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| 1 | How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related?显示文摘AIM:To investigate the prevalence of gastroesophageal reflux disease(GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux(LPR).METHODS:Between May 2011 and October 2011,41 consecutive patients with laryngopharyngeal symptoms(LPS) and laryngoscopic diagnosis of LPR were empirically treated with proton pump inhibitors(PPIs) for at least 8 wk,and the therapeutic outcome was assessed through validated questionnaires(GERD impact scale,GIS;visual analogue scale,VAS).LPR diagnosis was performed by ear,nose and throat specialists using the reflux finding score(RFS) and reflux symptom index(RSI).After a 16-d wash-out from PPIs,all patients underwent an upper endoscopy,stationary esophageal manometry,24-h multichannel intraluminal impedance and pH(MII-pH) esophageal monitoring.A positive correlation between LPR diagnosis and GERD was supposed based on the presence of esophagitis(ERD),pathological acid exposure time(AET) in the absence of esophageal erosions(NERD),and a positive correlation between symptoms and refluxes(hypersensitive esophagus,HE).RESULTS:The male/female ratio was 0.52(14/27),the mean age ± SD was 51.5 ± 12.7 years,and the mean body mass index was 25.7 ± 3.4 kg/m 2.All subjects reported one or more LPS.Twenty-five out of 41 patients also had typical GERD symptoms(heartburn and/or regurgitation).The most frequent laryngoscopic findings were posterior laryngeal hyperemia(38/41),linear indentation in the medial edge of the vocal fold(31/41),vocal fold nodules(6/41) and diffuse infraglottic oedema(25/41).The GIS analysis showed that 10/41 patients reported symptom relief with PPI therapy(P < 0.05);conversely,23/41 did not report any clinical improvement.At the same time,the VAS analysis showed a significant reduction in typical GERD symptoms after PPI therapy(P < 0.001).A significant reduction in LPS symptoms.On the other hand,such result was not recorded for LPS.Esophagitis was detected in 2/41 patients,and ineffective esophageal motility was found in 3/41 patients.The MII-pH analysis showed an abnormal AET in 5/41 patients(2 ERD and 3 NERD);11/41 patients had a normal AET and a positive association between symptoms and refluxes(HE),and 25/41 patients had a normal AET and a negative association between symptoms and refluxes(no GERD patients).It is noteworthy that HE patients had a positive association with typical GERD-related symptoms.Gas refluxes were found more frequently in patients with globus(29.7 ± 3.6) and hoarseness(21.5 ± 7.4) than in patients with heartburn or regurgitation(7.8 ± 6.2).Gas refluxes were positively associated with extraesophageal symptoms(P < 0.05).Overall,no differences were found among the three groups of patients in terms of the frequency of laryngeal signs.The proximal reflux was abnormal in patients with ERD/NERD only.The differences observed by means of MII-pH analysis among the three subgroups of patients(ERD/NERD,HE,no GERD) were not demonstrated with the RSI and RFS.Moreover,only the number of gas refluxes was found to have a significant association with the RFS(P = 0.028 andP = 0.026,nominal and numerical correlation,respectively).CONCLUSION:MII-pH analysis confirmed GERD diagnosis in less than 40% of patients with previous diagnosis of LPR,most likely because of the low specificity of the laryngoscopic findings. | Nicola de Bortoli Andrea Nacci Edoardo Savarino Irene Martinucci Massimo Bellini Bruno Fattori Linda Ceccarelli Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Vincenzo Savarino Stefano Berrettini Santino Marchi | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 2 | From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting显示文摘Fecal calprotectin(FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases(IBD). Many different methods of assessment have been developed and different cutoffs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome(IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. In IBD patients a correlation with both mucosal healing and histology was found, and there is increasing evidence that FC assessment can be helpful in monitoring disease activity and response to therapy as well as in predicting relapse, post-operative recurrence or pouchitis. Recently, its use in the context of a treat-to-target approach led to a better outcome than clinically-based therapy adjustment in patients with early Crohn's disease. In conclusion, FC measurement represents a cheap, safe and reliable test, easy to perform and with a good reproducibility. The main concerns are still related to the choice of the optimal cut-off, both for differentiating IBD from IBS, and for the management of IBD patients. | Maria Gloria Mumolo Lorenzo Bertani Linda Ceccarelli Gabriella Laino Giorgia Di Fluri Eleonora Albano Gherardo Tapete Francesco Costa | 2018 | World Journal of Gastroenterology2018，24，33： | 8 |
