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| 1 | Biliary complications after liver transplantation:current perspectives and future strategies显示文摘Importance:Liver transplantation(LT)is a life-saving therapy for patients with end-stage liver disease and with acute liver failure,and it is associated with excellent outcomes and survival rates at 1 and 5 years.The incidence of biliary complications(BCs)after LT is reported to range from 5%to 20%,most of them occurring in the first three months,although they can occur also several years after transplantation.Objective:The aim of this review is to summarize the available evidences on pathophysiology,risk factors,diagnosis and therapeutic management of BCs after LT.Evidence Review:a literature review was performed of papers on this topic focusing on risk factors,classifications,diagnosis and treatment Findings:Principal risk factors include surgical techniques and donor’s characteristics for biliary leakage and anastomotic biliary strictures and vascular alterations for non-anastomotic biliary strictures.MRCP is the gold standard both for intra-and extrahepatic BCs,while invasive cholangiography should be restricted for therapeutic uses or when MRCP is equivocal.About treatment,endoscopic techniques are the first line of treatment with success rates of 70-100%.The combined success rate of ERCP and PTBD overcome 90%of cases.Biliary leaks often resolve spontaneously,or with the positioning of a stent in ERCP for major bile leaks Conclusions and Relevance:BCs influence morbidity and mortality after LT,therefore further evidences are needed to identify novel possible risk factors,to understand if an immunological status that could lead to their development exists and to compare the effectiveness of innovative surgical and machine perfusion techniques. | Bianca Magro Matteo Tacelli Alessandra Mazzola Filomena Conti Ciro Celsa | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 12 |
| 2 | In Vitro Effects of Cyclosporine A and Tacrolimus on Regulatory T-Cell Proliferation and Function显示文摘 | Céline Miroux Olivier Morales Khaldoun Ghazal Samia Ben Othman Yvan de Launoit Véronique Pancré Filomena Conti Nadira Delhem | 2012 | Transplantation Journal2012，，2： | 2 |
| 3 | Liver transplantation using grafts with rare metabolic disorders显示文摘 | Astrid Schielke Filomena Conti Claire Goumard Fabiano Perdigao Yvon Calmus Olivier Scatton | 2014 | Digestive and Liver Disease2014，，： | 1 |
| 4 | COVID-19 in a liver transplant recipient:Could iatrogenic immunosuppression have prevented severe pneumonia?A case report显示文摘BACKGROUND Coronavirus disease(COVID)is a new and highly contagious infectious disease caused by the coronavirus(COVID-19 or severe acute respiratory syndrome coronavirus 2).There is limited data regarding the incidence and management of COVID-19 in immunocompromised patients’post-transplantation.In the pre-COVID-19 era,these patients were already at an increased risk of developing opportunistic infections.These often manifested with atypical symptoms.CASE SUMMARY We report another case of uneventful COVID-19 pneumonia in a 58-year old male who was 18 mo’post liver transplantation.He received tacrolimus monotherapy since July 2019.The clinical manifestations included only epigastric pain radiating to the right hypochondrium,nausea and vomiting.He had no fevers,cough,shortness of breath,anosmia or dysgeusia even if the chest computed tomography scan revealed an extension of the multiple patchy ground-glass density shadows to the upper lobe of the left lung too.He was hospitalised and received a course of oral chloroquine(200 mg×3 per day)for a period of 10 d.Interestingly,the COVID 19 infection was uneventful though there were no modifications to his tacrolimus dosing.He was successfully discharged.We performed subsequent follow-up via telemedicine.CONCLUSION In light of the current pandemic,it is even more important to identify how the liver recipient’s patients present and are managed,especially for immunosuppression treatment. | Anna Sessa Alessandra Mazzola Chetana Lim Mohammed Atif Juliana Pappatella Valerie Pourcher Olivier Scatton Filomena Conti | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
| 5 | Severe fibrosis in patients with recurrent hepatitis C after liver transplantation: A French experience on 250 patients over 15 years (the Orfèvre study)显示文摘 | Jér?me Dumortier Ephrem Salamé Bruno Roche Monika Hurtova Filomena Conti Sylvie Radenne Claire Vanlemmens Georges-Philippe Pageaux Faouzi Saliba Didier Samuel Philippe Compagnon Martine Neau-Cransac Yvon Calmus Olivier Guillaud Jean Gugenheim Mario Altier | 2014 | Clinics and Research in Hepatology and Gastroenterology2014，，： | 1 |
| 6 | Variability in Free Mycophenolic Acid Exposure in Adult Liver Transplant Recipients During the Early Posttransplantation Period显示文摘 | Anne Sophie Benichou Benoit Blanchet Filomena Conti Maryline Hornecker Denis Bernard Fabrice Taieb Olivier Scatton Halim Abbas Laura Harcouet Alain Dauphin Yvon Calmus Michel Tod | 2010 | Journal of Clinical Pharmacology2010，，10： | 1 |
| 7 | Factors Associated With Chronic Hepatitis in Patients With Hepatitis E Virus Infection Who Have Received Solid Organ Transplants显示文摘 | Nassim Kamar Cyril Garrouste Elizabeth B. Haagsma Valérie Garrigue Sven Pischke Cécile Chauvet Jérome Dumortier Amélie Cannesson Elisabeth Cassuto–Viguier Eric Thervet Filomena Conti Pascal Lebray Harry R. Dalton Robert Santella Nada Kanaan Marie Essig Ch | 2011 | Gastroenterology2011，，5： | 1 |
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