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| 1 | One-step generation of knockout pigs by zygote injection of CRISPR/Cas system显示文摘 | Tang Hai Fei Teng Runfa Guo Wei Li Qi Zhou | 2014 | Cell Research2014，24，3： | 131 |
| 2 | Current pattern of Chinese dialysis units: a cohort study in a representative sample of units显示文摘 | ZHOU Qiu-gen JIANG Jian-ping WU Sheng-jie TIAN Jian-wei CHEN Jiang-hua YU Xue-qing CHEN Ping-yan MEI Chang-lin XIONG Fei SHI Wei ZHOU Wei LIU Xu-sheng SUN Shi-ren XIE Di LIU Jun XU Xin HOU Fan-fan | 2012 | Chinese Medical Journal2012，，19： | 69 |
| 3 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 4 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 5 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 6 | Oral health status in Sichuan Province: findings from the oral health survey of Sichuan, 2015–2016显示文摘To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3–5 years,adolescents aged 12 years, and people aged 65–74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0.86 and 5.13, respectively, resulting in a prevalence of 63.47%, 37.20% and 83.20%, respectively.Relative to the high rate of decayed teeth, the prevalence of fillings was very low in all age groups(0.97%, 7.24% and 5.43%,respectively). In the 12-year-old adolescent group, only 3.61% had good pit and fissure sealing. In addition, the rate of dental fluorosis was 24.80%, and the Community Fluorosis Index value was 0.39. In the elder group, the community periodontal index was2.92. The prevalence in the elderly of having lost at least one tooth was 75.54%. Additionally, 4.44% of these participants were edentulous. The incidence of dental prosthesis was 51.75%, the proportion with a removable partial denture, a fixed denture, full dentures, dental implants and an informal fixed bridge was 21.59%, 11.45%, 4.64%, 0 and 16.67%, respectively. In this study,8.2% of the elderly participants were affected by different types of oral mucosal lesions. Among such lesions, recurrent aphthous ulcers were most prevalent(2.69%) and oral lichen planuses were second(1.6%). The conclusion presented in this survey is that oral diseases, especially dental caries and periodontal disease, are frequent and common in Sichuan province, China. Moreover, the treatment rate is very low, and primary prevention and treatment options are therefore urgently needed in this population. | Wei Yin Ying-Ming Yang Hong Chen Xue Li Zhuo Wang Li Cheng Qiu-Dan Yin Hong-Zhi Fang Wei Fei Fang-Lin Mi Min-Hai Nie Tao Hu Xue-Dong Zhou | 2017 | International Journal of Oral Science2017，9，1： | 30 |
| 7 | Eco-toxicity of petroleum hydrocarbon contaminated soil显示文摘Total petroleum hydrocarbons (TPH) contaminated soil samples were collected from Shengli Oilfield of China. Toxicity analysis was carried out based on earthworm acute toxicity, plant growth experiment and luminescent bacteria test. The soil was contaminated by-petroleum hydrogcarbons with TPH concentration of 10.57%. With lethal and sub-lethal rate as endpoint, earthworm test showed that the LD 50 (lethal dose 50%) values in 4 and 7 days were 1.45% and 1.37% respectively, and the inhibition rate of earthworm body weight increased with higher oil concentration. TPH pollution in the soil inhibited seed germination in both wheat and maize experiment when the concentration of petroleum was higher than 0.1%. The EC 50 (effective concentration 50%) for germination is 3.04% and 2.86% in maize and wheat, respectively. While lower value of EC 50 for root elongation was to be 1.11% and 1.64% in maize and wheat, respectively, suggesting higher sensitivity of root elongation on petroleum contamination in the soil. The EC 50 value in luminescent bacteria test was 0.47% for petroleum in the contaminated soil. From the experiment result, it was concluded that TPH content of 1.5% is considered to be a critical value for plant growth and living of earthworm and 0.5% will affect the activity of luminescent bacteria. | Jingchun Tang Min Wang Fei Wang Qing Sun Qixing Zhou | 2011 | Journal of Environmental Sciences2011，23，5： | 26 |
