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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Umbilical cord as a mesenchymal stem cell source for treating joint pathologies显示文摘Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life.Regrettably,the regeneration of articular cartilage is a continuing challenge for biomedical research.One of the most promising therapeutic approaches is cellbased tissue engineering,which provides a healthy population of cells to the injured site but requires differentiated chondrocytes from an uninjured site.The use of healthy chondrocytes has been found to have limitations.A promising alternative cell population is mesenchymal stem cells(MSCs),known to possess excellent proliferation potential and proven capability for differentiation into chondrocytes.The“immunosuppressive”property of human MSCs makes them an important candidate for allogeneic cell therapy.The use of allogeneic MSCs to repair large defects may prove to be an alternative to current autologous and allogeneic tissue-grafting procedures.An allogeneic cell-based approach would enable MSCs to be isolated from any donor,expanded and cryopreserved in allogeneic MSC banks,providing a readily available source of progenitors for cell replacement therapy.These possibilities have spawned the current exponential growth in stem cell research in pharmaceutical and biotechnology communities.Our objective in this review is to summarize the knowledge about MSCs from umbilical cord stroma and focus mainly on their applications for joint pathologies. | María Carmen Arufe Alexandre De la Fuente Isaac Fuentes Francisco Javier De Toro Francisco Javier Blanco | 2011 | World Journal of Orthopedics2011，2，6： | 7 |
| 3 | Subaxial cervical spine injury classification system: is it most appropriate for classifying cervical injury?显示文摘The cervical spine injury represents a potential devastating disease with 6%associated in-hospital mortality(Jain et al.,2015).Neurological deterioration ranging from complete spinal cord injury(SCI)to incomplete SCI or single radiculopathy are potential consequences of the blunt trauma over this region.The subaxial cervical spine accounts the vast majority of cervical inju- | Rafael Martínez-Pérez Francisco Fuentes Víctor S.Alemany | 2015 | Neural Regeneration Research2015，10，9： | 4 |
| 4 | Prevalence of tick-borne pathogens in ixodid ticks (Aeari: Ixodidae) collected from European wild boar ( Sus Scrofa ) and Iberian red deer (Cervus elaphus hispanicus) in central Spain显示文摘 | Jose de la Fuente Victoria Naranjo Francisco Ruiz - Fons | 2004 | Eur J Wildlife Res2004，50，4： | 1 |
| 5 | Complementary multianalytical approach to study the distinctive structural features of the main humic fractions in solution, gray humic acid, brown humic acid, and fulvic acid 显示文摘 | Baigorri Roberto Fuentes Malta Gonzalez-Gaitano Gustavo Garcta-Mina Jose M Almendros Gonzalo Gonzalez-Vila Francisco J | 2009 | Journal of Agricultural and Food Chemistry2009，57，8： | 1 |
| 6 | Effects of Probiotic Lactobacillus Casei DN-114 001 in Prevention of Radiation-Induced Diarrhea: Results From Multicenter, Randomized, Placebo-Controlled Nutritional Trial显示文摘 | Jordi Giralt José Perez Regadera Ramona Verges Jesus Romero Isabel de la Fuente Albert Biete Jesús Villoria Jose Maria Cobo Francisco Guarner | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，4： | 1 |
| 7 | Review of the El Soplao Amber Outcrop,Early Cretaceous of Cantabria,Spain显示文摘El Soplao 露头,最近在北西班牙(Cantabria ) 发现的早白垩纪琥珀存款,被显示了是有到目前为止在西班牙被发现了的节肢动物包括的琥珀的最大的地点。为琥珀,孢粉学, taphonomy 和那些以前出版了的节肢动物 bioinclusions 补充的 biogeochemistry 此处提供的相关数据。数据的这个集合为 El Soplao 沉积物的琥珀建议至少二植物的来源。? rst (类型 A 琥珀) 强烈支持与 Cheirolepidiaceae 有关的来源,并且第二(类型 B 琥珀) 显示出非特定的针叶树 biomarkers。有 Frenelopsis 的琥珀离开的类型(Cheirolepidiaceae ) 的分子的作文的比较强烈建议一种生物化学的亲密关系和普通植物的起源。初步的 palynologlcal 研究显示地区性的高分类的差异,主要蕨类植物孢子和裸子植物花粉谷物。根据初步的 palynologlcal 数据,这个区域由在副热带的气候下面使适应一个旱季的针叶树森林被住在。在一样的床上与琥珀联系的丰富的 charcoalified 木头是很可能加植物表皮支持了树脂生产和崽,和琥珀的随后的大累积的集中的侵蚀的 paleofires 的证据。另外,第一次在石块记录,在琥珀的 bioinclusions 被报导的 charcoalified 植物纤维。另外的相关 taphonomic 数据在两个都显示长暴露在上的一些琥珀片的表面上是 serpulids 和 bryozoans 的非凡的存在海洋或略有盐味水并且琥珀的一个混合集合。最后,昆虫 bioinclusions 的新调查结果,他们中的一些在石块记录不平常或显示出显著改编,被报导。在结论,为 El Soplao 琥珀露头的起源的一种记录情形被提供。 | María NAJARRO Enrique PENALVER Ricardo PEREZ-DE LA FUENTE Jaime ORTEGA-BLANCO Cesar MENOR-SALVAN Eduardo BARRON Carmen SORIANO Idoia ROSALES Rafael LOPEZ DEL VALLE Francisco VELASCO Fernando TORNOS Véronique DAVIERO-GOMEZ Bernard GOMEZ Xavier DELCLOS | 2010 | Acta Geologica Sinica(English Edition)2010，84，4： | 1 |
