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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Geographical characteristics of China’s wetlands derived from remotely sensed data显示文摘In this paper, we report the first wetland mapping of the entire China using Landsat enhanced thematic mapper plus (ETM+) data. These data were obtained from the Global Land Cover Facility at the University of Maryland spanning from 1999 to 2002. A total of 597 scenes of Landsat images were georeferenced and mosaiced. Manual image interpretation of satellite images was aided with elevation data, soil data, land cover/land use data and Google Earth. The minimum mapping unit is 10 pixel × 10 pixel, equivalent to 9 ha. The aim of our first round of mapping was only targeted at the boundary delineation of any type of wetland except those wetlands that are under agricultural use (i.e., paddy fields), which has already been well mapped by others. Our interpretation results indicate that a total of 359478 km2 of wetlands are of non-agricultural use. Among our preliminarily mapped wetland, 339353 km2 are inland wetland, 2786 km2 are non-agricultural artificial wetland, and 17609 km2 are coastal wetland. Because low-tide is rarely captured in satellite images, an under-estimation of coastal wetland is inevitable. We conducted some statistics based on our mapped wetlands and compared them with those previously obtained from a number of sources including a land cover/land use map made with satellite images during the late 1990s and early 2000s, a marshland map developed in approximately the same period, survey data of coastal wetland in early 1980s, and area data for approximately 400 larger patches of marshland in China compiled in 1996. Because some inconsistencies exist in the guidelines of those different wetland surveys, difference in area is expected. Some further comparison indicates that the wetland distributions derived from the preliminary wetland map are reasonable and more objective than other sources. The mapping process also indicated that the method adopted by us was efficient and cost-effective. We also found that in order to ensure comparability of the wetland maps developed at different times, a set of standard guidelines on the wetland categories to be mapped, and the mapping methods to be used must be well conceived, developed and effectively employed. We carried out some initial geographical analysis on the distribution of wetlands. | NIU ZhenGuo GONG Peng CHENG Xiao GUO JianHong WANG Lin HUANG HuaBing SHEN ShaoQing WU YunZhao WANG XiaoFeng WANG XianWei YING Qing LIANG Lu ZHANG LiNa WANG Lei YAO Qian YANG ZhenZhong GUO ZiQi DAI YongJiu | 2009 | Science China Earth Sciences2009，52，6： | 15 |
| 3 | Chaiqinchengqi decoction regulates necrosis-apoptosis via regulating the release of mitochondrial cytochrome c and caspase-3 in rats with acute necrotizing pancreatitis显示文摘OBJECTIVE: To explore the effect and the mechanism of Chaiqinchengqi decoction(CQCQD) on the apoptosis-necrosis switch of pancreatic acinar cells in acute necrotizing pancreatitis(ANP) in rats.METHODS: Sixty Sprague-Dawley rats were randomized into the control group, the ANP group and the CQCQD group. The acute pancreatitis(AP)model was induced by intraperitoneal injections of4 g/kg 8% L-Arginine(PH 7.0) twice with a 1 h interval. Rats in the CQCQD group were intragastrically administered CQCQD(20 mL/kg every 2 h, 3 times,then 20 mL/kg every 6 h, 3 times). Rats were killed at the 6 and 24 h after the induction of AP.The pancreatic tissues were collected for pathology and to isolate pancreatic acinar cells and mitochondria.RESULTS: CQCQD significantly ameliorated the severity of ANP by reducing the pancreatic histopathology score, indicated by lactate dehydrogenase levels at the 6 and 24 h. The CQCQD group promoted the apoptosis of pancreatic acinar cells by raising the apoptosis index compared with the ANP group and the control group. Mitochondrial cytochrome c at the 6 and 24 h in the