|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ankylosing spondylitis: etiology, pathogenesis, and treatments显示文摘Ankylosing spondylitis(AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain;additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen(HLA)?B27 and the interleukin?23/17 axis.However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. | Wei Zhu Xuxia He Kaiyuan Cheng Linjie Zhang Di Chen Xiao Wang Guixing Qiu Xu Cao Xisheng Weng | 2019 | Bone Research2019，7，3： | 30 |
| 2 | Nutritional composition and antioxidant activity of twenty mung bean cultivars in China显示文摘Interest in mung bean(Vigna radiata L.) as a functional food is growing; however, studies on the nutritional composition of major mung bean cultivars planted in China are limited.Twenty Chinese mung bean cultivars were collected and their nutritional compositions including starch, fat, protein, and phytochemicals were analyzed. The cultivars were found to have a high amount of resistant starch, accounting for 16.1%–22.3% of total starch, and balanced amino acid constitutions. Palmitic acid and linoleic acid were the two dominant fatty acids, accounting for respectively 32.4% and 36.1% of all of the assayed fatty acids. Four bound phenolic acids(syringic, caffeic, p-coumaric, and ferulic acids) and two free phenolic acids(caffeic and ferulic acids) were identified by HPLC. The antioxidant activity of 70%ethanol extracts from the 20 mung bean cultivars was evaluated. Their DPPH and ABTS+free-radical-scavenging capacity ranged from 28.13 ± 2.24 to 35.68 ± 0.71 μmol g-1and from3.82 ± 0.25 to 13.44 ± 1.76 μmol g-1, respectively. Significant positive correlations of ABTS+free-radical-scavenging capacity with total phenolic acids and total flavonoid contents were observed. These results suggest that Chinese mung bean cultivars are rich in balanced nutrients and that their phytochemicals should be considered as potential sources of natural antioxidants. | Zhenxing Shi Yang Yao Yingying Zhu Guixing Ren | 2016 | The Crop Journal2016，4，5： | 16 |
| 3 | Diurnal Variations of Precipitation over North China Regulated by the Mountain-plains Solenoid and Boundary-layer Inertial Oscillation显示文摘The mountain-plains solenoid(MPS) and boundary-layer inertial oscillation(BLO) are two typical regional forcings at the diurnal time scale. Their relative role in regulating the diurnal variations of summer rainfall over North China and their change under different monsoon conditions are studied using a 19-yr archive of satellite rainfall and reanalysis data. It is shown that both a strong MPS and BLO can increase nocturnal rainfall in the North China plains but exhibit evident regional differences. The MPS-induced nocturnal rainfall is relatively confined to the plains adjacent to mountains from late night to morning, due to the upward branch of the nighttime MPS. In contrast, the BLO-induced nocturnal rainfall strengthens from early evening and is more extensive in early morning over the open plains further east. The contrasting effect in the evening is related to the convergent(divergent) easterly anomaly in the plains under the BLO(MPS). The BLO also induces the relatively strong enhancement of moisture convergence and high humidity by the southerly anomaly at late night. On strong monsoon days, the nocturnal rainfall amount associated with the MPS and BLO increases considerably in the plains.Both regional forcings become effective in regulating the rainfall diurnal cycle with enhanced moisture convergence under monsoon conditions. Their induced diurnal amplitudes of moisture convergence can be comparable to the daily mean by monsoon flow. The regional forcings thus couple with monsoon flow to strengthen rainfall in the plains, particularly from late night to morning. The results highlight that a combination of regional and large-scale forcings can strongly regulate the warm-season climate. | He PAN Guixing CHEN | 2019 | Advances in Atmospheric Sciences2019，36，8： | 14 |