| 8 | Dietary fat, genes and insulin sensitivity显示文摘 | José López-Miranda Pablo Pérez-Martínez Carmen Marin Francisco Fuentes Javier Delgado Francisco Pérez-Jiménez | 2007 | Journal of Molecular Medicine2007，，3： | 1 |
| 9 | Regulatory T Cells in Human Autoimmune Thyroid Disease显示文摘 | Mónica Marazuela María A. García-López Nicté Figueroa-Vega Hortensia de la Fuente Brenda Alvarado-Sánchez Adriana Monsiváis-Urenda Francisco Sánchez-Madrid Roberto González-Amaro | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，9： | 1 |
| 10 | Influence of Flap Prefabrication on Seeding of Subcutaneously Injected Mesenchymal Stem Cells in Microvascular Beds in Rats显示文摘 | Andrés Rodríguez-Lorenzo María C. Arufe Alexandre de la Fuente Fernando Fernandez Francisco Blanco | 2014 | Annals of Plastic Surgery2014，，2： | 1 |
| 11 | Standardized multiplex one-step qRT-PCR for hepatitis A virus, norovirus GI and GII quantification in bivalve mollusks and water显示文摘 | Cristina Fuentes Susana Guix Francisco J. Pérez-Rodriguez Noemí Fuster Mónica Carol Rosa M. Pintó Albert Bosch | 2013 | Food Microbiology2013，，： | 1 |
| 12 | Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression显示文摘 | Jong Hun Lee Tin Oo Khor Limin Shu Zheng-Yuan Su Francisco Fuentes Ah-Ng Tony Kong | 2012 | Pharmacology and Therapeutics2012，，： | 1 |
| 13 | Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients显示文摘 | Enzo Candia David Díaz-Jiménez Patricia Langjahr Lucía E. Nú?ez Marjorie de la Fuente Nancy Farfán Francisco López-Kostner Mario Abedrapo Manuel Alvarez-Lobos George Pinedo Caroll J. Beltrán Carlos González María-Julieta González Rodrigo Quera Marcela A. | 2011 | Immunobiology2011，，6： | 1 |
| 14 | Conservative treatment with transurethral resection, neoadjuvant chemotherapy followed by radiochemotherapy in stage T2-3 transitional bladder cancer显示文摘 | Manuel Cobo Raquel Delgado Silvia Gil Ismael Herruzo Víctor Baena Francisco Carabante Pilar Moreno José Luis Ruiz Juan José Bretón M. José Rosal Carlos Fuentes Paloma Moreno Emilio García Esther Villar Jorge Contreras Inmaculada Alés Manuel Benavides | 2006 | Clinical and Translational Oncology2006，，12： | 1 |
| 15 | Familiarity-based recognition in the young, healthy elderly, mild cognitive impaired and Alzheimer’s patients显示文摘 | Salvador Algarabel Joaquín Escudero José Francisco Mazón Alfonso Pitarque Manuel Fuentes Vicente Peset Laura Lacruz | 2009 | Neuropsychologia2009，，10： | 1 |
| 16 | Contribution of Different Agronomic Practices and the Fungus Beauveria bassiana on the Coffee Berry Borer显示文摘 | Alberto Fernandez Turro Ernesto Castafieda Hidalgo Francisco Simon Ricardo Everton Kort Kamp Fernandes Juana Iris Duran Cos Odisa Baque Fuentes | 2013 | Journal of Life Sciences2013，7，9： | 0 |
| 17 | Evaluation of Commercial Active Carbons for the Removal of s-Triazine Herbicides from Waters显示文摘 | Francisco J. Rojas Moreno Manuel De La Fuente Darder Rafael MAarin Galvin Manuel Mayen Jose M.Rodriguez Mellado | 2011 | Journal of Chemistry and Chemical Engineering2011，5，2： | 0 |
| 18 | Acceptance of living liver donation among medical students: A multicenter stratified study from Spain显示文摘AIM: To analyze the attitude of Spanish medical students toward living liver donation(LLD) and to establish which factors have an influence on this attitude.METHODS: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain(n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire(PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student′s t test, χ2 test and logistic regression analysis.RESULTS: The completion rate was 95.7%(n = 9275). 89%(n = 8258) were in favor of related LLD, and 32%(n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude:(1) age(P = 0.008);(2) sex(P < 0.001);(3) academic year(P < 0.001);(4) geographical area(P = 0.013);(5) believing in the possibility of needing a transplant oneself in the future(P < 0.001);(6) attitude toward deceased donation(P < 0.001);(7) attitude toward living kidney donation(P < 0.001);(8) acceptance of a donated liver segment from a family member if one were needed(P < 0.001);(9) having discussed the subject with one's family(P < 0.001) and friends(P < 0.001);(10) a partner's opinion about the subject(P < 0.001);(11) carrying out activities of an altruistic nature; and(12) fear of the possible mutilation of the body after donation(P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD. | Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla | 2016 | World Journal of Gastroenterology2016，22，25： | 0 |
