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| 1 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 2 | Numerical simulation for the coupling effect of local atmospheric circulations over the area of Beijing,Tianjin and Hebei Province显示文摘Using the model system MM5.V3 and multi-layer grid nesting technique, we have done a multi-scale numerical simulation over the area of Beijing, Tianjin and Hebei Province to analyze the temperature and wind field there and study its local circulations. The results show a coupling effect of Urban Heat Island Circulation (UHIC), Mountain Valley Breeze (MVB) and Sea Land Breeze (SLB) occurs in this area when the synoptic system is weak. The SLB can penetrate deep into the mainland for about 200 km when it is blooming. MVB can extend to south and cover almost the whole plain area in Beijing. Both MVB and SLB are diurnal periodical; meanwhile the phase of MVB drops behind that of SLB for about six hours. As a local circulation, the UHIC weakens the two circulations above, and it also has a diurnal period. As a result, the coupling effect of circulations reveals not only different features in spring-summer period and autumn-winter period in a year but also the difference between early morn- ing to noonday and afternoon to night in a day. We noted the diffusion of contamination over the area around Beijing, and found the steady presence of a transport routine of contamination over North-China throughout the year caused by the Coupling Effect mentioned above. This find is important for studying the environment pollution in this area. | LIU ShuHua LIU ZhenXin LI Ju WANG YinChun MA YanJun SHENG Li LIU HePing LIANG FuMing XIN GuoJun WANG JianHua | 2009 | Science China Earth Sciences2009，52，3： | 20 |
| 3 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 4 | Effect of pH Value on Stress Corrosion Cracking of X70 Pipeline Steel in Acidic Soil Environment显示文摘The effect of pH value on the stress corrosion cracking(SCC) of API X70 pipeline steel in simulated acidic soil solutions was investigated by using slow strain rate test,electrochemical polarization curves,electrochemical impedance spectroscopy,and scanning electron microscopy.pH plays an important role in the susceptibility and electrochemical mechanism of SCC.The pH higher than 5 has no significant effect on electrochemical processes.By contrast,the pH lower than 5 intensifies cathodic hydrogen evolution reactions,thus increasing the cathodic current and corrosion potential.Under different pH values,the SCC mechanism of X70 pipeline steel varies among anodic dissolution(AD),hydrogen embrittlement(HE),and the combination of AD and HE(AD + HE) with variations of applied potential.At-850 mV SCE,the SCC mechanism is HE if pH is less than 4 or AD + HE if pH value is more positive. | Zhiyong LIU Cuiwei DU Xin ZHANG Fuming WANG Xiaogang LI | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，4： | 9 |
| 5 | Spatiotemporal characteristics of cultural sites and their driving forces in the Ili River Valley during historical periods显示文摘这研究使用 ArcGIS 在西北的中国在 Ili 河山谷分析文化地点的空间与时间的分发。它探索在这些地点之间的关系空间与时间的进化特征,人的历史,和自然环境。结果显示这些地点的数字和比例,和他们的出现的频率,在六个历史的时期期间展出了一个转换塑造 V 的变化趋势。在东方高、在转移到的开始的三个时期的向西空间的分发模式低在西方高、在东方低在后者期间三个时期,在人的活动的空间重心表明一个变化。这些地点主要在等级的斜坡上被散布 15,与他们在春天和秋天时期(770 BC476 BC ) 期间从 75% 增加的比例 Qin 王朝(221 BC207 BC ) 到 93.75% 在 Qing DynastyModern 时期期间。地点举起的集中的分发变了从在春天和秋天 PeriodQin 王朝,和西方的汉(206 BC8 ) 期间分级 48 南部、北的王朝(420589 ) ,到在后者期间分级 14 三个时期。地点的数字从高举起的山和山,并且从高斜坡显示出一个变的趋势到低举起的平原到低斜坡。特别地,这些地点从中间、在上游的区域展出了移植的一个特殊潮湿的进化模式到下游的区域,与位于典型干旱区域的地点的迁居模式对比。学习也认为显著地,影响分发和文化地点的空间与时间的进化的因素是人的因素和自然因素。 | WANG Fang YANG Zhaoping LUAN Fuming XIONG Heigang SHI Hui WANG Zhaoguo ZHAO XingYou QIN Wenmin WU Wenjie LI Dong | 2015 | Journal of Geographical Sciences2015，25，9： | 5 |
| 6 | A Novel Catalyst CuCl/1,10-Phenanthroline/N-Methylimidazole for the Oxidative Carbonylation of Ethanol to Diethyl Carbonate显示文摘 | MO Wanling, LI Guangxing, ZHU Yongqiang, XIONG Hui, MEI Fuming (Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China) | 2003 | 催化学报2003，24，1： | 4 |