ANP group were lower than that in the control group or the CQCQD group(0.67±0.13 vs 1.54±0.03 vs 0.81±0.09; 0.71±0.08 vs 1.55±0.09 vs 0.89±0.16, P<0.01). The cytochrome c levels in the cytoplasm at the 6 and 2 h in the CQCQD group were higher than in the control group(1.36±0.15 vs 0.67±0.04, 1.46±0.08 vs 0.59±0.09, P<0.01), or the ANP group(0.96±0.13, P>0.05;0.97±0.09, P<0.05). CQCQD increased caspase-3 activity over the ANP group at the 6 h.CONCLUSION: CQCQD can induce apoptosis and relieve the necrosis of pancreatic acinar cells via promoting the release of mitochondrial cytochrome c and increasing pancreatic caspase-3 activity in ANP rats. | Ziqi Lin Jia Guo Ping Xue Lei Huang Lihui Deng Xiaonan Yang Qing Xia | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 10 |
| 4 | Thermal convection thinning of the North China Craton: Numerical simulation显示文摘We used two-dimensional numerical simulations to investigate small-scale convection in the upper mantle-lithosphere system with depthand temperature-dependent viscosity. Our aim was to examine the mechanism of craton thinning by thermal convection. The model domain is 700 km deep and 700 km wide with a resolution of 71×71 nodes and 160000 markers. The velocity boundary conditions are free-slip along all the boundaries. A thermal insulation condition was applied at the two side walls, with constant temperatures for the top and bottom boundaries. We assumed an initial temperature of 273 K at the upper boundary and 1673 K at the lower boundary, and 1573 K at the bottom of the lithosphere (200 km depth) for the thick, cold, and stable North China Craton (NCC). We calculated the thermal evolution in the upper mantle when the temperature at its bottom is raised because of lower mantle convection or plumes. The temperature at the bottom of the upper mantle was set at 1773, 1873, 1973, and 2073 K for different models to study the temperature effect on the lithospheric thinning processes. Our end-member calculations show that with the bottom boundary raising the lithosphere can be thinned from a depth of 200 km to a depth of between 100 and 126.25 km. The thinning rates are at mm/y order of magnitude, and the thinning timescale is about 10 Ma. | QIAO YanChao GUO ZiQi SHI YaoLin | 2013 | Science China Earth Sciences2013，56，5： | 7 |
| 5 | AntarcticaLC2000:The new Antarctic land cover database for the year 2000显示文摘Antarctica plays a key role in global energy balance and sea level change.It has been conventionally viewed as a whole ice body with high albedo in General Circulation Models or Regional Climate Models and the differences of land cover has usually been overlooked.Land cover in Antarctica is one of the most important drivers of changes in the Earth system.Detailed land cover information over the Antarctic region is necessary as spatial resolution improves in land process models.However,there is a lack of complete Antarctic land cover dataset derived from a consistent data source.To fill this data gap,we have produced a database named Antarctic Land Cover Database for the Year 2000(AntarcticaLC2000) using Landsat Enhanced Thematic Mapper Plus(ETM+) data acquired around 2000 and Moderate Resolution Imaging Spectrometer(MODIS) images acquired in the austral summer of 2003/2004 according to the criteria for the 1:100000-scale.Three land cover types were included in this map,separately,ice-free rocks,blue ice,and snow/firn.This classification legend was determined based on a review of the land cover systems in Antarctica(LCCSA) and an analysis of different land surface types and the potential of satellite data.Image classification was conducted through a combined usage of computer-aided and manual interpretation methods.A total of 4067 validation sample units were collected through visual interpretation in a stratified random sampling manner.An overall accuracy of 92.3%and the Kappa coefficient of 0.836 were achieved.Results show that the areas and percentages of ice-free rocks,blue ice,and snow/firn are 73268.81 km2(0.537%),225937.26 km2(1.656%),and 13345460.41 km2(97.807%),respectively.The comparisons with other different data proved a higher accuracy of our product and a more advantageous data quality.These indicate that AntarcticaLC2000,the new land cover dataset for Antarctica entirely derived from satellite data,is a reliable product for a broad spectrum of applications. | HUI FengMing KANG Jing LIU Yan CHENG Xiao GONG Peng WANG Fang LI Zhan YE YuFang GUO ZiQi | 2017 | Science China Earth Sciences2017，60，4： | 5 |