| 4 | Evolution mechanisms of the intraseasonal oscillation associated with the Yangtze River Basin flood in 1998显示文摘With 1998 NCEP reanalysis data and the linear diagnostic equation for local me- ridional circulation, four main processes and the boundary effects with relatively large contribu- tions to the intraseasonal oscillation of the vertical branches of the East Asian meridional circula- tion are quantitatively identified among all the processes involved in the quasi-primitive equations used in the derivation of the linear diagnostic equation. The numerical results show that the main processes with maximal contributions in the lower latitudes include the latent heating and vertical transports of sensible heat. These processes are mainly associated with the tropical convective activities and result in the low-frequency cyclones in the lower latitudes. The main processes with maximal contributions in the higher latitudes are the horizontal transports of westerly momentum and horizontal temperature advections. These processes are mainly associated with the fluctua- tions in the westerlies and result in the low-frequency cyclones in the higher latitudes. The low-frequency cyclones propagating away from lower latitudes not only interact with those from higher latitudes to enhance the lifting of the moist air in the Yangtze River Basin (YRB), but also leave room for the development of the low-frequency anticyclones over the South China Sea (SCS). The southwesterly in the northwestern quadrant of the SCS anticyclones provides the YRB with abundant moisture. This favorable moisture condition along with the enhanced rising motion in the YRB leads to the extraordinary flood in 1998. | CHEN Guixing LI Weibiao YUAN Zhuojian WEN Zhiping | 2005 | Science China Earth Sciences2005，48，7： | 13 |
| 5 | Climatology of tropical cyclone tornadoes in China from 2006 to 2018显示文摘We surveyed the occurrence of tropical cyclone(TC) tornadoes in China from 2006 to 2018. There were 64 cataloged TC tornadoes, with an average of five per year. About one-third of the landfalling TCs in China were tornadic. Consistent with previous studies, TC tornadoes preferentially formed in the afternoon shortly before and within about 36 h after landfall of the TCs. These tornadoes mainly occurred in coastal areas with relatively flat terrains. The maximum number of TC tornadoes occurred in Jiangsu and Guangdong provinces. Most of the TC tornadoes were spawned within 500 km of the TC center. Two notable characteristics were found:(1) TC tornadoes in China mainly occurred in the northeast quadrant(Earth-relative coordinates) rather than the right-front quadrant(TC motion-relative coordinates) of the parent TC circulation;and(2) most tornadoes were produced by TCs with a relatively weak intensity(tropical depressions/storms), in contrast with the United States where most tornadoes are associated with stronger TCs. Further analyses showed that TC tornadoes in China tend to be spawned in an environment with large low-level storm relative helicity and large convective available potential energy taking entrainment effects into account. TC tornadoes were particularly active in 2018, with 24 reported tornadoes accounting for 37.5% of the total surveyed samples. The first recorded tornado outbreak in the modern history of China occurred in the envelope of TC Yagi(2018), in which 11 tornadoes were reported in association with significant midlevel intrusions of dry air and the interaction of Yagi with an approaching midlatitude midlevel trough. | Lanqiang BAI Zhiyong MENG Kenta SUEKI Guixing CHEN Ruilin ZHOU | 2020 | Science China Earth Sciences2020，63，1： | 9 |
| 6 | Long term follow up of clinical outcome between patellar resurfacing and nonresurfacing in total knee arthroplasty: Chinese experience显示文摘 | Feng Bin Weng Xisheng Lin Jin Jin Jin Qian Wenwei Wang Wei Qiu Guixing | 2014 | Chinese Medical Journal2014，，22： | 7 |
| 7 | Filamin B:The next hotspot in skeletal research?显示文摘Filamin B(FLNB)is a large dimeric actin-binding protein which crosslinks actin cytoskeleton filaments into a dynamic structure.Up to present,pathogenic mutations in FLNB are solely found to cause skeleta deformities,indicating the important role of FLNB in skeletal development.FLNB-related disorders are classifiedasspondylocarpotarsalsynostosis(SCT),Larsensyndrome(LS),atelosteogenesis(AO)boomerang dysplasia(BD),and isolated congenital talipes equinovarus,presenting with scoliosis,shortlimbed dwarfism,clubfoot,joint dislocation and other unique skeletal abnormalities.Several mecha?nisms of FLNB mutations causing skeletal malformations have been proposed,including delay of ossification in long bone growth plate,reduction of bone mineral density(BMD),dysregulation of muscle differentiation,ossification of intervertebral disc(IVD),disturbance of proliferation,differentiation and apoptosis in chondrocytes,impairment of angiogenesis,and hypomotility of osteoblast,chondrocyte and fibroblast.Interventions on FLNB-related diseases require prenatal surveillance by sonography,gene testing in high-risk carriers,andproper orthosis or orthopedic surgeries to correct malformations including scoliosis,cervical spine instability,large joint dislocation,and clubfoot.Gene and cell therapies for FLNB-related diseases are also promising but require further studies. | Qiming xu Nan Wu Lijia Cui Zhihong Wu Guixing Qiu | 2017 | Journal of Genetics and Genomics2017，44，7： | 5 |