| 8 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 9 | Magnifying narrow-band imaging endoscopy is superior in diagnosis of early gastric cancer显示文摘AIM:To evaluate the diagnostic effectiveness of white light endoscopy,magnifying endoscopy(ME),and magnifying narrow-band imaging endoscopy(ME-NBI) in detecting early gastric cancer(EGC).METHODS:From March 2010 to June 2012,a total of 3616 patients received screening for gastric cancer by magnifying endoscopy. There were 3675 focal gastric lesions detected using conventional high definition white light endoscopy(HD-WLE) in four different referentialhospitals that were recruited for further investigation using ME and ME-NBI. The images obtained from HD-WLE,ME,and ME-NBI were reviewed by four experienced endoscopists to evaluate their diagnostic effectiveness for EGC. The diagnosis of cancerous and non-cancerous lesions was conducted by evaluating the microvascular and microsurface patterns using the VS classification system. The final endoscopic diagnosis of each lesion was determined by consultation when a disagreement occurred. We used histopathological results as the gold standard for the diagnosis of EGC.RESULTS:Among the 3675 lesions found,1508 were validated by pathological findings as chronic gastritis,1279 as chronic gastritis with intestinal metaplasia,631 as low-grade neoplasia,and 257 as EGC. The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of HD-WLE for the diagnosis of EGC were 71.2%,99.1%,85.5%,97.9% and 97.1%,respectively. The results of ME for diagnosing EGC were 81.3%,98.8%,83.3%,98.6% and 97.6%,respectively. The results of ME-NBI for the diagnosis of EGC were 87.2%,98.6%,82.1%,99.0% and 97.8%,respectively. The diagnostic sensitivity and accuracy of paired ME and ME-NBI were significantly better than those of HD-WLE(P < 0.05).CONCLUSION:HD-WLE has a relatively high accuracy for diagnosing EGC and is an effective screening tool. Further investigations of ME and ME-NBI are required to achieve superior accuracy. | Hang Yu Ai-Ming Yang Xing-Hua Lu Wei-Xun Zhou Fang Yao Gui-Jun Fei Tao Guo Li-Qing Yao Li-Ping He Bang-Mao Wang | 2015 | World Journal of Gastroenterology2015，21，30： | 26 |
| 10 | Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus显示文摘By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. | Haiyang Yu Yuwei Zhao Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，4： | 25 |
| 11 | 电针和经皮穴位电刺激技术在生殖医学中的应用:专家共识(英文)显示文摘本文从传统针刺治疗不孕症的选穴依据与现代电针/经皮穴位电刺激技术的相关原理着手,从最优刺激参数选择、穴位辨证、疗程与治疗次数的确定及基本原理等方面阐述了电针/经皮穴位电刺激技术在多囊卵巢综合症、取卵镇痛、卵巢储备功能降低、胚胎移植以及男性少/弱精症等生殖领域中的具体应用。首次对电针/经皮穴位电刺激技术在生殖领域优势病种中的应用进行了系统的分析和总结,在最优刺激参数选择、穴位辨证、疗程与治疗次数的确定等方面提出了一系列专家共识,并为临床实践提供了指导意见和理论依据。 | Fan QU Rong LI Wei SUN Ge LIN Rong ZHANG Jing YANG Li TIAN Guo-gang XING Hui JIANG Fei GONG Xiao-yan LIANG Yan MENG Jia-yin LIU Li-ying ZHOU Shu-yu WANG Yan WU Yi-jing HE Jia-yu YE Song-ping HAN Ji-sheng HAN | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 24 |
| 12 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 13 | Incidence and predictors of radial artery spasm during transradial coronary angiography and intervention显示文摘背景光线的动脉痉挛(地岬) 是在 transradial 的最普通的复杂并发症冠的 angiography 和干预。在这研究,我们设计了用汉语在 transradial 过程期间调查地岬的发生,通过多重回归发现独立预言者,并且分析在后续期间的地岬的临床的效果。方法病人安排了收到 transradial 冠的 angiography 和干预连续地被注册。地岬的发生被记录。Univariate 分析被执行发现地岬的影响因素,并且逻辑回归分析被执行发现地岬的独立预言者。病人被要求 1 个月以后为对地岬的发生是的光线的 access.Results 的评价回来(112/1427 )7.8% 在所有病人收到了 transradial 过程。 Univariate 分析显示那幼仔( P=0.038 ),女性( P=0.026 ),光线的动脉的小直径( P < 0.001 ),糖尿病( P=0.026 ),吸烟( P=0.019 ),中等或严重的疼痛在光线的动脉管子期间( P < 0.001 ),失败起初存取尝试( P=0.002 ),大鞘( P=0.004 ),导管的数字(> 3 )( P=0.048 ),快速的基线心率( P=0.032 )和长操作时间( P=0.021 )与地岬被联系。逻辑回归给那女性看了(OR=1.745, 95% CI:1.148-3.846, P=0.024 ) ,小光线的动脉直径(OR=4.028, 95%CI:1.264-12.196, P=0.008 ) ,糖尿病(OR= 2.148, 95%CI:1.579-7.458, P=0.019 ) 并且失败的存取起初尝试(OR=1.468, 95%CI:1.212-2.591, P=0.032 ) 是地岬的独立预言者。后续在(28 慥?? | JIA De-an ZHOU Yu-jie SHI Dong-mei LIU Yu-yang WANG Jian-long LIU Xiao-li WANG Zhi-jian YANG Shi-wei GE Hai-long HU Bin YAN Zhen-xian CHEN Yi GAO Fei | 2010 | Chinese Medical Journal2010，，7： | 21 |
