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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Synthesis of phenothiazines from cyclohexanones and2- a m i n o b e n z e n e t h i o l s u n d e r t r a n s i t i o n - m e t a l - f r e econditions显示文摘 | Liao Yunfeng Jiang Pengcheng Chen Shanping | 2013 | RSC Adv2013，3，18： | 1 |
| 3 | Treating COVID-19 with Chloroquine显示文摘A novel coronavirus disease 2019(COVID-19)emerged around December 2019 in Wuhan,China and has spread rapidly worldwide(Lu et al.,2020).Until March 27,2020,the Chinese health authorities had reported 82082 confirmed COVID-19 cases in China with 3298 deaths and 381443 confirmed cases with 20787 deaths outside China.The World Health Organization(WHO)named the virus SARS-CoV-2,which belongs to a distinct clade from the human severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERSCoV)(Zhu et al.,2020). | Mingxing Huang Tiantian Tang Pengfei Pang Man Li Ruolan Ma Jiahui Lu Jingxian Shu Yingying You Binghui Chen Jiabi Liang Zhongsi Hong Huili Chen Ling Kong Dajiang Qin Duanqing Pei Jinyu Xia Shanping jiang Hong Shan | 2020 | Journal of Molecular Cell Biology2020，12，4： | 1 |
| 4 | Metal-Free Synthesis of Benzo[a]phenanthridines from Aromatic Aldehydes,Cyclohexanones,and Aromatic Amines显示文摘A three-component synthesis of benzo[a]phenanthridines from aromatic aldehydes,cyclohexanones,and aromatic amines has been developed,which is mediated by KI/DMSO/camphorsulfonic acid to afford a variety of functionalized benzo[a]phenanthridines in satisfactory yields.The present strategy provides a biaryl motif ortho to the nitrogen atom which has the potential to be used as ligand by further modification.With the advantages of readily available starting materials,transition-metal-free conditions,gram-scale synthesis,and broad substrate scope,this three-component protocol provides an efficient approach for the preparation of diverse benzo[a]phenanthridines. | Pingyu Jiang Zhifei Shan Shanping Chen Quanyuan Wang Shuxin Jiang Haolin Zheng Guo-Jun Deng | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 5 | Iron-catalyzed indolo[2,3-c]quinoline synthesis from nitroarenes and benzylic alcohols/aldehydes promoted by elemental sulfur显示文摘An iron-catalyzed strategy for the rapid synthesis of indolo[2,3-c]quinolines has been developed.This cascade reaction involving alcohol oxidation,nitro reduction,and oxidative annulation was achieved in a one-pot.The present protocol was started from mono-functionalized indoles and readily available benzylic alcohols/aldehydes,affording a variety of functionalized indolo[2,3-c]quinolines in satisfactory yields. | Rong Li Shuxin Jiang Haolin Zheng Hanwen Lei Zhi Huang Shanping Chen Guo-Jun Deng | 2022 | Green Synthesis and Catalysis2022，3，1： | 0 |
| 6 | Retrospective Clinical Analysis of 38 Cases of Pulmonary Embolism显示文摘Objectives To investigate the clinical feature of acute pulmonary embolism. Methods Retrospective clinical analysis was performed according to the data of 38 cases of pulmonary embolism. Results There were ground diseases and predisposing factors in 36 cases of pulmonary embolism among 38 cases, the ratio was 94.7%,among the total predisposing factors, tumor,cardiovascular disease,venous thrombosis of lower extremity, smoking and long-term bed were common. There was no specificity in clinical feature, physical sign and rout chest X ray, electrocardiography, and their appearances were diversified. There were specificity and sensitivity in echocardiogram (UCG) and D-dimer to some extent. But, the final diagnosis must depend on some special examinations, such as selective pulmonary arteriography, CTPA, MRA and so on. Conclusions The special examinations must be done to make a definite diagnosis to confirm pulmonary embolism when the high risk factors and ground diseases are existing. It is necessary to some cases when the clinical feature can not be explained by other diseases. | Ruiyun Liang Wei Zhang Wei Wu Shanping Jiang Zhiqiang Lǖ | 2007 | South China Journal of Cardiology2007，8，4： | 0 |
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