| 7 | TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation显示文摘Graft-versus-host 疾病(GVHD ) 是在造血的干细胞移植以后的最普通的复杂并发症。澄清像使用费的受体的角色 4 (TLR4 ) ,它是为细菌的 lipopolysaccharides (LPS ) 的主要受体在尖锐 GVHD 的发展,我们使用了一个 TLR4 大美人(TLR4 −/−) 老鼠 GVHD 模型并且分析了内在的免疫学的机制。当 TLR4 −/− 老鼠被用作骨头髓和 splenocyte 房间接枝施主或接受者时, GVHD 症状出现和死亡被推迟与相比野类型(TLR4 +/+) 老鼠。另外,组织病理学说的分析在 TLR4 −/− BALB/c 怪物,肝和小肠织物损坏与最小的淋巴球的渗入被减少。与 TLR4 +/+, TLR4 −/− 老鼠相对照,树枝状的房间没在处于一个不成熟的状态感应、留下的 LPS 期间表示 CD80, CD86, CD40, MHC-II 或 IL-12。而且, TLR4 −/− 鼠标怒气的能力支持 allogeneic T 房间增长的树枝状的房间和,特别地 T 助手房间 1 (Th1 ) 开发显然与 TLR4 +/+ 鼠标相比被稀释 interferon-γ 的树枝状的房间,和层次;(IFN-γ) 并且 IL-10, Th2 房间特定的 cytokines,在 TLR4 −/− BALB/c 比在 TLR4 +/+ BALB/c 妄想的老鼠。总的来说,我们的数据表明 TLR4 可以在 GVHD 和基因治疗可能提供的那指向的 TLR4 的致病起一个作用减少 GVHD 的风险的一条新处理途径。 | Yi Zhao Qiuyan Liu Li Yang Donghua He Lijuan Wang Jun Tian Yi Li Fuming Zi Hanying Bao Yang Yang Yuanyuan Zheng Jimin Shi Xingkui Xue Zhen Cai | 2013 | Cellular & Molecular Immunology2013，10，2： | 4 |
| 8 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 9 | An enrichment model using regular health examination data for early detection of colorectal cancer显示文摘Objective: Challenges remain in current practices of colorectal cancer(CRC) screening, such as low compliance,low specificities and expensive cost. This study aimed to identify high-risk groups for CRC from the general population using regular health examination data.Methods: The study population consist of more than 7,000 CRC cases and more than 140,000 controls. Using regular health examination data, a model detecting CRC cases was derived by the classification and regression trees(CART) algorithm. Receiver operating characteristic(ROC) curve was applied to evaluate the performance of models. The robustness and generalization of the CART model were validated by independent datasets. In addition, the effectiveness of CART-based screening was compared with stool-based screening.Results: After data quality control, 4,647 CRC cases and 133,898 controls free of colorectal neoplasms were used for downstream analysis. The final CART model based on four biomarkers(age, albumin, hematocrit and percent lymphocytes) was constructed. In the test set, the area under ROC curve(AUC) of the CART model was 0.88 [95%confidence interval(95% CI), 0.87-0.90] for detecting CRC. At the cutoff yielding 99.0% specificity, this model’s sensitivity was 62.2%(95% CI, 58.1%-66.2%), thereby achieving a 63-fold enrichment of CRC cases. We validated the robustness of the method across subsets of test set with diverse CRC incidences, aging rates, genders ratio, distributions of tumor stages and locations, and data sources. Importantly, CART-based screening had the higher positive predictive value(1.6%) than fecal immunochemical test(0.3%).Conclusions: As an alternative approach for the early detection of CRC, this study provides a low-cost method using regular health examination data to identify high-risk individuals for CRC for further examinations. The approach can promote early detection of CRC especially in developing countries such as China, where annual health examination is popular but regular CRC-specific screening is rare. | Qiang Shi Zhaoya Gao Pengze Wu Fanxiu Heng Fuming Lei Yanzhao Wang Qingkun Gao Qingmin Zeng Pengfei Niu Cheng Li Jin Gu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 10 | Hand Vein Recognition Algorithm Based on NMF with Sparsity and Clustering Property Constraints in Feature Mapping Space显示文摘Most of the existed vein features are lack of robustness to light intensity variation,and some algorithms rely on the specified vein data sets,which leads to the limitation of real applications.To solve the problems,we propose a novel vein recognition algorithm based on Nonnegative matrix factorization(NMF)with double regularization terms.The innovations of our algorithm are mainly reflected in the following two aspects:in order to improve feature robustness,a novel feature mapping function is designed to map the initial Histogram of oriented gradient(HOG)feature to a new space;to enhance the recognition performance,an effective NMF model is presented,which not only reduces feature dimension,but also optimizes the feature sparsity and clustering property simultaneously.Experiments show that the proposed algorithm can achieve satisfactory results in terms of False rejection rate(FRR)and False acceptance rate(FAR),which indicates that our algorithm is valuable for other classification problems. | JIA Xu SUN Fuming LI Haojie CAO Yudong | 2019 | Chinese Journal of Electronics2019，28，6： | 2 |