| 6 | Hexagonal boron nitride nanosheet for effective ambient N2 fixation to NH3显示文摘Industrial production of NH3 from N2 and H2 significantly relies on Haber-Bosch process,which suffers from high energy consume and CO2 emission.As a sustainable and environmentally-benign alternative process,electrochemical artificial N2 fixation at ambient conditions,however,is highly required efficient electrocatalysts.In this study,we demonstrate that hexagonal boron nitride nanosheet (h-BNNS) is able to electrochemically catalyze N2 to NH3.In acidic solution,h-BNNS catalyst attains a high NH3 formation rate of 22.4 μg·h-1·mg-1cat.and a high Faradic efficiency of 4.7% at-0.75 V vs.reversible hydrogen electrode,with excellent stability and durability.Density functional theory calculations reveal that unsaturated boron at the edge site can activate inert N2 molecule and significantly reduce the energy barrier for NH3 fonmation. | Ya Zhang Huitong Du Yongjun Ma Lei Ji Haoran Guo Ziqi Tian Hongyu Chen Hong Huang Guanwei Cui Abdullah M. Asiri Fengli Qu Liang Chen Xuping Sun | 2019 | Nano Research2019，12，4： | 5 |
| 7 | An improved Landsat Image Mosaic of Antarctica显示文摘A revised Landsat Image Mosaic of Antarctica (LIMA) is presented, using the 1073 multi-band scenes of the original Landsat-7 ETM+ LIMA image collection available at the United States Geological Survey (USGS: http://gffzza64998f73d704ee0hfc0nwk5cbpk96vxw.ffgz.tsg.suse.edu.cn/). Three improvements have been applied during the data processing: (1) DN saturation is adjusted by adopting a linear regression, which has a lower root mean square error than the ratio regression used by LIMA; (2) solar elevation angle is calculated using pixel-level latitude/longitude and the acquisition time and date of the central pixel of the scene, improving slightly upon the bilinear interpolation of the solar elevation angles of scene corners applied in LIMA; and (3) two additional image bands, Band 5 and Band 7, are sharpened using the panchromatic band (Band 8) and a Gram-Schmidt Spectral Sharpening algorithm to more easily distinguish snow, cloud and exposed rocks. The final planetary reflectance product is stored in 16-bit bands to preserve the full radiometric content of the scenes. A comparative statistical analysis among 12 sample regions indicates that the new mosaic has enhanced visual qualities, information entropy, and information content for land cover classification relative to LIMA. | HUI FengMing CHENG Xiao LIU Yan ZHANG YanMei YE YuFang WANG XianWei LI Zhan WANG Kun ZHAN ZhiFei GUO JianHong HUANG HuaBing LI XiuHong GUO ZiQi GONG Peng | 2013 | Science China Earth Sciences2013，56，1： | 4 |
| 8 | Bimetallic Metal-Organic Framework with High-Adsorption Capacity toward Lithium Polysulfides for Lithium–sulfur Batteries显示文摘The practical application of Li-S batteries is largely impeded by the“shuttle effect”generated at the cathode which results in a short life cycle of the battery.To address this issue,this work discloses a bimetallic metal-organic framework(MOF)as a sulfur host material based on Al-MOF,commonly called(Al)MIL-53.To obtain a high-adsorption capacity to lithium polysulfides(Li_(2)S_(x),4≤x≤8),we present an effective strategy to incorporate sulfiphilic metal ion(Cu^(2+))with high-binding energy to Li_(2)S_(x) into the framework.Through a one-step hydrothermal method,Cu^(2+) is homogeneously dispersed in Al-MOF,producing a bimetallic Al/Cu-MOF as advanced cathode material.The macroscopic