| 14 | The cutting-edge progress of immune-checkpoint blockade in lung cancer显示文摘Great advances in immune checkpoint blockade have resulted in a paradigm shift in patients with lung cancer.Immune-checkpoint inhibitor(ICI)treatment,either as monotherapy or combination therapy,has been established as the standard of care for patients with locally advanced/metastatic non-small cell lung cancer without EGFR/ALK alterations or extensive-stage small cell lung cancer.An increasing number of clinical trials are also ongoing to further investigate the role of ICIs in patients with early-stage lung cancer as neoadjuvant or adjuvant therapy.Although PD-L1 expression and tumor mutational burden have been widely studied for patient selection,both of these biomarkers are imperfect.Due to the complex cancer-immune interactions among tumor cells,the tumor microenvironment and host immunity,collaborative efforts are needed to establish a multidimensional immunogram to integrate complementary predictive biomarkers for personalized immunotherapy.Furthermore,as a result of the wide use of ICIs,managing acquired resistance to ICI treatment remains an inevitable challenge.A deeper understanding of the underlying biological mechanisms of acquired resistance to ICIs is helpful to overcome these obstacles.In this review,we describe the cutting-edge progress made in patients with lung cancer,the optimal duration of ICI treatment,ICIs in some special populations,the unique response patterns during ICI treatment,the emerging predictive biomarkers,and our understanding of primary and acquired resistance mechanisms to ICI treatment. | Fei Zhou Meng Qiao Caicun Zhou | 2021 | Cellular & Molecular Immunology2021，18，2： | 21 |
| 15 | Biological markers as predictive factors of response to neoadjuvant taxanes and anthracycline chemotherapy in breast carcinoma显示文摘背景:Neoadjuvant 化疗为潜在的预兆的因素的评估提供一个优秀模型。这研究的目的是在与 neoadjuvant taxane 和 anthracycline 化疗对待的乳癌病人评估不同生物因素的预兆的价值。方法:与 neoadjuvant taxanes 和 anthracycline 的 4 个周期对待的 135 个病人在这回顾的研究被包括。用预告的处理活体检视材料,免疫组织化学的研究为雌激素受体被执行(嗯) ,孕酮受体(PgR ) , HER-2, Ki-67 和 p53 蛋白质表示。在生物标记和临床、病理学的完全的反应(pCR ) 之中的协会被分析。结果:全面临床的反应是 86% ,包括 33% 临床的完全的反应(cCR ) 和 53% 临床的部分反应。pCR 只是 17% 。在 univariate 分析,仅仅在表示上的 HER-2 到 neoadjuvant 化疗(P=0.018 ) 的 cCR 是预兆的。在另外的生物因素和 cCR 之间的重要协会都没被发现。缺席嗯, PgR 表示并且 pCR 在 HER-2 的表示上是预兆的(P=0.002, 0.001, 0.01,分别地) 。Ki-67 和 p53 没能与 pCR 显示出一个协会。在里面多变量分析,在在预言 cCR (P=0.021 ) 作为一个独立变量仍然是的 HER-2 的表示上。然而,否定嗯是在预言 pCR (P=0.001 ) 维持了统计意义的唯一的参数。结论:病人与在 HER-2 和否定神经质的受体的表示上,地位是更可能的与相反的特征比那些对 neoadjuvant taxane 和 anthracycline 化疗作出回应。这些因素能为这政体用作预兆的标记。 | ZHOU Bo YANG De-qi XIE Fei | 2008 | Chinese Medical Journal2008，，5： | 20 |
| 16 | Immunosuppressive exosomes from TGF-pl gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells显示文摘 | Zhijian Cai Wei Zhang Fei Yang Lei Yu Zhou Yu JihHung Pan Lie Wang Xuetao Cao Jianli Wang | 2012 | Cell Research2012，22，3： | 20 |
| 17 | A Review of Seasonal Climate Prediction Research in China显示文摘The ultimate goal of climate research is to produce climate predictions on various time scales. In China, efforts to predict the climate started in the 1930 s. Experimental operational climate forecasts have been performed since the late 1950 s,based on historical analog circulation patterns. However, due to the inherent complexity of climate variability, the forecasts produced at that time were fairly inaccurate. Only from the late 1980 s has seasonal climate prediction experienced substantial progress, when the Tropical