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| 1 | Umbilical cord as a mesenchymal stem cell source for treating joint pathologies显示文摘Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life.Regrettably,the regeneration of articular cartilage is a continuing challenge for biomedical research.One of the most promising therapeutic approaches is cellbased tissue engineering,which provides a healthy population of cells to the injured site but requires differentiated chondrocytes from an uninjured site.The use of healthy chondrocytes has been found to have limitations.A promising alternative cell population is mesenchymal stem cells(MSCs),known to possess excellent proliferation potential and proven capability for differentiation into chondrocytes.The“immunosuppressive”property of human MSCs makes them an important candidate for allogeneic cell therapy.The use of allogeneic MSCs to repair large defects may prove to be an alternative to current autologous and allogeneic tissue-grafting procedures.An allogeneic cell-based approach would enable MSCs to be isolated from any donor,expanded and cryopreserved in allogeneic MSC banks,providing a readily available source of progenitors for cell replacement therapy.These possibilities have spawned the current exponential growth in stem cell research in pharmaceutical and biotechnology communities.Our objective in this review is to summarize the knowledge about MSCs from umbilical cord stroma and focus mainly on their applications for joint pathologies. | María Carmen Arufe Alexandre De la Fuente Isaac Fuentes Francisco Javier De Toro Francisco Javier Blanco | 2011 | World Journal of Orthopedics2011，2，6： | 7 |
| 2 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells显示文摘 | Arufe MC Lu M Kubo A | 2006 | Endocrinology2006，147，6： | 1 |
| 3 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells显示文摘 | Arufe MC Lu M Kubo A | 2006 | Endocrinology2006，147，6： | 1 |
| 4 | Chondrogenic potential of subpopulations of cells expressing mesenchymal stem cell markers dericed from human synovial membrances 显示文摘 | Arufe MC De la Fuente A Fuentes I | 2010 | J Cell Biochem2010，，4： | 1 |
| 5 | Differentiation of murine embryonic stem cells to thyrocytes requires insulin and insulin-like growth factor- 1 显示文摘 | Arufe MC Lu M Lin RY | 2009 | Biochem Biophys Res Commun2009，381，2： | 1 |
| 6 | Influence of flap prefabrication on seeding of subcutaneously injected mesenchymal stem cells in microvascular beds in rats 显示文摘 | Rodriguez-Lorenzo A Arufe MC De la Fuente A | 2014 | Ann Plast Surg2014，73，2： | 1 |
| 7 | A study among the population of Sevilla of death due to submersion 显示文摘 | Gamero J Romero JL Arufe MI | 1997 | Am J Forensic Med Pathol1997，18，1： | 1 |
| 8 | Chondrogenic po- tential of subpopulations of cells expressing mesenchymal stem cell markers derived from human synovial membranes 显示文摘 | Arufe MC De la Fuente A Fuentes I | 2010 | J Cell Biochem2010，111，4： | 1 |
| 9 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells显示文摘 | ARUFE M C LU M KUBO A | 2006 | Endo-crinology2006，147，6： | 1 |
| 10 | Directed differentiation of mouse embryonic stem cells into thyroid fol icular cells显示文摘 | Arufe MC Lu M Kubo A | | 0，，06： | 1 |
| 11 | Chondrogenic potential of subpopulations of cells expressing mesenchymal stem cell markers derived from human synovial membranes 显示文摘 | Arufe MC De la Fuente A Fuentes I | 2010 | J Cell Biochem2010，，4： | 1 |
| 12 | Influence of Flap Prefabrication on Seeding of Subcutaneously Injected Mesenchymal Stem Cells in Microvascular Beds in Rats显示文摘 | Andrés Rodríguez-Lorenzo María C. Arufe Alexandre de la Fuente Fernando Fernandez Francisco Blanco | 2014 | Annals of Plastic Surgery2014，，2： | 1 |
| 13 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells 显示文摘 | Arufe MC Lu M Kubo A | 2006 | Endocrinolo- gy2006，147，6： | 1 |
| 14 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells显示文摘 | ARUFE M C LU M KUBO A | 2006 | Endocrinology2006，147，6： | 1 |
| 15 | Differentiation of murine embryonic stem cells to thyrocytes requires insulin and insulin-like growth factor-1显示文摘 | Maria C. Arufe Min Lu Reigh-Yi Lin | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 16 | Effect of aging on behaviour of mesenchymal stem cells显示文摘Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called “mesenchymal stem cells” or “mesenchymal stromal cells (MSCs)”, contributes directly to the homeostatic maintenance of their organs;hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years. | Juan Antonio Fafián-Labora Miriam Morente-López María C Arufe | 2019 | World Journal of Stem Cells2019，11，6： | 1 |
| 17 | Directed differentiation of mouse embryonic stem cells into thyroid follicular eells 显示文摘 | Arufe MC Lu M Kubo A | 2006 | Endocrinology2006，147，6： | 1 |
| 18 | Chondrogenic poten-tial of subpopulations of cells expressing mesenchymal stem cell markers derived from human synovial membranes 显示文摘 | Arufe M C De la Fuente A Fuentes I | 2010 | Cell Bio-ehem2010，111，4： | 1 |
| 19 | Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation显示文摘 | ARUFE M C DE LA FUENTE A FUENTES BOQUETE I | 2009 | J Cell Biochem2009，108，1： | 1 |
| 20 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells显示文摘 | Arufe MC Lu M Kubo A | | 0，，： | 1 |
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