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| 1 | Short and long term fate of human AMSC subcutaneously injected in mice显示文摘AIM:To study the ability of human adipose-derived mesenchymal stem cells(AMSCs)to survive over the short and long term,their biodistribution and their biosafety in vivo in tumor-prone environments.METHODS:We subcutaneously injected human AMSCs from different human donors into immunodeficient SCID mice over both short-(2 and 4 mo)and long-(17 mo)term in young,and aged tumor-prone mice.Presence of human cells was studied by immunohistochemistry and polymerase chain reaction analysis in all organs of injected mice.RESULTS:Subcutaneously injected AMSCs did not form teratomas at any time point.They did not migrate but remained at the site of injection regardless of animal age,and did not fuse with host cells in any organ examined.AMSCs survived in vivo for at least 17 mo after injection,and differentiated into fibroblasts of the subdermic connective tissue and into mature adipocytes of fat tissue,exclusively at the site of injection.CONCLUSION:Our results support the assertion that AMSC may be safe candidates for therapy when injected subcutaneously because of their long term inability to form teratomas. | Pilar López-Iglesias Alejandro Blázquez-Martínez Jorge Fernández-Delgado Javier Regadera Manuel Nistal Maria P De Miguel | 2011 | World Journal of Stem Cells2011，3，6： | 5 |
| 2 | FLAG-IDA regimen (fludarabine,cytarabine,idarubicin and G-CSF) in the treatment of patients with high-risk myeloid malignancies 显示文摘 | de la Rubia J Regadera A Martin G | 2002 | Leuk Res2002，26，8： | 1 |
| 3 | Hypothy- roidism enhances tumor invasiveness and metastasis development 显示文摘 | Martinez-Iglesias O Garcia-Silva S Regadera J | 2009 | PLoS One2009，4，7： | 1 |
| 4 | The heterogeneity of paracetamol metabolism in Gilbert's disease 显示文摘 | Esteban Rodriguez A Perez-Mateo Regadera M | 1999 | Gastroenterol Hepatol1999，22，6： | 1 |
| 5 | Effects of Probiotic Lactobacillus Casei DN-114 001 in Prevention of Radiation-Induced Diarrhea: Results From Multicenter, Randomized, Placebo-Controlled Nutritional Trial显示文摘 | Jordi Giralt José Perez Regadera Ramona Verges Jesus Romero Isabel de la Fuente Albert Biete Jesús Villoria Jose Maria Cobo Francisco Guarner | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，4： | 1 |
| 6 | FLAG-IDA regimen (fluda rabine, cytarabine, idarubicin and G- CSF) in the treatment of patients with high-risk myeloid malignancies显示文摘 | Rubia J Regadera A Martin G | 2002 | Leuk Res2002，26，8： | 1 |
| 7 | Androgen insensitivity syndrome:an immunohistochemical,ultrastructural,and morphometric study显示文摘 | Regadera J Martinez-Garcia F Paniagua R | 1999 | Arch Pathol Lab Med1999，123，3： | 1 |
| 8 | Protozoan infectinns in the male genital tract显示文摘 | Martinez-Garcia F Regadera J Mayer R | 1996 | J Urol1996，156，21： | 1 |
| 9 | Thyroid hormone receptor beta1 acts as a potent suppressor of tumor invasiveness and metastasis显示文摘 | Martínez-Iglesias O Garcia-Silva S Tenbaum S P Regadera J Larcher F Paramio J M Vennstr(o)m B Aranda A | | 0，，02： | 1 |
| 10 | Protozoan infections in the male genital tract显示文摘 | Martinez-Garcia F Regadera J Mayer R | 1996 | J Urol1996，156，2： | 1 |
| 11 | Associated Marchiafava-Bignami disease,central pontine myelinolysis and Morel laminar sclerosis:a case report显示文摘 | Regadera JF Enriquez R Morales M | 1984 | Med Clin (Barc)1984，82，： | 1 |
| 12 | Androgen receptor expression in sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis显示文摘 | Martinez-Gareia F Gonzalez-Peramato P | 2001 | J Clin Endocrinol Metab2001，86，1： | 1 |