Ocean and Global Atmosphere project of the World Climate Research program(WCRP) was launched. This paper, following a brief description of the history of seasonal climate prediction research, provides an overview of these studies in China. Processes and factors associated with the climate variability and predictability are discussed based on the literature published by Chinese scientists. These studies in China mirror aspects of the climate research effort made in other parts of the world over the past several decades, and are particularly associated with monsoon research in East Asia. As the climate warms, climate extremes, their frequency, and intensity are projected to change, with a large possibility that they will increase. Thus, seasonal climate prediction is even more important for China in order to effectively mitigate disasters produced by climate extremes, such as frequent floods, droughts, and the heavy frozen rain events of South China. | WANG Huijun FAN Ke SUN Jianqi LI Shuanglin LIN Zhaohui ZHOU Guangqing CHEN Lijuan LANG Xianmei LI Fang ZHU Yali CHEN Hong ZHENG Fei | 2015 | Advances in Atmospheric Sciences2015，32，2： | 20 |
| 18 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 19 | Impact of CYP2C19 polymorphism and smoking on response to clopidogrel in patients with stable coronary artery disease显示文摘有阿司匹林和 clopidogrel 的背景双反血小板治疗是为经历经皮的冠的干预(一种总线标准) 阻止 thrombotic 事件的病人的确定的基础。现在的学习被进行检验 CYP2C19 681GA 多型性并且香烟吸烟是否在由于稳定的心绞痛经历选任的冠的 stent 放置的 722 个中国汉病人之中在对 clopidogrel.Methods 的反应上有独立或交互的效果, 300 mg clopidogrel 的装载剂量被给所有病人和 75 mg 的每日的维护剂量最少 12 个月。CYP2C19 681GA 多型性是 genotyped。血小板反应被轻发射度 aggregometry (LTA ) 与导致的 5 mol/L 腺苷 diphosphate (自动数据处理) 测量。差的反应被定义为 10% 或少些在在装载结果显示出的 clopidogrel.Results 的剂量以后的基线和 24 个小时的聚集之间的绝对差别对 clopidogrel 差反应在 105 个病人(14.5%) 被介绍。总的来说,遗传型 GA/AA 搬运人是可能的是穷人应答的盒子(19.6% 对 11.0% , P=0.001 ) 与机会比率(或) 1.971 (95% CI:1.296-2.998, P=0.002 ) ,与 GG 同质接合体相比。与不抽烟的人相比,同时,吸烟者显示出更低的率差反应(10.9% 对 17.3% , P=0.015 ) 与或 0.582 (95% CI:0.374-0.904, P=0.016 ) 。有 GG 遗传型的吸烟者有最低风险与或 0.487 (95% CI:0.246-0.961, P=0.038 ) 当有 GA/AA 遗传型的不抽烟的人有最高的风险时与或 1.823 差反应(95% CI:1.083-3.068, P=0.024 ) ,与有 GG 遗传型的不抽烟的人相比。然而,在我们的学习显示了的遗传型和 smoking.Conclusion 之间没有重要相互作用那两个 CYP2C19 多型性和吸烟独立地影响的反应到 clopidogrel。 | LIU Xiao-li WANG Zhi-jian YANG Qing GE Hai-long GAO Fei LIU Yu-yang SHI Dong-mei ZHAO Ying-xin ZHOU Yu-jie | 2010 | Chinese Medical Journal2010，，22： | 19 |
| 20 | A landscape shape index-based sampling approach for land cover accuracy assessment显示文摘Spatial sampling design is one of the key steps in land cover accuracy assessment,and many traditional sampling approaches may not achieve credible spatial sampling due to the high spatial heterogeneity of land cover.This paper characterizes the spatial heterogeneity with three-level LSIs and determines the subsequent sample sizes and their spatial distributions.The three-level LSIs are rLSI in a region,cLSI for each land cover class and uLSI in each geographic sampling unit in the region.The rLSIs are used to derive appropriate sample sizes in the target regions.The cLSIs are used to assure that larger sample numbers are allocated to land cover classes with higher spatial heterogeneity.The uLSIs provide useful measures for selecting optimal geographic units in which sample sites will be located.This LSI-based sampling approach can derive the sample sizes and determine their distributions in an adaptive way according to the spatial heterogeneity.An experimental case study further demonstrates that the LSI-based sampling approach obtains more appropriate sample sizes for each region,sufficient sample numbers for rare classes,and optimal sample distributions in the geographical space. | CHEN Fei CHEN Jun WU Hao HOU DongYang ZHANG WeiWei ZHANG Jun ZHOU XiaoGuang CHEN LiJun | 2016 | Science China(Information Sciences)2016，59，12： | 17 |
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