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| 1 | Cholangiocarcinoma:principles and current trends显示文摘BACKGROUND:Cholangiocarcinoma(CCA)is a lethal cancer of the biliary epithelium,originating from the liver(intrahepatic),at the confluence of the right and left hepatic ducts(hilar)or in the extrahepatic bile ducts.It is a rare malignancy associated with poor prognosis.DATA SOURCES:We searched the PubMed/MEDLINE database for relevant articles published from 1989 to 2008.The search terms used were related to 'cholangiocarcinoma' and its ' treatment'.Although no language restrictions were imposed initially,for the full-text review and final analysis,our resources only permitted the review of articles published in English.This review deals with the treatment of cholangiocarcinoma,the principles and the current trends.RESULTS:The risks and prognostic factors,symptoms and differential diagnosis are thoroughly discussed.In addition,the tools of preoperative diagnosis such as endoscopic retrograde cholangiopancreatography,digital image analysis,fluorescence in situ hybridization and magnetic resonance cholangiopancreatography are reviewed.Moreover,the treatment of CCA is discussed.CONCLUSIONS:The only curative treatment available is surgical management.Unfortunately,many patients present with unresectable tumors,the majority of whom die within a year of diagnosis.Surgical treatment involves major resections of the liver,pancreas and bile duct,with considerable mortality and morbidity.However,in selected cases and where indicated,appropriate management with aggressive surgery may achieve a good outcome with a prolonged survival expectancy. | George N Zografos Athanasios Farfaras Flora Zagouri Dimosthenis Chrysikos Kostas Karaliotas | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 14 |
| 2 | Protective and defensive roles of non-glandular trichomes against multiple stresses:structure-function coordination显示文摘As superficial structures,non-glandular trichomes,protect plant organs against multiple biotic and abiotic stresses.The protective and defensive roles of these epidermal appendages are crucial to developing organs and can be attributed to the excellent combination of suitable structural traits and chemical reinforcement in the form of phenolic compounds,primarily fl avonoids.Both the formation of trichomes and the accumulation of phenolics are interrelated at the molecular level.During the early stages of development,non-glandular trichomes show strong morphological similarities to glandular ones such as the balloon-like apical cells with numerous phenolics.At later developmental stages,and during secondary wall thickening,phenolics are transferred to the cell walls of the trichomes.Due to the diff use deposition of phenolics in the cell walls,trichomes provide protection against UV-B radiation by behaving as optical fi lters,screening out wavelengths that could damage sensitive tissues.Protection from strong visible radiation is also aff orded by increased surface light refl ectance.Moreover,the mixtures of trichome phenolics represent a superfi-cial chemical barrier that provides protection against biotic stress factors such as herbivores and pathogens.Although the cells of some trichomes die at maturity,they can modulate their quantitative and qualitative characteristics during development,depending on the prevailing conditions of the external biotic or abiotic environment.In fact,the structure and chemical constituents of trichomes may change due to the particular light regime,herbivore damage,wounding,water stress,salinity and the presence of heavy metals.Hence,trichomes represent dynamic protective structures that may greatly aff ect the outcome of many plant–environment interactions. | George Karabourniotis Georgios Liakopoulos Dimosthenis Nikolopoulos Panagiota Bresta | 2020 | Journal of Forestry Research2020，31，1： | 5 |
| 3 | Renal failure and cirrhosis: A systematic review of mortality and prognosis显示文摘 | Giuseppe Fede Gennaro D’Amico Vasiliki Arvaniti Emmanuel Tsochatzis Giacomo Germani Dimosthenis Georgiadis Alberto Morabito Andrew Kenneth Burroughs | 2011 | Journal of Hepatology2011，，4： | 4 |
| 4 | A framework for inspection of dies attachment on PCB utilizing machine learning techniques显示文摘Decision Support Systems are considered as a robust technology able to provide an advantage to several manufacturing companies.As part of the Z-Fact0r EU project Early Stage-Decision Support System,a framework for the inspection of a printed circuit boards(PCB)and the inference of faults,regarding the excess or insufficient glue,is proposed.For the inspection of the PCB,a pixel-based vector of the regions of interest is utilized and several very popular in research community machine learning algorithms are tested on their performance on fault recognition.In order to determine the most efficient and effective classifier,a schema of Monte Carlo simulations for each classification algorithm and set of hyper-parameters was performed.Simulation results show a superiority of the support vector machine(SVM)classifier with polynomial and radial basis function kernels,compared to the rest.The best overall classifier was the SVM polynomial(accuracy:81.39%,f-measure:78.72%). | Thanasis Vafeiadis Nikolaos Dimitriou Dimosthenis Ioannidis Tracy Wotherspoon Gregory Tinker Dimitrios Tzovaras | 2018 | Journal of Management Analytics2018，5，2： | 3 |