| 3 | Acute syndesmotic injuries in ankle fractures:From diagnosis to treatment and current concepts显示文摘A stable and precise articulation of the distal tibiofibular syndesmosis maintains the tibiofibular relationship,and it is essential for normal motion of the ankle joint.The disruption of this joint is frequently accompanied by rotational ankle fracture,such as pronation-external rotation,and rarely occurs without ankle fracture.The diagnosis is not simple,and ideal management of the various presentations of syndesmotic injury remains controversial to this day.Anatomical restoration and stabilization of the disrupted tibiofibular syndesmosis is essential to improve functional outcomes.In such an injury,including inadequately treated,misdiagnosed and correctly diagnosed cases,a chronic pattern characterized by persistent ankle pain,function disability and early osteoarthritis can result.This paper reviews anatomical and biomechanical characteristics of this syndesmosis,the mechanism of its acute injury associated to fractures,radiological and arthroscopic diagnosis and surgical treatment. | Francesco Pogliacomi Massimo De Filippo Daniele Casalini Alberto Longhi Fabrizio Tacci Rocco Perotta Francesco Pagnini Silvio Tocco Francesco Ceccarelli | 2021 | World Journal of Orthopedics2021，12，5： | 3 |
| 4 | Are the Clinical and Pathological Features of Differentiated Thyroid Carcinoma Really Changed over the Last 35 Years? Study on 4187 Patients from a Single Italian Institution to Answer this Question显示文摘 | Rossella Elisei Eleonora Molinaro Laura Agate Valeria Bottici Lucio Masserini Claudia Ceccarelli Francesco Lippi Lucia Grasso Fulvio Basolo Generoso Bevilacqua Paolo Miccoli Giancarlo Di Coscio Paolo Vitti Furio Pacini Aldo Pinchera | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，4： | 1 |
| 5 | Clinically-Staged T3N0 Rectal Cancer: Is Preoperative Chemoradiotherapy the Optimal Treatment?显示文摘 | Raffaele Lombardi Dajana Cuicchi Carmine Pinto Francesca Fabio Bruno Iacopino Stefano Neri Maria Lucia Tardio Claudio Ceccarelli Ferdinando Lecce Giampaolo Ugolini Sara Pini Piergiorgio Tullio Mario Taffurelli Francesco Minni Andrea Martoni Bruno Cola | 2010 | Annals of Surgical Oncology2010，，3： | 1 |
| 6 | Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival显示文摘 | Mario Falchetti Calogero Saieva Ramona Lupi Giovanna Masala Piera Rizzolo Ines Zanna Ketty Ceccarelli Francesco Sera Renato Mariani-Costantini Gabriella Nesi Domenico Palli Laura Ottini | 2008 | Human Pathology2008，，6： | 1 |
| 7 | Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma显示文摘 | Devendra Singh Joseph Minhow Chan Pietro Zoppoli Francesco Niola Ryan Sullivan Angelica Castano Eric Minwei Liu Jonathan Reichel Paola Porrati Serena Pellegatta Kunlong Qiu Zhibo Gao Michele Ceccarelli Riccardo Riccardi Daniel J. Brat Abhijit Guha Ken Ald | 2012 | Science2012，，6099： | 1 |
| 8 | Deep reinforcement learning for quantum multiparameter estimation显示文摘Estimation of physical quantities is at the core of most scientific research,and the use of quantum devices promises to enhance its performances.In real scenarios,it is fundamental to consider that resources are limited,and Bayesian adaptive estimation represents a powerful approach to efficiently allocate,during the estimation process,all the available resources.However,this framework relies on the precise knowledge of the system model,retrieved with a fine calibration,with results that are often computationally and experimentally demanding.We introduce a model-free and deep-learning-based approach to efficiently implement realistic Bayesian quantum metrology tasks accomplishing all the relevant challenges,without relying on any a priori knowledge of the system.To overcome this need,a neural network is trained directly on experimental data to learn the multiparameter Bayesian update.Then the system is set at its optimal working point through feedback provided by a reinforcement learning algorithm trained to reconstruct and enhance experiment heuristics of the investigated quantum sensor.Notably,we prove experimentally the achievement of higher estimation performances than standard methods,demonstrating the strength of the combination of these two black-box algorithms on an integrated photonic circuit.Our work represents an important step toward fully artificial intelligence-based quantum metrology. | Valeria Cimini Mauro Valeri Emanuele Polino Simone Piacentini Francesco Ceccarelli Giacomo Corrielli NicolòSpagnolo Roberto Osellame Fabio Sciarrino | 2023 | Advanced Photonics2023，5，1： | 0 |
| 9 | 树脂粘结固定局部义齿:10年随访显示文摘目的评估从1993-2003年期间,在托里诺大学修复科及几个私人门诊制作的树脂粘结固定局部义齿的生存率。
材料和方法整个分析包括以下变量:基牙的预备,制作粘结固定局部义齿的合金的种类,金属粘结界面的处理和预备,粘结时的隔湿方法,粘结剂的种类,修复体类型,基牙数目,修复体中包含的缺失牙的数目。
结果以第1次脱粘结或失败为准,所测量的五年生存率是85%,10年生存率是71%。
结论在修复体粘结时使用橡皮障会减少脱粘结的危险性,而其它的参数对生存率的影响没有差别。 | Guido Audenino Gianni Giannella Gian Marco Morello Manuela Ceccarelli Stefano Carossa Francesco Bassi 杨坚(译) 冯海兰(校) | 2007 | 中国口腔医学继续教育杂志2007，10，3： | 0 |
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