| 8 | Near-infrared spectroscopy(NIRS) evaluation and regional analysis of Chinese faba bean(Vicia faba L.)显示文摘To analyze the nutritional composition of faba bean(Vicia faba L.) seed, estimation models were developed for protein, starch, oil, and total polyphenol using near infrared spectroscopy(NIRS). Two hundred and forty-four samples from twelve producing regions were measured in both milled powder and intact seed forms. Partial least squares(PLS) regression was applied for model development. The model based on ground seed powder was generally superior to that based on the intact seed. The optimal seed powder-based models for protein, starch, and total polyphenol had coefficients of correlation(r2) of 0.97, 0.93 and 0.89, respectively. The relationship between nutrient contents and twelve producing areas was determined by two-step cluster analysis. Three distinct groupings were obtained with region-constituent features, i.e., Group 1 of high oil, Group 2 of high protein, and Group 3 of high starch as well as total polyphenol. The clustering accuracy was 79.5%. Moreover, the nutrition contents were affected by seeding date, longitude, latitude, and altitude of plant location. Cluster analysis revealed that the differences in the seed were strongly influenced by geographical factors. | Jiaojiao Wang Hao Liu Guixing Ren | 2014 | The Crop Journal2014，2，1： | 3 |
| 9 | Spatial differences in soybean bioactive components across China and their influence by weather factors显示文摘Bioactive components are partially responsible for the nutritional and health benefits of soybeans. Four major bioactive components: isoflavones, oligosaccharides, phospholipids,and saponins, were quantified in 763 soybean samples collected from widely distributed regions across China from 2010 to 2013. A majority of the tested bioactive components showed generally declining trends from the north(high latitude) to the south(low latitude).A positive relationship between total oligosaccharides(TO) and altitude was observed. Total isoflavones(TI), phospholipids(TP) and TO were negatively correlated with cumulative temperature above or equal to 15 °C(AT15) and mean daily temperature(MDT), but positively correlated with diurnal temperature range(DTR) and hours of sunshine(HS).Total saponins(TS) were negatively correlated with MDT but positively correlated with rainfall(RF), whereas TO were negatively correlated with RF. Path-coefficient analysis showed that, besides genotype differences, temperature and HS during the reproductive period influenced TI and TP contents, while temperature and RF influenced TS and TO. The effects of weather factors on soybean bioactive components in diverse regions of China were characterized. These findings will be helpful in promoting soybean production for functional food purposes. | Wenwen Song Ruping Yang Xiushi Yang Shi Sun Srinivasa Rao Mentreddy Bingjun Jiang Tingting Wu Shiyan Tian Enoch Sapey Cunxiang Wu Wensheng Hou Guixing Ren Tianfu Han | 2018 | The Crop Journal2018，6，6： | 3 |
| 10 | A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound显示文摘A novel sprayable adhesive is established(ZnMet-PF127)by the combination of a thermosensitive hydrogel(Pluronic F127,PF127)and a coordination complex of zinc and metformin(ZnMet).Here we demonstrate that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation,angiogenesis,collagen formation.Furthermore,we find that ZnMet could inhibit reactive oxygen species(ROS)production through activation of autophagy,thereby protecting cell from oxidative stress induced damage and promoting healing of skin wound.ZnMet complex exerts better effects on promoting skin wound healing than ZnCl2 or metformin alone.ZnMet complex also displays excellent antibacterial activity against Staphylococcus aureus or Escherichia coli,which could reduce the incidence of skin wound infections.Collectively,we demonstrate that sprayable PF127 could be used as a new drug delivery system for treatment of skin injury.The advantages of this sprayable system are obvious:(1)It is convenient to use;(2)The hydrogel can cover irregular skin defect sites evenly in a liquid state.In combination with this system,we establish a novel sprayable adhesive(ZnMet-PF127)and demonstrate that it is a potential clinical treatment for traumatic skin defect and burn skin injury. | Zhengwei Liu Wanze Tang Jiayi Liu Yingying Han Qinnan Yan Yuechao Dong Xiaomei Liu Dazhi Yang Guixing Ma Huiling Cao | 2023 | Bioactive Materials2023，，2： | 3 |