| 5 | Flap reconstruction of the knee: A review of current concepts and a proposed algorithm显示文摘A literature search focusing on flap knee reconstruction revealed much controversy regarding the optimal management of around the knee defects. Muscle flaps are the preferred option, mainly in infected wounds. Perforator flaps have recently been introduced in knee coverage with significant advantages due to low donor morbidity and long pedicles with wide arc of rotation. In the case of free flap the choice of recipient vessels is the key point to the reconstruction. Taking the published experience into account, a reconstructive algorithm is proposed according to the size and location of the wound, the presence of infection and/or 3-dimensional defect. | Andreas Gravvanis Antonios Kyriakopoulos Konstantinos Kateros Dimosthenis Tsoutsos | 2014 | World Journal of Orthopedics2014，5，5： | 2 |
| 6 | EGFR as a prognostic marker for gastric cancer显示文摘 | Theodore L Nikolaos X Dimosthenis Z | 2008 | World J Surg2008，32，6： | 1 |
| 7 | Rotation invariant hand-drawn symbol recognition based on a dynamic time warping model显示文摘 | Alicia Fornés Josep Lladós Gemma Sánchez Dimosthenis Karatzas | 2010 | International Journal on Document Analysis and Recognition (IJDAR)2010，，3： | 1 |
| 8 | Exposure to major volatile organic compounds and carbonyls in European indoor environments and associated health risk 显示文摘 | DIMOSTHENIS A S SPYROS P K ALBERTO G IOANNIS L L ATHANASIOS K | 2011 | Environment International2011，37，4： | 1 |
| 9 | Smart, Autonomous and Reliable Internet of Things 显示文摘 | Dimosthenis Kyriazis Theodora Varvarigou | 2013 | Procedia Computer Science2013，，4： | 1 |
| 10 | Determination of UV-filter residues in bathing waters by liquid chromatography UV-diode array and gas chromatography-mass spectrometry after micelle mediated extraction-solvent back extraction 显示文摘 | Giokas Dimosthenis L Sakkas Vasilios A Albanis Triantafyllos A | 2005 | J Chromatogr A2005，1077，1： | 1 |
| 11 | The winter-red-leaf syndrome in Pistacia lentiscus : Evidence that the anthocyanic phenotype suffers from nitrogen deficiency, low carboxylation efficiency and high risk of photoinhibition显示文摘 | Constantinos Nikiforou Dimosthenis Nikolopoulos Yiannis Manetas | 2011 | Journal of Plant Physiology2011，，18： | 1 |
| 12 | Spe eiation of phosphorus fractionation in river sedi ments by explanatory data analysis显示文摘 | Christos Z Katsaounos Dimosthenis L | 2007 | Water Re search2007，41，： | 1 |
| 13 | Paclitaxel and carboplatin as first-line chemotherapy combined with gefitinib (IRESSA) in patients with advanced breast cancer: a phase I/II study conducted by the Hellenic Cooperative Oncology Group显示文摘 | George Fountzilas Dimitrios Pectasides Anna Kalogera-Fountzila Dimosthenis Skarlos Haralambos P. Kalofonos Christos Papadimitriou Dimitrios Bafaloukos Stefanos Lambropoulos Savvas Papadopoulos Helen Kourea Christos Markopoulos Helen Linardou Dimitrios Mav | 2005 | Breast Cancer Research and Treatment2005，，1： | 1 |
| 14 | Effects of Interleukin-6 on Depression Risk in Dialysis Patients显示文摘 | Sonikian Makrouhi Metaxaki Polyxeni Papavasileiou Dimitrios Boufidou Fotini Nikolaou Chrysoula Vlassopoulos Dimosthenis Vlahakos Demetrios V | 2010 | American Journal of Nephrology2010，，4： | 1 |
| 15 | Effects of IFRS Adoption on Tax-induced Incentives for Financial Earnings Management: Evidence from Greece显示文摘 | Nikolaos I. Karampinis Dimosthenis L. Hevas | 2013 | International Journal of Accounting2013，，2： | 1 |
| 16 | Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic显示文摘 | Nikiforos Kapranos Eftichia Petrakou Cathrin Anastasiadou Dimosthenis Kotronias | 2003 | Fertility and Sterility2003，，： | 1 |
| 17 | Development of stir bar sorptive-dispersive microex- traction mediated by magnetic nanoparticles and its analytical application to the determination of hy- drophobic organic compounds in aqueous media 显示文摘 | JUAN LB ALBERTO C DIMOSTHENIS LG | 2014 | Journal of Chromatography A2014，，1362： | 1 |
| 18 | Quantification of Tumor Microvascularity with Respiratory Gated Contrast Enhanced Ultrasound for Monitoring Therapy显示文摘 | Michalakis Averkiou Marios Lampaskis Konstantina Kyriakopoulou Dimosthenis Skarlos Georgios Klouvas Costas Strouthos Edward Leen | 2010 | Ultrasound in Medicine & Biology2010，，1： | 1 |
| 19 | New Insights into Uric Acid Effects on the Progression and Prognosis of Chronic Kidney Disease显示文摘 | Vassilis Filiopoulos Dimitrios Hadjiyannakos Dimosthenis Vlassopoulos | 2012 | Renal Failure2012，，4： | 1 |
| 20 | Characterization, magnetic and transport properties of polyaniline synthesized through interfacial polymerization 显示文摘 | PANAGIOTIS D DIMOSTHENIS S NICHOLAOS B | 2007 | Polymer2007，48，11： | 1 |
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