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| 1 | High tacrolimus intra-patient variability is associated with graft rejection,and de novo donor-specific antibodies occurrence after liver transplantation显示文摘AIM To investigate the role of tacrolimus intra-patient variability(IPV) in adult liver-transplant recipients.METHODS We retrospectively assessed tacrolimus variability in a cohort of liver-transplant recipients and analyzed its effect on the occurrence of graft rejection and de novo donor-specific antibodies(dn DSAs), as well as graft survival during the first 2 years posttransplantation. Between 02/08 and 06/2015, 116 patients that received tacrolimus plus mycophenolate mofetil(with or without steroids) were included. RESULTS Twenty-two patients(18.5%) experienced at least one acute-rejection episode(BPAR). Predictive factors for a BPAR were a tacrolimus IPV of > 35% [OR = 3.07 95%CI(1.14-8.24), P = 0.03] or > 40% [OR = 4.16(1.38-12.50), P = 0.01), and a tacrolimus trough level of < 5 ng/mL [OR=3.68(1.3-10.4), P =0.014]. Thirteen patients(11.2%) developed at least one dn DSA during the follow-up. Tacrolimus IPV [coded as a continuous variable: OR = 1.1, 95%CI(1.0-1.12), P = 0.006] of > 35% [OR = 4.83, 95%CI(1.39-16.72), P = 0.01] and > 40% [OR = 9.73, 95%CI(2.65-35.76), P = 0.001] were identified as predictors to detect dn DSAs. IPV did not impact on patient-or graft-survival rates during the follow-up. CONCLUSION Tacrolimus-IPV could be a useful tool to identify patients with a greater risk of graft rejection and of developing a de novo DSA after liver | Arnaud Del Bello Nicolas Congy-Jolivet Marie Danjoux Fabrice Muscari Laurence Lavayssière Laure Esposito Anne-Laure Hebral Julie Bellière Nassim Kamar | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 2 | Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation显示文摘Acute humoral rejection (AHR) is uncommon after ABO-compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specif ic antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. She was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Liver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. She was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Liver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy. | Nassim Kamar Laurence Lavayssière Fabrice Muscari Janick Selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 3 | Crystallographically Selective Nanopatterning of Graphene on SiO_(2)显示文摘Graphene has many advantageous properties,but its lack of an electronic band gap makes this two-dimensional material impractical for many nanoelectronic applications,for example,field-effect transistors.This problem can be circumvented by opening up a confinement-induced gap,through the patterning of graphene into ribbons having widths of a few nanometres.The electronic properties of such ribbons depend on both their size and the crystallographic orientation of the ribbon edges.Therefore,etching processes that are able to differentiate between the zigzag and armchair type edge terminations of graphene are highly sought after.In this contribution we show that such an anisotropic,dry etching reaction is possible and we use it to obtain graphene ribbons with zigzag edges.We demonstrate that the starting positions for the carbon removal reaction can be tailored at will with precision. | Péter Nemes-Incze Gábor Magda Katalin Kamarás LászlóPéter Biró | 2010 | Nano Research2010，3，2： | 4 |