| 11 | Comparisons of phaseolin type and α-amylase inhibitor in common bean(Phaseolus vulgaris L.)in China显示文摘The objective of this study was to characterize the phaseolin type and a-amylase(αAI) level in common bean(Phaseolus vidgaris L.) accessions deposited in the Chinese National Genebank.The 40 accessions sampled were common varieties originating in Asia,North America,South America,Europe,and Africa.No Inca(I-) phaseolin was observed in the accessions.Only four accessions contained Tendergreen(T-) phaseolin and the remaining36 contained Sanilac(S-) phaseolin.aAI proteins extracted from nine accessions showed higher a-amylase inhibitory activity than the control(Phase 2,IC_(50) = 0.65 μg).These common bean accessions have potential use as nutraceutical ingredients. | Yang Yao Yibo Hu Yingying Zhu Yue Gao Guixing Ren | 2016 | The Crop Journal2016，4，1： | 3 |
| 12 | Variation and trends in dough rheological properties and flour quality in 330 Chinese wheat varieties显示文摘The objective of this study was to investigate variation and trends in dough rheological properties and flour quality traits in 330 Chinese wheat varieties. The dough rheological properties of development time(DT), stability time(ST), and farinograph quality number(FQN)were evaluated, as well as the flour quality traits of protein(PC), wet gluten content(WGC), and sedimentation value(SV). The coefficients of variation of DT(40.5%), ST(58.1%), and FQN(42.4%) were higher than those of PC(9.1%), WGC(10.1%), and SV(15.3%). Normal distributions were observed for the flour quality indices but not for the rheological parameters. SV was strongly correlated with the three rheological parameters and accordingly might be used as a primary indicator for dough rheological property evaluation. Our results showed that there has been marked improvement in dough rheological properties for Chinese wheat varieties released since 1986, while flour quality has remained stable. | Xiushi Yang Li Wu Zhihua Zhu Guixing Ren Sancai Liu | 2014 | The Crop Journal2014，2，4： | 2 |
| 13 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 14 | Influence of Coastal Marine Boundary Layer Jets on Rainfall in South China显示文摘Coastal marine boundary layer jets(CMBLJs)play an important role in coastal and inland rainfall in South China.Using 21 years of ERA5 and CMORPH rainfall data,two main CMBLJs are found,one on each side of Hainan Island(named BLJ-WEST and BLJ-EAST),which are always strengthened jointly.Both CMBLJs often occur in the pre-summer rainy season and exhibit an evident diurnal cycle with a maximum at night.With the emergence of the CMBLJs,rainfall is significantly enhanced in South China,particularly downstream of each CMBLJ.The response of rainfall to the CMBLJs is mainly attributed to convergence at the terminus of each CMBLJ,terrain-induced lifting,and relevant atmospheric stratification.Coastal rainfall downstream of the BLJ-WEST is much weaker than that downstream of the BLJ-EAST because of higher CIN over the Beibu Gulf,which is caused by lower temperature lapse rates and adiabatic heating in the lee of the Annamite Range.The inland rainfall increases along with CMBLJ intensity,whereas coastal rainfall reaches a maximum in the presence of moderate CMBLJs rather than stronger CMBLJs.Stronger CMBLJs induce stronger dynamic lifting but higher CIN near the coastal area.Additionally,CAPE near the coast does not become highest with strongest CMBLJs,because the CAPE generation contributed by coastal dynamic lifting can be offset by the negative contribution caused by the horizontal advection of cold and dry air from the Indochina Peninsula.Therefore,anomalous dynamic lifting,moisture flux convergence,and CAPE/CIN associated with CMBLJ intensity jointly result in anomalous rainfall. | Yu DU Yian SHEN Guixing CHEN | 2022 | Advances in Atmospheric Sciences2022，39，5： | 2 |
| 15 | Treatment of keloids by highdose-rate brachytherapy: a seven-year study显示文摘 | Guix B Henriquez I Andres A | 2001 | Int Radiat Oncol Biol Phys2001，50，1： | 1 |
| 16 | Drying of American ginseng (Panax quinquefolium) roots by microwave hot air combination 显示文摘 | REN Guixing CHEN Feng | 1998 | Journal of Food Engineering1998，35，： | 1 |
| 17 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
| 18 | Drying of american ginseng (Panax quinquefolium) roots by microwave-hot air combination显示文摘 | REN Guixing CHEN Feng | 1998 | Journal of Food Engineering1998，35，4： | 1 |
| 19 | Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression显示文摘 | Biswas S Guix M Rinehart C | 2007 | Clin Invest2007，117，5： | 1 |
| 20 | The physiology and pathophysiology of nitric oxide in the bmin显示文摘 | Guix FX Uribesalgo I Coma M | 2005 | 76(2):1262005，76，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员