| 11 | Removal of F- and organic matter from coking wastewater by coupling dosing FeCl3 and AlCl3显示文摘Coagulation and precipitation is a widely applied method to remove F-from wastewater.In this work,the effect of coagulation on the removal of F-and organic matter from coking wastewater was studied using Al Cl3and Fe Cl3as compound coagulants.The removal rates of F-and organic matter under different coagulant doses and p H conditions were investigated.The results show that the highest removal rates of F-by Al Cl3and Fe Cl3are 94.4%and 25.4%,respectively;when the dosage is 10 mmol/L,the TOC removal rates of Fe Cl3and Al Cl3reach 20.4%and 34.7%,respectively.Therefore,the removal rate of F-by Al Cl3is higher than that of Fe Cl3,but the removal rate of organic matter by Fe Cl3is relatively higher.The addition of Ca2+can promote the removal of F-,but the removal rate of organic matter decreases.In addition,by investigating the effects of different p H and Fe–Al ratio on the removal rate,the removal effect of adding Fe Cl3and Al Cl3at the same time was discussed.The results show that the most suitable working condition for the removal of organic matter and F-is that the p H is 6.5 and the molar ratio of Al/Fe is 8:2.Overall,the removal mechanism of F-and organic matter in coking wastewater by Fe Cl3and Al Cl3was explored in this study.The experimental results can provide reference for the advanced treatment of coking wastewater. | Shuo Li Mengjie Liu Fuming Meng Xia Hu Wenzheng Yu | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 12 | A novel catalyst for transesterification of dimethyl carbonate with phenol to diphenyl carbonate : samarium trifluoromethanesulfnnate显示文摘 | Mei Fuming Li Guangxing Nie Jin | 2002 | J Mol Catal A Chem2002，184，： | 1 |
| 13 | Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer:neoSCORE trial显示文摘Dear Editor,Lung cancer is the predominant cause of cancer-related deaths globally,with non-small cell lung cancer(NSCLC)accounting for 85%of all cases.1 The five-year overall survival(OS)after surgery remains poor because of the high rate of postoperative recurrence and metastasis.Recently,immune checkpoint inhibitors(ICIs)have shown promising efficacy in resectable NSCLC. | Miner Shao Jie Yao Yunke Wang Lufeng Zhao Baizhou Li Lili Li Zuqun Wu Zexin Chen Junqiang Fan Fuming Qiu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 14 | Am(Ⅲ) adsorption on oxides of aluminium and silicon:effects of humic substances,pH,and ionic strength显示文摘 | Tao Zuyi Li Weijuan Zhang Fuming | 2003 | J Colloid Interface Sci2003，265，： | 1 |
| 15 | The transesterification of dimethyl carbonate with phenol over Mg-Al-hydrotalcite catalyst显示文摘 | Mei Fuming Pei Zhi Li Guangxing | 2004 | Organic Process Research & Development2004，8，3： | 1 |
| 16 | Hip replacement surgery in patients with ankylosing spondylitis显示文摘 | Nystad TW Fumes O Havelin LI | 2014 | Ann Rheum Dis2014，73，6： | 1 |
| 17 | Early postoperative mortality after 67 548 total hip replacements:causes of death and thromboprophylaxis in 68 hospitals in Norway from 1987 to 1999 显示文摘 | Engesaeter LB Havelin LI Fumes O | 2002 | Acta Orthop Scand2002，73，： | 1 |
| 18 | The transesterification of dimethyl carbonate with phenol over Mg-Al-hydrotalcite catalyst显示文摘 | Mei Fuming Pei Zhi Li Guangxing | 2004 | Organic Process Research & Development2004，8，3： | 1 |
| 19 | The thermodynamic re-assessment of the Cu–Zr system显示文摘 | Na Wang Changrong Li Zhenmin Du Fuming Wang Weijing Zhang | 2006 | Calphad2006，，4： | 1 |
| 20 | The transes- terification of dimethyl carbonate with phenol over Mg-Al-hydrotalcite catalyst 显示文摘 | Mei Fuming Pei Zhi Li Guangxing | 2004 | Org Pro Res Dev2004，8，： | 1 |
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