| 4 | 经皮椎体成形联合125I粒子植入术治疗胸椎转移瘤合并椎体后缘缺损患者的疗效和安全性显示文摘目的分析经皮椎体成形联合125I粒子植入术(PVPI)治疗胸椎转移瘤合并椎体后缘缺损患者的安全性和有效性。方法回顾性分析2017年11月至2019年5月云南省肿瘤医院收治的64例胸椎转移瘤患者的临床资料,其中椎体后缘缺损者(研究组)32例,无椎体后缘缺损者(对照组)32例。对PVPI手术关键技术进行改良,采用二次封堵法和斜面穿刺针推注骨水泥旋转填充技术减少渗漏,治疗研究组32例患者的42节椎体。32例对照组患者的54节椎体行PVPI手术。分别于术后第2天、1个月、3个月和6个月对两组患者进行随访,比较两组患者的近期疗效、远期疗效和安全性等指标。结果64例患者均顺利完成手术治疗,研究组和对照组患者的视觉模拟评分、卡氏功能状态评分在术后第2天、1个月、3个月和6个月均较术前得到不同程度地改善,两组差异均无统计学意义(均P>0.05)。研究组和对照组患者的骨水泥量分别为(2.36±0.20)ml和(2.39±0.17)ml,差异无统计学意义(P=0.482);125I粒子植入量分别为(30.63±0.91)个和(32.56±0.68)个,差异无统计学意义(P=0.925)。研究组和对照组患者的部分缓解率分别为81.3%和87.5%,疾病稳定率分别为12.5%和9.4%,差异无统计学意义((均P>0.05)。研究组患者的中位总生存时间(OS)为13.0个月,中位无进展生存时间(PFS)为8.0个月;对照组患者的中位OS为14.0个月,中位PFS为8.0个月,差异均无统计学意义(均P>0.05)。研究组患者共有6节(14.3%)椎体出现骨水泥渗漏,其中2节(4.8%)为椎管内渗漏,4节(9.5%)为椎旁骨水泥渗漏。对照组患者共出现7节(13.0%)椎旁骨水泥渗漏。两组患者骨水泥渗漏情况的差异无统计学意义(P=0.097)。两组患者的骨水泥渗漏均未造成脊髓损伤等严重并发症。结论应用PVPI治疗椎体后缘缺损的胸椎转移瘤患者,只要进行术中技术改良,注意控制骨水泥分布等问题,仍能获得较好的临床疗效和安全性。 | 王体颖 杨祚璋 陈家会 柳艳 Santosh Kamar 陈秋云 袁涛 杨兴海 张晶 王操 Surendra Parsad Yadav Shrijan Shrestha 杨义豪 李东奇 | 2020 | 中华肿瘤杂志2020，42，12： | 2 |
| 5 | Hepatitis E显示文摘 | Nassim Kamar Richard Bendall Florence Legrand-Abravanel Ning-Shao Xia Samreen Ijaz Jacques Izopet Harry R Dalton | 2012 | The Lancet2012，，9835： | 2 |
| 6 | Hepatitis E in developed countries: current status and future perspectives显示文摘 | Dalton Harry R Kamar Nassim Izopet Jacques | 2014 | Future Microbiology2014，，12： | 2 |
| 7 | Hepatitis E virus and chronic hepatitis in organ-transplant recipients显示文摘 | Kamar N Selves J Mansuy JM | 2008 | New Engl J Med2008，358，8： | 1 |
| 8 | The effect of aging on the shape of the proximal femur显示文摘 | Noble PC Box GG Kamaric E | 1995 | Clin Orthop Relat Res1995，，316： | 1 |
| 9 | Three-dimensional shape of the dysplastic femur: implications for THR 显示文摘 | Noble PC Kamaric E Sugano N | 2003 | Clin Orthop Relat Res2003，，417： | 1 |
| 10 | Long- term results of conversion from calcineurin inhibitors to sirolimus in 150 maintenance kidney transplant patients 显示文摘 | GARROUSTE C KAMAR N GUILBEAU FRUGIER C | 2012 | Exp Clin Transplant2012，10，2： | 1 |
| 11 | Long-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus 显示文摘 | Bumbea V Kamar N Ribes D | 2005 | Nephrol Dial Transplant2005，20，11： | 1 |
| 12 | Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection 显示文摘 | Kamar N Rostaing L Abravanel F | 2010 | Gastroenterology2010，139，5： | 1 |
| 13 | Developing and validating trust measures for E - -commerce: An integrative typology 显示文摘 | MCKNIGHT D H CCHOUDHURY V KAMAR C | 2002 | Information Systems Research2002，13，3： | 1 |
| 14 | The effect of angiotensin - converting enzyme inhibitors on the progression of chronic renal failure 显示文摘 | BERNADET MONROZIES P ROSTAINING L KAMAR N | 2002 | Presse Med2002，31，36： | 1 |
| 15 | Long-term results in renal transplant patients with allcgraft dysfunction after switching from calcineurin inhibitors to sirolimus显示文摘 | Bumbea V Kamar N Ribes D et aI | | 0，，11： | 1 |
| 16 | Predictive factors for posttransplant diabetes mellitus within one-year of liver transplantation 显示文摘 | Oufroukhi L Kamar N Muscari F | 2008 | Transplantation2008，85，10： | 1 |
| 17 | Hepatitis E virus - related cirrhosis in kidney- and kidney- pancreas- transplant recipients 显示文摘 | Kamar N Mansuy J M Cointault O | 2008 | Am J Transplant2008，8，8： | 1 |
| 18 | Three-month pegylated interferon-alpha-2a therapy for chronic hepatitis E virus infection in a haemodialysis patient 显示文摘 | Kamar N Abravanel F Garrouste C | 2010 | Nephrol Dial Transplant2010，25，8： | 1 |
| 19 | NMR structural characterization of substrates bound to N-acetylglucosaminyltransferase V显示文摘 | Macnaughtan M A Kamar M Alvarez-Manilla G | 2007 | J Mol Biol2007，366，： | 1 |
| 20 | Hepatitis E 显示文摘 | Kamar N Bendall R Legrand AF | 2012 | Lan- cet2012，379，9835： | 1 |
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