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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | 直肠癌根治术中的盆腔自主神经保护:30年变迁显示文摘全直肠系膜切除(TME)理念及微创技术(如腹腔镜结直肠手术和机器人手术)的出现大大提高直肠癌的外科疗效。然而,术后排尿功能和性功能障碍率仍然较高,从而给患者造成巨大的痛苦,同时也会给手术医生带来困扰。新辅助和辅助放疗应用的增多也带来了更多的功能问题。在本文中,我们对盆腔神经解剖的目前认识进行了评价,将盆腔神经分为肠系膜下动脉根部、侧盆壁及泌尿生殖器官周围等区域,探讨了在这些区域如何进行手术操作。同时,我们也讨论了过去30年不同手术方式(包括开腹、腹腔镜和机器人)的功能状况。 | Min-Hoe Chew Yu-Ting Yeh Evan Lim Francis Seow-Choen | 2016 | Gastroenterology Report2016，4，3： | 5 |
| 3 | CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes显示文摘 | Luke A. Gilbert Matthew H. Larson Leonardo Morsut Zairan Liu Gloria A. Brar Sandra E. Torres Noam Stern-Ginossar Onn Brandman Evan H. Whitehead Jennifer A. Doudna Wendell A. Lim Jonathan S. Weissman Lei S. Qi | 2013 | Cell2013，，2： | 2 |
| 4 | Factors influencing laparo-scopic colorectal operative duration and its effect on clinical out- come显示文摘 | Evans C Lim J Gatzeu C | 2012 | Surg Laparosc Endosc Percutan Tech2012，22，5： | 1 |
| 5 | Fecal porphyrin abnormalities in a patient with features of Rotor's syndrome显示文摘 | Evans J Lefkowitch J Lim CK | 1981 | Gastroenterology1981，81，6： | 1 |
| 6 | Factors influencing he compliance of patients using oxygen concentratorsfor long-term home oxygen therapy显示文摘 | Walshaw M J Lim R Evans C C | 1990 | Respir Med1990，84，3： | 1 |
| 7 | Initial effects of UV-B radiation on stem surfaces of Stenocereus thurberi ( organ pipe cacti) 显示文摘 | Evans L S Sullivan J H Lim M | 2001 | Environmental and Experimental Botany2001，46，2： | 1 |
| 8 | Initial effects of UV-B radiation on stem surfaces of Stenocereus thurberi (organ pipe cacti)显示文摘 | Evans L S Sullivan J H Lim M | 2001 | Environmental and Experimental Botany2001，46，2： | 1 |
| 9 | Impulse control and related disorders in Parkinson' s disease:review显示文摘 | Lim SY Evans AH Miyasaki JM | | 0，，： | 1 |
| 10 | Initial effects of UVB radiation on stem surfaces of Stenocereus thurberi ( organ pipe cacti) 显示文摘 | Evans L S Sulliv A N J H Lim M | 2001 | Environmental and Experimental Botany2001，46，2： | 1 |
| 11 | Factors influencing laparoseopic colorectal operative duration and its effect on clinical outcome显示文摘 | Evans C Lim J Gatzen C | 2012 | Surg Endose2012，22，5： | 1 |
| 12 | The sheep erythropoietingene ; molecular cloning and effect of hemorrhage on plasma eryth-ropoietin and renal/liver messenger RNA in adult sheep 显示文摘 | FU P EVANS B LIM G B | 1993 | 93(2) :107-1161993，93，2： | 1 |
| 13 | Erratum to:MRI breast screening in high-risk women:cancer detection and survival analysis显示文摘 | Evans DG Kesavan N Lim Y | 2014 | Breast Cancer Res Treat2014，145，3： | 1 |
| 14 | Factors Influencing Laparoscopic Colorectal Operative Duration and its Effect on Clinical Outcome显示文摘 | Charles Evans Jeffrey Lim Christopher Gatzen Andrew Huang | 2012 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2012，，5： | 1 |
| 15 | Implementa-tion and preliminary clinical experience with the use ofceiling mounted mobile high field intraoprative magneticrenonance imaging between two operating rooms 显示文摘 | Chicoinc M R Lim C C Evans J A | 2011 | Acta Neurochir Suppl2011，109，： | 1 |
| 16 | Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy显示文摘 | Lutucuta S Bachireddy P Youker K Evans A Entman M | 2001 | Circulation2001，103，6： | 1 |
| 17 | CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes显示文摘 | Luke A. Gilbert Matthew H. Larson Leonardo Morsut Zairan Liu Gloria A. Brar Sandra E. Torres Noam Stern-Ginossar Onn Brandman Evan H. Whitehead Jennifer A. Doudna Wendell A. Lim Jonathan S. Weissman Lei S. Qi | 2013 | Cell2013，，2： | 1 |
| 18 | Factors influencing laparoscopic colorectal operative duration and its effect on clinical outcome显示文摘 | Evans C Lim J Gatzen C | 2012 | Surg Laparosc Endosc Percutan Tech2012，22，5： | 1 |
| 19 | Heat shock protein 90 is a promising target for effective growth inhibitionof gastrointestinal neuroendocrine tumors显示文摘 | Christoph Gloesenkamp Bianca Nitzsche Alice Lim Emmanuel Normant Evan Vosburgh Mark Schrader Matthias Ocker Hans Scherübl Michael H?pfner | 2012 | International Journal of Oncology2012，，： | 1 |
| 20 | Genome sequence of enterohaemorrhagic Escherichia coli O157:H7显示文摘 | Perna NT Plunkett G 3rd Burland V Mau B Glasner JD Rose DJ Mayhew GF Evans PS Gregor J Kirkpatrick HA Pósfai G Hackett J Klink S Boutin A Shao Y Miller L Grotbeck EJ Davis NW Lim A Dimalanta ET Potamousis KD Apodaca J Anantharaman TS Lin J Yen G Schwartz DC Welch RA Blattner FR | 2001 | Nature2001，409，6819： | 1 |
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