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9篇 您的检索式：作者名="Fiona Doetsch"

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		题名	作者	年代	出处	被引量
	1	肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.	Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone	2010	中华神经外科疾病研究杂志2010，9，1：	16
	2	Identification of neural stem cells in the adult vertebrate brain显示文摘	Arturo Alvarez-Buylla Bettina Seri Fiona Doetsch	2002	Brain Research Bulletin2002，，6：	1
	3	Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain显示文摘	Fiona Doetsch Isabelle Caillé Daniel A. Lim Jose Manuel García-Verdugo Arturo Alvarez-Buylla	1999	Cell1999，，6：	1
	4	Adnlt subventricular zone neuronal precursors continue to proliferate and migrate in the, absence of the olfactory bulb J显示文摘	Barry Kirschenbaum Fiona Doetsch Carlos Lois	1999	Neurosci1999，19，：	1
	5	Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain显示文摘	Fiona Doetsch Isabelle Caillé Daniel A. Lim Jose Manuel García-Verdugo Arturo Alvarez-Buylla	1999	Cell1999，，：	1
	6	A Specialized Vascular Niche for Adult Neural Stem Cells显示文摘	Masoud Tavazoie Lieven Van der Veken Violeta Silva-Vargas Marjorie Louissaint Lucrezia Colonna Bushra Zaidi Jose Manuel Garcia-Verdugo Fiona Doetsch	2008	Cell Stem Cell2008，，3：	1
	7	ldentification of neural stem cells in the aduh vertebrate brain显示文摘	Arturo Alvarez-Buylla Bettina Seri Fiona Doetsch	2002	Brain Research2002，57，6：	1
	8	Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells显示文摘	Erika Pastrana Violeta Silva-Vargas Fiona Doetsch	2011	Cell Stem Cell2011，，5：	1
	9	Quantitative chemical proteomics reveals a Plkl inhibitor-compromised cell death pathway in human cells显示文摘	Monika Raab Fiona Pachl Andrea Kraemer Elisabeth Kurunci-Csacsko Christina Doetsch Rainald Knecht Sven Becker Bernhard Kuster Klaus Strebhardt	2014	Cell Research2014，24，9：	0

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