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| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 3 | Recipient Interleukin-28B Rs12979860 C/T Polymorphism and Acute Cellular Rejection After Liver Transplantation: Role of the Calcineurin Inhibitor Used显示文摘 | Davide Bitetto Carlo Fabris Edmondo Falleti Ezio Fornasiere Claudio Avellini Sara Cmet Annarosa Cussigh Elisabetta Fontanini Mario Pirisi Stefano Ginanni Corradini Manuela Merli Antonio Molinaro Pierluigi Toniutto | 2012 | Transplantation Journal2012，，10： | 2 |
| 4 | High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer显示文摘 | Sriparna Ghosh Catherine A.W. Sullivan Maciej P. Zerkowski Annette M. Molinaro David L. Rimm Robert L. Camp Gina G. Chung | 2008 | Human Pathology2008，，12： | 2 |
| 5 | Call admission control and resource management issues for real-time VBR traffic in ATM-satellite networks 显示文摘 | Iera A Molinaro A Marano S | 2000 | IEEE J Select Areas Commun2000，18，11： | 1 |
| 6 | Expertise and peripheral autonomic activity during the preparation phase in shooting events 显示文摘 | Guillot A Collet C Molinaro C | 2004 | Percept Mot Skills2004，98，2： | 1 |
| 7 | Characteris- tics associated with recurrence among women with ductal carcinoma in situ treated by lumpectomy显示文摘 | KERLIKOWSKE K MOLINARO A CHA I | 2003 | J Natl Cancer Inst2003，95，22： | 1 |
| 8 | Postoperative bowel obstruction after laparoscopic and open appendectomy in children: a 15-year experience 显示文摘 | Kaselas C Molinaro F Lacreuse I Becmeur F | 2009 | J Pediatr Surg2009，44，8： | 1 |
| 9 | Tissue Kallikrein Actions at the Rabbit Natural or Recombinant Kinin B2 Receptors显示文摘 | Houle S Molinaro G Adam A | 2003 | Hypertension(S0194- 911X)2003，41，3： | 1 |
| 10 | Traffic management techniques to face the effects of intrinsic delays in geostationary satellite networks 显示文摘 | Iera A Molinaro A Marano S | 2002 | IEEE Trans on Wireless Communications2002，1，1： | 1 |
| 11 | Haloperidol-loaded in- tranasally administered lectin functionalized poly (ethylene glycol )-block-poly ( d, 1 )-lactic-co-glycolic acid ( PEG-PL- GA) nanoparticles for the treatment of schizophrenia显示文摘 | Piazza J Hoare T Molinaro L | 2014 | Eur J Pharm Biopharm2014，87，1： | 1 |
| 12 | The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with gliomadagger显示文摘 | Lupo JM Molinaro AM Essock-Burns E | 2015 | Neuro Oncol2015，34，4： | 1 |
| 13 | An algorithm for finding the zero crossing of time signals with Lipschitzean derivatives显示文摘 | Daponte P Grimaldi D Molinaro A | 1995 | Measurement1995，16，1： | 1 |
| 14 | Association between increased mortality and mild thyroid dysfunction in cardiac patients 显示文摘 | IERVASI G MOLINARO S LANDI P | 2007 | Arch Intern Med2007，167，14： | 1 |
| 15 | Ectopic pregnancies in unusual loca- tions 显示文摘 | Molinaro TA Barnhart KT | 2007 | Semin Reprod Med2007，25，2： | 1 |
| 16 | Call admission control and resource management issues for real-time VBR traffic in ATM-satellite networks显示文摘 | IERA A MOLINARO A MARANO S | 2000 | IEEE Journal on Selected Areas in Communications2000，18，11： | 1 |
| 17 | Neolignans from arum italicum显示文摘 | Greca M D Molinaro A Monaco P | 1994 | Phytochemistry1994，35，3： | 1 |
| 18 | Aerospace communications for emergency applications显示文摘 | Berioli M Molinaro A Morosi S | | 0，，11： | 1 |
| 19 | Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis显示文摘 | Kerlikowske K Molinaro AM Gauthier ML | 2010 | J Natl Cancer Inst2010，102，9： | 1 |
| 20 | Priming,Induction and Modulation of Plant Defence Responses by Bacterial Lipopolysaccharides显示文摘 | NEWMAN M A DOW J M MOLINARO A | 2007 | J Endotoxin Res2007，13，2： | 1 |
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