| 13 | FLAG - IDA regimen (fludarabine, cytarabine, idarubicin and G - CSF) in the treatment of patients with high risk myeloid malignancies 显示文摘 | de - la Rubia J Regadera A Moscardo F | 2002 | leuk Res2002，26，： | 1 |
| 14 | Hypothyroidism enhances tumor invasiveness and metastasis development显示文摘 | Martinez-Iglesias O Garcia-Silva S Regadera J | | 0，，7： | 1 |
| 15 | Sustained gastrointestinal colonization and systemic dissemination by Candida albicans,Candida tropicalis and Candida parapsilosis in adult mice显示文摘 | Mellado E Cuenca-Estrella M Regadera J | 2000 | Diagn Microbiol Infect Dis2000，38，1： | 1 |
| 16 | FLAGDA regimen (fludarabine, cytarabine, idarubicin and G - CSF) in the treatment of patients with high - risk myeloid malignancies 显示文摘 | de - la Rubia J Regadera A Moscardo F | 2002 | leuk Res2002，26，8： | 1 |
| 17 | Hypothyroidism enhances tumor invasiveness and metastasis development显示文摘 | Martinez Iglesias O Garcia-Silva S Regadera J | 2009 | PLoS One2009，4，7： | 1 |
| 18 | A wound-like inflammatory aortic response in chronic portal hypertensive rats显示文摘 | Natalia de las Heras María-Angeles Aller Beatriz Martín-Fernández María Miana Sandra Ballesteros Javier Regadera Victoria Cachofeiro Jaime Arias Vicente Lahera | 2012 | Molecular Immunology2012，，2： | 1 |
| 19 | Splanchnic-aortic inflammatory axis in experimental portal hypertension显示文摘Splanchnic and systemic low-grade inflammation has been proposed to be a consequence of long-term prehepatic portal hypertension.This experimental model causes minimal alternations in the liver,thus making a more selective study possible for the pathological changes characteristic of prehepatic portal hypertension.Low-grade splanchnic inflammation after longterm triple partial portal vein ligation could be associated with liver steatosis and portal hypertensive intestinal vasculopathy.In fact,we have previously shown that prehepatic portal hypertension in the rat induces liver steatosis and changes in lipid and carbohydrate metabolism similar to those produced in chronic inflammatory conditions described in metabolic syndrome in humans.Dysbiosis and bacterial translocation in this experimental model suggest the existence of a portal hypertensive intestinal microbiome implicated in both the splanchnic and systemic alterations related to prehepatic portal hypertension.Among the systemic impairments,aortopathy characterized by oxidative stress,increased levels of proinflammatory cytokines and profibrogenic mediators stand out.In this experimental model of long-term triple portal vein ligated-rats,the abdominal aortic proinflammatory response could be attributed to oxidative stress.Thus,the increased aortic reduced-nicotinamide-adenine dinucleotide phosphate[NAD(P)H]oxidase activity could be associated with reactive oxygen species production and promote aortic inflammation.Also,oxidative stress mediated by NAD(P)H oxidase has been associated with risk factors for inflammation and atherosclerosis.The splanchnic and systemic pathology that is produced in the long term after triple partial portal vein ligation in the rat reinforces the validity of this experimental model to study the chronic low-grade inflammatory response induced by prehepatic portal hypertension. | Maria-Angeles Aller Natalia de las Heras Maria-Paz Nava Javier Regadera Jaime Arias Vicente Lahera | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 20 | Endogenous angiotensin Ⅱ and cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rots 显示文摘 | Peiro C Rodriguez AM Angulo J Regadera J Marin J Sanchez CF | 1998 | Cell Physiol Biochem1998，8，1： | 1 |
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