| 19 | Targeting obesity-related inflammation in skin cancer: molecular and epigenetic insights for cancer chemoprevention by dietary phytochemicals显示文摘Non-melanoma skin cancer(NMSC) is one of the most common cancers in the US, although the role of obesity in skin cancer remains unclear. In vivo studies have consistently demonstrated that obese mice challenged with UVB radiation show increased skin tumorigenesis in comparison with leaner control mice. Growing evidence suggests that enhanced inflammation, oxidative stress and impaired apoptosis may play important roles in the development of skin cancer. Interventions such as voluntary exercise and the surgical removal of parametrial fat have been demonstrated to be effective in reducing adipose tissue that may influence the development of skin cancer; however, these interventions are not achievable in all obese patients. Therefore, the use of dietary natural phytochemicals that may modify and reverse the deregulated molecular and epigenetic events related to obesity and cancer development might represent a potential therapeutic modality due to their potential efficacy and low toxicity. In this review, we aim to provide the molecular and epigenetic basis of the NMSC-obesity relationship and to highlight the potential anti-cancer chemopreventive benefits of dietary phytochemicals such as sulforaphane and epigallocatechin-3-gallate. | Ximena Paredes-Gonzalez Francisco Fuentes Yaoping Lu 江亚伍 | 2016 | Journal of Chinese Pharmaceutical Sciences2016，25，4： | 0 |
| 20 | Evaluation of patient visual comfort and repeatability of refractive values in non-presbyopic healthy eyes显示文摘AIM: To evaluate the intra-operator repeatability in healthy subjects using the WAM-5500 auto-kerato/refractometer and the i Trace aberrometer, to compare the refractive values and the subjective refraction obtained with both devices and to determine which of these three spherocylindrical corrections allows the subject to achieve the best visual comfort.·METHODS: Forty-two non-presbyopic healthy eyes of42 subjects were enrolled in this prospective study.Refractive values were compared, evaluating the repeatability, the relationship between the methods and the best visual comfort obtained.·RESULTS: Sphere, cylinder and axis results showed good intraclass correlation coefficients(ICC); the highest ICC was obtained using the spherical refraction with the autorefractometer and the aberrometer, achieving levels of 0.999 and 0.998, respectively. The power vector(PV)was calculated for each refraction method, and the results indicated that there were no statistically significant differences between them(P >0.05). Direct comparison of PV measurements using the three methods showed that aberrometer refraction gave the highest values, followed by the subjective values; the autorefractometer gave the lowest values. The subjective method correction was most frequently chosen as the first selection. Equal values were found for theautorefractometer and the aberrometer as the second selection.·CONCLUSION: The i Trace aberrometer and the WAM-5500 auto-kerato/refractometer showed high levels of repeatability in healthy eyes. Refractive corrections with the aberrometer, the autorefractometer and subjective methods presented similar results, but spherocylindrical subjective correction was the most frequently selected option. These technologies can be used as complements in refractive evaluation, but they should not replace subjective refraction. | Francisco Segura Ana Sanchez-Cano Carmen Lopez de la Fuente Lorena Fuentes-Broto Isabel Pinilla | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 0 |
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