Li2S4 solution permeation test indicates that the Al/Cu-MOF has better adsorption capacity to lithium polysulfides than monometallic Al-MOF.The sulfur-transfusing process is executed via a melt-diffusion method to obtain the sulfur-containing Al/CuMOF(Al/Cu-MOF-S).The assembled Li-S batteries with Al/Cu-MOF-S yield improved cyclic performance,much better than that of monometallic AlMOF as sulfur host.It is shown that chemical immobilization is an effective method for polysulfide adsorption than physical confinement and the bimetallic Al/Cu-MOF,formed by incorporation of sulfiphilic Cu^(2+) into porous MOF,will provide a novel and powerful approach for efficient sulfur host materials. | Pengbiao Geng Meng Du Xiaotian Guo Huan Pang Ziqi Tian Pierre Braunstein Qiang Xu | 2022 | Energy & Environmental Materials2022，5，2： | 4 |
| 9 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 10 | Cationic conjugated polymers as signal reporter for label-free assay based on targets-mediated aggregation of perylene diimide quencher显示文摘Herein, we reported a new label-free and fluorescence turn-on biosensor based on cationic conjugated poly(9,9-bis(6'-N,N,N-trimethylammonium)hexyl)fluorine phenylene)(PFP) and perylene diimide derivatives(PDI). Cationic PFP, single-stranded nucleic acid and PDI were used as signal reporter, probe and fluorescence quencher, respectively. In the presence of nucleic acids, they form complexes with PFP and PDI through strong electrostatic attraction interactions, resulting in PDI aggregating on nucleic acids and fluorescence of PFP being quenched. When nucleic acids are hydrolyzed by enzymes or their conformation is changed via recognizing targets, the effective aggregation of PDI is disrupted and the quenching ability is decreased. Thus the fluorescence of PFP recovers significantly. By taking advantage of the mechanism, we construct a new biosensor for endonuclease and small molecules detection. Here, S1 nuclease and bisphenol A are used as model systems. The detection limit of the SI nuclease and BPA are1.0×10^(-6)U/mL and 0.05 ng/mL, respectively. Our method is sensitive, cost-effective and simple, and provides a new platform for bioanalysis. | Limin Guo Ziqi Zhang Yanli Tang | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 11 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 12 | Is there anassociation between mild cognitive impairment and dietary patternin chinese elderly?Results from a cross-sectional populationstudy显示文摘 | ZIQI WANG BIRONG DONG GUO ZENG | 2010 | BMC Public Health2010，10，： | 1 |
| 13 | Erratum to“Impact of satellite blood culture on early diagnosis of sepsis”[Journal of Intensive Medicine volume 2(2022)56–60]显示文摘The publisher regrets the article titled“Impact of satellite blood culture on early diagnosis of sepsis,”[1]published on pages 56-60,Issue 1,Volume 2 in Journal of Intensive Medicine(http://gffzz9a2937bbd76e4fd3sfc0nwk5cbpk96vxw.ffgz.tsg.suse.edu.cn/science/article/pii/S2667100X21000475)contains a mistake in Abstract.The sentence in the Results“median ICU lengths of stay were 18.00 days and 23.50 days”should be“median lengths of hospital stays were 18.00 days and 23.50 days”.The publisher would like to apologize for any inconvenience caused. | Ziqi Guo Bo Guo Shanmei Wang Huifeng Zhang Wenxiao Zhang Bingyu Qin Huanzhang Shao | 2022 | Journal of Intensive Medicine2022，2，2： | 1 |
| 14 | Towards the Deep Convergence of Communication and Computing in RAN: Scenarios, Architecture, Key Technologies, Challenges and Future Trends显示文摘To accommodate the diversified emerging use cases in 5G,radio access networks(RAN)is required to be more flexible,open,and versatile.It is evolving towards cloudification,intelligence and openness.By embedding computing capabilities within RAN,it helps to transform RAN into a natural cost effective radio edge computing platform,offering great opportunity to further enhance RAN agility for diversified services and improve users’quality of experience(Qo E).In this article,a