7 | Vermifiltration as a stage inreuse of swine wastewater:monitoring methodology on anexperimental farm显示文摘 | Li Y S Robin P Cluzeau D | 2008 | Ecol Eng2008，32，4： | 1 |
| 8 | Dietary fiber in extru- ded cereals : limitations and opportunities 显示文摘 | Robin F Schuchmann H P Palzer F | 2012 | Trends in Food Science & Technology2012，28，： | 1 |
| 9 | Cultural shift towards sustainability'in the construction industry of Hong Kong显示文摘 | Yip Robin C P Poon C S | 2009 | Journal of Environmental Management2009，90，11： | 1 |
| 10 | Gaseous emissions from composting bark/manure mixtures 显示文摘 | Morand P Peres G Robin P emissions during composting | 2005 | Compost Science & Utilization2005，13，1： | 1 |
| 11 | Maximum likelihood from incomplete data via the EM algorithm显示文摘 | Dempster A P Laird N M Robin D B | 1977 | Journal of the Royal Statistical Society1977，39，1： | 1 |
| 12 | Uric acid and urea in relation to protein catabolism in long-term fasting geese显示文摘 | ROBIN J P CHEREL Y GIRARD H | 1987 | Journal of Comparative Physiology B:Biochemical Systemic and Environmental Physiology1987，157，4： | 1 |
| 13 | Predicting the flexural loaddeflection response of steel fibre reinforced concrete from strain, crack-width,fibre pull-out and distribution data 显示文摘 | Jones P A Austin S A Robins P J | 2008 | Materialsand Structures2008，41，3： | 1 |
| 14 | The effect of international institutional factors on properties of accounting eamings显示文摘 | Ball R Kotharis P Robin A | 2000 | Journal of Accounting and Economics2000，29，1： | 1 |
| 15 | Formation of spinels in cosmic objects during atmospheric entry: A clue to the Cretaceous-Tertiary boundary event显示文摘 | Robin E Bonte P Froget L | 1992 | Earth and Planetary Science Letters1992，108，4： | 1 |
| 16 | The flow around a surface-mounted cube in uniform and turbulent streams显示文摘 | CASTRO I P ROBINS A G | 1977 | J Fluid Mech1977，79，2： | 1 |
| 17 | Fabric analysis using the intercept method显示文摘 | LAUNEAU P ROBIN P Y F | 1996 | Tectonophysics1996，267，1： | 1 |
| 18 | Efficacy of clorsulon and of an ivermectin-clorsulon combinations in the treatment of adult Fasciola hepatica infection in cattle显示文摘 | Gane P | 1990 | Revue-de-Medecine-Veterinaire1990，141，8： | 1 |
| 19 | Estimating time varying risk premier in the term structure: the ARCH-M model显示文摘 | Engle R F Lilien D M Robins R P | 1987 | Econometrics1987，55，2： | 1 |
| 20 | Low-dose thoracoab- dominal irradiation for the treatment of refractory chronic graft- versus-host disease显示文摘 | Robin M Guardiola P Girinsky T | 2005 | Transplantation2005，80，5： | 1 |
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