logical architecture enabling deep convergence of communication and computing in RAN is proposed based on O-RAN.The scenarios and potential benefits of sharing RAN computing resources are first analyzed.Then,the requirements,design principles and logical architecture are introduced.Involved key technologies are also discussed,including heterogeneous computing infrastructure,unified computing and communication task modeling,joint communication and computing orchestration and RAN computing data routing.Followed by that,a VR use case is studied to illustrate the superiority of the joint communication and computing optimization.Finally,challenges and future trends are highlighted to provide some insights on the potential future work for researchers in this field. | Nan Li Qi Sun Xiang Li Fengxian Guo Yuhong Huang Ziqi Chen Yiwei Yan Mugen Peng | 2023 | China Communications2023，20，3： | 1 |
| 15 | Facile synthesis of sulfurized polyacrylonitrile composite as cathode for high-rate lithium-sulfur batteries显示文摘Sulfurized polyacrylonitrile(SPAN)as a promising cathode material for lithium sulfur(Li-S)batteries has drawn increasing attention for its improved electrochemical performance in carbonate-based electrolyte.However,the relatively poor electronic and ionic conductivities of SPAN limit its high-rate and lowtemperature performances.In this work,a novel one-dimensional nanofiber SPAN(SFPAN)composite is developed as the cathode material for Li-S batteries.Benefitting from its one-dimensional nanostructure,the SFPAN composite cathode provides fast channels for the migration of ions and electronics,thus effectively improving its electrochemical performance at high rates and low temperature.As a result,the SFPAN maintains a high reversible specific capacity^1200 mAh g−1 after 400 cycles at 0.3 A g−1 and can deliver a high capacity of^850 mAh g−1 even at a high current density of 12.5 A g−1.What is more,the SFPAN can achieve a capacity of^800 mAh g−1 at 0℃and^1550 mAh g−1 at 60℃,thus providing a wider temperature range of applications.This work provides new perspectives on the cathode design for high-rate lithium-sulfur batteries. | Jingwei Xiang Zezhou Guo Ziqi Yi Yi Zhang Lixia Yuan Zexiao Cheng Yue Shen Yunhui Huang | 2020 | Journal of Energy Chemistry2020，29，10： | 1 |
| 16 | Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy显示文摘Objective:Lung cancer is the most common cause of cancer-related deaths worldwide.Somatic copy number alterations(SCNAs)have been used to predict responses to therapies in many cancers,including lung cancer.However,little is known about whether they are predictive of radiotherapy outcomes.We aimed to understand the prognostic value and biological functions of SCNAs.Methods:We analyzed the correlation between SCNAs and clinical outcomes in The Cancer Genome Atlas data for 486 patients with non-small cell lung cancer who received radiotherapy.Gene set enrichment analyses were performed to investigate the potential mechanisms underlying the roles of SCNAs in the radiotherapy response.Our results were validated in 20 patients with lung adenocarcinoma(LUAD)receiving radiotherapy.Results:SCNAs were a better predictor of progression-free survival(PFS)in LUAD(P=0.024)than in lung squamous carcinoma(P=0.18)in patients treated with radiotherapy.Univariate and multivariate regression analyses revealed the superiority of SCNAs in predicting PFS in patients with LUAD.Patients with stage I cancer and low SCNA levels had longer PFS than those with high SCNA levels(P=0.022).Our prognostic nomogram also showed that combining SCNAs and tumor/node/metastasis provided a better model for predicting long-term PFS.Additionally,high SCNA may activate the cell cycle pathway and induce tumorigenesis.Conclusions:SCNAs may be used to predict PFS in patients with early-stage LUAD with radiotherapy,in combination with TNM,with the aim of predicting long-term PFS.Therefore,SCNAs are a novel predictive biomarker for radiotherapy in patients with LUAD. | Fan Kou Lei Wu Yan Guo Bailu Zhang Baihui Li Ziqi Huang Xiubao Ren Lili Yang | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 17 | Emerging Metal Single-Atom Materials:From Fundamentals to Energy Applications显示文摘CONSPECTUS:With the development of nanotechnology and characterization techniques,it has been realized that the reactivity of metal nanoparticles mainly depends on some unsaturated coordination atoms on the surface.However,only a small fraction of the surface exposed atoms can access the reactants and act as reactive sites,resulting in low utilization of metal atoms.Moreover,due to the complex structure of metal nanoparticles,the metal atoms exposed on the surface are likely to be in different chemical environments and may act as multiple active centers to catalyze the reactants,which brings great difficulties in the establishment of the structure−activity relationship of metal nanoparticles. | Yiju Li Yin Zhou Changshuai Shang Muhammad Yousaf Ziqi Guo Shaojun Guo | 2022 | Accounts of Materials Research2022，3，11： | 1 |
| 18 | Segmented Au/PtCo heterojunction nanowires for efficient formic acid oxidation catalysis显示文摘Exploring a new strategy for the removal of adsorbed CO (CO^(*)) on a Pt surface at a low potential is the key to achieving enhanced catalysis for the formic acid oxidation reaction (FAOR);however, the development of such a strategy remains a significant challenge. Herein, we report a class of Au/PtCo heterojunction nanowires (HNWs) as efficient electrocatalysts for accelerating the FAOR. This heterojunction structure and the induced Co alloying effects can facilitate formic acid adsorption/activation on Pt with high CO tolerance, generating the FAOR pathway from dehydration to dehydrogenation. The optimized Au_(23)/Pt_(63)Co_(14) HNWs showed the highest specific and mass activities of 11.7 mA cm^(−2)Pt and 6.42 A mg^(−1)Pt reported to date, respectively, which are considerably higher than those of commercial Pt/C. DFT calculations confirmed that the electron-rich Au segment enhances the electronic activity of the PtCo NWs, which not only allows the construction of a highly efficient electron transfer channel for the FAOR but also suppresses CO formation. | Yingjun Sun Bolong Huang Yingjie Li Yingnan Qin Ziqi Fu Mingzi Sun Lei Wang Shaojun Guo | 2021 | Fundamental Research2021，1，4： | 1 |
| 19 | The Effect of Janus Nanospheres on the Phase Separation of Immiscible Polymer Blends via Dissipative Particle Dynamics Simulations 显示文摘 | HUANG Manxia LI Ziqi GUO Hongxia | 2012 | Soft Matter2012，8，： | 1 |
| 20 | Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer显示文摘Platinum-based chemotherapy resistance is a key factor of poor prognosis and recurrence in hepatocellular carcinoma(HCC).Herein,RNAseq analysis revealed that elevated tubulin folding cofactor E(TBCE)expression is associated with platinum-based chemotherapy resistance.High expression of TBCE contributes to worse prognoses and earlier recurrence among liver cancer patients.Mechanistically,TBCE silencing significantly affects cytoskeleton rearrangement,which in turn increases cisplatin-induced cycle arrest and apoptosis.To develop these findings into potential therapeutic drugs,endosomal pH-responsive nanoparticles(NPs)were developed to simultaneously encapsulate TBCE siRNA and cisplatin(DDP)to reverse this phenomena.NPs(siTBCE+DDP)concurrently silenced TBCE expression,increased cell sensitivity to platinum treatment,and subsequently resulted in superior anti-tumor effects both in vitro and in vivo in orthotopic and patient-derived xenograft(PDX)models.Taken together,NP-mediated delivery and the co-treatment of siTBCE+DDP proved to be effective in reversing chemotherapy resistance of DDP in multiple tumor models. | Senlin Li Siyu Chen Zhihui Dong Xingdong Song Xiuling Li Ziqi Huang Huiru Li Linzhuo Huang Ganyuan Zhuang Ran Lan Mingyan Guo Wende Li Phei Er Saw Lei Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
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